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OF

ofloxacin (Floxin Otic)

✓ Approved

Daiichi Sankyo Company Limited · 小分子 · 小分子

什么是 ofloxacin？

ofloxacin 是一种小分子，由Daiichi Sankyo Company Limited研发。该药已获批，用于治疗相关适应症，给药途径：Others、Topical。

药物档案

商品名Floxin Otic
公司Daiichi Sankyo Company Limited
药物类别小分子
给药途径Others, Topical
状态Approved
来源： ClinicalTrials.gov, Daiichi Sankyo Company Limited

治疗适应症

ofloxacin 针对 4 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsOtitis externa✓ Approved
Infections and infestationsOtitis media✓ Approved
Ear and labyrinth disordersExternal ear inflammation✓ Approved
Ear and labyrinth disordersMiddle ear inflammation✓ Approved

相关研究文献

PubMedFrontiers in microbiology2026-09-04

Identification, antimicrobial susceptibility test, and pathogenicity analysis of Shigella flexneri from cynomolgus monkey (Macaca fascicularis).

Qian Ziyao Z, Li Heling H, Zhang Long L, Chen Zhigang Z et al.

Shigella flexneri (S. flexneri) is an important zoonotic pathogen. Infections caused by this bacterium in nonhuman primates, especially cynomolgus monkeys (Macaca fascicularis), represent major health risks and biosecurity concerns for laboratory animal facilities. Characterizing S. flexneri isolates originating from captive cynomolgus monkeys is essential for implementing targeted disease prevention and control strategies. In this present study, strain MF041021 was isolated from fecal samples of a dysenteric cynomolgus monkey. Species identification was accomplished using 16S rRNA gene sequencing. Additional phenotypic and genotypic characterizations included detection of virulence genes, antimicrobial susceptibility testing against clinically important agents, and screening for antimicrobial resistance genes. Pathogenicity of the isolate was evaluated via intraperitoneal inoculation in C57BL/6 mice. The isolate MF041021 (GenBank accession: PZ779204) was identified as S. flexneri by 16S rRNA sequencing. Sequence analysis revealed that the 16S rRNA gene of this isolate shared over 97.1% similarity with those of ten S. flexneri strains derived from various hosts deposited in GenBank, with the highest similarity (99.9%) observed with a human-derived strain (CP050985). Virulence gene profiling demonstrated that the isolate harbored four virulence-associated genes (ipaC, ipaH, ial, and shet1A), while the sen gene was absent. Pathogenicity was pronounced in C57BL/6 mice. Antimicrobial susceptibility testing showed that the isolate was resistant to ampicillin but susceptible to ciprofloxacin, imipenem, meropenem, levofloxacin, cotrimoxazole, and ofloxacin. Resistance gene analysis identified tetB, ampC, ant (3')-Ia, and aadA1. The cynomolgus monkey-derived S. flexneri isolate MF041021 demonstrated substantial pathogenic potential, harboring multiple virulence factors and antimicrobial resistance genes. Its close phylogenetic relationship with human-derived strains, as evidenced by 16S rRNA gene analysis, underscores the need for enhanced biosecurity, standardized husbandry practices, and prudent antimicrobial stewardship in laboratory macaque colonies. These findings from this single clinical isolate provide valuable case-level reference data for the diagnosis, prevention, and control of S. flexneri infection in captive non-human primates.

PMID 42694904
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PubMedInternational journal of pharmaceutics2026-09-03

Design and preclinical evaluation of a pH-responsive combined drug in situ gel for management of cellulitis.

Maiti Arnab Kumar AK, Mukherjee Maitreyee M, Datta Aparna A, Bhakta Pravanjan P

Global disease patterns are being rapidly reshaped by environmental changes such as rising temperatures, pollution, and more frequent natural disasters. Notable effects include a rise in skin infections, such as cellulitis, as well as upper respiratory and urinary tract infections. Cellulitis, an acute bacterial infection predominantly caused by S. aureus and Streptococcus species, is clinically challenging due to recurrence, primarily because of antimicrobial resistance and limitations of standard systemic therapies. Oral antibiotics like ofloxacin, though effective, are associated with significant suboptimal drug localization, systemic adverse effects and necessitate reliable and more targeted therapeutic approaches. This study reports the development and optimization of a pH-sensitive nanoparticle-loaded in situ gel for the local management of cellulitis. As the encapsulating polymer, Eudragit® S100 was used to load Ofloxacin via the nanoprecipitation method and optimized through Design of Experiments, achieving high entrapment efficiency of ∼96% and a nano size of 85-110 nm. These nanoparticles were incorporated into a Carbopol-HPMC-based in situ gel containing lidocaine to provide immediate pain-relieving action. The system exhibited pH-triggered sol-gel transition, enhanced viscosity under simulated wound conditions, and sustained drug release following controlled kinetics. In vitro and ex vivo studies demonstrated prolonged drug release post permeation, effective antimicrobial activity driven by MIC and MBC tests, and improved retention. In vivo evaluation in S. aureus-infected rat models confirmed reduced lesion severity, absence of skin irritation, inflammation and accelerated healing. Overall, this dual-delivery platform renders a promising scheme for concurrent pain management and sustained antimicrobial therapy, potentially improving patient compliance by altering therapeutic outcomes in cellulitis treatment.

PMID 42685878
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PubMedEnvironmental science & technology2026-09-03

Deriving Antibiotic Thresholds Under a One Health Framework: Integrating Bioaccumulation and Human Exposure in the Yangtze River Estuary Food Web.

Xu Ya-Qian YQ, Li Qian Q, Zhang Xinyang X, Guo Xingpan X et al.

Antibiotics are widely detected in aquatic environments, yet current environmental thresholds rarely integrate ecological and human health risks under a One Health framework. Here, we developed a bioaccumulation- and human exposure-based approach to derive health-protective environmental thresholds for antibiotics in the Yangtze River Estuary (YRE). Total antibiotic concentrations averaged 6.64 ± 5.91 ng/L in water, 9.65 ± 7.55 ng/g in sediment, and 56.4 ± 80.9 ng/g in aquatic organisms, with significant cross-compartmental variability and distinct compositional patterns among environmental matrices. Chloramphenicol (CAP) exhibited the strongest bioaccumulation potential (BCF up to 20,190 L/g) and was the only compound showing trophic magnification (TMF = 2.97), whereas most other antibiotics displayed trophic dilution. Derived thresholds ranged from 2.04 × 10-5-434 ng/L for water and 3.01 × 10-4-17.0 ng/g for sediment, several orders of magnitude lower than thresholds derived using traditional ecotoxicity-based approaches in previous studies. CAP, norfloxacin, and ofloxacin were identified as priority risk compounds, demonstrating that even moderate environmental concentrations can bioaccumulate through aquatic food webs and pose notable dietary exposure risks to consumers. This framework provides a more protective basis for antibiotic pollution management and environmental standard development under a One Health perspective.

PMID 42689822
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PubMedSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026-09-03

[Characteristics and Drug Resistance Analysis of Urogenital Mycoplasma Infections in Patient Specimens From Non-Gynecologic Departments].

Zhou Dan D, Yuan Yu Y, Liu Ya Y, Xiao Yuling Y

To analyze the epidemiological characteristics and drug resistance patterns of urogenital mycoplasma infections in patient specimens from non-gynecologic departmentsat West China Hospital, Sichuan University between 2020 and 2024, and to provide evidence for clinical diagnosis, treatment, and antimicrobial stewardship of mycoplasma infections in non-gynecologic patients. A total of 856 Mycoplasma culture specimens were retrospectively analyzed in the study. All specimens were submitted for lab analysis by urology, dermatovenereology, and other relevant departments (excluding gynecology) of our hospital between 2020 and 2024. Mycoplasma culture, identification, and antimicrobial susceptibility testing were performed using the bioMérieux colorimetric kit (France). The detection rate, species distribution, demographic characteristics, and antimicrobial resistance profiles of mycoplasma infections were analyzed accordingly. The overall positivity rate was 14.02% (120/856), with urethral secretions constituting the predominant specimen type (48.33%). Ureaplasma spp. infections accounted for 89.17% (107/120), Mycoplasma hominis infections for 4.17% (5/120), and co-infections for 6.66% (8/120). Among patients with non-gynecologic urogenital mycoplasma infections, the positive rate in women (24.67%) was higher than that in men (8.27%) (P < 0.05), with women exhibiting a 2.98-fold higher risk of infection (risk ratio [RR] = 2.98, 95% CI: 2.12-4.19) compared to men. The peak incidence occurred in the 30-39 age group (50.00%). High resistance to quinolones was prevalent, with resistance rates exceeding 80% for both ofloxacin and ciprofloxacin. Among macrolides, josamycin exhibited the highest susceptibility rate (93.33%). Among tetracycline-class antibiotics, all isolates were 100% susceptible to doxycycline. Urogenital mycoplasma infections are predominantly caused by Ureaplasma spp. infection, with higher incidence among women and individuals aged 30-39 years. When clear clinical indications are present, tetracycline-class antibiotics, such as doxycycline, should be considered preferential therapeutic options. Special attention should also be given to the high rates of macrolide resistance of Mycoplasma hominis infections and co-infections.

PMID 42688535
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PubMedJournal of hazardous materials2026-09-01

Switching charge transfer direction in heterojunctions: A competition of two driving forces.

Wei Xing-Peng XP, Meng Yuan Y, Yang Yu-Ting YT, Ni Hong-Gang HG

The charge transfer pathway and corresponding heterojunction type rely on the combined effects of the material's inherent properties and the interface structure. Herein, we report a crystal facet-dependent switching of charge transfer direction in TiO2/Ni3S4 composites via the competition of two driving forces (work function difference and interfacial bonding). Experimental and theoretical calculations demonstrate that when the dominant contact facet of Ni3S4 transitions from (022) to (113), the density of interfacial Ti-S bonds significantly increases. These Ti-S bonds, polarized by the electronegativity difference between S (2.58) and Ti (1.54), generate a driving force competing with the work function driving force. This competition can determine the charge transfer direction and the heterojunction type, leading to distinct active species generation: TiO2/Ni3S4-3 (S-scheme) produce •O2-, •OH, and •SO4-, while TiO2/Ni3S4-7 (type-II) generates only •OH and •SO4-, and ultimately resulting in different degradation pathways with ofloxacin as the model pollutant. This work highlights the important role of interfacial bonding in determining charge transfer direction, and introduces a "driving force competition" concept for regulating heterojunction types.

PMID 42679565
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PubMedTurkish journal of pharmaceutical sciences2026-09-01

Development of Mucoadhesive Nanofiber as an Alternate Therapeutic Regimen for Subclinical Endometritis in Cattle.

Kumari Priyanka P, Yadav Shivlal S, Tripathi Ashutosh A, Shukla Manish Kumar MK et al.

Subclinical endometritis in cattle is still a problem that has a detrimental effect on dairy production and fertility. Traditional intrauterine or systemic antibiotic treatments frequently result in suboptimal uterine drug levels, encourage resistance, and increase the possibility of drug residues in food items. The current study aimed to treat subclinical endometritis in repeat breeders by creating and testing an ofloxacin (Ofx)-loaded mucoadhesive polyvinyl alcohol/chitosan nanofiber using the electrospinning technique. The process constants were optimised using a central composite design to create a uniform nanofiber with maximum mechanical properties. Furthermore, in vitro (drug release, antibacterial activity), ex vivo (mucoadhesion and retention), and in vivo (endometrial cytology and plasma drug concentration) parameters were evaluated. The scanning electron microscopy image of Ofx nanofiber suggests a diameter of 190-210 nm and tensile strength of 1.33 tensile strength with an entrapment efficiency of 97.54 ± 0.89%. Ofx delivered via nanofiber exhibited sustained release of Ofx up to 216 hours. Ex vivo assessments demonstrated stronger adherence and higher retention, while in vitro studies showed no cytotoxic effects. In vivo studies on the cattle suggested suitability for localized intrauterine administration. These findings indicate that encapsulation of Ofx in nanofibers stabilises the formulation and offers enhanced treatment efficiency compared to a conventional treatment regimen for subclinical endometritis in repeated breeders. Ofx-loaded nanofibers offer a novel and promising localized and mucoadhesive drug delivery approach for subclinical endometritis in cattle. Future research must prioritise further in vivo validation, long-term reproductive effects, and resistance management to translate into practical veterinary uses.

PMID 42678218
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