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immunoglobulin G

✓ Approved

Quimbiotec · 多克隆抗体 · 多克隆抗体

什么是 immunoglobulin G？

immunoglobulin G 是一种多克隆抗体，由Quimbiotec研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

公司Quimbiotec
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Quimbiotec

治疗适应症

immunoglobulin G 针对 4 个适应症，涉及 4 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersGuillain-Barre syndrome✓ Approved
Skin and subcutaneous tissue disordersPurpura✓ Approved
Immune system disordersImmunodeficiency✓ Approved
Infections and infestationsBorna virus infection✓ Approved

相关研究文献

PubMedCureus2026-10-27

Mixed Autoimmune Hemolytic Anemia as the Initial Manifestation of Systemic Lupus Erythematosus: A Case Report.

Iqbal Tariq T, Chivero Cleopatra C, Farhana Sharmin S

Mixed autoimmune hemolytic anemia (mAIHA) is a rare subtype of autoimmune hemolytic anemia (AIHA) characterized by the coexistence of warm (immunoglobulin G (IgG)) and cold (immunoglobulin M (IgM)) autoantibodies. It may occur as a primary disorder or secondary to underlying conditions, including systemic lupus erythematosus (SLE). We report the case of a 16-year-old female who presented with severe hemolytic anemia as the initial manifestation of SLE. On admission, her hemoglobin was 34 g/L with marked reticulocytosis and a positive direct antiglobulin test (DAT) demonstrating both IgG and IgM antibodies, confirming mAIHA. Immunological investigations revealed positive antinuclear antibody (ANA), anti-double-stranded DNA (anti-dsDNA) antibody, and anti-Smith antibody, supporting a diagnosis of SLE. At the time of the first presentation, she had no other clinical features suggestive of SLE. She was treated with blood transfusions and corticosteroids, resulting in significant improvement, and was discharged on a tapering prednisolone regimen. Shortly after, she was readmitted with a malar rash, arthralgia, joint swelling, nephrotic-range proteinuria, and worsening renal function. She was subsequently diagnosed with SLE complicated by lupus nephritis and recurrent AIHA. Following the rheumatology and nephrology review, she received intravenous methylprednisolone and was transferred to a tertiary care center for renal biopsy and further management. Renal biopsy demonstrated focal segmental glomerulosclerosis (FSGS). Further treatment with prednisolone, mycophenolate mofetil, intravenous belimumab, and hydroxychloroquine resulted in an excellent clinical response, with follow-up confirming remission. This case highlights mAIHA as a rare initial presentation of SLE and underscores the importance of early recognition, close monitoring, and multidisciplinary management, as patients presenting with AIHA may be at increased risk of developing lupus nephritis and other severe SLE-related complications.

PMID 42936060
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PubMedVeterinary sciences2026-10-27

Exploratory Evaluation of Refractometric, Biochemical, and Body Weight Change Parameters for Diagnosing Failure of Passive Transfer in Puppies.

Kara Halime H, Şenel Yasin Y, Kaya Ufuk U, Güven Mustafa M et al.

Failure of passive transfer (FPT) is an important determinant of survival in neonatal puppies. Practical indirect indicators that could serve as alternatives to measuring serum immunoglobulin G (IgG) have not yet been adequately characterized. In this exploratory study, 76 Turkish Kangal puppies aged 48 ± 4 h, born to 12 dams (mean age 40.2 months) were evaluated. Serum IgG measured by ELISA was the reference method, with values below 2.3 g/L classified as FPT. Whole-blood, fresh-serum, and frozen-thawed serum Brix values were evaluated together with serum total protein, albumin, globulin, gamma-glutamyl transferase, canine parvovirus antibody levels, and percentage change in body weight from birth to sampling, using receiver operating characteristic analysis. FPT was identified in six puppies (7.9%). The area under the curve (AUC) values for total protein, globulin, and percentage change in body weight were 0.986, 0.981, and 0.948, respectively, with the associated cutoffs considered exploratory; each detected all six cases with 82.9-94.3% specificity. Fresh-serum Brix showed moderate discrimination (AUC: 0.771), whereas whole-blood Brix was inconclusive (AUC: 0.432). Total protein, globulin, and early body weight change are promising screening indicators for detecting FPT. However, because of the limited number of cases, their cutoffs should be validated in larger populations, including other breeds, before clinical use.

PMID 42944217
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PubMedAntioxidants (Basel, Switzerland)2026-10-27

Protective Effects of Dietary Epigallocatechin-3-Gallate in Weaned Pigs Exposed to Oxidative Stress.

Duan Qiming Q, Li Xiang X, Xie Kunhong K, Yu Aibing A et al.

Epigallocatechin-3-gallate (EGCG), a major catechin in green tea, possesses antioxidant and immunomodulatory properties. We hypothesized that dietary EGCG supplementation before oxidative challenge would attenuate Diquat-induced redox disturbance and help maintain intestinal epithelial integrity and immune-related homeostasis in weaned pigs. To test this hypothesis, 32 weaned piglets were assigned to a 2 × 2 factorial arrangements involving dietary EGCG supplementation (0 or 50 mg/kg) and saline or Diquat challenge (10 mg/kg body weight). Dietary EGCG increased serum superoxide dismutase activity and immunoglobulin A, G, and M concentrations and decreased serum IL-1β, whereas Diquat decreased superoxide dismutase activity and immunoglobulin concentrations and increased TNF-α (p < 0.05). A significant EGCG × Diquat interaction was detected for serum total antioxidant capacity (p = 0.020), which was increased by EGCG in Diquat-challenged pigs (Sidak-adjusted p = 0.001). Significant interactions were also observed for duodenal and jejunal ZO-1 immunoreactivity, jejunal sIgA immunoreactivity, and jejunal epithelial apoptosis (p < 0.05). Under Diquat challenge, EGCG increased ZO-1 and sIgA immunoreactivity and reduced TUNEL-positive staining (adjusted p < 0.05). Intestinal gene-expression responses were segment dependent: EGCG was associated with increased IL-10 and FOXP3 expression and with reduced expression of IL-17, IL-22, RORγT, STAT3, caspase-3, caspase-9, and BAX in several intestinal segments, particularly in Diquat-challenged pigs. Collectively, the observed findings indicate associations between dietary EGCG supplementation and systemic antioxidant and immune indices, epithelial barrier-related characteristics, immune-cell phenotypes, and mucosal transcriptional responses. Given the number of outcomes examined and the absence of a global multiplicity adjustment, these findings should be interpreted as exploratory and do not establish a specific protective mechanism.

PMID 42939844
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PubMedCurrent opinion in nephrology and hypertension2026-10-27

Advances in HLA desensitization for kidney transplant candidates.

Chandran Sindhu S, Huang Edmund E, Vo Ashley A, Jordan Stanley S

Human leukocyte antigen (HLA) sensitization is a significant barrier to kidney transplantation. The goal of HLA desensitization is to increase access to transplantation and reduce the risk of antibody-mediated rejection and graft loss. This review outlines currently used therapies and highlights novel strategies for HLA desensitization. Important advances include promising data on imlifidase, a novel immunoglobulin G (IgG) endopeptidase that cleaves IgG molecules into Fc and F(ab)'2 fragments, negating antibody-dependent cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). A positive phase III study will likely lead to FDA approval in December 2026. Additionally, initial reports of HLA desensitization using ant-CD38 monoclonal antibodies, bispecific T cell engagers targeting B-cell maturation antigen (BCMA), and chimeric antigen receptor T cells targeting CD19 and BCMA, suggest improved efficacy at HLA antibody reduction and lower risk of posttransplant DSA rebound. Newer, more potent agents targeting pathogenic IgG molecules, B-cells and plasma cells are likely to improve the efficacy of HLA desensitization regimens. As data emerge from ongoing clinical trials, the clinical applicability of such therapies will depend, in addition to efficacy, on their safety profile, cost and complexity of use.

PMID 42936964
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PubMedOne health (Amsterdam, Netherlands)2026-10-27

Epidemiology of animal bites and post-exposure vaccination coverage in Davao City, Philippines: A five-year retrospective cohort study, 2019-2023.

Hinay Alfredo A AA, Parilla-Sarabia April Joy AJ, Reyes Jennifer Ashley H JAH, Lopez Mariel Phoebe M MPM et al.

Rabies remains a major public health threat in the Philippines, particularly in urban areas such as Davao City, where frequent animal bites from domestic reservoirs increase the transmission risk at the human-animal-environment interface. Detailed epidemiological data on animal bites and post-exposure prophylaxis (PEP) coverage are limited. This One Health-framed retrospective cohort study describes trends in bite incidents, assesses PEP coverage, and identifies gaps in rabies prevention efforts from 2019 to 2023. Surveillance data from the Davao City Animal Bite Treatment Centers captured 98,442 cases. Dogs caused 63.5% of bites, with a significant upward trend (p = 0.027; τ = 1.0, 95% CI 0.200-1.800); cat bites (36.4%) rose sharply, indicating an emerging reservoir challenge. Children ≤15 years of age showed a significant increase (p = 0.027). The 3rd congressional district had the most pronounced rise across demographics and exposure categories. Tissue culture vaccine coverage remained at 100%, equine rabies immunoglobulin rose from 18.5% to 85.9%, whereas human rabies immunoglobulin remained low post-COVID. Despite universal TCV access, immunoglobulin gaps limit its control. Rising cat bites and severe exposures demand integrated One Health strategies, enhanced surveillance, animal vaccination, and supply chain strengthening, to achieve zero human rabies deaths by 2030.

PMID 42935849
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PubMedPharmaceutics2026-10-27

Molecular Interactions of Bioactive Peptides with Proteins and DNA.

Kotynia Aleksandra A, Krzyżak Edward E, Czyżnikowska Żaneta Ż, Marciniak Aleksandra A

Background: This study investigates the molecular recognition of two biologically active peptides (P1 and P2) by key biomacromolecular targets. The studied peptides were previously identified in Babylon snail hydrolysates and have been shown to exhibit antioxidant and cytotoxic activities against Caco-2 colorectal cancer cells. Given their reported biological potential, we decided to investigate both compounds from a different perspective. Their interactions with human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lysozyme (LYS), immunoglobulin G (IgG), and DNA were evaluated. Methods, Results and Conclusions: Spectroscopic analyses revealed concentration-dependent binding of the studied peptides to plasma proteins under investigations. Notably, peptide binding did not substantially alter the secondary structure of the target proteins, indicating that complex formation occurs without significant structural perturbation. Molecular docking further supported the formation of peptide-protein complexes, highlighting the contribution of hydrogen bonding and hydrophobic contacts to molecular recognition. The combined spectroscopic and docking results were consistent with a predominantly non-intercalative, possibly minor-groove-associated interaction with ctDNA. Taken together, these findings provide a comparative physicochemical characterization of the interactions of P1 and P2 with selected proteins and ctDNA. These findings provide insight into the molecular recognition properties of P1 and P2 and support further investigation of their biological relevance.

PMID 42942842
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