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IVIG (Privigen / IVIG, liquid, CSL / IgPro10)

✓ Approved

CSL Behring · 多克隆抗体 · 多克隆抗体

什么是 IVIG？

IVIG 是一种多克隆抗体，由CSL Behring研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Privigen, IVIG, liquid, CSL, IgPro10
公司CSL Behring
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, CSL Behring

治疗适应症

IVIG 针对 9 个适应症，涉及 6 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersPurpura✓ Approved
Immune system disordersImmunodeficiency✓ Approved
Nervous system disordersMultifocal motor neuropathy✓ Approved
Musculoskeletal and connective tissue disordersScleroderma✓ Approved
Nervous system disordersGuillain-Barre syndrome✓ Approved

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相关研究文献

PubMedFrontiers in medicine2026-09-10

Case Report: Balancing immunosuppression and infection-intravenous immunoglobulin in anti-HMGCR immune-mediated necrotizing myopathy complicated by severe pneumonia.

Fu Jing J, Zhao Qiong Q, Lou Jing-Bo JB, Tang Gui-Hua GH et al.

A 65-year-old male with a 3-year history of atorvastatin use presented with progressive proximal muscle weakness, dysphagia, and markedly elevated creatine kinase (2,277 U/L). Initially misdiagnosed with polymyositis, he deteriorated with severe pneumonia, septicemia, and type I respiratory failure requiring mechanical ventilation. Interleukin-6 rose from 12.83 to 610.9 pg/mL during sepsis. After confirmation of anti-HMGCR antibody positivity (18 arbitrary units [AU], cutoff >10 AU) via line blot assay, we discontinued methotrexate, maintained methylprednisolone at 40 mg, and initiated intravenous immunoglobulin (IVIG) 0.4 g/kg/day for 5 days with broad-spectrum antibiotics. Within two weeks, proximal muscle strength (MRC scale) improved from 2/5 to 4/5, IL-6 normalized to 8.56 pg/mL, and respiratory failure resolved. This case suggests that IVIG may serve as a safe immunomodulatory bridge in critically ill IMNM patients with severe infections.

PMID 42718719
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PubMedFrontiers in medicine2026-09-10

Diagnostic challenge of GAD65-associated autoimmune encephalitis mimicking post-traumatic complications in an older adult: a case report.

Huang Xiuqing X, Zhang Qile Q, Huang Li L, Xu Jian J

Glutamic acid decarboxylase 65 (GAD65) antibody-associated autoimmune encephalitis is an uncommon immune-mediated neurological disorder with heterogeneous neuropsychiatric manifestations. Diagnosis is particularly challenging in older adults when symptoms of recent traumatic brain injury (TBI) overlap with structural or metabolic conditions. We report a 79-year-old man who developed recurrent headache, progressive confusion, abnormal behavior, poor oral intake, intermittent myoclonic jerks, and low-grade fever after TBI complicated by chronic subdural hematoma. Initial laboratory testing revealed hyponatremia, and the working diagnosis was post-traumatic brain syndrome with syndrome of inappropriate antidiuretic hormone secretion (SIADH). Although serum sodium was corrected and nocturnal agitation partially improved, persistent daytime confusion, cognitive impairment, behavioral abnormalities, and low-grade fever prompted further investigation. Cerebrospinal fluid (CSF) analysis showed mild inflammatory changes with pleocytosis and elevated protein. CSF metagenomic next-generation sequencing (mNGS) and paraneoplastic antibody testing were negative, whereas the autoimmune encephalitis panel was positive for GAD65 antibody at a titer of 1:32. Whole-body positron emission tomography-computed tomography (PET-CT) did not reveal malignancy. The diagnosis was therefore revised to GAD65 antibody-associated autoimmune encephalitis. Because high-dose corticosteroids were considered unsuitable owing to his history of gastric ulcer and previous gastrointestinal bleeding, he was treated with intravenous immunoglobulin (IVIG) at a total dose of 2 g/kg divided over 3 consecutive days followed by oral azathioprine 50 mg daily. His fever resolved within 1 week, and his mental status and responsiveness gradually improved. At 6-month follow-up, he had achieved near-baseline mental status, was able to walk with a cane, and was almost fully independent in daily activities, without relapse or serious treatment-related adverse events. This case highlights the diagnostic difficulty of recognizing autoimmune encephalitis after TBI. The clinical overlap between post- traumatic syndrome and immune-mediated brain injury often delays diagnosis, emphasizing the value of targeted CSF autoantibody testing in atypical cases. Traumatic brain injury may obscure the onset of GAD65-associated autoimmune encephalitis. Early recognition and a corticosteroid-sparing immunotherapy strategy (IVIG and azathioprine) can yield favorable outcomes in elderly patients with medical comorbidities.

PMID 42718506
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PubMedThe journal of physical chemistry letters2026-09-10

Many-Body Screening Drives Nanoscale Core-Level Variation at the Water Interface.

Chakraborty Poulami P, Voora Vamsee K VK

The depth at which the interfacial behavior of liquid water transitions into bulk behavior is critical toward understanding atmospherically relevant processes. Using intrinsic chemical shifts of O1s core levels, we demonstrate that the bulk electronic behavior emerges within 6 Å of the vacuum-liquid interface. This rapid onset is in remarkable agreement with observations from nonlinear vibrational spectroscopy yet has a different physical origin of electronic dielectric screening. Within the interfacial region, we observe an intrinsic core-level bending of 1.0 eV. Using many-body methods, we show that the level bending is driven by differences in optical dielectric screening, which is a final state effect, in the interfacial region compared to the bulk rather than by differences in the hydrogen-bonding network. However, the local hydrogen-bonding motifs majorly contribute to the distribution of shifts in liquid water. On the vacuum side, the O1s core-level energies attain the gas-phase values at a distance of 10 Å from the interface. We discuss the implications of our findings toward obtaining depth resolution of solutes at liquid interfaces.

PMID 42720327
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PubMedPhysical chemistry chemical physics : PCCP2026-09-10

Molecular hyperpolarisability as a screening descriptor for second-order nonlinear optics in ferroelectric nematic liquid crystals.

Parton-Barr Charles C, Sebastian Nerea N, Mandle Richard J RJ

Ferroelectric nematic liquid crystals combine fluidity with macroscopic polar order. Although the archetypal NF material RM734 exhibits large nonlinear optical coefficients, most known ferroelectric nematics were designed without consideration of optical nonlinearity. Here, we assess whether electronic-structure calculations can be used to identify promising nonlinear optical candidates within known polar liquid-crystal materials. Frequency-dependent molecular hyperpolarisability tensors were calculated using a range of DFT methods and basis sets, then converted to macroscopic d-coefficients using an oriented-gas model with empirical 〈P1〉 and 〈P3〉 values. Calculated values were benchmarked against available experimental d33, d15, and d13/d31 coefficients for representative materials. We find that absolute values depend strongly on method and bulk-parameter assumptions, whereas relative trends are more useful for screening. Explicit conformer averaging does not consistently improve agreement with experiment. Applying the best-performing single-conformer protocols to a broader polar liquid-crystal dataset identifies candidate materials with enhanced predicted nonlinear optical response and reveals simple design rules based on donor-acceptor asymmetry, conjugation length, and linker choice.

PMID 42717900
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PubMedAngewandte Chemie (International ed. in English)2026-09-10

Insights on Dual-Functional Ionic Liquid Interfacial Layer for Efficient CO2 Electroreduction to C2+ Products in Acid.

Cheng Aofei A, Feng Jiaqi J, Cheng Jiaxin J, Wang Yanlin Y et al.

Electrocatalytic CO2 reduction reaction (CO2RR) in acidic electrolyte is hindered by severe hydrogen evolution reaction (HER) and inefficient C-C coupling, leading to poor selectivity toward multicarbon (C2+) products. Here, we construct a dual-functional interfacial layer by modifying a CuO catalyst with the ionic liquid choline triazole ([Cho][Triz]). This interfacial layer simultaneously regulates the active hydrogen (*H) supply pathway to suppress HER and stabilizes key C-C coupling intermediates, thereby promoting C2+ product formation. Comprehensive in situ spectroscopic characterizations and theoretical simulations reveal that the ionic liquid interfacial layer disrupts the continuous hydrogen-bond network of interfacial water, suppresses hydronium (H3O+) transport from the bulk electrolyte, and accelerates water dissociation to generate *H species, thereby promoting intermediate hydrogenation and inhibiting HER. Meanwhile, the hydroxyl groups in the ionic liquid stabilize the *CHO intermediate and facilitate the energetically favorable asymmetric *CHO-*CO coupling pathway. Benefiting from this dual-functional regulation, the [Cho][Triz]-modified CuO catalyst delivers a C2+ Faradaic efficiency of 81.1% at 800 mA cm-2 in 1 M KCl/0.05 M H2SO4 electrolyte. Notably, the Faradaic efficiency of ethanol is approximately 2.2 times higher than that of CuO.

PMID 42720200
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PubMedScientific reports2026-09-10

Time-of-flight neutron radiography for differentiating ice and water during phase transitions in natural porous media.

Lombardo Michael M, Lee Jongmin J, Fees Amelie A, Carreon Ruiz Eric Ricardo ER et al.

Measurement of coexistent liquid water and ice distributions is useful for many materials and systems such as fuel cells, concrete, snow, and soil. Energy-resolved neutron imaging is a promising technique for these measurements by exploiting differences in neutron cross-section between ice and water at cold neutron energies. Until now, energy-resolved neutron imaging techniques have only been used with relatively thin and non-natural samples. Given the importance of liquid water and ice distributions in many natural porous materials, we investigated the feasibility of using time-of-flight neutron radiography for two natural porous materials. Two exploratory experiments were performed with a model system of glass beads (simple soil analogue) and a natural snow sample with sample thicknesses of 5 mm. The experiments demonstrated that the relative attenuation could be used to distinguish between liquid and solid water phases as well as to dynamically track the phase transition within these porous materials. The results also demonstrated that significant challenges with respect to the scattering in thick samples, inconsistent thicknesses associated with spatial variations of the porosity, and time-variant structures of the porous matrix remain.

PMID 42716953
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