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hyaluronic acid (Provisc)

✓ Approved

Novartis AG · 治疗药物

什么是 hyaluronic acid？

hyaluronic acid 是一种治疗药物，由Novartis AG研发。该药已获批，用于治疗相关适应症。

药物档案

商品名Provisc
公司Novartis AG
状态Approved
来源： ClinicalTrials.gov, Novartis AG

治疗适应症

hyaluronic acid 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresAdjuvant therapy✓ Approved
Eye disordersDry eyePreclinical

相关研究文献

PubMedBiomolecules2026-10-27

Hyaluronic Acid-Based Nanoplatforms for Photoacoustic Monitoring of Phototherapy.

Jeong Yongjae Y, Jo Dongyoung D, Choi Wonseok W, Kim Ki Su KS et al.

Photoacoustic imaging is a noninvasive imaging modality with considerable potential for theranostic applications, providing high-resolution visualization of molecular and physiological responses to treatment. Among the diverse materials investigated for constructing theranostic nanoplatforms, hyaluronic acid has attracted substantial interest because of its biocompatibility, hydrophilicity, chemical modifiability, and affinity for CD44 receptors, which are frequently overexpressed in various cancer cells. Moreover, appropriately engineered hyaluronic acid-based formulations offer opportunities for localized and transdermal delivery, potentially reducing the need for systemic administration and expanding the applicability of noninvasive phototherapy, particularly for superficial lesions. In this review, we summarize recent advances in hyaluronic acid-based nanoplatforms for photoacoustic imaging-monitored phototherapy, categorized into photothermal therapy, photodynamic therapy, and their combination. We further discuss their material design, targeting and delivery mechanisms, photoacoustic monitoring capabilities, therapeutic performance, and key challenges for clinical translation.

PMID 42939763
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PubMedPolymers2026-10-27

Fabrication and Characterization of Polylactic Acid/Hyaluronic Acid/Collagen Nanofibers for Tendon Tissue Engineering.

Akdag Zekiye Z, Kazdal Cengiz C, Yildiz Elif Nur EN, Kanli Zehra Z et al.

Tendons are highly elastic connective tissues that transfer mechanical loads from muscle to bone, and their healing is often slow and incomplete because of limited vascularization. Tissue engineering approaches are therefore emerging as promising alternatives to support tendon repair. In this study, polylactic acid (PLA)-based nanofibers containing hyaluronic acid (HA) and collagen (COL), intrinsic components of the extracellular matrix, were fabricated by blend and coaxial electrospinning. Matrices of identical overall composition were produced by both configurations, so that the contribution of nanofiber architecture could be isolated from that of chemical composition; the coaxial nanofibers comprised a load-bearing PLA/COL core and a PLA/HA shell, reproducing the collagen-rich tendon proper and the hyaluronic acid-rich gliding surface of native tendon. Mean fiber diameters ranged from 319 ± 82 nm for neat PLA to 854 ± 220 nm for the coaxial nanofibers, approximately twice that of the compositionally identical blend nanofibers (454 ± 110 nm). Tensile strength increased from 2.108 MPa for neat PLA to 4.94 MPa for PLA/COL, and the coaxial nanofibers retained a comparable value (4.651 MPa, p > 0.05) despite the incorporation of HA. In human mesenchymal stem cells, viability was maintained or increased over 7 days on the coaxial scaffolds but declined markedly on the blend scaffolds, indicating that the core-shell architecture is more favorable for tendon tissue regeneration.

PMID 42942595
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PubMedAdvances in gerontology = Uspekhi gerontologii2026-10-27

[Signaling molecules and skin aging: Targeted prevention approaches in molecular cosmetology.]

Khabarov V N VN, Zhukova I K IK, Kravtsova I V IV, Drobintseva A O AO et al.

Chronic genotoxic stress leads to the development of inflammaging in human skin fibroblasts, a condition characterized by the accumulation of DNA damage, overexpression of pro-inflammatory factors, and degradation of the extracellular matrix, which makes it important to find ways to correct these processes. Hydrogel preparations based on hyaluronic acid with chelated forms of micronutrients are considered promising. Therefore, the aim of this study was to investigate the effect of a hyaluronic acid-based hydrogel with a chelated form of zinc and silicon on the expression of cellular aging biomarkers CCN1, IL-8, Ki-67, MMP-3, NF-κB/p65, and TIMP1 in human skin fibroblast cultures under genotoxic stress. Inflammaging modeling was performed on human dermal fibroblasts by exposure, causing a critical threshold of damage to chromosomal DNA. In the experimental samples, a preparation based on hyaluronic acid with a chelated form of zinc and silicon was added to the culture, after which the expression of these biomarkers was evaluated. The results showed that genotoxic stress in this model activates the degradation of extracellular matrix proteins and causes a sharp increase in the expression of IL-8, CCN1, and NF-κB. In all the samples studied, the addition of the preparation to a culture of fibroblasts exposed to genotoxic stress resulted in a significant restoration of the proliferative (associated with Ki-67) and biosynthetic functions of dermal fibroblasts, as well as a decrease in key markers of inflammaging. Thus, a hyaluronic acid-based preparation with a chelated form of zinc and silicon effectively corrects the molecular signs of cellular aging and the inflammatory phenotype under genotoxic stress, which justifies its potential use for the prevention and correction of age-related skin changes.

PMID 42935340
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PubMedBiomaterials science2026-10-27

Chitosan-hyaluronic acid nanoparticles with time-dependent mucoadhesive and mucus penetrating behaviour to overcome pathological lung mucus.

Barretta Marco M, Della Sala Francesca F, Marino Giuseppe G, di Gennaro Mario M et al.

Bacterial infections are a major complication in pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS), aggravated by multidrug-resistant bacteria and the presence of pathological mucus that limits antibiotics efficacy. To address this challenge, drug-free chitosan/hyaluronic acid (CS/HA) nanoparticles were developed through a one-step ionic gelation method. By modulating the CS/HA ratio and HA molecular weight, stable, spherical nanoparticles with sizes ranging from 75 to 210 nm and positive ζ-potentials between +22 and +34 mV were obtained. FTIR confirmed electrostatic stabilization. The nanoparticles exhibited a unique time-dependent behavior: initial adherence to pathological mucus for local retention, followed by a hydration-driven surface rearrangement enabling mucus barrier penetration. This sequential mucoadhesive-to-mucus-penetrating transition is reported for the first time for a drug-free carbohydrate network. Biological assays demonstrated excellent biocompatibility with healthy and diseased human lung fibroblasts (HLF, HLF COPD and A549), alongside significant antioxidant activity. Moreover, the nanoparticles exerted dose-dependent, intrinsic antimicrobial effects against major respiratory pathogens, including Staphylococcus aureus and Pseudomonas aeruginosa. Overall, by engineering a dynamically adaptive interface, this work crucially resolves the historical trade-off between mucosal retention and diffusion, establishing a promising nanotherapeutic strategy for combating multidrug-resistant pulmonary infections directly at the mucus site.

PMID 42936924
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PubMedJournal of clinical periodontology2026-10-27

Influence of the Occupying Proportion of Mineralised Particles Within the Grafted Volume on Subsequent Volume Shrinkage: A Preclinical Study on Rabbit Calvaria.

Choi Ji-Su JS, Hwang Betül B, Lee Min-Yong MY, Cho Sang-Hyun SH et al.

To evaluate whether mineral particle occupancy within the grafted volume influences volumetric stability and bone regeneration, and to compare particulate grafts, collagenated grafts, hyaluronic acid-conjugated particulates and mechanical manipulation in a vertical augmentation model. Ten New Zealand white rabbits received four standardised vertical calvarial defects and filled with saline-hydrated particulate deproteinised porcine bone mineral (Control), intact collagenated bone blocks (CBM), hydrated and mechanically crushed collagenated blocks (cCBM) or particulate grafts mixed with hyaluronic acid (HA). Grafts were placed in sealed plastic cylinders. Animals were sacrificed at 2 and 8 weeks. Volumetric stability and mineralised tissue volume were assessed by micro-computed tomography, and the total augmented area, new bone formation, residual material and particle length were evaluated by histological and histomorphometric analyses. Data were analysed using linear mixed-effects models. Mineralised tissue volume increased over time in Control, CBM and HA groups but decreased in cCBM (time × material interaction, p = 0.020). At 8 weeks, total augmented area was preserved in Control and CBM, whereas significant volumetric shrinkage occurred in cCBM and HA (p < 0.01). New bone formation increased in all groups but was highest in the Control group. Residual material area remained stable but was higher in Control and CBM than in cCBM and HA, and particle length was reduced in mechanically manipulated groups. Given the limitations of this model, binder incorporation and mechanical manipulation may affect particle occupancy and volumetric stability. Reducing graft manipulation may enhance space maintenance and facilitate bone regeneration.

PMID 42935113
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PubMedMaterials today. Bio2026-10-27

Microneedle-mediated co-delivery of biomimetic melanin and pro-regenerative factors for oxidative and immune modulation in vitiligo.

Liang Jingyao J, Liu Wenyan W, Jiang Yu Y, Yu Yihui Y et al.

Vitiligo lesions are characterized by elevated epidermal oxidative stress, cytotoxic immune activation, and impaired melanogenesis, while conventional topical therapies often fail to modulate these pathogenic events due to limited skin penetration and therapeutic depth. To address these challenges, a dual-layer gelatin methacryloyl (GelMA)/hyaluronic acid methacryloyl (HAMA)//hyaluronic acid (HA) (Gel//HA) microneedle system was engineered. The inner HA layer rapidly dissolves upon insertion, releasing keratinocyte-membrane-coated artificial melanin nanoparticles (MPDA) to achieve early reactive oxygen species (ROS) scavenging and targeted delivery to keratinocytes. The outer Gel hydrogel layer enables sustained intradermal delivery of basic fibroblast growth factor (bFGF) and tyrosinase (TYR), supporting melanocyte survival and restoring melanin synthesis. The microneedles exhibited robust mechanical strength (0.234 ± 0.014 N/needle) with a penetration depth of approximately 300-350 μm. In vitro, the cumulative release of bFGF and TYR reached 65% and 70% within the first 72 h, respectively, and subsequently increased more gradually to 92.1% and 90.7% by day 21. In vitro, the combined administration of MPDA, bFGF, and TYR, mitigated H2O2-induced oxidative injury and enhanced keratinocyte viability. In a monobenzone-induced mouse model, Gel@bFGF/TYR//HA@MPDA treatment markedly promoted repigmentation, restored epidermal melanin deposition, and reduced the expression of CD8, IFN-γ, and TNF-α. Transcriptomic analysis further revealed suppression of ferroptosis-related genes and reactivation of the Wnt-Frizzled-MITF melanogenic signaling axis. This spatially designed microneedle system provides coordinated antioxidant, immunomodulatory, and pro-melanogenic effects, offering a promising localized therapeutic strategy for vitiligo.

PMID 42936486
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