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cisplatin powder (Randa / IA CALL)

✓ Approved

Nippon Kayaku Co.,Ltd. · 小分子 · 小分子

什么是 cisplatin powder？

cisplatin powder 是一种小分子，由Nippon Kayaku Co.,Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intraarterial Injection。

药物档案

商品名Randa, IA CALL
公司Nippon Kayaku Co.,Ltd.
药物类别小分子
给药途径Injectable (Others), Intraarterial Injection
状态Approved
来源： ClinicalTrials.gov, Nippon Kayaku Co.,Ltd.

治疗适应症

cisplatin powder 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Hepatic cancer✓ Approved

相关研究文献

PubMedOncology letters2026-09-10

CCT2 defines a highly cisplatin-resistant and poor-prognosis subtype of lung adenocarcinoma.

Mao Huafang H, Su Chao C, Han Xiaoliang X, Wang Guoxia G

Cisplatin-based chemotherapy is a standard treatment for lung adenocarcinoma (LUAD), yet acquired cisplatin resistance remains a marked cause of treatment failure. The molecular mechanisms driving cisplatin resistance in LUAD have not been fully elucidated. The present study integrated bulk transcriptomic data, genomic mutation profiles and single-cell RNA sequencing data to systematically investigate cisplatin resistance in LUAD. Resistance-associated genes were identified through differential expression, survival analysis and database integration. Unsupervised clustering was used to define cisplatin resistance-associated subtypes. Functional characteristics were explored using pathway enrichment, immune infiltration, tumor mutation burden and weighted gene co-expression network analysis. A machine learning framework incorporating 101 algorithms was applied to identify key genes and construct a prognostic model. Single-cell analyses and in vitro experiments were performed to validate the biological role of the core gene. Molecular docking and molecular dynamics simulations were conducted to identify potential therapeutic compounds. A total of two molecular subtypes with distinct cisplatin resistance levels and prognostic outcomes were identified. The high-resistance subtype exhibited enhanced cell cycle activity, DNA repair signaling and immune heterogeneity. Machine learning analysis revealed a five-gene signature, with chaperonin-containing TCP1 subunit 2 (CCT2) emerging as a key regulator of cisplatin resistance. Single-cell analyses showed that CCT2 was predominantly enriched in resistant epithelial cell subpopulations. Functional experiments demonstrated that CCT2 knockdown significantly inhibited cell proliferation and enhanced cisplatin sensitivity in LUAD cell lines. A number of candidate compounds targeting CCT2 exhibited stable binding in silico. The present findings identified CCT2 as a key mediator of cisplatin resistance in LUAD and provided potential therapeutic strategies to overcome chemotherapy resistance.

PMID 42719221
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PubMedJournal of microbiology and biotechnology2026-09-10

Bacillus subtilis DES-59 Modulates Microbial Community Structure and Aroma Formation in Cigar Fermentation to Improve the Quality of Heat-Not-Burn (HnB) Tobacco.

Liang Lu-Xin LX, Zhu Ming-Jun MJ, Zhao Lu L

Cigar tobacco is characterized by high protein and low sugar contents, which limits the sensory performance of cigar-flavored heat-not-burn (HnB) products. In this study, Yunxue 6 cigar tobacco powder was fermented with Bacillus subtilis DES-59 for 7 days under solid-state culture at 25oC and 65% relative humidity. Compared with the control group, fermented tobacco exhibited a 10.55% reduction in protein, alongside 30.10% and 47.86% increases in total free amino acids and reducing sugars, respectively. Py-GC/MS analysis at 350°C showed increased release of pyrolytic aroma compounds, with the relative abundances of esters, aldehydes / ketones, and phenols increasing by 86.95%, 58.53%, and 35.69%, respectively. Sensory evaluation of HnB cigarettes manufactured from the fermented tobacco powder showed an overall sensory score improvement from 79.00 to 83.00, mainly driven by enhanced aroma and flavor. High-throughput sequencing demonstrated that inoculation reshaped the bacterial community, increasing the relative abundance of Bacillus from 12.20% to 52.40%. PICRUSt functional prediction suggested an increased functional potential for amino acid and carbohydrate metabolism in the treated group. Overall, inoculation with B. subtilis DES-59 was associated with changes in the chemical composition, bacterial community structure, pyrolysis-derived aroma profile, and sensory characteristics of cigar tobacco powder. These findings provide preliminary evidence supporting the potential application of B. subtilis DES-59 in the fermentation of cigar tobacco powder for the development of cigar-flavored raw materials for HnB products.

PMID 42717702
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PubMedExperimental and therapeutic medicine2026-09-10

PDK1/AKT signaling is involved in the anti-tumor effect of gramine and cisplatin chemoresistance in ovarian cancer cells.

Wang Haiyan H, Zheng Ruiming R, Wang Bujun B, Hong Sumiao S et al.

Ovarian cancer (OC) remains one of the most lethal gynecologic malignancies, with limited therapeutic options and poor long-term prognosis. Gramine, an indole alkaloid predominantly derived from the rhizomes of Arundo donax L., has demonstrated antitumor activity in various cancer types; however, its effects and mechanistic basis in OC have not been systematically investigated. In the present study, the biological activity of gramine in OC cells were evaluated using cell counting kit-8, colony formation and EdU assays for proliferation; TUNEL staining for apoptosis; and wound healing and Transwell assays for migration and invasion. Western blotting was performed to examine underlying molecular changes. The present results showed that gramine significantly suppressed OC cell proliferation, migration and invasion, while promoting cell apoptosis. Mechanistically, gramine reduced PDK1 protein levels, and enforced PDK1 overexpression largely reversed the suppressive effects of gramine on malignant phenotypes. Consistently, PDK1 restoration also attenuated gramine-induced downregulation of phosphorylated AKT. Furthermore, gramine enhanced the sensitivity of OC cells to cisplatin, an effect associated with PDK1/AKT signaling inhibition. Collectively, these findings suggest that gramine inhibits malignant progression and attenuates cisplatin resistance in OC cells, at least in part, through blockade of the PDK1/AKT pathway. Although limited to in vitro models, this work provides preliminary evidence supporting further exploration of gramine as a potential research tool or lead compound in OC.

PMID 42719404
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PubMedAAPS PharmSciTech2026-09-10

Solid Lipid Nanoparticles Based Dry Powder Inhalers for Enhanced Drug Delivery Against Lung Diseases.

Onel Cagla C, Pirincci Tok Yagmur Y, Ozsoy Yildiz Y

The global incidence of lung diseases associated with high mortality and morbidity rates is projected to rise in the coming years. Conventional therapies face limitations such as low bioavailability and systemic side effects with oral administration, as well as poor patient compliance and frequent dosing with traditional inhalers. These shortcomings have created an urgent need for novel pulmonary drug delivery systems. In recent years, nanoparticulate drug carriers have gained significance for their potential to enable targeted lung delivery and reduced dosing frequency. Among them, solid lipid nanoparticles (SLNs) have attracted considerable attention due to their biocompatible and biodegradable structures, controlled release capabilities, organic solvent-free production processes and favorable aerodynamic behavior. This review provides a comprehensive perspective to guide the rational design of SLN-based dry powder inhaler (DPI) systems by integrating formulation strategies, production techniques, surface functionalization, and DPI development, with the goal of enhancing therapeutic outcomes in respiratory diseases such as cancer, infections, chronic obstructive pulmonary disease, and cystic fibrosis.

PMID 42717150
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PubMedAAPS PharmSciTech2026-09-10

Spray Freeze Drying for Solid Formulations of RNA Lipid Nanoparticles.

Arte Kinnari Santosh KS, Sapkota Rachana R, Patil Chanakya D CD, Huang Yijing Y et al.

Spray-freeze drying (SFD) is a promising drying technique for stabilizing RNA lipid nanoparticles (RNA-LNPs) by converting them into solid-state formulations. This study examined the impact of the SFD process and the widely utilized stabilizing disaccharides, such as sucrose and trehalose, on the major properties (e.g. particle size, encapsulation efficiency) of RNA-LNPs post drying. Various process parameters, such as atomization, freezing, and drying temperature, were systematically evaluated, along with the impact of incorporating annealing post freezing step. Surface area measurements, solid-state particle size analysis, scanning electron microscopy, powder X-ray diffraction and solid-state NMR spectroscopy were employed to gain deeper insights into powder characteristics and matrix mobility. Our findings demonstrated that sucrose provided superior stabilization as compared to trehalose in our tested formulations and processes. Moreover, incorporation of the annealing process enhanced LNP stability. Results from the stability study revealed that the annealed 10% and 20% sucrose formulations maintained their stability, highlighting the potential of optimized SFD processing for producing solid formulations of RNA-LNPs.

PMID 42717177
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PubMedAngewandte Chemie (International ed. in English)2026-09-10

Hydraulicity in Organic Polymers Enabled by Hydrophobization Upon Water-Triggered Curing of Hydrophilic Chains.

Tokumitsu Rei R, Uebo Shio S, Takahashi Akira A, Otsuka Hideyuki H

Water-curing capability of cementitious materials, commonly known as hydraulicity, is key to their widespread use through simply mixing powder with water to form desired robust structures. However, hydraulicity has been difficult to achieve for organic materials due to the lack of a strategy for wet curing while ensuring water resistance after curing. Here, we report unprecedented hydraulicity in an organic polymer enabled by an unusual water-induced polarity inversion, in which the reaction of a hydrophilic polymer with water induces hydrophobization via sol-gel reaction of silatrane. A model study using a low-molecular-weight silatrane revealed that water drives the sol-gel reaction, which is autocatalyzed by triethanolamine generated in situ. A silatrane-containing polymer, prepared by conventional free-radical polymerization, was obtained as a powder but rapidly plasticized upon addition of water. The formed sticky putty gradually transformed first into a soft hydrogel and finally into a rigid solid through hydrophobization associated with the formation of silsesquioxane structures. This unique behavior enabled not only wet molding into desired structures but also underwater adhesion, as demonstrated by repairing a broken vial and bonding substrates. These findings provide a versatile design strategy for organic materials exhibiting hydraulicity.

PMID 42717841
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