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isosorbide mononitrate (Mono Mack 50D / Mono Mack)

✓ Approved

Novartis AG · 小分子 · 小分子

什么是 isosorbide mononitrate？

isosorbide mononitrate 是一种小分子，由Novartis AG研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Mono Mack 50D, Mono Mack
公司Novartis AG
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Novartis AG

治疗适应症

isosorbide mononitrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAngina pectoris✓ Approved

相关研究文献

PubMedInorganic chemistry2026-09-07

Sustainable Recovery of Dibutyl Terephthalate from Aromatic Polyester Waste via Solvothermal Alcoholysis.

Matuszak Karolina K, Petrus Rafał R, Lis Tadeusz T

In this work, a series of homometallic and heterometallic aryloxides, including [M'6(sal-Me)6] (M'+ = Li+ (1), Na+ (2), K+ (3)), [M'(sal-Me)]n (M'+ = Rb+ (4), Cs+ (5)), [Mg2(sal-Et)4(EtOH)2] (6), [Zn4(sal-Me)8] (7), [Ca3(sal-Me)6(EtOH)2] (8), [M2M'2(sal-Me)6(X)x] (where M2+ = Mg2+ and M'+ = Li+ (9), Na+ (10), K+ (11); M2+ = Zn2+ and M'+ = Li+ (13), Na+ (14), K+ (15); or M2+ = Ca2+ and M'+ = Li+ (16), Na+ (17), K+ (18) with X = THF or MeOH and x = 0, 2, 4), [MgRb(μ-H2O)(sal-Me)3(H2O)0.5]n (12), [Mg4Na2(sal-Me)6(sal)2(THF)4] (19), [CaLi6(sal-Me)8] (20), [Ca4M'(μ5-OH)(sal-Et)8(EtOH)] (M'+ = Na+ (21), K+ (22)), [ZnLi2(sal-Me)4(THF)2] (23), and [ZnM'2(sal-R)4]n (for M' = Na and R = Et (24), M' = K and R = Me (25)), were investigated as catalysts for the chemical recycling of postconsumer poly(ethylene terephthalate) (PET) and poly(ethylene-co-isosorbide-co-1,4-cyclohexanedimethylene terephthalate) (PEICT) waste. The catalytic performance of metal aryloxides was evaluated in relation to their chemical composition, solid-state structures, and solution behavior, allowing general trends in the catalytic activity of alkali metal and divalent metal aryloxides (Mg2+, Ca2+, Zn2+) and their heterometallic combinations to be established. Key factors governing catalytic activity, reaction mechanisms, and the formation of reaction intermediates are also discussed.

PMID 42704149
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PubMedInternational journal of surgery case reports2026-09-06

Controlled hypotension therapy with isosorbide dinitrate for postoperative bleeding of transurethral resection of the prostate.

Li Zihao Z, Li Hongliang H, Chen Zhenzhuo Z, Wang Li L et al.

Postoperative bleeding is a well-known complication of transurethral resection of the prostate (TURP). This study aims to evaluate the efficacy and safety of controlled hypotension using isosorbide dinitrate (ISDN) as a treatment for refractory postoperative bleeding after TURP when conventional non-surgical treatments have failed. A retrospective analysis was conducted of eight patients who experienced postoperative bleeding following TURP and did not respond to standard non-surgical interventions. Patients were treated with an intravenous infusion of ISDN to induce controlled hypotension. The hemostatic effect was subsequently observed and evaluated once the mean arterial pressure was lowered to a target range of 66-73 mmHg. Hemostasis was achieved rapidly in all eight patients following the induction of controlled hypotension. The treatment demonstrated a highly satisfactory clinical effect, and no severe adverse events or complications were observed during or after the intervention. Controlled hypotension via intravenous ISDN is a safe, rapidly effective, and promising therapeutic alternative for managing refractory postoperative bleeding after TURP when conventional non-surgical measures fail.

PMID 42699463
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-03

Bio-Based Transparent Self-Healable Polyimides Enabled by Isosorbide-Derived Dianhydride Design and Aliphatic Chain-Mobility Regulation.

Jang Jisu J, Kang Woojin W, Seo Yeongseok Y, Bae Gyu Hyoung GH et al.

Transparent self-healable polyimides are attractive for flexible, wearable, and sustainable electronic devices, but achieving high transparency, rapid healing, and mechanical robustness within a single material remains challenging. Herein, we report a bio-based aliphatic-aromatic polyimide platform that addresses this challenge through the cooperative molecular design of an isosorbide-derived dianhydride (ISSDA), 4,4'-oxydiphthalic anhydride, cystamine, and a bio-based long-chain aliphatic diamine (DDA). Unlike conventional aromatic polyimides, the nonplanar and nonconjugated ISSDA structure reduces charge-transfer complex formation and prevents compact chain packing, enabling high optical transparency in a self-healable polyimide network. The DDA segment further introduces controlled chain flexibility, lowers the effective healing barrier, and improves segmental mobility required for dynamic disulfide exchange. As a result, the optimized film achieved over 95% transmittance above 650 nm, thermal healing within 4 min at 150°C, and only a 7.8% loss in toughness after healing. DFT/TD-DFT analyses confirmed that ISSDA suppresses and blueshifts the near-UV electronic transitions relevant to visible transparency, while WAXD analysis revealed enlarged interchain d-spacing and increased amorphous packing. This study provides a bio-derived and structurally tunable route to transparent, tough, and rapidly self-healable engineering polyimides.

PMID 42689332
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-08-30

Isosorbide-Based Optically Clear Adhesives With Ultrahigh Transparency and Rapid Strain Recovery for Flexible Displays.

Choi Yoonji Y, Lee Geonwoo G, Kim Yeonseo Y, Jin Dahyun D et al.

Flexible and foldable displays require optically clear adhesives (OCAs) that combine ultrahigh optical transparency with mechanical resilience under repeated deformation. However, conventional acrylic-based OCAs often fail to achieve both properties simultaneously. Herein, we synthesized a polyurethane diacrylate (PUDA) crosslinker incorporating biomass-derived isosorbide and photostable 1,3-bis(isocyanatomethyl)cyclohexane (H6XDI) for flexible display adhesives. The segmented polyurethane architecture forms a mechanically flexible yet robust network, enabling rapid strain recovery while maintaining ultrahigh optical transparency. Furthermore, the incorporation of an isosorbide-based PUDA crosslinker introduces a biomass-derived component and preserves excellent optical properties due to its intrinsically low birefringence. As a result, the PUDA crosslinked OCA exhibits exceptional optical transmittance (99.8%) and maintains high transparency (98.6%) even at 50% tensile strain, alongside low modulus, stable adhesion, and clean debonding behavior. These results highlight the potential of PUDA OCAs for high-performance and energy-efficient foldable display applications.

PMID 42669159
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PubMedJournal of colloid and interface science2026-08-28

Hydrogen-bond-mediated cross-sheath associations couple Li+ solvation with interfacial chemistry in lithium metal batteries.

Cheng Min M, Zhou Xu X, Chen Zixuan Z, Chen Junhao J et al.

Extending the lifetime of lithium metal batteries requires electrolyte strategies that coordinate Li+ solvation with interfacial chemistry. Here, we introduce hydrogen-bond-mediated cross-sheath molecular association as a design principle for an ether-based localized high-concentration electrolyte. Spectroscopic analyses, noncovalent-interaction calculations and ab initio molecular dynamics simulations indicate that 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (TTE) and fluoroethylene carbonate (FEC) reside predominantly in the outer solvation environment, whereas 1,2-diethoxyethane (DEE) remains an important inner-shell solvent. The pre-associated FEC-TTE motif exhibits a stronger overall association with DEE than isolated TTE, providing a plausible molecular bridge between the outer and primary solvation environments. This cross-sheath association contributes to weaker average Li+-DEE coordination and increased participation of bis(fluorosulfonyl)imide (FSI-) and isosorbide dinitrate (ISDN), yielding a compact, anion-enriched local solvation structure. At the electrode interface, the reconstructed solvation environment cooperates with the reduction chemistry of FEC, FSI- and ISDN to suppress excessive solvent decomposition and promote a homogeneous LiNxOy/LiF-rich solid electrolyte interphase. Consequently, Li||Li symmetric cells sustain stable plating/stripping for approximately 1354 h at 1 mA cm-2 and 1 mAh cm-2, while high-loading Li||LiFePO4 cells cycle for approximately 1188 cycles at 1 C. Unlike conventional approaches focused primarily on direct regulation of the first Li+ solvation shell, this work demonstrates that engineering molecular associations across solvation environments offers an effective route to couple solvation redistribution with interfacial film formation.

PMID 42660070
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PubMedDiseases (Basel, Switzerland)2026-08-26

Comparative Effects of Heart Failure Medications on Cardiac Remodeling via the Hydrogen Sulfide (H2S) Pathway: A Systematic Review.

Ahmed Mohamed Thabit MT, Yousef Bashir A BA, Ozsarlak-Sozer Gonen G, Yagdi Tahir T et al.

The aim of this study was to determine whether direct evidence shows that contemporary guideline-directed heart failure (HF) pharmacotherapies influence cardiac remodeling through hydrogen sulfide (H2S) signaling, and to define the resulting evidence gap. A systematic review was conducted according to PRISMA 2020. PROSPERO CRD420251238589. MEDLINE (PubMed), Web of Science, Scopus, and the Cochrane Library; searches were initiated in March 2025, covered publications from January 2007 onward, and were last updated in November 2025. Primary studies had to include (A) an HF or cardiac-remodeling model, (B) an HF-relevant pharmacological intervention, (C) direct assessment or manipulation of H2S biology, and (D) at least one cardiac-remodeling endpoint. Of the 40,796 unique records screened, 50 reports underwent full-text assessment and 14 unique studies were included. No study demonstrated that the remodeling benefits of ACE inhibitors, ARBs, ARNIs, beta-blockers, MRAs, hydralazine/isosorbide dinitrate, or SGLT2 inhibitors are mediated by endogenous H2S signaling. Doiron et al. evaluated empagliflozin with or without the H2S donor SG1002 in experimental HFpEF; the combination improved several outcomes beyond empagliflozin alone, but this adjunctive design does not establish H2S mediation of empagliflozin action. Most eligible evidence concerned exogenous H2S donors in animal models and reported improvements in fibrosis, hypertrophy, oxidative stress, mitochondrial injury, and cardiac function. The overall certainty was low because of preclinical predominance, heterogeneous models and H2S assays, donor-specific pharmacology, and incompletely reported randomization and blinding. The principal finding is negative but clinically important: direct evidence that H2S mediates established HF pharmacotherapy is currently absent. H2S remains a promising experimental therapeutic candidate rather than an established shared mechanism or clinically validated treatment target.

PMID 42645107
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