cisplatin powder (Randa / IA CALL)

✓ Approved

什么是 cisplatin powder？

cisplatin powder 是一种小分子，由Nippon Kayaku Co.,Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intraarterial Injection。

药物档案

商品名	Randa, IA CALL
公司	Nippon Kayaku Co.,Ltd.
药物类别	小分子
给药途径	Injectable (Others), Intraarterial Injection
状态	Approved

来源： ClinicalTrials.gov, Nippon Kayaku Co.,Ltd.

治疗适应症

cisplatin powder 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域	疾病/病症	分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)	Hepatic cancer	✓ Approved

相关研究文献

PubMedInternational journal of cancer2026-07-27

Clinical Relevance of BACH1 Expression in Non-Small Cell Lung Cancer.

Liu Jing J, Schneider Marc A MA, Held Julia J, Wrenger Sabine S et al.

BTB and CNC homolog 1 (BACH1) is a redox-sensitive transcription factor implicated in tumor progression, metabolic reprogramming, and therapy resistance in several cancers. However, its prognostic significance and role in therapy resistance in non-small cell lung cancer (NSCLC) remain unclear. BACH1 mRNA and protein expression were quantified in resected lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) tissues and matched non-tumor lung tissues and correlated with clinicopathological parameters, adjuvant chemotherapy status, and disease-free survival (DFS). Prognostic value was assessed using Kaplan-Meier and multivariate Cox regression analyses. In vitro, BACH1 expression was evaluated in seven NSCLC cell lines. Cisplatin sensitivity was determined by Annexin V apoptosis assays, and BACH1 silencing in H1975 and H1437 cells was used to assess effects on cisplatin response, migration, and colony formation. BACH1 expression was lower in LUAD and LUSC than in matched normal lung tissues but was higher in stage III tumors and in patients receiving adjuvant chemotherapy. In LUAD, high BACH1 expression was associated with shorter DFS, particularly in adjuvant chemotherapy. A significant interaction between BACH1 expression and chemotherapy suggested that the benefit of cisplatin-based treatment differed according to BACH1 status. Across seven NSCLC cell lines, BACH1 expression positively correlated with cisplatin resistance (r = 0.44, p = 0.035). BACH1 silencing enhanced cisplatin-induced cell death, suppressed migration, and clonogenic growth in H1975 and H1437 cells. Collectively, these findings identify BACH1 as a potential prognostic and predictive biomarker in chemotherapy-treated LUAD and support a functional role for BACH1 in mediating cisplatin resistance.

PMID 42503861

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PubMedGels (Basel, Switzerland)2026-07-27

Investigating the Performance of Asphalt Modified with Rubber Powder and Surface Organic Layered Double Hydroxides.

Fang Chenze C, Guo Xu X, Chen Yuanzhao Y, Li Zhenxia Z et al.

In order to promote the sustainable development of road engineering, this study used waste tire rubber powder (RP) and surface organic layered double hydroxide (SOM-LDHs) to modify 70# matrix asphalt. The Box-Behnken design response surface method with three factors (rubber powder content, surface organic layered double hydroxide content, shear temperature) and three responses (penetration, ductility, softening point) was used to optimize the preparation parameters. The optimum formula was determined to be 21.7% rubber powder content, 4.8% surface organic layered double hydroxide content, and 160 °C shear temperature. The effect of the modifier on the surface morphology was analyzed using a rotating film oven test and ultraviolet aging test. The high and low temperature rheological properties of asphalt were evaluated by dynamic shear rheometer (DSR), bending beam rheometer (BBR), and the multi-stress creep recovery test (MSCR). The microstructure was observed by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The aging mechanism was investigated by Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The results show that after aging, the complex shear modulus of rubber powder/surface organic layered double hydroxide composite modified asphalt is the highest, which is 27.35% higher than that of matrix asphalt. The rutting factor reaches 79.86 kPa at 46 °C, the phase angle decreases by 11.83% after UV aging, and the high temperature plastic deformation resistance is the best. In the low temperature range of -18 °C to -24 °C, the creep stiffness of the composite modified asphalt is about 30% lower than that of the matrix asphalt, while the m value is increased by about 15%, and the low temperature stress relaxation performance is significantly improved. The strain recovery rate of composite modified asphalt under 3.2 kPa stress reaches 78.5%, and the unrecoverable creep compliance is as low as 0.18 kPa-1, which is better than that of matrix asphalt and single rubber powder modified asphalt.

PMID 42505323

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PubMedJournal of medicinal chemistry2026-07-27

Molecular Construction and Anti-Bladder Cancer Study of Novel TOP1/PARP1 Dual-Target Inhibitors.

Wang Wenchao W, Li Dan D, Liu Jin J, Li Lei L et al.

Bladder cancer is a malignant tumor with a high incidence and mortality worldwide. Clinically, DNA-damaging agents such as cisplatin, irinotecan, and gemcitabine are commonly used, but their efficacy is often limited by acquired resistance. A key resistance mechanism involves the upregulation of PARP1 in response to drug-induced DNA single-strand breaks (SSBs), which diminishes the therapeutic effect. To overcome this obstacle, we designed and synthesized a series of united TOP1/PARP1 inhibitors that simultaneously induce SSBs via TOP1 inhibition and block their repair via PARP1 inhibition, converting repairable SSBs to lethal double-strand breaks (DSBs). Among these, compound D5 exhibited excellent dual-target inhibitory activity and effectively overcame cisplatin resistance, demonstrating potent antitumor efficacy in vitro and in vivo (TGI = 65.7%). Collectively, D5 represents a promising TOP1/PARP1 inhibitor for overcoming resistance to conventional DNA-damaging chemotherapies.

PMID 42504569

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PubMedLangmuir : the ACS journal of surfaces and colloids2026-07-27

Cholesteryl-Modified Amino Acid-Derived Organogelators: Their Versatile Removal Behaviors toward Various Organic Pollutants in Contaminated Water.

Zhang Xin X, Gao Yuan Y, Wang Xinyue X, Yu Ziqian Z et al.

The development of techniques for removing organic pollutants from water is of great practical significance for improving the human living environment. Low-molecular-weight organogelators (LMWOGs) can remove organic pollutants from water through multiple mechanisms. In this work, we report two amino acid-based gelators (CH-1 and CH-2) bearing a cholesteryl group, synthesized through a single-step procedure, both of which could form gels in several organic liquids. Systematic testing showed that these two gelators can remove various organic pollutants from water using different methods. Gelator CH-2 can directly use its powder to adsorb paraquat, achieving a removal efficiency of over 96%. CH-1 not only serves as a phase-selective gelator in powder form to remove undissolved nitrobenzene from water but also effectively removes the majority of dissolved nitrobenzene. Moreover, the removal efficiency of 88% significantly exceeds that of previously reported data. Additionally, the gel obtained from CH-1 in methyl benzoate, when used in a gel column, can rapidly and effectively remove phenol from water. Overall, the developed gelators, with advantages such as simple synthesis, environmental friendliness, reusability, and efficient decontamination, show great potential for applications in the removal of organic pollutants.

PMID 42503713

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PubMedInorganic chemistry2026-07-27

Topological Z2 Invariants in the Metallic Bismuthide Series A1-xT2Bi2 (A = Na, K, Rb, Cs; T = Zr, Hf; x = 0-0.27).

Werhahn Dominik D, Griggel Carina F CF, Johrendt Dirk D

The bismuthides A1-xT2Bi2 (A = Na, K, Rb, Cs; T = Zr, Hf; x = 0 - 0.27(2)) were synthesized as air-sensitive black powders with small metallic crystals. X-ray powder diffraction determined their tetragonal structure with space group I4/mmm as a ternary ordered i5-superstructure of bcc packing. This is an isopointal variant of the Er2Mg2Ru structure type, with interatomic distances and density functional theory (DFT) calculations suggesting layers of edge-sharing TBi5 pyramids alternating with layers of alkali metal in a cubic coordination. Electrical resistivity measurements of Rb1-xHf2Bi2 show metallic behavior matching the crystal and powder appearance. Magnetic susceptibility measurements show a weak, nearly temperature-independent paramagnetic signal suggesting Pauli paramagnetism. Analysis of the fully relativistic band structure employing the Fu-Kane approach reveals nontrivial topological properties characterized by Z2 = (1;111) and Z4 = 3 invariants for all eight compounds. This robust topological nature remains unaffected by the substitution of alkali metal and transition metal components, demonstrating that nontrivial topology is an intrinsic property of this structure type, driven by the strong spin-orbit coupling of the bismuth sublattice.

PMID 42503778

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PubMedInsects2026-07-27

House Cricket (Acheta domesticus) as a Promising Functional Ingredient: A Synoptical Review on Nutritional Value, Technological Properties and Sustainability Perspectives.

Oliveira Filipa F, Vítor Rute F RF, Silva Maria Manuela MM, Dias Igor I

The house cricket (Acheta domesticus) is among the edible insect species authorized under the European Union novel food framework and is increasingly explored as a food ingredient. This review synthesizes current evidence on its nutritional composition, techno-functional properties, safety, sustainability, and application potential for human consumption. A. domesticus powder is a nutrient-dense ingredient, with reported protein contents ranging from 57.4 to 76.19 g/100 g dry material, together with a relevant amino acid profile, unsaturated lipid fraction, chitin-associated fiber, and selected minerals and vitamins. Its techno-functional profile, including water absorption capacity around 175%, oil absorption capacity around 140%, and emulsifying capacity around 77.7%, supports applications in bakery products, snacks, pasta, meat analogs, and protein-enriched foods. From a sustainability perspective, reported feed conversion ratios around 1.5-1.9 and controlled indoor rearing strengthen its relevance for scalable production, although outcomes depend on substrate choice, energy inputs, production scale, and processing conditions. Safety issues, especially allergenicity, cross-reactivity, microbial control, and contaminant monitoring, remain central to industrial use. Overall, A. domesticus powder has emerged and should be regarded as a nutritionally valuable, technologically versatile and promising functional ingredient for sustainable food innovation.

PMID 42505860

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cisplatin powder (Randa / IA CALL)

什么是 cisplatin powder？

药物档案

治疗适应症

相关研究文献

Clinical Relevance of BACH1 Expression in Non-Small Cell Lung Cancer.

Investigating the Performance of Asphalt Modified with Rubber Powder and Surface Organic Layered Double Hydroxides.

Molecular Construction and Anti-Bladder Cancer Study of Novel TOP1/PARP1 Dual-Target Inhibitors.

Cholesteryl-Modified Amino Acid-Derived Organogelators: Their Versatile Removal Behaviors toward Various Organic Pollutants in Contaminated Water.

Topological Z2 Invariants in the Metallic Bismuthide Series A1-xT2Bi2 (A = Na, K, Rb, Cs; T = Zr, Hf; x = 0-0.27).

House Cricket (Acheta domesticus) as a Promising Functional Ingredient: A Synoptical Review on Nutritional Value, Technological Properties and Sustainability Perspectives.

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