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hyaluronic acid (Provisc)

✓ Approved

Novartis AG · 治疗药物

什么是 hyaluronic acid？

hyaluronic acid 是一种治疗药物，由Novartis AG研发。该药已获批，用于治疗相关适应症。

药物档案

商品名Provisc
公司Novartis AG
状态Approved
来源： ClinicalTrials.gov, Novartis AG

治疗适应症

hyaluronic acid 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresAdjuvant therapy✓ Approved
Eye disordersDry eyePreclinical

相关研究文献

PubMedGels (Basel, Switzerland)2026-07-27

Temporal Hierarchy of Hydrogels and Orthobiologic Therapies for Knee Osteoarthritis.

Costa Fábio Ramos FR, Martins Rubens R, Protásio Netto João J, Costa Vinicius Calumby VC et al.

Knee osteoarthritis is commonly managed with intra-articular therapies that differ widely in composition, mechanism, and clinical persistence, yet the duration of their benefit is discussed inconsistently, which limits practical comparison between ozone, hyaluronic acid, platelet-derived products, and cell-rich orthobiologics. In this narrative review we examine the mechanism-driven temporal behavior of these therapies, focusing on the physicochemical, biomechanical, biological, and regenerative factors that influence how long a clinical response persists. By temporal hierarchy we mean the mechanistically informed pattern by which therapies differ in the duration of their physicochemical presence, biological activity, and clinical benefit, not a ranking of efficacy or a claim of equivalence. Read against this definition, ozone occupies the shortest end of the spectrum; conventional hyaluronic acid shows intermediate persistence; modified hyaluronic acid hydrogels may extend activity through improved rheology and enzymatic resistance; platelet-rich plasma and injectable platelet-rich fibrin provide more sustained biological signaling; and bone marrow aspirate concentrate and stromal vascular fraction may act over longer periods through trophic and paracrine pathways. Heterogeneity in study design, patient selection, and outcome reporting still limits firm conclusions, and standardized reporting of product characteristics and time-related endpoints will be essential to validate or refine the proposed framework.

PMID 42505291
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PubMedDentistry journal2026-07-27

Deciphering Nano-Bio Interactions of Hyaluronic Acid-Clove Carbon Dots for Multifunctional Endodontic Nanotherapy.

Aruchamy Mohanprasanth M, Thirumalaivasan Natesan N

Background:Streptococcus mutans (S. mutans) plays a major role in dental biofilm-related infections and contributes to antimicrobial resistance. Therefore, the development of biocompatible nanomaterials with antibacterial, antibiofilm, and regenerative properties is important for dental applications. Methods: In this study, hyaluronic acid and clove extract were used as natural precursors to synthesize hyaluronic acid-clove carbon dots (HCCDs) through a hydrothermal method. The synthesized HCCDs were characterized by XRD, FTIR, TEM, SEM, SAED and EDAX analysis. The antibacterial and antibiofilm activities against S. mutans were tested. Cell viability tests, AO/PI staining, morphological observation and wound-healing assays were used to evaluate cytocompatibility in MG-63 cells. Results: A broad peak (23.449) observed from XRD coincided with an amorphous graphitic carbon structure. TEM images showed the presence of a spherical nanostructure with an average size of 4 ± 2 nm. The FTIR result verified the presence of hydroxyl, carbonyl and oxygen-containing functional groups on the HCCD surface. Their synthesized HCCDs exhibited noteworthy antibacterial and antibiofilm activity with an MIC of 62.5 µg/mL against the S. mutans. Low toxicity toward MG-63 cells was observed, with 86% cell viability at 200 µg/mL in the cytocompatibility study. Additional good cellular compatibility was confirmed using AO/PI staining and morphological analysis. Furthermore, normal cell migration was observed, as wound healing assays showed no significant difference in closure between the treated and control groups. Conclusion: HCCDs exhibited antibacterial, antibiofilm, biocompatible, and wound-healing properties, highlighting their potential for dental nanomedicine and the treatment of oral biofilm-associated infections.

PMID 42505757
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PubMedGels (Basel, Switzerland)2026-07-27

From ECM Aging to Mechanobiological Restoration: Injectable Fillers and Dermal Fibroblast Mechanotransduction-A Narrative Review.

Marchetti Francesco F, Habib Mahmoud M Fahmy MMF, Basso Matteo M

Skin aging reflects the accumulation of molecular damage and a progressive disruption of dermal mechanical homeostasis. Fragmentation and disorganization of the dermal extracellular matrix (ECM) impair force transmission to resident fibroblasts. Reduced cell spreading and mechanical force generation are associated with increased matrix metalloproteinase expression and reduced collagen synthesis, partly through c-Jun/AP-1 activation and attenuation of TGF-β/TβRII signaling. Reduced YAP/TAZ mechanosignaling has also been linked to cGAS-STING-dependent senescence in experimental models. However, its causal role in aging human dermis remains unresolved. This narrative review considers dermal mechanobiology as an integrative framework alongside ultraviolet exposure, oxidative stress, glycation, and cellular senescence. It examines how injectable fillers may influence the dermal mechanical microenvironment. A filler's material properties may constitute a mechanical exposure, although bulk rheological measurements do not define force transmission at the cellular scale. Human in vivo studies of cross-linked hyaluronic acid provide the most direct evidence that enhanced structural support is associated with fibroblast spreading, activation of TGF-β-related signaling, and increased type I collagen deposition. Evidence for calcium hydroxylapatite and other biostimulatory fillers is complementary but more heterogeneous. A composite of PEGDE-cross-linked hyaluronic acid and calcium hydroxylapatite microspheres is considered as an explicitly preliminary example. This review defines the current evidence, its key limitations, and the mechanistically informed studies needed to determine whether, and which, fillers can meaningfully modify dermal mechanobiology.

PMID 42505292
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PubMedGels (Basel, Switzerland)2026-07-27

Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications.

Măciuceanu Zărnescu Bogdan Mircea BM, Pîrvulescu Bunea Diana Cristina DC, Niculescu Adelina-Gabriela AG, Scafa Udriște Alexandru A et al.

Hyaluronic acid (HA) is a glycosaminoglycan that is found within the body and has both structural and signaling functions in the extracellular matrix. HA is biocompatible and biodegradable; it has a high water content and binds directly to certain cell-surface proteins. Due to these characteristics, it is considered a promising component for the design of biomaterials for regenerative wound healing. This review covers the most recent findings on the use of HA-based biomaterials in soft tissue repair, while also incorporating earlier, foundational studies relevant to the field, focusing on HA's characteristics, cellular interactions, design, and preclinical and clinical results. The physicochemical characteristics of HA and their influence on cellular responses and tissue regeneration are discussed to show how material properties can be adjusted for specific therapeutic purposes. There have been great advances in chemically modified composite scaffolds and HA matrices, which offer better mechanical stability and controlled degradation. At the same time, new delivery systems have been built using HA, from nanoparticles to gene delivery platforms and growth factors, and these have given the material an active role as a therapeutic agent rather than just a passive one. This narrative review covers the clinical evidence for the effectiveness of commercial products for acute and diabetic wounds, as well as burns and chronic wounds, and discusses where their use is indicated. In the end, the current limitations of the research and future applications and directions are discussed.

PMID 42505337
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PubMedJournal of controlled release : official journal of the Controlled Release Society2026-07-27

A copper nanoplatform with irreversible electroporation induces cuproptosis via lipid reprogramming and remodels tumor immunity in pancreatic cancer.

Jiang Shaotao S, Huang Yuelin Y, Tao Na N, Liu Tuo T et al.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most treatment-refractory malignancies, largely due to its dense stromal architecture and limited intratumoral drug penetration. Here, we developed a hyaluronic acid-modified polypyrrole-copper nanoparticle (PLGA-Cuppy@HA, mCuppy) for copper delivery and irreversible electroporation (IRE)-assisted therapy. To optimize therapeutic performance, copper loading and HA surface modification were systematically tuned, resulting in a formulation with balanced physicochemical properties, efficient CD44-mediated cellular uptake, and favorable biological activity. When combined with IRE, mCuppy exhibited enhanced intratumoral retention, improved 3D spheroid penetration, and increased intracellular uptake, which were associated with IRE-induced membrane permeabilization and improved intratumoral distribution. Mechanistically, integrated transcriptomic and metabolomic analyses revealed that the combination treatment induced profound metabolic reprogramming associated with cuproptosis, including dysregulation of pantothenate/CoA biosynthesis, unsaturated fatty acid metabolism, and glycerolipid metabolism. These alterations were accompanied by lipoylated protein aggregation, lipid droplet accumulation, and mitochondrial dysfunction. Notably, additional analyses of cell death pathways suggested that, while cuproptosis represents a dominant mechanism, apoptosis and lipid metabolism-associated stress responses may also contribute to the overall therapeutic effect. In orthotopic PDAC models, mCuppy combined with IRE achieved marked tumor suppression and promoted antitumor immune remodeling, including dendritic cell maturation, increased CD8+ T-cell infiltration, and M1 macrophage polarization. Together, this study demonstrates that IRE-potentiated copper nano therapy induces metabolic vulnerability, cuproptosis, and immune remodeling in PDAC, providing a promising strategy for stromal-rich pancreatic cancer.

PMID 42503313
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PubMedACS applied materials & interfaces2026-07-27

Biomimetic Cascade-Responsive Natural-Synthetic Composite Hydrogel for Acne Lesion Microenvironment Modulation.

Zhou Qi Q, Zhang Kexin K, Fan Yinuo Y, Feng Linhan L et al.

Acne vulgaris is a multifactorial inflammatory skin disorder driven by abnormal follicular keratinization, microbial dysbiosis, and persistent inflammation. However, existing monotherapies often fail to simultaneously address these multiple interrelated pathological processes. Herein, a mussel-inspired, cascade-responsive natural-synthetic hydrogel (HCM) was developed for localized acne therapy through modulation of the lesion microenvironment. This hydrogel forms a three-dimensional network via dynamic Schiffbase cross-linking between oxidized hyaluronic acid (OHA) and chitosan (CS), endowing it with structural integrity, self-healing properties, and pH-responsiveness. Salicylic acid (SA) was chemically grafted onto CS chains (SA-g-CS) to mitigate local irritation and enable sustained release. Furthermore, curcumin-loaded mesoporous polydopamine nanoparticles (mPDA@Cur) were introduced to confer near-infrared-triggered photothermal antibacterial activity and antioxidant capacity. Under 808 nm near-infrared irradiation, HCM hydrogel exhibited good photothermal conversion and effectively inhibited Propionibacterium acnes (P. acnes), Staphylococcus aureus (S. aures), and Escherichia coli (E. coli), with inhibition rates as high as 97.2, 86.4, and 87.1%, respectively. In vitro studies further demonstrated favorable cytocompatibility, efficient reactive oxygen species scavenging, and enhanced fibroblast migration. In an SD rat acne model, HCM hydrogel combined with near-infrared irradiation significantly inhibited bacterial colonization, alleviated local inflammatory and tissue edema, and reduced inflammatory cell infiltration. Moreover, collagen deposition and lesion repair were promoted by it via downregulation of proinflammatory factors like IL-1β and TNF-α. Collectively, HCM integrates photothermal antibacterial activity, sustained drug delivery, antioxidative anti-inflammatory regulation, and tissue-repair capability to enable coordinated modulation of the acne lesion microenvironment. This work thus provides a promising material design strategy for localized treatment of acne and other inflammation-related skin disorders.

PMID 42504447
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