北京若生智能科技有限公司
Drug Database
LI

lidocaine hydrochloride (3268 / lignocaine, Anesiva / ALGRX 3268)

✓ Approved

Marathon Pharmaceuticals · SCN9A · 小分子

什么是 lidocaine hydrochloride？

lidocaine hydrochloride 是一种小分子，由Marathon Pharmaceuticals研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intradermal Injection。

药物档案

商品名3268, lignocaine, Anesiva, ALGRX 3268
公司Marathon Pharmaceuticals
药物类别小分子
分子靶点SCN9A
给药途径Injectable (Others), Intradermal Injection
状态Approved
来源： ClinicalTrials.gov, Marathon Pharmaceuticals

作用机制

分子靶点

lidocaine hydrochloride 作用于 1 个分子靶点：

SCN9Asodium voltage-gated channel alpha subunit 9 (SFNP, GEFSP7)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

lidocaine hydrochloride 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersAnaesthesia✓ Approved
Nervous system disordersSensory loss✓ Approved

相关研究文献

PubMedInternational journal of molecular sciences2026-10-27

Influence of UV Irradiation Source and of Carboxylic Acid Additives on the Kinetics of Photodegradation of Five Tricyclic Antidepressant Drugs in Aqueous Medium.

Ciuca Maria D MD, Racovita Radu C RC

Use of antidepressant medication has increased substantially nowadays. Investigations of their photostability in aqueous environment are therefore needed both for shelf life assessment of liquid pharmaceutical formulations and for development of wastewater remediation technologies. In this work, the comparative kinetics of photodegradation of five tricyclic antidepressants (TCAs) in aqueous solution was studied under direct photolysis using UVA, UVB, and UVC sources, respectively. A gas chromatography-mass spectrometry (GC-MS) method was developed and validated intra-laboratory for accurate quantification of the five TCAs (amitriptyline hydrochloride AMI, doxepin hydrochloride DOX, imipramine hydrochloride IMI, clomipramine hydrochloride CLO, trimipramine maleate TRI) in the course of photodegradation. UVC photolysis yielded the highest rates of photodegradation, followed by UVB and then UVA. The molecular structure and UV absorption characteristics of individual TCAs were shown to influence photodegradation rates as well. Specifically, heteroatoms (N, O, Cl) present in the molecule and redshifted UV absorption bands increased photosensitivity typically in the order: AMI < IMI < TRI < CLO < DOX. The effect that some mono- and polycarboxylic acids dissolved in the aqueous solutions had on TCA photodegradation kinetics under UVC was also investigated and, for most TCAs, rates were faster and durations required for their complete photodegradation decreased generally in the order: citric > oxalic > maleic > benzoic acid. Furthermore, citric acid was reused for a second round of TCA photodegradation and showed rate enhancement effects very close to those exhibited in the first round.

PMID 42941717
阅读全文 →
PubMedPharmaceutics2026-10-27

Impact of Process Parameters on the Quality Attributes of High-Dose Metformin Hydrochloride Film-Coated Tablets.

Duc Nguyen Tan NT, Nguyen Dang-Khoa DK, Liet Huynh Thanh HT, Thiet Nguyen Huynh NH et al.

Background/Objectives: Formulating high-dose metformin hydrochloride film-coated tablets is challenging due to the poor flowability and compressibility inherent to high drug loading. To ensure process robustness and consistent product quality, understanding the impact of manufacturing variables is crucial. This study evaluated the effects of key process parameters on the quality attributes of 1000 mg metformin hydrochloride tablets to establish optimal processing conditions for reliable production. Methods: The manufacturing process, comprising wet granulation, compression, and film coating, was investigated to evaluate the influence of key process parameters on tablet quality attributes. Granules were characterized for bulk density, tapped density, and compressibility index. Core tablets were evaluated for physical appearance, weight variation, hardness, and dissolution at a 45 min sampling point across various compression forces and tableting speeds. Film-coating efficiency was assessed based on coating quality, dissolution behavior, and stability. Favorable manufacturing conditions were empirically identified through single-variable optimization and statistical analysis. Results: Wet granulation conducted at a chopper speed of 1400 rpm for 7 min yielded granules with the lowest compressibility index (11.88%), demonstrating significantly improved flowability. Compression at a force of 10 kN and a speed of 40 rpm produced core tablets with acceptable appearance, robust hardness (7.06-7.37 kP), and complete drug release (100%). Tablet hardness was governed by a strong interaction between compression force and tableting speed (partial η2 = 0.929, p < 0.001) rather than by either factor alone: at 20 kN, hardness collapsed sharply once tableting speed reached 30 rpm, coincident with mild capping, identifying this force-speed combination as a process-failure condition. For the coating process, maintaining a tablet bed surface temperature of 40 °C ensured optimal coating uniformity without compromising product quality. Dissolution profile comparison against a coated reference product in the primary dissolution medium (pH 6.8) yielded f2 similarity values above 50 for all eight core tablet conditions, and stability testing under accelerated/thermal-stress conditions (up to 65 °C) confirmed maintained dissolution, assay, and related-substance (1-cyanoguanidine) compliance for both the test and reference products. The optimized manufacturing conditions successfully produced film-coated tablets that conformed to all predetermined quality specifications. Conclusions: Manufacturing process parameters significantly influenced the quality attributes of high-dose metformin hydrochloride film-coated tablets. Proper selection and control of these processing conditions ensured consistent granule properties, optimal tablet quality, and enhanced manufacturing robustness.

PMID 42942796
阅读全文 →
PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Propolis vs. Chlorhexidine Gluconate and Benzydamine Hydrochloride on Sequelae After Third Molar Surgery: A Randomized Controlled Trial.

Bayramoğlu Zeynep Z, Halıcı Zekai Z, Özakar Emrah E, Sevinç Özakar Rukiye R

Background. Impacted lower third molar surgery is characterized by postoperative sequelae such as pain, edema, and trismus. While chlorhexidine (CHX) is the gold-standard antiseptic, its side effects prompt the search for natural alternatives. The aim of this study is to examine the effects of propolis gargle on wound healing following third molar surgery and to compare it with chlorhexidine gluconate and benzydamine hydrochloride (CHX+BENZ). Methods. In this prospective, randomized, double-blind, active-controlled trial, 52 patients were assigned to 3% Propolis (n = 24) or 0.12% CHX+BENZ (n = 28) groups. Mouthwashes were applied twice daily from postoperative days 2 to 7, and pain (VAS), edema, and trismus were evaluated preoperatively and on days 2 and 7. Statistical significance was set at p < 0.05. Results. No significant differences were found in pain and trismus (p > 0.05). However, the Propolis group exhibited significantly lower edema on day 2 compared to the CHX+BENZ group (p = 0.004), and complication rates were also notably lower in the Propolis group. Conclusions. The novel, non-alcoholic 3% propolis mouthwash demonstrated no statistically significant differences in short-term pain and trismus outcomes compared to CHX+BENZ, alongside a statistically smaller day-2 facial edema measurement. While these findings support its potential as a supportive oral rinse following third molar surgery, adequately powered prospective trials are warranted to validate these preliminary observations before routine clinical adoption.

PMID 42943312
阅读全文 →
PubMedPeerJ2026-10-27

Pulsed electric field-mediated elimination of yeast [PSI +] prion is variant dependent and affects cell growth dynamics.

Jonutyte-Trembo Neda N, Versockienė Justina J, Katauskas Gvidas G, Novickij Vitalij V et al.

Yeast Saccharomyces cerevisiae is a widespread model system in which mechanisms of prion induction and elimination have been identified. New and safe substances and methods are being sought to eliminate prions from cells. In this research, we applied guanidinium hydrochloride (GuHCl) alone and in combination with pulsed electric field treatment against [PSI +] prion. The analysis of cell culture optical density and doubling time showed that the method of [PSI +] prion elimination increases cell doubling time, with combined treatment having a more severe impact on cell growth than GuHCl treatment alone. Additionally, we found that both elimination methods can impact the optical culture density achieved by [psi -] cells. However, the cells in which the [PSI +] prion has been eliminated by GuHCl alone are able to reach the same optical density as unaffected [psi -] cells and a higher optical density than the affected [psi -] cells by GuHCl alone. These findings suggest that the presence and subsequent removal of the [PSI +] prion influence early exponential growth, revealing lasting effects on cell growth dynamics that are distinct from previously reported effects on stationary phase survival. This work highlights how prion elimination strategies, including chemical and electric field treatments, can impact post-curing growth behavior in yeast cells.

PMID 42936698
阅读全文 →
PubMedAdvanced materials (Deerfield Beach, Fla.)2026-10-27

Threo-Chiral Cation Additive Enables Ordered Lattice Adsorption and Enhanced Operational Stability of Perovskite Photovoltaics.

Gao Yilin Y, Liu Guozhen G, Xu Bingying B, Zhang Yinjuan Y et al.

Chiral molecular engineering is an effective strategy to modulate crystallization and mitigate nonradiative defects in perovskite solar cells (PSCs). However, unconstrained bond rotation often leads to spatial mismatch between chiral molecules and the perovskite lattice, hindering effective defect coordination. Herein, we introduce threo-chiral cation additive of (2S,3R)-2-amino-3-hydroxybutanamide hydrochloride (ThrA) to achieve precise perovskite lattice regulation. Benefiting from methyl‑induced steric hindrance originating from its dual chiral‑center threo‑configuration, ThrA acquires a conformationally locked rigid stereostructure and further facilitates thermodynamically‑favored parallel‑to‑lattice multi‑site synergistic adsorption via hydrogen bonding and Pb coordination. Such stereoselective "lock-and-key" interaction reduces lattice surface energy, guides preferential (100) crystal growth, and simultaneously suppresses lattice distortion and ion migration. Consequently, the ThrA-modified inverted PSCs achieve a champion efficiency of 26.68% (certified 26.31%), while 65 cm2 large-area module delivers a promising PCE of 22.78% (certified 22.12%), representing one of the outstanding certification efficiencies for perovskite modules of comparable size. Unencapsulated devices retain 90% of their initial efficiency after 1000 h thermal aging (ISOS-D-2) and maintain 92% performance after 2000 h continuous maximum power point tracking (ISOS-L-2). This work demonstrates that the stereostructure of additive is decisive for precise perovskite crystallization modulation, providing advanced stereochemical strategy toward high-efficiency and ultra-stable perovskite photovoltaics.

PMID 42935295
阅读全文 →
PubMedMedicine2026-10-27

Stepwise acupuncture exploration followed by ultrasound-guided needle-knife release combined with local infiltration for chronic intercostal muscle-related myofascial pain: A case report.

Ou Yuyang Y, Li Dan D, Li Guanghan G, Li Hui H

Intercostal muscle-related myofascial pain can be difficult to localize when superficial tenderness is absent because the muscles lie deep to the thoracic musculature and close to the pleura. We report a case in which stepwise muscle-specific acupuncture provided ancillary localization information before targeted treatment. A 73-year-old man presented with a 3-year history of persistent right posterolateral chest wall heaviness and dull pain, predominantly involving the fourth to tenth intercostal spaces. The resting numerical rating scale (NRS) score was 8, and no definite superficial tender point was identified. Clinical and imaging evaluations excluded more plausible cardiopulmonary, pleural, osseous, spinal, herpetic, or neuropathic causes. More than 1 month of sequential acupuncture targeting the trapezius, rhomboid, multifidus, erector spinae, and serratus muscles produced no meaningful improvement. When exploration reached the suspected deep intercostal layer, ultrasound-guided acupuncture reproduced the habitual pain and produced mild relief. This response was interpreted as hypothesis-generating localization information rather than confirmatory evidence and contributed to a provisional diagnosis of intercostal muscle-related myofascial pain. The patient underwent 4 weekly sessions of ultrasound-guided needle-knife release combined with local infiltration of 0.25% lidocaine and compound betamethasone. The intercostal anatomy and needle tip were monitored in real time using an out-of-plane approach. The NRS score decreased from 8 to 5 immediately after the first treatment and further decreased to 1 one week after the fourth treatment. Pain completely resolved at the 1-, 3-, and 6-month follow-ups, with no treatment-related adverse events. Stepwise muscle-specific acupuncture may provide ancillary localization information when conventional examination cannot identify a deep chest wall pain generator. Ultrasound-guided needle-knife release combined with local infiltration targeting the suspected intercostal muscle was associated with sustained improvement and may represent a potential treatment approach for selected patients with deep intercostal muscle-related myofascial pain.

PMID 42937795
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多lidocaine hydrochloride