北京若生智能科技有限公司
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elastase (elastase / Elaszym)

✓ Approved

Eisai Co., Ltd. · 治疗药物

什么是 elastase？

elastase 是一种治疗药物，由Eisai Co., Ltd.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名elastase, Elaszym
公司Eisai Co., Ltd.
状态Approved
来源： ClinicalTrials.gov, Eisai Co., Ltd.

治疗适应症

elastase 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersArteriosclerosis✓ Approved

相关研究文献

PubMedAntioxidants (Basel, Switzerland)2026-10-27

Circulating ELAFIN Is Associated with a Distinct Renal-Inflammatory Phenotype in Type 2 Diabetes Mellitus.

Krasińska Beata B, Urbanowicz Tomasz T, Kang Minseung M, Baek Siwon S et al.

ELAFIN (peptidase inhibitor 3, PI3) is an endogenous inhibitor of neutrophil elastase and proteinase 3, but its circulating profile in type 2 diabetes mellitus (T2DM) and cardiovascular disease remains poorly characterized. We investigated circulating ELAFIN in patients undergoing elective coronary angiography and explored its associations with metabolic, inflammatory, renal, cardiac, and angiographic phenotypes. Forty-three consecutive clinically stable patients undergoing elective coronary angiography, including nine with T2DM, were prospectively enrolled. Plasma ELAFIN was quantified by ELISA. Associations with clinical and laboratory variables were assessed using non-parametric comparisons, correlation analyses, and parsimonious multivariable regression. Discrimination analyses were considered exploratory. Median ELAFIN was 5.03-fold higher in patients with T2DM than in those without T2DM (31.2 [28.3-36.2] vs. 6.2 [5.5-7.0] ng/mL; p < 0.001; Cliff's δ = 0.85). The association remained pronounced after adjustment for age, sex, and renal function. ELAFIN was positively correlated with REG3A and creatinine, and inversely correlated with eGFR, whereas no significant associations were observed with angiographic coronary stenosis, LVEF, or NT-proBNP. Circulating ELAFIN was markedly elevated in T2DM and associated predominantly with renal and inflammatory characteristics rather than anatomical coronary disease or left ventricular dysfunction. Because oxidative stress and protease activity were not directly measured, their relationship with ELAFIN remains hypothesis-generating. These findings require validation in larger prospective cohorts.

PMID 42939889
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PubMedMolecules (Basel, Switzerland)2026-10-27

Evaluation of Atractylodes macrocephala Koidz Extract as a Multi-Functional Natural Ingredient for Skin Barrier Repair.

Liu Huan H, Yu Le L, Yang Chang-Yin CY, Zhao Yu-Qiang YQ et al.

Epidermal barrier damage triggers sensitive skin disorders. Synthetic skin repair agents frequently incur irritation, whereas medicinal and edible herbal ingredients offer milder alternatives. As a traditional Chinese medicinal herb, Atractylodes macrocephala Koidz remains inadequately characterized regarding its epidermal barrier repair efficacy. This work systematically characterized the barrier restoring capacity of A. macrocephala extract (AKE) via keratinocyte injured models, biochemical assays, spectroscopic interaction analysis, molecular docking and a tape stripping-induced mouse model of skin barrier impairment. AKE promoted keratinocyte migration, alleviated sodium lauryl sulfate triggered oxidative injury and enhanced ceramide synthesis. Moreover, AKE inhibited hyaluronidase, collagenase and elastase activities. Fluorescence quenching spectroscopy and thermodynamic analysis demonstrated spontaneous binding between AKE constituents and these skin degrading enzymes. At 50 μg/mL, AKE downregulated expression of pro-inflammatory cytokines interleukin (IL)-6 and IL-8 by suppressing the NF-κB inflammatory cascade, and restored occludin and keratin levels (p < 0.01 vs. the model group). It also exerted anti-Microsporum gypseum activity, with a minimum inhibitory concentration (MIC) of 92.36 ± 1.03 μg/mL, which alleviated inflammation and pruritus associated with dermatomycosis. In barrier-damaged mice, topical application of AKE recovered 81.2% of epidermal integrity (p < 0.001 vs. the model group) and normalized skin biomarkers. UHPLC-ESI-HRMS/MS combined with molecular docking identified atractylenolide I-II as potential bioactive compounds. In summary, AKE repairs damaged epidermis through multi-target modulation, indicating promising potential as a natural functional candidate for skin barrier repair.

PMID 42943783
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PubMedJournal of inflammation research2026-10-27

NETosis-PANoptosis Crosstalk in Colitis-Associated Colorectal Cancer: Mechanistic Links, Biomarkers, and Therapeutic Prospects.

Wang Jing J, Tang Bowen B, Zhang Wenwen W, Kong Ailin A et al.

Colitis-associated colorectal cancer (CAC) is a serious long-term complication of inflammatory bowel disease (IBD) that develops through a chronic inflammation-dysplasia-carcinoma sequence. Persistent mucosal inflammation promotes epithelial barrier disruption, oxidative and genotoxic stress, dysregulated repair, and immune remodeling, thereby creating conditions that favor malignant transformation. Neutrophil extracellular trap (NET) formation and PANoptosis-an inflammatory programmed cell-death process integrating pyroptotic, apoptotic, and necroptotic machinery-represent two potentially interconnected components of this inflammatory environment. This narrative review examines the biological links between NETosis and PANoptosis in CAC, with emphasis on NET-derived nucleic acids, histones, myeloperoxidase, neutrophil elastase, reactive oxygen species, damage-associated molecular patterns, pattern-recognition receptor signaling, and cytokine networks. We further discuss microbiota-derived metabolites, candidate biomarkers, and therapeutic implications. Importantly, evidence is considered according to disease context: findings demonstrated in CAC are distinguished from mechanistic observations derived from IBD, sporadic colorectal cancer, and other inflammatory or tumor models, which are used to identify biologically plausible but not yet CAC-validated connections. Current data support bidirectional links between neutrophil activation and inflammatory epithelial cell death, but direct demonstration of a complete NETosis-PANoptosis feedback loop in human CAC remains limited. By bringing together these previously dispersed lines of evidence, this review clarifies where the NETosis-PANoptosis relationship is supported, where it remains inferential, and which molecular intersections may be most relevant for biomarker development and therapeutic investigation in CAC.

PMID 42936766
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PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

The Network Pharmacology of Rosmarinic Acid and Elucidating the Wound Healing Potential of a Rosmarinic Acid-Enriched Trachystemon orientalis Extract.

Badem Merve M, Kanbolat Şeyda Ş, Ulas Çolak Nevin N, Subaş Tuğba T et al.

Background/Objectives:Trachystemon orientalis (L.) D. Don has been reported to be used in folk medicine for the treatment of inflammatory wounds and for its contained rosmarinic acid, a phenolic compound known for its antioxidant, anti-inflammatory, antimicrobial, and wound healing properties. This study aimed to obtain a rosmarinic acid-enriched extract from the aerial parts of T. orientalis and evaluate its in vitro wound healing potential. Methods: Extraction conditions were optimized using fractional factorial design and Box-Behnken optimization. Rosmarinic acid content was quantified by RP-HPLC. A rosmarinic acid-enriched extract was compared with a maceration extract and isolated rosmarinic acid. Elastase, hyaluronidase, and collagenase inhibitory activities were determined. Cytotoxicity was evaluated on L929 fibroblasts using the MTT assay, and non-cytotoxic concentrations were assessed for their effects on in vitro wound healing by scratch assay. In addition, in silico target prediction and network pharmacology analyses were performed using rosmarinic acid. Results: Optimization successfully yielded a rosmarinic acid-enriched extract from T. orientalis. The rosmarinic acid-enriched extract inhibited wound-related enzymes and enhanced wound closure in the scratch assay. Network pharmacology analysis showed putative molecular targets and signaling pathways potentially associated with the wound healing activity of rosmarinic acid, especially those involved in inflammatory responses, extracellular matrix remodeling, and tissue regeneration. Conclusions: The rosmarinic acid-enriched extract exhibited promising in vitro wound healing-related activity through the inhibition of extracellular matrix degrading enzymes and promotion of wound closure. Furthermore, network pharmacology analysis provided preliminary mechanistic insights based on computational predictions.

PMID 42943331
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PubMedERJ open research2026-10-27

Long-term safety and efficacy of lumacaftor/ivacaftor in children aged ≥12 months of age with cystic fibrosis: a 96-week open-label study.

Zemanick Edith T ET, McColley Susanna A SA, Linnemann Rachel W RW, Rayment Jonathan H JH et al.

We evaluated long-term safety and efficacy of lumacaftor (LUM)/ivacaftor (IVA) in children aged 12 to <24 months with cystic fibrosis (CF) homozygous for F508del. This international, 96-week, phase 3, open-label study enrolled children who completed parent study 809-122 (after 2-week washout) or were LUM/IVA-naïve. The primary end-point was safety and tolerability. The secondary efficacy end-point was change from baseline in sweat chloride concentration. 52 children (39 from 809-122; 13 LUM/IVA-naïve) participated. Mean±sd exposure to LUM/IVA was 597±162 days. All children had at least one adverse event, which were mostly mild (32.7%) or moderate (55.8%) in severity and consistent with common manifestations of CF or early childhood illnesses. One child (1.9%) discontinued study drug due to a treatment-emergent adverse event of increased alanine/aspartate aminotransferases that resolved after discontinuation. 12 (23.1%) children had serious adverse events, none of which was considered related to LUM/IVA. At week 96, mean absolute change from pre-treatment baseline in sweat chloride concentration was -21.0 (95% CI -27.6 to -14.3) mmol·L-1. Growth parameters, which did not change significantly, were in the normal range throughout the 96-week treatment period. Improvements from baseline were observed in mean fecal elastase-1, fecal calprotectin, and serum immunoreactive trypsinogen. LUM/IVA remained generally safe and well-tolerated over 96 weeks. Improvements in sweat chloride concentration and markers of pancreatic function and intestinal inflammation were consistent with the parent study. These results demonstrate the long-term safety and efficacy of LUM/IVA in the 12 to 24-month-old population.

PMID 42935985
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PubMedPlants (Basel, Switzerland)2026-10-27

Multi-Target Anti-Aging and Wound-Healing Potential of Libyan Thymus vulgaris and Thymus capitatus Essential Oils: Integrated GC-MS, Network Pharmacology, Molecular Docking, and In Vitro Evaluation.

Suliman Sara Nasser SN, Al-Masawri Anwagy A, Hassan Madiha A MA, Abouzeid Sara S

Thymus vulgaris (TV) and Thymus capitatus (TC) are traditionally used for skin-related disorders, but their comparative chemical composition and multi-target skin-protective mechanisms remain insufficiently characterized. In this study, essential oils from aerial parts collected in eastern Libya were analyzed by GC-MS and evaluated using network pharmacology, molecular docking, enzyme-inhibition and antioxidant assays, and a human fibroblast scratch-wound/RT-qPCR model. GC-MS identified 39 constituents, accounting for 98.95% and 99.23% of the TV and TC oils, respectively; carvacrol (41.38%) and thymol (20.91%) predominated in TV, whereas thymol (41.06%) and carvacrol (13.02%) predominated in TC. Chemometric comparison with 28 published oils per species (PCA and hierarchical clustering) classified the TC oil as a thymol chemotype, found in only seven of 28 regional T. capitatus oils (18 were carvacrol type), and the TV oil as a carvacrol-rich type most similar to Moroccan oils. Network pharmacology identified 1074 core targets linked to 14 skin-associated conditions and prioritised 50 hub genes, including NFKB1 and RELA. Docking of 129 compound-target pairs showed that 84 (65%) achieved docking scores ≤-5.0 kcal/mol. TC showed stronger elastase, tyrosinase, hyaluronidase, and 5-LOX inhibition, whereas TV exhibited stronger COX-2 inhibition and antioxidant activity. At a low-toxicity concentration (1.99 µg/mL), TC was associated with accelerated fibroblast wound closure, which may reflect both migration and proliferation, and with increased COL1A1, ITGA11, and HAS2 and decreased MMP1 mRNA expression. Overall, the two oils displayed complementary multi-target anti-aging, anti-inflammatory, and antioxidant activities in vitro and in silico, with TC additionally suggesting pro-regenerative potential in fibroblasts, supporting their further investigation as topical cosmeceutical candidates.

PMID 42943190
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