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acetylsalicylic acid + clopidogrel (Copregrel / Coprigrel)

✓ Approved

Chong Kun Dang Pharmaceutical · PTGS1 · 小分子

什么是 acetylsalicylic acid + clopidogrel？

acetylsalicylic acid + clopidogrel 是一种小分子，由Chong Kun Dang Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Copregrel, Coprigrel
公司Chong Kun Dang Pharmaceutical
药物类别小分子
分子靶点PTGS1, PTGS2, P2RY12
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Chong Kun Dang Pharmaceutical

作用机制

分子靶点

acetylsalicylic acid + clopidogrel 作用于 3 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
P2RY12purinergic receptor P2Y12 (P2Y(ADP), P2Y(cyc))
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

acetylsalicylic acid + clopidogrel 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersThrombosis✓ Approved

相关研究文献

PubMedGeobiology2026-09-10

Origins of Improved Hardness in Bioinspired Aragonite Precipitated Under Simulated Biologic Conditions.

Chomhom Boontharee B, Farfan Gabriela A GA, Greeves Samantha S, Penkman Kirsty K et al.

Biogenic aragonite is a composite of mineral and biomolecules that exhibits superior material properties compared to its inorganic analog. This superiority underpins the success of the bioaragonite structures which support coral reefs and shell fisheries, yet the mechanisms improving the physical resilience of bioaragonite are not well understood. In this study, aragonite is synthesised under chemical conditions which simulate those of calcification sites in marine organisms. Aspartic acid, glutamic acid, and glycine in solution are incorporated into the aragonite at concentrations typically observed in marine biominerals and are observed to significantly improve aragonite Vickers hardness. Aspartic acid is incorporated more efficiently than glutamic acid or glycine, but for comparable amounts of amino acid incorporation, glycine improves aragonite hardness significantly more than either aspartic or glutamic acid. Glycine and glutamic acid incorporation reduce the aragonite grain size, thereby improving resilience to indentation via energy dissipation along grain boundaries. In contrast, aspartic acid also improves hardness on a smaller scale, possibly due to crystal structure distortions. These results suggest that amino acid incorporation influences biogenic aragonite hardness via multiple mechanisms and provide a prototype for exploring the influence of more complicated biomineral proteins.

PMID 42720183
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PubMedThe AAPS journal2026-09-10

Verification of a Physiologically-based Pharmacokinetic Model for Predicting CYP3A4-mediated Simvastatin and Simvastatin Acid Drug-drug Interactions.

Morse Bridget L BL, Han Bing B, Alberts Jeffrey J JJ, Posada Maria M MM et al.

Simvastatin is a commonly prescribed medication and a sensitive CYP3A4 substrate requiring dosage modification with CYP3A4 precipitants. Unlike other CYP3A4 substrates, grapefruit juice (GFJ) causes the largest increase in simvastatin exposure of any CYP3A4 inhibitor, leading to misunderstanding of simvastatin fraction escaping CYP3A4 metabolism in the gut (Fg, CYP3A4) and fraction metabolized by CYP3A4 in the liver (fm,CYP3A4). Simvastatin is a prodrug that is converted to the active simvastatin acid, though the mechanisms responsible for in vivo simvastatin acid formation are not well-understood. GFJ also decreases the simvastatin acid:simvastatin exposure ratio, suggesting inhibition of simvastatin acid formation. In the current work, we used a static approach to define simvastatin CYP3A4 parameters, using clinical data with index substrate midazolam; estimated simvastatin Fg,CYP3A4 and fm,CYP3A4 were ~ 0.4 and ~ 0.9, respectively. In vitro data assessing the stability of simvastatin and simvastatin acid demonstrated rapid conversion in gastric fluid that was highly pH-dependent. A simvastatin PBPK model was constructed incorporating these CYP3A4 parameters and simvastatin acid formation in stomach, intestine and plasma. The model reproduced the nonlinear pharmacokinetics of simvastatin and CYP3A4 precipitant effects, thus qualifying the model for prediction of CYP3A4-mediated interactions on both simvastatin and simvastatin acid. Simvastatin overall Fg was estimated as ~ 0.2, lower than the Fg,CYP3A4 due to additional intestinal esterase-mediated formation of simvastatin acid. The simvastatin-GFJ effect was explained by inhibition of this intestinal simvastatin acid formation, along with CYP3A4 inhibition. The unique effect of food on the simvastatin acid:simvastatin exposure ratio could also be replicated using this PBPK model.

PMID 42717157
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PubMedFrontiers in microbiology2026-09-10

Topical compound acid peeling remodels scalp microbiota and lipid homeostasis in seborrheic dermatitis: a multi-omics study.

Zhang Hongyan H, Shi Yetan Y, Hu Lifang L

Current therapeutic options for scalp seborrheic dermatitis (SSD) remain suboptimal, highlighting the demand for more effective and safe treatment strategies. To investigate the efficacy and underlying mechanisms of a novel 7.5% five-acid compound formulation for the treatment of SSD. A total of 319 patients diagnosed with SSD at the dermatology outpatient clinic were enrolled. All patients received four sessions of scalp compound acid therapy and were included in efficacy and safety analyses. A subgroup of 30 male participants from the 319-patient cohort underwent scalp sampling before and after treatment for combined microbiomic and lipidomic detection. Meanwhile, 10 matched male SSD patients who did not received compound acid therapy were enrolled as the control group for multi-omics analyses. All 319 SSD patients presented marked relief of scalp erythema, scaling and pruritus after repeated compound acid treatment, with only 6 individuals experiencing temporary mild scalp irritation after the initial treatment. Integrated microbiomic and lipidomic analyses were restricted to a male subcohort (30 treated patients and 10 matched untreated male SSD controls). Within this male subgroup, the relative abundance of the genus Staphylococcus and the genus Malassezia were significantly lowered post-treatment. And the observed lipid alterations may be linked to changes in antioxidant response, inflammatory signaling and fatty acid metabolic pathways. Lipidomic profiling suggests that compound acid peeling may rebalance scalp lipid profiles, accompanied by elevated levels of barrier-protective antioxidant phosphatidylcholines, reduced pro-inflammatory oxidized fatty acids, and altered core fatty acid biosynthesis pathways. The topical scalp compound acid therapy effectively alleviates clinical symptoms in SSD patients and represents a promising novel therapeutic approach.

PMID 42718769
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PubMedScientific reports2026-09-10

Lauric-acid-rich Hermetia illucens meal modulates lipid metabolism in the liver and the fatty acid profile in piglet tissues.

Szczepanik Kinga K, Małgorzata Świątkiewicz Ś, Piotr Dobrowolski D, Oczkowicz Maria M

This study investigated whether a diet rich in lauric acid, based on Hermetia illucens (HI) larvae meal, would induce measurable changes in lipid-related metabolic pathways in the liver and in the fatty acid composition of tissues. Twenty-four weaned piglets were assigned to three dietary groups: control (0% HI), 2.5% HI, and 5% HI. Multilevel analyses, including histology, biochemical assays, fatty acid profiling, and gene expression, were performed to assess liver function and metabolic adaptations of animal organisms. Dietary HI markedly reshaped the tissue lipid composition, increasing the levels of saturated fatty acids (SFA) and reducing polyunsaturated fatty acids (PUFA) in both muscle and adipose tissue (P < 0.001), with strong correlations with the amount of dietary lauric acid (C12:0). Despite these systemic changes, liver enzyme activity and oxidative stress markers remained unchanged, indicating the preservation of hepatic function. Histological analysis revealed a significant reduction in hepatic collagen content (P < 0.001), suggesting extracellular matrix remodeling, and a tendency toward increased glycogen accumulation (P = 0.055), indicative of altered substrate utilization. At the molecular level, HI supplementation modulated the expression of genes associated with cholesterol metabolism and cellular energy balance, including CYP7A1, DHCR24, and PRPS2. Although most transcriptional changes were modest, the combined biochemical, histological, and lipidomic data suggested coordinated metabolic adaptations. Collectively, these findings suggest that dietary inclusion of lauric-acid-rich Hermetia illucens larvae meal is associated with adaptive changes in hepatic metabolism, altered fatty acid composition, reduced collagen deposition, and changes in tissue lipid distribution, without evidence of hepatic dysfunction or oxidative imbalance. These results indicate that HI larvae meal may influence hepatic metabolism and tissue lipid composition, with potential implications for animal physiology and meat quality.

PMID 42717231
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PubMedJournal of clinical biochemistry and nutrition2026-09-10

Hypoglycemia and altered bile acid metabolism are linked to latent iron deficiency in young Japanese women.

Ishikawa Sena S, Miyazawa Rika R, Yokoyama Fumika F, Sawamura Daisuke D et al.

Iron deficiency anemia (IDA) remains a prevalent health issue, especially among Japanese women, and may be influenced by dietary patterns and lipid metabolism. This study aimed to investigate the association between circulating bile acid (BA) concentrations and iron-related biomarkers in young Japanese women. Blood biochemical and anthropometric data were collected from 33 healthy young women aged 20. The participants can be divided into two groups based on the levels of total-iron binding capacity (TIBC), although their hemoglobin and ferritin levels were in the normal ranges. When participants were divided based on TIBC, the low TIBC group showed significantly higher levels of 12-hydroxylated, non-12-hydroxylated, and total BAs, as well as significantly lower blood glucose levels compared to the normal group (p<0.05). Positive correlations were observed between TIBC and specific BA species, such as glycolithocholic acid (ρ = 0.3993, p<0.0288), cholic acid (ρ = 0.4767, p<0.0077), and taurocholic acid (ρ = 0.4423, p<0.0144). Additionally, transferrin levels were positively correlated with glycolithocholic acid (ρ = 0.3649, p<0.0474). These findings suggest that TIBC may serve as an early indicator of hypoglycemia, reflecting preclinical metabolic disturbance, in addition to being a latent IDA marker.

PMID 42719915
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PubMedEpidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil2026-09-10

Ferrous Sulfate and Folic Acid Supplementation in Pregnant People in Primary Health Care: a Cross-Sectional Study, Criciúma, 2022.

Campos-Rosa Jhonatan J, Puchivailo Ricardo Augusto Cardoso RAC, Schäfer Antônio Augusto AA, Meller Fernanda de Oliveira FO et al.

To evaluate the prevalence and factors associated with supplementation of ferrous sulfate and folic acid in pregnant people. A cross-sectional, representative study with pregnant people treated in Primary Health Care in Criciúma, Santa Catarina, in 2023. Ferrous sulfate and folic acid supplements were evaluated based on the prenatal booklet for pregnant people. The prevalence of supplementation was calculated with their respective 95% confidence intervals (95%CI). Crude and adjusted Poisson regression analyses (hierarchical model) were performed, estimating prevalence ratios (PR) and their respective 95%CI, to verify the associated factors. A total of 428 pregnant people were interviewed. Of these, 97.4% used ferrous sulfate supplementation during pregnancy, and 93.7% folic acid. The analyses indicated that the use of ferrous sulfate was higher in older pregnant people, with PR 1.06 (95%CI 0.99; 1.13), and who consumed alcohol during pregnancy, with PR 1.04 (95%CI 1.00; 1.08). Regarding the use of folic acid, it was higher among pregnant people who had at least six prenatal visits, with PR 1.10 (95%CI 1.01; 1.20). The results indicate high iron and folic acid supplementation among pregnant people in Primary Health Care. The identification of associated factors can guide more targeted and effective intervention strategies by Health Management.

PMID 42718097
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