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elastase (elastase / Elaszym)

✓ Approved

Eisai Co., Ltd. · 治疗药物

什么是 elastase？

elastase 是一种治疗药物，由Eisai Co., Ltd.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名elastase, Elaszym
公司Eisai Co., Ltd.
状态Approved
来源： ClinicalTrials.gov, Eisai Co., Ltd.

治疗适应症

elastase 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersArteriosclerosis✓ Approved

相关研究文献

PubMedChemistry & biodiversity2026-09-10

Comparative Phytochemical and Biological Evaluation of Four Thymus Species From Türkiye for Dermocosmetic Applications.

Özdemir Nath Ebru E, Campos Pierre-Eric PE, Le Cabec Audrey A, Gündoğan Gül İpek Gİ et al.

Species of Thymus have long been used in Anatolia for wound healing and skin disorders. This study characterized metabolites and biological activities of four taxa-Thymus leucostomus (TL), Thymus sipyleus (TS), Thymus brachychilus (TB), and Thymus migricus (TM)-using UHPLC-HRMS/MS-based molecular networking, anti-aging enzyme inhibition assays, and cellular models (L929 fibroblasts, HaCaT keratinocytes, HUVEC endothelial cells). All taxa showed triterpene-rich profiles, though TL was enriched in polymethoxylated flavonoids and TM in diterpenes. Extracts strongly inhibited hyaluronidase, collagenase and elastase, with more modest tyrosinase inhibition; the highest values were recorded for TB (hyaluronidase, 89.64%), TM (elastase, 78.31%), and TL (collagenase, 82.92%; tyrosinase, 39.74%). Biologically, TL demonstrated the broadest cytocompatibility and significantly enhanced wound closure in fibroblast (≈84.7%) and keratinocyte (≈71.3%) models. TL and TS achieved nearly complete endothelial wound closure, suggesting potential pro-regenerative effects. TL showed lower cytotoxicity in HaCaT and HUVEC cells (IC50 ≈ 0.5 mg/mL), whereas TM exhibited stronger cytotoxicity in keratinocytes (IC50 ≈ 0.1025 mg/mL). TM moderately increased intracellular ROS levels in L929 fibroblasts, while TL and TS maintained ROS levels closer to control conditions. Overall, TL and TS displayed more balanced in vitro profiles regarding wound closure, oxidative balance, and enzyme inhibition, whereas TM required more cautious concentration-dependent interpretation.

PMID 42720075
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PubMedInternational journal of cosmetic science2026-09-10

Chaves thermal spring water formulation: Substantiating anti-ageing and anti-inflammatory effects.

Rocha Pedro Emanuel PE, Faustino Margarida M, Pedrosa Silvia Santos SS, Alves Maria José MJ et al.

Thermal spring waters are known for their distinctive mineral compositions, which provide health-promoting, antioxidant, immunomodulatory and skin barrier-reinforcing effects. Historically valued for therapeutic use, these waters have recently gained renewed interest as active components in cosmetic and dermatological formulations. Previous works characterized one of Portugal's most renowned thermal waters from Chaves, revealing its potential as a dermatological base ingredient due to its anti-inflammatory effects, namely the reduction of interleukin-6 in stimulated human keratinocytes. In vivo assays further demonstrated improved skin barrier function, as evidenced by decreased transepidermal water loss and enhanced hydration without disturbing the skin microbiota. Building on these results, a new formulation was developed using Chaves thermal water as both solvent and active ingredient, combined with natural extracts of mallow (Malva sylvestris) and cucumber (Cucumis sativus), and the natural chelating agent sodium phytate to achieve a high natural index. This formulation was compared with the isolated thermal water to evaluate synergistic bioactivities. A formulation containing ~80% Chaves thermal spring water, Malva sylvestris and Cucumis sativus extracts and sodium phytate was prepared and characterized. Antioxidant activity (ABTS/DPPH), ferrous ion chelation and inhibition of matrix metalloproteinase-1, tyrosinase and elastase were evaluated. Anti-inflammatory effects were assessed in particulate matter-stimulated HaCaT keratinocytes by measuring interleukin-6 and interleukin-1α (Enzyme-Linked Immunosorbent Assay (ELISA)). Antimicrobial screening against Staphylococcus aureus and Staphylococcus epidermidis was performed using growth curves. This formulation was compared with the isolated thermal water to evaluate synergistic bioactivities. The results revealed a substantial increase in antioxidant capacity, as shown by enhanced ABTS radical scavenging activity and stronger inhibitory effects on ageing-related enzymes, including matrix metalloproteinase-1, tyrosinase and elastase. Anti-inflammatory activity was confirmed through reductions in both interleukin-1α and interleukin-6 levels, the former showing notable improvement compared with the thermal water. Overall, this study demonstrates that combining Chaves thermal spring water with synergistic natural extracts yields a multifunctional cosmetic ingredient with amplified antioxidant, anti-inflammatory and anti-ageing properties, offering strong potential for advanced skin care applications.

PMID 42717854
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PubMedJournal of pediatric gastroenterology and nutrition2026-09-10

Exocrine pancreatic function and highly effective modulators: A dual center retrospective study.

Cerchione Raffaele R, Tosco Antonella A, Cimbalo Chiara C, Capasso Francesca F et al.

Highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators (HEMTs) have significantly improved outcomes in people with cystic fibrosis (CF). Their impact on established pancreatic disease remains uncertain. We aimed to evaluate the effects of HEMTs on exocrine pancreatic function in children with CF. This retrospective dual-center observational study included children with CF treated with HEMTs for at least 12 months at the CF centers of Naples and Florence, Italy. Patients received elexacaftor/tezacaftor/ivacaftor (ETI) or ivacaftor (IVA). Fecal elastase-1 (FE-1), body mass index (BMI) z-score, sweat chloride, ppFEV1, pancreatic enzyme replacement therapy (PERT) use and history of recurrent acute pancreatitis (RAP) were evaluated at baseline and during follow-up. Patients with EPI were categorized as responders if FE-1 increased by ≥100 μg/g. A total of 136 children (median age 11 years) were included. At baseline, 116/136 (85.3%) had EPI. Median FE-1 increased from 7.5 μg/g (interquartile range [IQR] 7.5-11) at baseline to 11.9 μg/g (IQR 7.5-21) after 12 months (p < 0.01). An increase in FE-1 was observed in 55/116 patients (47.4%), while a clinically relevant increase (≥ 100 μg/g) occurred in 5 patients at 12 months and in 3 additional patients at 24 months. One patient reached repeated FE-1 values in the pancreatic-sufficient range and discontinued PERT under clinical and nutritional monitoring. Significant improvements were observed in BMI z-score, ppFEV1, and sweat chloride (p < 0.01). Among pancreatic-sufficient patients, none with prior RAP experienced recurrence during follow-up. Clinically meaningful FE-1 improvement in established EPI appears limited, although a subset of younger patients may show meaningful improvement. HEMTs may also reduce pancreatitis recurrence in pancreatic-sufficient individuals.

PMID 42720211
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PubMedCureus2026-09-10

Late-Diagnosed Cystic Fibrosis in an Octogenarian With an Atypical Phenotype of Pancreatic Sufficiency and Preserved Pulmonary Function.

Hranec Brenda B, Hudson Luke L, Layish Daniel D

Cystic fibrosis (CF) was historically described as a severe childhood disease associated with pancreatic destruction, malnutrition, recurrent respiratory infection, and early mortality. Advances in sweat chloride testing, cystic fibrosis transmembrane conductance regulator (CFTR) gene discovery, newborn screening, multidisciplinary care, and CFTR modulator therapy have transformed the natural history of the disease. However, CF remains clinically heterogeneous, and patients with residual CFTR function may present later in life with chronic bronchiectasis, sinus disease, atypical respiratory infections, or nonspecific gastrointestinal symptoms. Diagnosis in advanced age is uncommon and may be delayed when pancreatic function is preserved and sweat chloride values are intermediate. An 87-year-old woman with late-diagnosed cystic fibrosis was followed longitudinally for chronic sinopulmonary disease. She had a history of recurrent sinus infections and was evaluated at a tertiary institution, where CF was diagnosed at approximately age 62. Her family history was notable for a maternal aunt who died from an unspecified respiratory illness. Diagnostic evaluation demonstrated an intermediate sweat chloride value of 41 mmol/L and CFTR testing showing one copy of F508del, M470V polymorphism, and a rare C76W variant. Her phenotype included chronic bronchiectasis, chronic sinusitis with nasal polyps, two prior sinus surgeries, and prior Mycobacterium avium complex infection treated in 1995. She had pancreatic sufficiency, with normal fecal elastase and no clinical response to pancreatic enzyme replacement therapy. Pulmonary function testing showed preserved lung function with stage I obstruction, including FEV1 1.33 L, 89% predicted; FVC 1.95 L, 85% predicted; and FEV1/FVC ratio of 68%, stable compared with the prior year. Her course was also notable for osteoporosis with prior vertebral compression fractures, which limited tolerance of vest-based airway clearance. Management included airway clearance with an oscillatory positive expiratory pressure device, individualized bronchodilator therapy due to tachycardia with albuterol, surveillance respiratory cultures, nutritional and weight monitoring, otolaryngology follow-up for chronic sinusitis and nasal polyps, osteoporosis management, and treatment with vanzacaftor/tezacaftor/deutivacaftor, to which she reported symptomatic improvement. This case highlights an uncommon late-diagnosed CF phenotype in an octogenarian with pancreatic sufficiency, intermediate sweat chloride, chronic sinopulmonary disease, preserved lung function, and new isolation of Pseudomonas aeruginosa. The case emphasizes that preserved pancreatic function and advanced age do not exclude CF and that adult patients with chronic bronchiectasis, sinus disease, and atypical respiratory infections should be evaluated for CFTR dysfunction when clinically appropriate.

PMID 42719490
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PubMedJournal of cardiothoracic and vascular anesthesia2026-09-08

Sivelestat Sodium versus Standard Care for Prevention of Postoperative Lung Injury and Acute Respiratory Distress Syndrome in Adult Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass:A Systematic Review and Meta-Analysis.

Shahbaz Hunain H, Rayyan Syed Muhammad SM, Iqbal Mueed M, Shahzaib Muhammad M et al.

Cardiopulmonary bypass (CPB) during cardiac surgery induces a systemic inflammatory response that can result in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), with high associated mortality. Sivelestat sodium, a selective neutrophil elastase inhibitor, targets this pathway, but its perioperative efficacy remains uncertain. This study aimed to evaluate the efficacy and safety of perioperative sivelestat sodium versus standard care in adults undergoing cardiac surgery with CPB. PubMed, Embase, and Cochrane databases were searched from inception to May 2026, following PRISMA guidelines (PROSPERO registered). Randomized controlled trials and observational cohort studies were included. The primary outcome was the incidence of ARDS; secondary outcomes included all-cause mortality, arterial partial pressure of oxygen (PaO₂)/fraction of inspired oxygen (FiO₂) ratio, duration of mechanical ventilation, and intensive care unit ICU length of stay (LOS). Random-effects models were used, with Peto odds ratio (OR) for sparse data. Heterogeneity was assessed using the I² statistic, and certainty was evaluated using GRADE. Six studies (2 RCTs, 4 cohort studies; n = 834 patients) were included, all from East Asia. Pooled estimates favored sivelestat across outcomes but were not statistically significant due to heterogeneity. ARDS incidence (k = 2) showed a Peto OR of 0.19 (95% confidence interval [CI], 0.03-1.16; I² = 91.3%). Mortality (k = 5) yielded an OR of 0.69 (95% CI, 0.35-1.39; I² = 36.7%), with 1 RCT showing significant benefit. Mechanical ventilation duration and ICU LOS were reduced but not significantly so. Evidence certainty was very low. Sivelestat shows consistent directional benefit in CPB-associated pulmonary outcomes, but heterogeneity limits statistical significance. Larger multicenter RCTs are needed to confirm efficacy and define clinical use.

PMID 42711146
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PubMedZhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi2026-09-07

[Pancreatic atrophy and pancreatic exocrine insufficiency after allogeneic hematopoietic stem cell transplantation: a case report and literature review].

Shan Y Y, Ye P P PP, Pei R Z RZ, Chen D D et al.

A 60-year-old male patient with acute B-cell lymphoblastic leukemia received allogeneic hematopoietic stem cell transplantation from an unrelated donor. He was transplanted with 6.22×10(8) mononuclear cells/kg and 6.27×10(6) CD34(+) cells/kg, and engraftment was confirmed at +11 days. Eighteen months post-transplant, the patient developed persistent diarrhea and continued weight loss, which was unresponsive to antidiarrheal, immunosuppressive, and antimicrobial treatments. After abdominal CT, pancreatic magnetic resonance imaging, and fecal elastase-1 tests, he was diagnosed with pancreatic atrophy and severe pancreatic exocrine insufficiency. Symptoms significantly improved following pancreatic enzyme replacement therapy.

PMID 42706162
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