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iontophoretic system (Smart patch / Actyve)

✓ Approved

Vyteris · 治疗药物

什么是 iontophoretic system？

iontophoretic system 是一种治疗药物，由Vyteris研发。该药已获批，用于治疗相关适应症，给药途径：Transdermal。

药物档案

商品名Smart patch, Actyve
公司Vyteris
给药途径Transdermal
状态Approved
来源： ClinicalTrials.gov, Vyteris

治疗适应症

iontophoretic system 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

相关研究文献

PubMedActa histochemica et cytochemica2026-09-10

A Simple Mammalian Whole Embryo Culture System to Study High-Temperature Effects on Development.

Nagata Tatsuhiro T, Saito Daigo D, Yoshida Yumi Y, Tojima Sayaka S et al.

Whole embryo culture is a unique system for developing rodent embryos outside the uterus. This system enables the observation and manipulation of mammalian embryos during specific periods of embryonic development. Established techniques utilize a rotating bottle system that continuously supplies oxygen. However, commercial devices are currently unavailable, making the new implementation of this system virtually impossible. Furthermore, the conventional device had limitations in temperature settings, making embryonic development studies impossible under conditions deviating from the optimal temperature for mammalian embryos. In this study, we developed a simple rotating culture system that can be installed in a commercially available incubator. Embryo growth and physiological status in this devise are equivalent to those in embryos cultured in the conventional system. Using this system, we clarified the harmful effects of hyperthermia during the early stages of mouse embryonic development. This device is fully suitable for whole embryo culture in mammals and provides a foundation for verifying embryonic development states in rodents under various temperature conditions.

PMID 42718947
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PubMedRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie2026-09-10

Morphological comparative study between a fifth-generation adhesive system and a universal system in total-etch mode applied at the cervical region.

Cojocaru Claudia Ioana CI, Manolea Horia Octavian HO, Călin Claudiu C, Mărăşescu Petre Costin PC et al.

For both direct and indirect restorations at the cervical level, the preparation aims to ensure only enamel bonding, due to its proven performance over time. This study sought to evaluate the adhesion to the cervical tooth structure. The aim of the study was to morpho-structurally compare a two-step adhesive system with a universal system in total-etch mode, starting from the hypothesis of the presence of only enamel as the bonding substrate at the level of cavities prepared to the standard depth of 0.4 mm, located 2 mm coronal to the cementoenamel junction. Each adhesive system was assigned a batch of three tooth samples with standard prepared and filled cavities. From each tooth sample, three sections were cut in bucco-lingual direction at the level of the fillings. The sections were prepared for examination by scanning electron microscopy (SEM), using a specific protocol for demineralization and deproteinization. The fifth generation system presented well-represented enamel micro-retentions. Hiatuses were observed at the level of the dentin hybrid layer, despite the formation of intra-tubular resin plugs. The universal system presented less evident micro-retentions on enamel. The thickness of the adhesive layer of the universal system presented higher values compared to the fifth generation system, for both hard dental tissues. Minimal preparations may present dentin exposure, depending on the location of the cervical termination. Acid etching before applying the universal system increased its performance. In the case of enamel, the fifth generation system shows a more favorable adhesion, due to micro-mechanical retention.

PMID 42717457
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PubMedIEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society2026-09-10

100-degree Non-Contact Retinal Imaging in Mice Using a Multimodal Vis-OCT and SLO System.

Song Siyu S, Liang Guangru Ben GB, Ni Shuibin S, Hormel Tristan T TT et al.

This study reports a non-contact, multimodal visible-light OCT (vis-OCT) and scanning laser ophthalmoscopy (SLO) system for in vivo mouse retinal imaging that achieves a single-shot 100° (visual angle) field of view (FOV). By performing repeated B-scans at the same location, the system enables OCT angiography (OCTA). With a long working distance (6.4 mm), the system also allows ready realignment without disrupting native ocular optics or physiology. We validated system performance in transgenic mice expressing fluorescently labeled microglia, including both healthy mice and oxygen-induced retinopathy (OIR) models. Images from the device clearly resolve individual nerve fiber bundles, inter-plexus capillaries, and individual microglia. Hyaloid vessel shadows and tortuous vessels in OIR mice are also discernible. Together, these capabilities provide a platform for the comprehensive assessment of vascular dysfunction and microglia behavior, offering a promising tool for investigating retinal diseases that affect the peripheral regions.

PMID 42719486
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PubMedPlant-environment interactions (Hoboken, N.J.)2026-09-10

Design and Deployment of a Regulation-Compliant Infrared Heating System for UK Field Trials.

Faci Isabel I, Rogerson Paul P, Simmonds James J, Hewitt Martyn M et al.

Free-air warming systems are essential for simulating climate change in field conditions, yet most are not designed to meet UK or EU health and safety standards. We present the design and field deployment of a hexagonal temperature-free air controlled enhancement (T-FACE) system that meets UK and EU health and safety requirements for outdoor electrical equipment, as advised by our institutional Health and Safety team. The system uses real-time, temperature-responsive control with multiple sensors to maintain a consistent temperature differential between heated and ambient temperature experimental plots, achieving a mean warming of +4°C against a target of +5°C. We describe its engineering design, performance, costs, and key operational challenges, particularly related to heater reliability under continuous use. We tested the T-FACE system during the winter months of a field sown wheat crop. As a proof-of-concept, phenotypic evaluation in a single season showed preliminary effects of heating on heading date (7-14 days earlier), plant height, spike length, and spikelet number, consistent with the system inducing biologically meaningful warming. This proof-of-concept provides a scalable, regulation-compliant approach for studying crop responses to climate warming under realistic field conditions.

PMID 42719111
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PubMedNeuromodulation : journal of the International Neuromodulation Society2026-09-10

Management of Intrathecal Baclofen Pump System Malfunction and the Value of the Radio-Opaque Catheter Dye Study: A Retrospective Data Analysis of 49 Pump System Investigations Over a Seven-Year Period.

Lee Heesook H, Betteridge Nicola N, Keenan Elizabeth E, Farrell Rachel R et al.

Timely and thorough investigation of intrathecal baclofen (ITB) pump system malfunction is essential for optimal spasticity management. We reviewed seven years of investigation data to determine the value of the radio-opaque catheter dye study (RCDS) in confirming suspected ITB pump system malfunctions. A retrospective review of electronic medical records was conducted for patients admitted under the author's spasticity service for ITB pump system investigation or catheter revision surgery from January 2018 to December 2024 (a seven-year period). Demographic data, investigation results, and ITB dose at various stages were collected and compared. In the ITB cohort of 188 patients, 41 patients experienced at least one suspected ITB system malfunction (49 admissions). There were five admissions where investigations were not performed, all of which proceeded to catheter revision based on a strong clinical suspicion of catheter malfunction. Catheter access port (CAP) procedures were completed in 44 admissions; in nine of these, it was not possible to aspirate, and all nine proceeded directly to catheter revision. Of the 35 successful CAP procedures, 22 proceeded to RCDS; only one was positive and went directly to catheter revision surgery. Thirteen of the 21 admissions with a negative RCDS underwent lumbar puncture (LP) boluses; eight of these demonstrated a superior effect to pump boluses, suggesting catheter malfunction. Of the eight admissions with negative RCDS without LP, four went on to have catheter revision due to a clear history of fluctuating spasticity. In total, 31 of the 49 admissions investigated showed evidence of catheter malfunction; 27 proceeded to operating theatre for revision surgery. The RCDS showed a high false-negative rate and provided a low value in identifying ITB pump system malfunction. Instead, careful clinical assessment, early CAP procedure, and consideration of a pump ITB bolus with or without a comparison LP bolus are more valuable and effective.

PMID 42720639
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PubMedJournal of applied microbiology2026-09-10

Heterologous Surface Display of Serratia marcescens-Derived Laccase and Its Decolorization Performance toward Azo Dyes.

Tan Fumin F, Pan Ying Y, Li Qifeng Q, Fan Enguo E et al.

Laccase represents a high-value green catalyst with extensive industrial application prospects. The aim of this study is to construct a laccase surface-displaying recombinant strain LacA-BL21 by fusing LacA from Serratia marcescens with Escherichia coli (E. coli) Ag43 autotransport system, optimize its enzyme production and dye decolorization parameters, verify the surface display system efficiency, and evaluate its potential for industrial wastewater bioremediation. In this study, we generated the surface-displaying strain LacA-BL21 by fusing laccase (LacA) from S. marcescens with the Ag43 autotransport system from E. coli. The enzyme activity results indicate that the recombinant laccase exhibits optimal catalytic activity at 45°C and pH 4.0. Key parameters affecting enzyme production were systematically optimized and LacA-BL21 achieved a maximum laccase activity of 43.66 ± 1.45 U mL-1 in TB medium supplemented with 4% methanol, 1.77 times that of the wild-type strain ZH-5. Furthermore, qRT-PCR analysis demonstrated that the relative transcription level of the target gene in the LacA-BL21 was 1.91-fold higher than that in the wild-type strain ZH-5, verifying the high efficiency of the surface display system for laccase heterologous expression. Dye decolorization assays using simulated wastewater were performed to evaluate the catalytic performance of recombinant LacA-BL21 system, and the results indicated outstanding decolorization efficacy toward various dye substrates. Following systematic process optimization, the crude preparation containing recombinant LacA achieved an 82.17% decolorization rate for Congo red simulated wastewater within 2 hours. This study constructs a surface display system for laccase expression, which exhibits exceptional catalytic efficiency and favorable decolorization capability toward azo dyes, thereby harboring substantial promise for the bioremediation of industrial wastewater.

PMID 42720414
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