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Loxosceles Immune F(Ab)2 (Reclusmyn)

✓ Approved

Instituto Bioclon · 多克隆抗体 · 多克隆抗体

什么是 Loxosceles Immune F(Ab)2？

Loxosceles Immune F(Ab)2 是一种多克隆抗体，由Instituto Bioclon研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Reclusmyn
公司Instituto Bioclon
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Instituto Bioclon

治疗适应症

Loxosceles Immune F(Ab)2 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsVenom poisoning✓ Approved

相关研究文献

PubMedPhysical chemistry chemical physics : PCCP2026-07-27

The dual delocalization descriptor: first- and second-order responses of bond-resolved electron sharing.

Kenouche Samir S

This work introduces a dual delocalization descriptor (DDD) defined through the first-order (f(1)AB) and second-order (f(2)AB) responses of the interatomic delocalization index to variations in the total electron number. The DDD quantifies the response of interatomic electron sharing to variations in the total electron number, providing a bond-resolved measure of electron redistribution upon electron addition or removal. Positive (negative) values indicate a net increase (decrease) in interatomic electron sharing, as determined by the relative contributions of electron-attachment and electron-removal channels. An explicit comparison of occupation-number formulations demonstrates that bilinear forms (Ángyán-Loos-Mayer type) yield well-defined, finite response functions that decouple inter-orbital and self-delocalization contributions. By contrast, square-root functionals (Müller type) do not admit a well-defined one-sided derivative with respect to electron number, making their response formalisms non-differentiable at integer electron numbers within the PPLB ensemble framework. This establishes functional differentiability with respect to electron number as a key requirement for constructing bond-level derivative descriptors. The analytical DDD is shown to consistently recover bond-resolved finite-difference trends across a series of aromatic systems while relying exclusively on the electronic properties of the neutral reference state.

PMID 42504830
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PubMedBulletin of experimental biology and medicine2026-07-27

Comparative Evaluation of the Effects of Agar and Biofilm Cultures of Francisella tularensis on the Immunological Reactivity of Experimental Animals.

Dubrovina V I VI, Starovoitova T P TP, Pyatidesyatnikova A B AB, Ivanova T A TA et al.

We studied immunogenic properties of biofilm and agar cultures of Francisella tularensis strains. Analysis of the interaction of F. tularensis biofilm cultures with macrophages from experimental animals showed that the bacteria adapt to adverse conditions by forming biofilms, thereby increasing their virulence and subsequently suppressing the functional activity of immune cells. Biofilm formation in 7-day-old cultures of F. tularensis strains was associated with an increase in the virulent potential, which led to a decrease in the mean survival time and the overall survival rate of the experimental animals.

PMID 42507088
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PubMedMetabolites2026-07-27

Effects of Fluoride and 8:2 FTOH on β-Cell Calcium Signaling and Insulin Homeostasis: An Exploratory Study.

Trevizol Juliana Sanches JS, Okamoto Motoki M, Yamashita Shohei S, Kuriki Nanako N et al.

Background/Objectives: Fluoride (F) is widely used in public water fluoridation to prevent dental caries, and an optimal level of F has been linked to improved glucose metabolism in animal models. Per- and polyfluoroalkyl substances (PFAS), including fluorotelomer alcohols (FTOHs), are persistent environmental contaminants with potential effects on pancreatic function. Methods: This in vitro and in vivo study investigated the effects of 8:2 FTOH and F (NaF) on pancreatic β-cells, focusing on Ca2+ homeostasis, insulin secretion, and the GPR40 pathway. Results: Results showed that 8:2 FTOH alters Ca2+ influx in a dose-dependent, biphasic manner, enhancing it at low doses and inhibiting it at high doses, while F increased Ca2+ signaling at high doses. High-dose 8:2 FTOH also downregulated GPR40 protein in βTC-6 pancreatic cells and modulated pathways related to lipid metabolism, endoplasmic reticulum stress, and insulin regulation in the mouse pancreas by proteomic analyses (in vivo). Conclusions: These findings exploratory indicate that both PFAS and F can impact β-cell function through complex mechanisms, potentially affecting Ca2+ homeostasis. This work highlights the hormesis effect of F and provides novel insights into the pancreatic effects of environmentally relevant PFAS exposures, emphasizing the need for further mechanistic studies at low, human-relevant doses.

PMID 42506423
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PubMedAnalytical methods : advancing methods and applications2026-07-27

A ratiometric fluorescent probe based on benzothiazole with a large Stokes shift for fluoride ion sensing in living cells, animals and plants.

Zhou Qi Q, Hu Wen W, Xiao Ke K, Yao Yongxue Y et al.

The sensitive and selective detection of fluoride ions (F-) is of great significance in both environmental and biological systems. A novel near-infrared ratiometric fluorescent probe, PC-SZ-TBS, was designed and synthesized by rationally linking dicyanoisophorone with 2-(2-hydroxyphenyl)benzothiazole. The probe operates via F--triggered cleavage of the silicon-oxygen bond, resulting in a distinct fluorescence color change from yellow to bright red, along with significant fluorescence enhancement at 700 nm. Spectroscopic studies revealed that PC-SZ-TBS exhibits a low detection limit of 2.22 × 10-6 mol L-1 toward F-, maintains excellent stability over a pH range of 4-10, and displays high selectivity with minimal interference from competing species. Biocompatibility assays demonstrated that PC-SZ-TBS possesses low cytotoxicity and robust cell permeability in 4T1 cells, as well as favorable imaging capabilities in living organisms including zebrafish and Arabidopsis thaliana, enabling effective visualization of F- in biological tissues. Furthermore, PC-SZ-TBS was successfully applied to determine F- in real samples such as tap water, lake water, Chinese baijiu, and various fruits. Integrated with a smartphone-based RGB analysis platform, a strong linear correlation between the R/G ratio and F- concentration (R2 = 0.9978) was established, allowing for real-time, portable semi-quantitative detection of F-. This work provides a reliable and versatile tool for the visual monitoring of fluoride ions in both environmental and biological contexts.

PMID 42507105
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PubMedVaccines2026-07-27

Potential Roles of Gamma-Delta T Cells in a Bacterial Immun-Ization Model.

Talbot Lee Anne LA, Manjikian Raffi R, Bitsaktsis Constantine C

Background/Objective: Francisella tularensis is a highly infectious intracellular pathogen that causes severe pulmonary tularemia following aerosol exposure, yet no licensed vaccine exists. Because infection initiates at the respiratory mucosa, understanding mechanisms of protective pulmonary immunity is critical for mucosal vaccine development. This study investigated the role of lung-resident γδ T cells following intranasal immunization with inactivated F. tularensis (iFt) and subsequent lethal challenge with live vaccine strain (LVS). Methods: Mice were intranasally immunized with iFt and later challenged with lethal LVS. Pulmonary immune responses were evaluated using flow cytometry and cytokine analysis. Recruitment of γδ and αβ T cells, production of IL-17 and IFN-γ, neutrophil infiltration, and γδ T cell memory phenotypes were assessed in naïve and immunized mice following infection. Results: Primary LVS infection induced rapid recruitment of γδ T cells to the lung beginning on Day 2 post-infection, preceding significant αβ T cell accumulation. Increased pulmonary IL-17 and IFN-γ correlated with expansion of IL-17- and IFN-γ-associated γδ T cell populations. Following iFt immunization, mice demonstrated enhanced survival after lethal LVS challenge, accompanied by early increases in pulmonary IL-17 and IL-17 producing γδ T cells. Immunized mice also exhibited expansion of effector memory and central memory γδ T cell populations associated with IL-17 production. Conclusions: These findings identify IL-17 producing γδ T cells as contributors to early mucosal immunity following intranasal vaccination against F. tularensis and suggest that targeting lung-resident γδ T cells may support the development of next-generation mucosal vaccines against respiratory pathogens.

PMID 42506627
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PubMedJournal of fungi (Basel, Switzerland)2026-07-27

An ABC-B Transporter Helps Protect Fusarium graminearum Against Enniatin Toxicity.

Harris Linda J LJ, Bosnich Whynn W, Johnston Anne A, Schneiderman Danielle D et al.

Fusarium graminearum and F. avenaceum often co-contaminate Canadian durum wheat grain, resulting in the co-deposition of species-specific mycotoxins, including trichothecenes produced by F. graminearum and enniatins produced by F. avenaceum. These mycotoxins pose significant risks to human and animal health. Although these fungi commonly co-occur in infected wheat, relatively little is known about how they interact during host infection. Interactions between the two species were examined using co-inoculation experiments on durum wheat spikes. In pathology trials, co-inoculations often reduced both disease severity and trichothecene accumulation compared with inoculations of F. graminearum alone, despite F. graminearum greatly out-competing F. avenaceum in total fungal biomass. Transcriptomic profiling identified strong induction of the F. graminearum ABC transporter gene FgABCB8 during co-inoculation with an enniatin-producing F. avenaceum strain. When F. graminearum was grown in vitro, FgABCB8 was induced upon exposure to F. avenaceum culture filtrate, or the related cyclohexadepsipeptides enniatin B1 or beauvericin. Heterologous expression of FgABCB8 in yeast provided partial protection against enniatin and beauvericin toxicity. Gene disruption of FgABCB8 increased F. graminearum sensitivity to enniatins. These findings demonstrate that FgABCB8 expression enhances the ability of F. graminearum to tolerate enniatin-producing fungi.

PMID 42506285
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