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atenolol + nifedipine (nifedipine/atenolol / Bresben / Niften)

✓ Approved

AstraZeneca UK Limited · ADRB1 · 小分子

什么是 atenolol + nifedipine？

atenolol + nifedipine 是一种小分子，由AstraZeneca UK Limited研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名nifedipine/atenolol, Bresben, Niften
公司AstraZeneca UK Limited
药物类别小分子
分子靶点ADRB1, CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, AstraZeneca UK Limited

作用机制

分子靶点

atenolol + nifedipine 作用于 2 个分子靶点：

ADRB1adrenoceptor beta 1 (B1AR, RHR)
CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CaV1.2, CACNL1A1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

atenolol + nifedipine 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

相关研究文献

PubMedRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2026-10-25

Atosiban versus nifedipine for the management of preterm labor: a systematic review and meta-analysis of randomized controlled trials.

Pascon Alessandro A, Fumes Ana Júlia AJ, Rüdinger Nícolas Hammad NH, da Costa Ricardo Filipe Alves RFA et al.

To compare the efficacy, maternal safety, and neonatal outcomes of atosiban versus nifedipine in the management of preterm labor, with particular attention to neonatal intensive care unit (NICU) admission rates. PubMed, EBSCOHost, ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform (ICTRP), and the Cochrane Central Register of Controlled Trials were systematically searched up to May 25, 2025. No language restrictions were applied. Randomized controlled trials (RCTs) comparing atosiban and nifedipine in women with clinically diagnosed preterm labor were included, provided they reported at least one outcome related to pregnancy prolongation. Six RCTs comprising 1,070 patients met inclusion criteria. Two reviewers independently extracted data on efficacy, maternal adverse effects, and neonatal outcomes using a standardized form. Risk of bias was assessed with the Cochrane Risk of Bias 2 (RoB 2) tool. Pooled analyses showed no significant difference between atosiban and nifedipine in delaying delivery for 48 hours (risk ratio [RR] 1.09; 95% confidence interval [CI] 0.97-1.23) or 7 days (RR 1.04; 95% CI 0.89-1.22). Atosiban was associated with a significantly lower risk of maternal headache, hypotension, and tachycardia. Atosiban was associated with a non-statistically significant trend toward higher NICU admission (RR 1.36; 95% CI 0.97-1.94; p=0.079), an estimate derived from only two RCTs with substantial heterogeneity (I2=69.8%) and warranting cautious interpretation. No significant differences were observed for neonatal death, sepsis, or hemorrhagic disease. Atosiban and nifedipine offer comparable tocolytic efficacy. Atosiban carries a more favorable maternal safety profile but shows a non-significant trend toward higher NICU admission warranting confirmation in larger trials. Tocolytic selection should therefore be individualized, weighing maternal tolerability against this uncertain neonatal signal.Systematic Review Registration: PROSPERO CRD420251065426.

PMID 42923929
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PubMedPharmaceutical research2026-10-24

Time-Lapse Macro Imaging and LLM-Assisted Phenotypic Analysis of Release Dynamics in Nifedipine Controlled-Release Tablets.

Xu Ke K, Yang Yixiang Y, Chen Yuling Y, Zhang Xinzi X et al.

To develop an exploratory flow-through time-lapse macro-imaging framework combining rule-based image analysis and multimodal large language models (LLMs) for comparing release phenotypes of nifedipine osmotic pump tablets. Sixteen marketed products, comprising Adalat OROS and 15 generics, were imaged in triplicate for 36 h under sequential pH 1.0 (2 h) and pH 6.8 (34 h) conditions at 37 ± 0.5°C. Images acquired every 30 s were analyzed using a pixel color-based drug similarity method (PCDS), the Dis-GPT agent, and a pharmaceutical knowledge-base-assisted DIS Chatflow. The framework captured drug-layer extrusion, local aggregation, release continuity, and push-layer morphology. Eight generics (02, 03, 04, 10, 12, 13, 15, and 16) were classified as similar to the reference by all three methods. Product 08 was consistently classified as different, exhibiting granular extrusion, bead-like aggregation, and reduced continuity; products 06 and 07 showed method-dependent deviations in release timing and push-layer extrusion. Flow-through time-lapse imaging revealed process-level release features not represented by cumulative dissolution profiles. Combining transparent pixel-based measurements with structured LLM analysis provides an exploratory framework for comparing visible release phenotypes and generating hypotheses about release mechanisms in controlled-release tablets.

PMID 42920046
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PubMedCureus2026-10-23

Newly Diagnosed Graves' Disease Followed by the Discovery of a Cavernous Internal Carotid Artery Aneurysm Causing Panhypopituitarism: A Case Report.

Touffaha Ibrahim M IM, Elhomsy Georges G

Sellar and parasellar vascular lesions are rare causes of pituitary dysfunction and may mimic pituitary adenomas or other sellar masses. Cavernous internal carotid artery (ICA) aneurysms can cause hypopituitarism through compression of the pituitary gland or stalk, but diagnosis may be delayed when symptoms are initially attributed to a more common endocrine disorder. We report a 37-year-old man who presented with six weeks of unintentional weight loss, fatigue, heat intolerance, excessive sweating, anxiety, tremor, and tachycardia. Initial evaluation showed suppressed thyroid-stimulating hormone (TSH), elevated total triiodothyronine (T3), positive thyrotropin receptor antibody, positive thyroid-stimulating immunoglobulin, and a hypervascular thyroid gland on ultrasound, consistent with Graves' disease. He was started on methimazole and atenolol. Although thyroid function tests improved, he developed persistent neck discomfort, prompting contrast-enhanced computed tomography (CT), which revealed an enhancing sellar mass. Magnetic resonance imaging (MRI) showed a T2-hypointense sellar lesion with internal flow artifact, and CT angiography confirmed a saccular aneurysm of the cavernous segment of the right ICA. Pituitary hormone evaluation demonstrated secondary adrenal insufficiency, central hypothyroidism, hypogonadotropic hypogonadism, growth hormone (GH) deficiency, and mild hyperprolactinemia, consistent with panhypopituitarism from pituitary compression. The patient was started on prednisone and levothyroxine, and atenolol and prednisone were subsequently discontinued before endovascular embolization was performed. At follow-up, symptoms improved, but panhypopituitarism persisted. This case highlights the importance of reassessing patients when endocrine symptoms evolve despite an initially appropriate diagnosis.

PMID 42910339
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PubMedAnalytical chemistry2026-10-20

DES-Based Green Synthesis of 2D Fluorescent Molybdenum Disulfide for Highly Sensitive and Selective Detection of Nifedipine.

Ullah Rafee R, Rehman Shams Ur SU, Khan Adnan A, Wu Hui-Fen HF

Highly fluorescent 2D MoS2-x nanosheets exhibiting intense blue emission were synthesized using a green chemistry approach, utilizing DES as both the reaction medium and a surface passivating agent. The material was synthesized via a hydrothermal method, followed by ultrasonication-assisted exfoliation to yield ultrathin nanosheets with enhanced photoluminescence properties. The 2D MoS2-x nanosheets demonstrated strong fluorescence at λem = 420 nm when excited at λex = 330 nm. These nanosheets were employed as a fluorescence probe for the detection of the calcium channel blocker drug nifedipine (NIF) via a fluorescence quenching mechanism. Upon addition of NIF, the fluorescence of the 2D MoS2-x nanosheets was quenched due to electron transfer from the nanosheets to the electron-deficient NIF molecules, combined with the inner filter effect (IFE). The nanosheets enabled highly sensitive and selective detection of NIF, with photoluminescence spectroscopy revealing a broad linear detection range of 0.6-360 nM (R2 = 0.993) and an exceptionally low limit of detection (LOD) of 0.40 nM. The system showed high selectivity toward NIF over structurally similar compounds, drugs, and common metal ions. The sensor was effectively applied for the detection of NIF in urine and Lotus Pond water samples, highlighting its potential for practical pharmacological monitoring. This study presents a sustainable and effective approach for fabricating DES-assisted 2D nanosheets for trace-level analyte detection.

PMID 42899538
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PubMedAmerican journal of hypertension2026-10-19

Amlodipine and Nifedipine Associations with B-Type Natriuretic Peptide in Women with Hypertension and Heart Failure with Preserved Ejection Fraction.

Harada Eisaku E, Yamada Toshihiro T, Mizuno Yuji Y, Arima Yuichiro Y et al.

Calcium channel blockers (CCBs) are frequently prescribed to manage hypertension in patients with heart failure with preserved ejection fraction (HFpEF). However, whether individual dihydropyridine agents exert uniform class effects on myocardial wall stress remains unclear. This retrospective, single-center observational study analyzed 465 consecutive patients with hypertension and HFpEF (354 women and 111 men) evaluated at Kumamoto Kinoh Hospital between May 2012 and July 2018. Multivariable linear regression models assessed associations between individual dihydropyridine CCBs (amlodipine vs. nifedipine) and plasma log-transformed B-type natriuretic peptide (lnBNP) levels. In multiple imputation models among women, adjusted differences in lnBNP relative to no-CCB were 0.236 (95% CI, 0.031 to 0.441) for nifedipine and -0.118 (95% CI, -0.273 to 0.037) for amlodipine. Direct linear contrasts in women confirmed lower lnBNP levels with amlodipine than with nifedipine (adjusted difference, -0.355; 95% CI, -0.562 to - 0.147). In men, the corresponding amlodipine-versus-nifedipine difference was -0.051 (95% CI, -0.697 to 0.595; P=0.876). The formal sex-by-drug interaction contrast in complete-case analysis yielded an adjusted difference of - 0.424 (95% CI, -1.055 to 0.208; P = 0.188), with male precision constrained by sample size (7 male nifedipine users). In women with hypertension and heart failure with preserved ejection fraction, amlodipine use was associated with lower adjusted ln(BNP) levels than nifedipine use. These observational findings challenge the assumption of an interchangeable dihydropyridine class effect on myocardial wall stress, suggesting that individual pharmacological profiles-rather than uniform class-level equivalence-warrant attention in clinical evaluations.

PMID 42895302
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PubMedBriefings in bioinformatics2026-10-19

Metabolomics workbench: data-driven classification and correlation analysis between metabolite classes, biomarkers, and drugs.

Khandokhin Mikhail M MM, Sokolov Aleksandr A, Oskolkov Nikolay N, Fredriksson Robert R et al.

Public repositories now accumulate an unprecedented amount of metabolomics data. Despite the opportunities for large-scale meta-analyses opened by these repositories, the deposited data rarely becomes systematically re-analyzed. We conducted a systematic metadata-based re-analysis of all human blood metabolomics studies in the Metabolomics Workbench performed using Orbitrap or QTOF mass spectrometry, encompassing 44 165 samples. After harmonizing metabolites with PubChem identifiers and embedding them using SMILES representations, we generated a map of 6752 blood metabolites forming 25 structural clusters, and subsequently performed correlation analysis between these clusters, biomarkers, and drugs. Analysis of 337 120 metabolite pairs detected in at least 10 studies showed that structurally related clusters display correlated abundances (ρ up to 0.6). Correlation patterns among established clinical biomarkers revealed candidate metabolic correlates, several with ρ > 0.7. We also developed open-source software enabling similar analyses for any metabolite across the Workbench data explored. Additionally, curating drug-containing datasets enabled meta-analyses for compounds such as acetaminophen, metoprolol, and atenolol, identifying both known and novel metabolic signatures. Besides the biological insights, we have found that Orbitrap and QTOF tend to detect different metabolites, but they give quantitatively coherent results on overlapping compounds. Overall, the present study provides the methodology and software to perform large-scale mining of public metabolomics data enabling its re-analysis to obtain novel biomedical insights.

PMID 42894388
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