北京若生智能科技有限公司
Drug Database
CE

cetirizine (QZYTIR / JDP207 / Quzyttir)

✓ Approved

Hospira Inc · HRH1 · 小分子

什么是 cetirizine？

cetirizine 是一种小分子，由Hospira Inc研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection、Intravenous (IV)。

药物档案

商品名QZYTIR, JDP207, Quzyttir
公司Hospira Inc
药物类别小分子
分子靶点HRH1
给药途径Injectable (Others), Intramuscular (IM) Injection, Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Hospira Inc

作用机制

分子靶点

cetirizine 作用于 1 个分子靶点：

HRH1histamine receptor H1 (HH1R, H1R)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

cetirizine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersUrticaria✓ Approved

相关研究文献

PubMedExperimental hematology2026-09-03

Mast Cell Derived Histamine Negatively Regulates Hematopoiesis.

Klein Bailey R BR, Smith Julianne N P JNP, Katabathula Ramachandra R, Rashmil Ritisha R et al.

Mast cells (MCs) are well known for their roles in immunity, but their influence on hematopoietic stem cell (HSC) regulation remains poorly defined. Here, we identify MC-derived histamine as a suppressor of hematopoiesis. MC-deficient "SASH" mice exhibited increased bone marrow HSC frequency, a transcriptional quiescence signature, and resistance to myeloablative chemotherapy, associated with niche remodeling, including increased HSC-supportive stromal populations and elevated maintenance factor expression, and improved engraftment of wild-type donor cells. Reciprocal transplants showed this phenotype is driven by the recipient niche rather than an HSC-intrinsic property, and MC-derived secretory factors were directly sufficient to suppress HSCs in vitro and in vivo. Pharmacologic H1 receptor blockade with cetirizine, an FDA-approved inverse agonist, phenocopied the SASH model, expanding HSCs and enhancing both early recovery and long-term reconstitution in transplant settings, while exogenous histamine reversed the SASH phenotype. Supporting clinical relevance, electronic health record analysis revealed that antihistamine use was associated with elevated white blood cell counts in humans. These findings establish mast cell-derived histamine as a suppressor of hematopoiesis and suggest that H1R antagonism may offer a tractable strategy to enhance hematopoietic regeneration. Teaser Abstract: Mast cell-derived histamine restrains hematopoietic stem cell activity by shaping the bone marrow niche. Blocking histamine signaling with the FDA-approved antihistamine cetirizine expands the stem and progenitor pool and accelerates hematopoietic recovery after transplant, pointing to a repurposable strategy for boosting blood regeneration in patients.

PMID 42692326
阅读全文 →
PubMedIndian journal of pharmacology2026-09-02

Levocetirizine-induced paradoxical fixed drug eruption: A case report with causality assessment.

Remesh Ambili A, Lekshmi Madhavi S MS, Reshmi Subramaniam S

Fixed drug eruptions (FDE) are drug-induced skin reactions that repeatedly occur at the same anatomical site. The skin lesions are usually clear hyperpigmented patches that may develop into blisters. The skin response involves type IV delayed hypersensitivity reactions and is caused by drug-specific memory CD8 T-cells located at the affected skin site. Levocetirizine, an H1-selective second-generation piperazine antihistamine, has a good safety profile and is used to treat the skin reactions. Its nonprescription availability leads to self-medication and unrecognised adverse drug reactions (ADR). FDE due to levocetirizine, as well as with cetirizine, is less common in the literature. This case was reported to our ADR Monitoring Center and causality was assessed as probable and preventable. This case shows that antihistamines such as levocetirizine can trigger FDE in susceptible individuals. Improving clinical awareness through robust Pharmacovigilance activities, educating patients about triggers, and discouraging self-medication are crucial for preventing recurrence.

PMID 42683994
阅读全文 →
PubMedFrontiers in medicine2026-08-28

Second-generation H1 antihistamines for the treatment of chronic urticaria: a network meta-analysis.

Li Zixuan Z, Zhang Juan J, Zheng Yaqi Y, Zhang Mingyan M et al.

To evaluate the efficacy and safety of 10 commonly used second-generation H1 antihistamines (cetirizine, levocetirizine, loratadine, desloratadine, ebastine, bilastine, olopatadine, rupatadine, fexofenadine, and mizolastine) at licensed doses in treating chronic urticaria using network meta-analysis. Seven electronic databases were searched, including PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and Chinese Biomedical Literature Service System. Relevant literature from inception to the end of December 2025 was retrieved. Studies meeting the criteria were selected, and network meta-analysis was performed using Stata 16 software. A total of 54 studies involving 7,290 patients were included. Network meta-analysis indicated that olopatadine, mizolastine, bilastine, and levocetirizine were more effective than placebo in improving total symptom scores. All 10 drugs were superior to placebo in reducing itching scores, although only fexofenadine achieved statistical significance. For reducing wheal scores, ebastine was significantly more effective than mizolastine and loratadine. Regarding adverse reactions, no significant differences were observed between any of the drugs and placebo, with fexofenadine having the lowest adverse reaction rate. Sensitivity analyses excluding highrisk studies confirmed the robustness of findings across all outcomes. Based on current evidence, olopatadine at licensed dose exhibited the best efficacy in reducing total symptom scores. Fexofenadine was most effective for improving itching scores and ebastine was optimal for reducing wheal scores. In addition, fexofenadine had the lowest incidence of adverse reactions. However, the conclusions of this study still need to be validated by further high-quality randomized controlled trials.

PMID 42662818
阅读全文 →
PubMedFrontiers in oncology2026-08-15

Paraneoplastic dermatomyositis-like syndrome preceding diagnosis of small cell lung cancer: a case report.

Wang Jinwei J, Jiang Meiling M, Chen Kun K, Zhang Bo B et al.

Paraneoplastic syndromes (PNS) are frequently misdiagnosed as independent neurological, endocrine, cutaneous, or rheumatic immune disorders due to their low incidence, highly variable, and complex clinical presentations. Currently, when faced with clinically unexplainable phenomena, PNS is seldom considered in the differential diagnosis. A 68-year-old non-smoking Chinese male presented with insidious digital clubbing in 2021 and refractory cutaneous eruptions in 2023, which were initially diagnosed as granulomatous rosacea and erythroderma. However, treatment with ketotifen, cetirizine, and the immunosuppressant cyclosporine led only to partial regression of the rash, with persistent pruritus. Approximately 3 years after the insidious onset of digital clubbing and 1 year after the skin lesions flared, in April 2024, chest PET/CT scan revealed a mass in the left lower lobe and a nodule in the dorsal segment of the right lower lobe. A biopsy confirmed extensive-stage small cell lung carcinoma (SCLC).His dermatological manifestations, which progressed to edema and dysphagia, and ancillary examination results were subsequently attributed to a paraneoplastic dermatomyositis-like syndrome. Chemotherapy for SCLC resulted in resolution of the skin lesions and disease control. This case underscores the critical role of PNS as an early indicator of occult malignancy and highlights the therapeutic challenges in managing paraneoplastic dermatomyositis-like syndrome.

PMID 42601934
阅读全文 →
PubMedThe American journal of emergency medicine2026-08-11

Rabies post-exposure prophylaxis after previous immediate hypersensitivity: A case report.

Duyan Murat M, Akcimen Mehmet M, Balci Dilara D, Has Halit H

Rabies is almost invariably fatal after symptom onset but is preventable with timely post-exposure prophylaxis. A 23-year-old woman presented after a category III stray-cat bite. In 2022, tongue swelling and generalized urticaria had occurred immediately after her first rabies vaccine dose, and the series was discontinued. Because the new exposure was high risk and she was not fully immunized, prophylaxis was administered in a resuscitation area with intramuscular epinephrine and advanced airway equipment immediately available. Equine rabies immunoglobulin and vaccine were given after antihistamine and corticosteroid premedication. Only transient localized erythema occurred. After the first two doses were tolerated during 16- and 8-h observation periods, the third and fourth doses were administered after oral cetirizine with 4-h monitoring in a standard monitored area. After individualized assessment, prophylaxis may be completed despite previous immediate hypersensitivity when full resuscitation preparedness and progressive de-escalation of monitoring are used. Premedication does not prevent anaphylaxis and must not replace prompt epinephrine treatment.

PMID 42580000
阅读全文 →
PubMedNaunyn-Schmiedeberg's archives of pharmacology2026-08-10

Paracetamol-induced hepatic injury following intentional self-poisoning: a case report and therapeutic considerations.

Misbah Ul Haq Mohammed M, Yousuf Khan Amer Khan AK, Mohiuddin Mohammed M, Fareedullah Mohammed M

Paracetamol (acetaminophen) overdose is a common cause of drug-induced hepatocellular injury and represents an important clinical emergency requiring timely evaluation and evidence-based management. N-acetylcysteine (NAC) remains the established antidote for preventing the progression of hepatic injury when administered promptly. We describe the case of an 18-year-old female who intentionally ingested eight tablets of paracetamol (650 mg each; total dose 5.2 g) and four tablets of cetirizine (10 mg each) following psychosocial distress. On presentation, she reported abdominal pain and had a history of transient altered consciousness prior to hospital arrival. Initial biochemical evaluation demonstrated mild hepatocellular injury, with serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels of 250 IU/L and 300 IU/L, respectively, while serum bilirubin and coagulation parameters (PT/INR) remained within normal limits, indicating the absence of acute liver failure. Following clinical assessment, the patient underwent gastric decontamination and received the standard intravenous NAC regimen, supportive therapy, serial monitoring of liver function, and comprehensive psychiatric evaluation. Liver enzyme concentrations progressively declined during hospitalization, reaching AST 60 IU/L and ALT 70 IU/L by day 3, with complete clinical recovery and no evidence of hepatic complications. Psychiatric assessment identified underlying psychosocial factors contributing to the intentional overdose, and appropriate pharmacological treatment and follow-up were initiated before discharge. This case demonstrates that favorable outcomes can be achieved through early risk assessment, guideline-directed NAC therapy, serial biochemical monitoring, and multidisciplinary management addressing both the toxicological and psychosocial aspects of intentional paracetamol overdose.

PMID 42573610
阅读全文 →

注册免费账户还可查看另外 1858 篇文献

免费注册查看全部文献 →

了解更多cetirizine