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Loxosceles Immune F(Ab)2 (Reclusmyn)

✓ Approved

Instituto Bioclon · 多克隆抗体 · 多克隆抗体

什么是 Loxosceles Immune F(Ab)2？

Loxosceles Immune F(Ab)2 是一种多克隆抗体，由Instituto Bioclon研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Reclusmyn
公司Instituto Bioclon
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Instituto Bioclon

治疗适应症

Loxosceles Immune F(Ab)2 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsVenom poisoning✓ Approved

相关研究文献

PubMedCurrent opinion in nephrology and hypertension2026-10-27

Advances in HLA desensitization for kidney transplant candidates.

Chandran Sindhu S, Huang Edmund E, Vo Ashley A, Jordan Stanley S

Human leukocyte antigen (HLA) sensitization is a significant barrier to kidney transplantation. The goal of HLA desensitization is to increase access to transplantation and reduce the risk of antibody-mediated rejection and graft loss. This review outlines currently used therapies and highlights novel strategies for HLA desensitization. Important advances include promising data on imlifidase, a novel immunoglobulin G (IgG) endopeptidase that cleaves IgG molecules into Fc and F(ab)'2 fragments, negating antibody-dependent cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). A positive phase III study will likely lead to FDA approval in December 2026. Additionally, initial reports of HLA desensitization using ant-CD38 monoclonal antibodies, bispecific T cell engagers targeting B-cell maturation antigen (BCMA), and chimeric antigen receptor T cells targeting CD19 and BCMA, suggest improved efficacy at HLA antibody reduction and lower risk of posttransplant DSA rebound. Newer, more potent agents targeting pathogenic IgG molecules, B-cells and plasma cells are likely to improve the efficacy of HLA desensitization regimens. As data emerge from ongoing clinical trials, the clinical applicability of such therapies will depend, in addition to efficacy, on their safety profile, cost and complexity of use.

PMID 42936964
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PubMedJournal of clinical medicine2026-10-27

Acute Care and Rehabilitation After Low-Trauma Hip Fractures in Older Adults-Pathways and Functional Outcomes: A Retrospective Cohort Study.

Cioffi Eva E, Müller Karl K, Ivanova Silviya S, Fava Altes Albert Antoni AA et al.

Background/Objectives: This study describes, first, healthcare pathways, including inpatient rehabilitation, and, second, functional outcomes for these low-trauma hip fracture (LTHF) types (femoral neck (FN-F), trochanteric (Tr-F), and acetabulum/periprosthetic (Ac/Pp-F) fractures). Methods: This single-center, retrospective cohort study, 2020-2023, included patients aged ≥65 years, with FN-F, Tr-F, or Ac/Pp-F, admitted to inpatient rehabilitation. Pathways comprised acute care, inpatient rehabilitation, and temporary care homes, bounded by pre-fracture situation and discharge destination. Pairwise Standardized Mean Differences (SMDs) were calculated to determine between-group differences. Results: Of 294 individuals (mean age 81.0 ± 7.4 years; 191 (65%) women; 152 Tr-F, 118 FN-F, and 24 Ac/Pp-F), four main pathways were identified: (1) acute care to inpatient rehabilitation in 208 (70.7%) individuals, (2) temporary care home stays before rehabilitation in 25 (8.5%), (3) temporary care home stays after rehabilitation in 17 (5.8%), and (4) re-hospitalization in 44 (15.0%). Median pathway length was 33.0 days (IQR 26.0-40.0) for FN-F, 35.0 (IQR 29.0-46.0) for Tr-F, and 60.5 (IQR 37.0-86.5) for Ac/Pp-F. Between-group differences in pathway type were moderate to large (SMDs: FN-F vs. Tr-F = 0.47; FN-F vs. Ac/Pp-F = 1.25; Tr-F vs. Ac/Pp-F = 0.84), and for length, small to large (SMDs: FN-F vs. Tr-F = 0.36; FN-F vs. Ac/Pp-F = 1.2; Tr-F vs. Ac/Pp-F = 0.69). Overall, 246 (83.7%) returned to a permanent private living setting. A total of 88 (29.9%) required new or increased home support or care. At discharge from rehabilitation, among participants who completed the program, the Functional Independence Measure and the Timed Up and Go test showed small-to-moderate between-group differences. Conclusions: Individuals with FN-F, Tr-F, and Ac/Pp-F fractures follow healthcare pathways in different frequencies and have different pathway durations. The findings may support the identification of future opportunities to improve continuity of healthcare, including orthogeriatric management and specialized rehabilitation.

PMID 42941587
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PubMedMedicine2026-10-27

Determining the cognitive function differences between different types of physically active students: Cross-sectional analysis.

Al Mutairi Abdullah A, Al-Ramadan Mohammed M, Abo Qarin Mahdi I MI, Al-Abbas Mohammed S MS et al.

Physical activity plays a vital role in improving mental health. Cognitive functions, including memory, attention, and problem-solving, can be influenced by various factors and interventions. This study aimed to determine cognitive function differences among different types of physically active students. A cross-sectional study was conducted at Imam Abdulrahman Bin Faisal University, Dammam. A convenience sampling method was employed to recruit 99 participants (42 minimally and 57 hyperactive active). Inclusion criteria were: age between 20 to 30 years, enrollment as a physical therapy student, willingness to provide informed consent, and ability to complete computerized cognitive tests. Exclusion criteria included: history of neurological or psychiatric disorders, current use of medications affecting cognitive function, self-reported visual or motor impairments affecting test performance, and inability to understand the study procedures. Physical activity was measured using the International Physical Activity Questionnaire short form. Cognitive functions, including working memory and attention, were assessed through computerized tests of memory automaticity and the Flanker task on a laptop screen. Data were analyzed using the Statistical Package for the Social Sciences (IBM SPSS version 28.0.1.0, New York). One-way analysis of variance was used to determine differences between groups, and Pearson correlation coefficient tests were used to examine relationships between variables. There were no significant differences in cognitive function between minimally active and hyperactive participants. (Attention [F = 1.75, P = .19], Working memory (Accuracy in consistent 1 and 2 [F = .53, P = .47], [F = 3.57, P = .06]; Accuracy in varied 1 and 2 [F = 1.54, P = .22], [F = 1.48, P = .23]; Response time in consistent 1 and 2 [F = .001, P = .97], [F = .11, P = .74]; Response time in varied 1 and 2 [F = .036, P = .85], [F = 1.80, P = .18])). No significant relationship was observed between cognitive function and physical activity. The study findings revealed that neither minimal physical activity nor hyperphysical activity significantly affects cognitive functions in physical therapy students. The results indicate that physical activity is not responsible for improvement in cognitive tasks within the recruited population. While physical activity may help enhance cognitive functions during the early and middle parts of life and also protect against age-related cognitive decline in older age, more research is needed.

PMID 42937732
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PubMedAnimals : an open access journal from MDPI2026-10-27

Allele and Genotype Frequencies of Production Trait SNPs in Crossbred Heifers of the Colombian Caribbean.

Ahumada Velasco Marcos M, Rodríguez Serrano Andrés Camilo AC, Corrales Álvarez Juan David JD, Cárdenas Beltrán Jesús María JM et al.

The Colombian Caribbean dual-purpose livestock system (Bos taurus × Bos indicus) is an important source of milk and beef, yet molecular characterization of trait-associated markers remains limited. This study characterized allele and genotype frequencies of 29 single-nucleotide polymorphisms (SNPs) associated with meat quality and milk production traits in 1585 crossbred heifers from five departments of the Colombian Caribbean. DNA was extracted from hair follicles and genotyped with the Axiom™ Bovine 100K Array. Markers spanned genes for muscle growth and proteolysis (CAPN1, CAST, MSTN), energy metabolism (LEP, DGAT1), and milk protein composition (CSN2, CSN3, PAEP, GH1, GHR, ABCG2). Hardy-Weinberg equilibrium (HWE) was assessed by chi-squared test. Of the 29 markers, 21 were polymorphic and testable: 19 conformed to HWE and 2 deviated (PAEP_239, PAEP_312). The remaining 8 were monomorphic. Approximately 48% of loci showed very high favorable allele frequencies (q > 0.99 or p > 0.99), whereas 52% maintained intermediate heterozygosity. CSN3_526 reached near-fixation of the favorable B allele (q = 0.996), consistent with selection for cheese yield, whereas CAST_282 and CAST_2870 showed high heterozygosity (f(AB) ≈ 0.47-0.48), indicating substantial remaining variation at these loci. These findings provide the first descriptive dual meat-and-milk SNP frequency profile for these crossbred heifers and a molecular baseline for the future development of bioeconomic selection indices in tropical dual-purpose systems. Frequencies are reported at the pooled and department-stratified levels; the results are descriptive and require phenotypic validation before any inference on marker effects or suitability for selection.

PMID 42939201
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PubMedInternational journal of molecular sciences2026-10-27

pH-Responsive Erdafitinib Liposomes with FGFR3 Targeting for Intravesical Bladder Cancer Therapy.

Liang Hongxia H, Li Galong G, Zhang Wenli W, Wang Wei W et al.

Fibroblast growth factor receptor 3 (FGFR3) is a key oncogenic driver in bladder cancer (BCa). Although erdafitinib, the pioneering FGFR3 inhibitor, is approved for clinic use, its oral administration frequently causes inadequate therapeutic effect and side effects. Here, we report a pH-responsive and erdafitinib-loaded liposomal nanosystem with surface modification of anti-FGFR3 antibodies (Phl-erda@Ab), which demonstrates improved antitumor effects in intravesical instillation therapy. In RT112 cells, we evaluated targeted uptake and antiproliferative activity. In vivo, we assessed intravesical retention, antitumor efficacy, and histopathological markers (TUNEL, Ki67) in a BCa xenograft BALB/C nude mouse model, alongside systemic safety profiling. The Phl-erda@Ab exhibited sharp pH sensitivity, releasing 49% of the drug payload within 1 h at pH 5.3 while maintaining minimal release at pH 7.4 and 6.5. Liposome retention after intravesical instillation was doubled compared with non-targeted Phl-erda in mice. The Phl-erda@Ab intravesical therapy demonstrated effective antitumor activity, including maximal necrosis, the highest TUNEL-positive apoptotic index, and the lowest Ki67 proliferation index, compared to other groups. No significant pathological damage to major organs was observed. In summary, Phl-erda@Ab enables FGFR3-targeted, pH-triggered intravesical delivery with enhanced intravesical retention, improved antitumor activity, and favorable local safety, providing preclinical evidence to support clinical translation in FGFR3-overexpressing BCa.

PMID 42941789
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PubMedMicroorganisms2026-10-27

Molecular Evolution of the HMPV-A Fusion Gene Reveals Lineage-Specific Diversification and Structural Conservation.

Harada Kazuhiko K, Mizukoshi Fuminori F, Shirai Tatsuya T, Kimura Ryusuke R et al.

Human metapneumovirus genotype A (HMPV-A) comprises genetically diverse lineages, but whether F-gene diversification is accompanied by changes in the conserved fusion (F) protein remains unclear. We analyzed 500 PARNAS-selected HMPV-A F gene sequences from 25 countries collected between 1982 and 2025 using time-scaled phylogenetics, Bayesian skyline analysis, evolutionary-rate and patristic-distance estimation, codon-based selection analysis, sequence-identity profiling, and structural epitope modeling. Three phylogenetically distinct clusters were identified. Cluster 1 diverged from the common ancestor of Clusters 2 and 3 around 1927. Cluster 3 comprised 435 representative sequences and showed the highest estimated evolutionary rate, greatest phylogenetic diversity, and the most pronounced recent demographic fluctuations. The overall evolutionary rate was 9.20 × 10-4 substitutions/site/year. Despite nucleotide-level diversification, whole-protein identity exceeded 97% in all clusters, 299 codons (approximately 55%) were consistently under negative selection, whereas positive-selection signals were limited and method-specific, with MEME identifying codons 188 and 271 and FUBAR identifying codon 528. Major neutralizing antibody-binding regions were largely conserved, and the six modeled representatives showed similar global F-protein backbone structures and predicted epitope-surface distributions, although A61S and K143T occurred within neutralizing antibody-binding sites and require experimental evaluation. These findings demonstrate lineage-specific F gene diversification under strong functional constraint and support the HMPV F protein as a broadly conserved intervention target.

PMID 42943624
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