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Loxosceles Immune F(Ab)2 (Reclusmyn)

✓ Approved

Instituto Bioclon · 多克隆抗体 · 多克隆抗体

什么是 Loxosceles Immune F(Ab)2？

Loxosceles Immune F(Ab)2 是一种多克隆抗体，由Instituto Bioclon研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Reclusmyn
公司Instituto Bioclon
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Instituto Bioclon

治疗适应症

Loxosceles Immune F(Ab)2 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsVenom poisoning✓ Approved

相关研究文献

PubMedJAC-antimicrobial resistance2026-09-10

Performance of the Sensititre YeastOne assay compared with EUCAST E.Def 9.4 against Fusarium clinical isolates: focus on voriconazole and amphotericin B.

Chen Pao-Yu PY, Wu Un-In UI, Liu Wang-Da WD, Huang Yu-Tsung YT et al.

Despite the global emergence of Fusarium infections, data validating commercial antifungal susceptibility testing against these moulds remain scarce. We evaluated the performance and optimal reading time of the Sensititre YeastOne (SYO) assay against Fusarium clinical isolates compared with the EUCAST reference method. This two-centre study (2011-2023) analysed 123 Fusarium isolates identified via two-step molecular sequencing. In vitro susceptibilities to voriconazole and amphotericin B were evaluated using SYO (24 h and 48 h readouts) versus the EUCAST E.Def 9.4 broth microdilution reference method (48 h readout). Essential agreement (EA) was defined as a ±2 log2 dilution difference; >90% was acceptable. Fusarium solani species complex (FSSC) dominated the cohort (85.3%), predominantly F. keratoplasticum and F. pseudensiforme. EUCAST testing revealed high MIC50/MIC90 values of voriconazole (>16/>16 mg/L) and amphotericin B (2/16 mg/L). While 65% (80/123) of isolates displayed positivity by SYO at 24 h, median spectrophotometric growth was significantly greater at 48 h than at 24 h [0.37 (IQR 0.315-0.403) versus 0.18 (0.151-0.206)]. At 48 h, EA approached acceptability for voriconazole (92.7%) and amphotericin B (89.4%). Voriconazole categorical agreement (CA) among FSSC was 88.6% and reached 96.9% for F. pseudensiforme. For amphotericin B, SYO MICs clustered around 4-8 mg/L, yielding 100% very major error for F. keratoplasticum and F. pseudensiforme but 100% CA for F. falciforme, F. petroliphilum and non-FSSC. Voriconazole and amphotericin B susceptibility determined by SYO cannot universally replace reference methods due to failure to detect non-WT to amphotericin B for prevalent species within FSSC. However, alongside accurate species-level molecular identification, SYO provides actionable susceptibility data for validated species-antifungal combinations.

PMID 42718997
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PubMedFrontiers in endocrinology2026-09-10

Limb salvage in diabetic foot necrotizing fasciitis complicated by extensively drug-resistant Acinetobacter baumannii: a case report of an integrative treatment approach.

Tian Yecen Y, Shi Yue Y, Liu Peng P, Xu Qiang Q et al.

When diabetic foot ulcers (DFUs) complicated by necrotizing fasciitis (NF) show persistent culture positivity for extensively drug-resistant Acinetobacter baumannii (XDR-AB), systemic antimicrobial options are severely limited, posing a severe challenge to limb salvage. Exploring integrative intervention strategies in this setting is of great clinical significance. A 59-year-old patient was admitted with a 20-day history of a right foot ulcer and a 10-year history of poorly controlled type 2 diabetes mellitus. The patient was initially diagnosed with diabetic foot ulcer, which progressed to lower-limb necrotizing fasciitis and septic shock requiring intensive care unit (ICU) supportive treatment. Due to persistent recovery of XDR-AB from wound cultures and severely limited effective systemic antibiotic options, the team used traditional Chinese medicine (TCM) as adjunctive therapy alongside standard debridement, vacuum sealing drainage (VSD), and intensive care support. Following the intervention, the patient's systemic inflammatory markers gradually stabilized despite persistent culture positivity, without recurrent sepsis. With the progressive clearance of necrotic tissue and the growth of healthy granulation tissue, the team successfully performed staged skin grafting while wound cultures remained positive on days 65 and 109, with complete graft take after both procedures. After 115 days of comprehensive treatment, the right lower limb wound stabilized, and the limb was successfully salvaged, allowing for a smooth discharge. For complex cases of DFUs complicated by NF and XDR-AB culture positivity where antibiotics are severely restricted, the addition of TCM to standard multidisciplinary care was associated with infection control and wound repair and may represent an exploratory limb-salvage approach. However, its generalizability and exact efficacy require further validation through subsequent research.

PMID 42718580
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-09-10

Ab Initio Thermoelectric Transport Calculations of Alloyed Half-Heuslers.

Kumar Ankit A, Sahni Bhawna B, Neophytou Neophytos N

We examine the effect of alloying in the electronic transport of half-Heusler thermoelectric materials from fully ab initio transport considerations. For this, we develop a novel method that computes appropriate supercells of alloys and couples them with Boltzmann transport considering the full energy/momentum dependence of all relevant scattering processes, described using first-principles extracted parameters. In alloys, such as Ti 1 - x Zr x NiSn , Zr 1 - x Hf x NiSn , and Hf 1 - x Ti x NiSn , only minor electronic structure changes are observed with x. This translates into minor TE power factor changes upon alloying. For TaFeSb-type materials, isovalent (Nb) and aliovalent (Ti/Zr/Hf) alloying/doping change the band structure significantly, making it more susceptible to band splitting, which leads to significant PF reductions by up to 50%. Thus, although zone-end high valley degeneracy is favorable for TEs, alloying reduces part of this PF advantage. On the other hand, the additional benefit of thermal conductivity reduction upon alloying still improves the figure of merit z T , showing that in some cases the ultimate performance of these materials can reach a z T = 2 at high temperatures.

PMID 42717510
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PubMedRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie2026-09-10

SARS-CoV-2-related immune dysregulation and biologically plausible pathways to lymphomagenesis: a PRISMA-ScR-based scoping review.

Toboltoc Paul Cătălin PC, Vekony Adela A, Gagiu Ioana I

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related immune dysregulation has generated interest in diagnostic pathology because infection-related inflammation, long coronavirus disease (COVID)-related immune disturbance, and post-vaccination lymphoid reactions may overlap with lymphoid-biological mechanisms and complicate the distinction between reactive lymphoid proliferations and lymphoid neoplasia. This scoping review aimed to map biologically plausible pathways through which SARS-CoV-2-associated immune perturbation may intersect with lymphomagenesis-related mechanisms, emphasizing diagnostic implications rather than causality. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). PubMed∕MEDLINE, Scopus, and Web of Science were searched from January 2020 to March 2026, with selected pre-2020 sources retained for mechanistic or diagnostic relevance. Sources were charted across mechanistic, immunological, virological, clinicopathological, and diagnostic domains. After screening and eligibility assessment, 63 sources were retained for thematic synthesis. Evidence clustered around lymphoma-relevant but non-specific mechanisms, including inflammatory signaling, impaired immune surveillance, latent oncogenic viral reactivation, prolonged germinal-center activity with activation-induced cytidine deaminase (AID)-related genomic vulnerability, and lymphoid microenvironment remodeling. These mechanisms appear most relevant in predisposed hosts with chronic immune dysregulation, latent viral infection, defective deoxyribonucleic acid (DNA) repair, or occult abnormal lymphoid clones. Infection and vaccination are distinct contexts, because infection may produce broader immune disruption, whereas most post-vaccination nodal events are reactive and self-limited. Current evidence supports biological plausibility rather than a direct or generalizable causal relationship. The main diagnostic implication is careful clinicopathological correlation and distinction between reactive lymphoid proliferations and lymphoid neoplasia in post-COVID-19 and post-vaccination settings.

PMID 42717452
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PubMedMolecular and clinical oncology2026-09-10

Tumor microenvironment-mediated resistance to immune checkpoint inhibitors in non-small cell lung cancer: Mechanisms, combination strategies and clinical perspectives (Review).

Mu Jiange J, Xu Qiqi Q

Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-associated mortality worldwide. Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-ligand 1 (PD-L1) and cytotoxic T lymphocyte-associated protein 4 have transformed the treatment landscape of NSCLC. However, primary and acquired resistance limit durable clinical benefit. The current review article aimed to summarize tumor microenvironment-mediated resistance as an interconnected biological process rather than a collection of isolated factors. Immunosuppressive myeloid populations, regulatory lymphocytes, cancer-associated fibroblasts, extracellular matrix remodeling, vascular endothelial growth factor-driven vascular dysfunction, hypoxia, transforming growth factor-β signaling and metabolic reprogramming cooperate with defects in antigen presentation, dysregulation of serine/threonine kinase 11/Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/stimulator of interferon genes and oncogenic driver signaling to generate immune-desert (minimal immune cell infiltration), immune-excluded (immune cells retained outside tumors) or exhausted immune-inflamed (immune-cell infiltration with functional exhaustion) phenotypes. The present review also critically evaluated combination therapeutic strategies, distinguishing phase III-supported standards from early-phase clinical or preclinical approaches, while highlighting considerations associated with patient selection, toxicity and the evolving regulatory context. Finally, an operational biomarker framework integrating PD-L1 expression, tumor mutational burden, interferon γ-associated signatures, spatial profiling, circulating tumor DNA, exosomal biomarkers and microbiome features was proposed to guide precision immunotherapy in NSCLC.

PMID 42719683
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PubMedWellcome open research2026-09-10

SARS-CoV-2 memory response in non-hospitalised cases: immunology in the context of a population-based cohort study.

Mitchell Ruth E RE, Kibble Milla M, Santopaolo Marianna M, Milodowski Emily E et al.

The study of non-hospitalised COVID-19 cases provides a context for improved understanding of the immune response to existing and new infections. Population-based cohorts provide a unique opportunity to do this in relation to rich longitudinal pre- and pan-pandemic data. The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has subsequently followed participants for over 30 years. A study comprising three clinic visits was implemented, in response to the COVID-19 pandemic, amongst ALSPAC participants to measure SARS-CoV-2 specific humoral and cellular responses longitudinally. Here we present data from the first clinic in December 2020 before the start of the UK vaccination campaign and examine associations with a set of exemplar pre- and pan-pandemic health factors. We observed humoral and cellular memory immune responses to SARS-CoV-2 infection in mild cases of COVID-19 up to 9 months post-infection. Symptomatic infection elicited a memory immune response of greater magnitude, though there was variation in response in both asymptomatic and symptomatic individuals. We examined health factors associated with severe COVID-19 and found that cardio-metabolomic, respiratory and immune-related health factors associate with a memory immune response of higher magnitude. For example, in older participants (mean age 58 years), higher BMI was associated with an immune memory response of greater magnitude, particularly with anti-S and anti-N binding antibodies. We set out to illustrate the use of cohort studies to deliver detailed immunological data and to provide example analyses of how life course health factors can be examined in relation to the immune response following a widespread and novel infection. We expanded this assessment to include longitudinally assessed traits, opening up the potential for the more common use of longitudinal population studies for the better understanding the aetiology of infection outcome.

PMID 42718410
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