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octreotide acetate (OOA / oral octreotide / Octreolin)

✓ Approved

Chiasma, Inc. · SSTR2 · 小分子

什么是 octreotide acetate？

octreotide acetate 是一种小分子，由Chiasma, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名OOA, oral octreotide, Octreolin
公司Chiasma, Inc.
药物类别小分子, 多肽类
分子靶点SSTR2, SSTR5
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Chiasma, Inc.

作用机制

分子靶点

octreotide acetate 作用于 2 个分子靶点：

SSTR2somatostatin receptor 2 (SST2)
SSTR5somatostatin receptor 5 (SST5, SS-5-R)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

octreotide acetate 针对 6 个适应症，涉及 4 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersAcromegaly✓ Approved
Endocrine disordersCarcinoid syndromePhase II
Hepatobiliary disordersPortal hypertensionPhase II
Vascular disordersHypertensionPhase I
Gastrointestinal disordersPancreatitisPhase I

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相关研究文献

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Antioxidant Activities of Pentacyclic Triterpenes From Melipona beecheii Propolis and Their Semisynthetic Derivatives.

Santana-Hernández Aarón A, Yam-Puc Alejandro A, Yah-Nahuat Pamela P, Vargas-Vargas María M et al.

Four principal fractions (I-IV) were obtained from the Melipona beecheii propolis. GC-MS analysis of these fractions allowed us to recognize 11 pentacyclic triterpenes (PTs), fraction I [β-amyrin acetate (1), germanicol acetate (2), moretenol acetate (3) and 24-methylencycloartan-3-ol acetate (4)]; fraction II [marsformosanone (5), β-amyrenone (6), germanicone (7) and lupenone (8)]; fraction III [β-amyrin (9) and, glutinol (10)]; and fraction IV [9 and α-amyrin (11)]. This is the first time that triterpenes 7 and 10 are reported in the propolis of M. beecheii. Three semisynthetic derivatives were prepared: the reduction of fraction II and the acetylation and oxidation of fraction IV. The ethanolic extract of propolis and fraction III presented the highest free DPPH radical scavenging capacity at 53.89 ± 8.39% and 47.77 ± 0.91%, respectively, using a concentration of 10 mg/mL. In contrast, the reducing power of Fe (III) analysis showed a strong reducing power of Fe(III) for all fractions and their derivatives with an EC50 = 0.8-1.0 mg/mL.

PMID 42720076
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PubMedJCEM case reports2026-09-10

Metastatic proinsulin-secreting tumor: a rare cause of persistent hypoglycemia.

Heins Robert J RJ, Yazji John J, Eber Philip P, Furlan Stefanie S

Proinsulin-secreting neuroendocrine tumors (NETs) are a rare cause of severe hypoglycemia, characterized by normal or low insulin levels and disproportionate elevations of proinsulin. Clinical features and optimal management of unresectable cases remain poorly defined, in part due to such few cases described in the literature. We describe a 47-year-old female with metastatic large-cell neuroendocrine carcinoma who presented with obstructive jaundice and was incidentally found to have profound, asymptomatic fasting hypoglycemia. Initial insulin and C-peptide levels were within reference ranges, but proinsulin concentrations were markedly elevated. The patient developed recurrent, refractory hypoglycemia requiring high-dose corticosteroids, glucagon, diazoxide, octreotide, and ultimately central-line infusion of 70% concentrated dextrose via total parenteral nutrition. Glycemic control could not be achieved despite maximal medical therapy, and the patient experienced rapid clinical deterioration leading to comfort-focused hospice management. This case highlights the diagnostic challenges of proinsulin-driven hypoglycemia and underscores the need for earlier recognition and improved treatment pathways for patients with proinsulin-secreting NETs.

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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Manipulating the Buried Interfacial Dipole: The Role of Pyridine Acetate-Hydrochloride Isomers in Carbon-Based Perovskite Solar Cells Prepared in Air.

Shi Yifei Y, Gong Jianwen J, Wang Xu X, Hu Shuming S et al.

The buried interface between tin oxide and perovskite is the key factor for non-radiative recombination and energy level mismatch, which limits the performance and stability of perovskite solar cells. This work explores a simple interfacial dipole engineering strategy, where three pyridine acetate-hydrochloride (PAH) isomer molecules (2-PAH, 3-PAH, and 4-PAH) are used to modify the SnO2 electron transport layer. The 3-PAH-modified layer can control the work function of tin oxide, achieve the best energy level alignment, and improve the crystallization quality of the perovskite film, thereby effectively suppressing interface recombination and promoting electron extraction. All the devices are prepared in air, and the device optimized by 3-PAH achieved a champion energy conversion efficiency of 14.31% and demonstrated stability. Subsequent to an 800 h placement in an N2 glove box or a 340 h exposure to an air environment, the unencapsulated target devices that were modified by 3-PAH maintained 80.7% and 81.3% of their initial efficiency.

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Narrative review of the current management of ectopic varices: an update.

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Ectopic varices are a rare complication of portal hypertension that occur outside the esophagogastric region and represent a potentially life-threatening source of gastrointestinal bleeding. Treatments are frequently guided by institutional experience rather than standardized treatment algorithms due to their rarity and variable anatomy. This narrative review summarizes the epidemiology, clinical presentation, diagnostic evaluation, and management strategies. A literature review was performed using PubMed and Google Scholar. Given that much of the available evidence consists of case reports, case series, and retrospective studies, no time restrictions were applied to the search. The search strategy broadly included studies relevant to ectopic varices, and no language restrictions were applied. Ectopic varices account for small proportion of variceal hemorrhage but are associated with significant morbidity and mortality. Clinical presentation varies according to anatomic location. Cross-sectional imaging, endoscopy and angiography play important roles in diagnosis and treatment planning. In the absence of bleeding, nonselective beta-blockers are the primary medical therapy to reduce portal pressure and prevent hemorrhage. For suspected or confirmed bleeding, prompt hemodynamic stabilization is essential, and splanchnic vasoactive agents such as octreotide or terlipressin should be initiated without delay even prior to confirmatory testing. Systemic vasopressors are reserved for patients in shock. Endoscopic band ligation and sclerotherapy are first-line treatment options after initiating vasopressor therapy, although their use may be limited by anatomical accessibility. If endoscopic therapy is unsuccessful or not feasible, interventional radiology (IR) techniques such as transjugular intrahepatic portosystemic shunt (TIPS), antegrade transvenous obliteration (ATO), retrograde transvenous obliteration (RTO), and recanalization of chronically occluded visceral veins are pursued based on patient anatomy and portal hemodynamics. Surgical interventions are reserved for refractory cases. Management of ectopic varices requires an individualized, multidisciplinary approach that incorporates medical, endoscopic, IR, and surgical therapies.

PMID 42719266
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PubMedACS omega2026-09-10

Determination of Molecular Interactions between Copper Pigments and Soybean Oil Alkyd Resins in Paints: A Spectroscopic Study.

Costa Thiago Guimarães TG, Candeias António José Estêvão Grande AJEG, Gazotto Enzo Gimenes EG, Júnior Feik Amil de Campos FAC et al.

Alkyd paints are widely used in modern painting and can be obtained commercially or prepared from pure materials. Various formulations can be used to obtain these paints. Copper pigments can be found in various works of art and in industrial paints. The use of these pigments in modern resins can be a low-cost alternative for different applications. However, studies must be conducted to ensure safety when applying these paints. In this work, the interaction of Cu-(II) present in malachite, azurite, and copper acetate pigments with soybean oil-based alkyd resins when subjected to heat treatment above 50 °C was characterized. The results show that paintings containing malachite and azurite exhibited colorimetric ΔE values of 2.77 and 3.72, respectively, showing no significant chromatic change during the studied heat period. Fourier transform infrared (FTIR) spectroscopy revealed a decrease in the intensity of ester and phthalic groups in the resin over time, indicating that reactions occurred in these groups during the sample aging process. Raw copper acetate was initially present in the dimeric form; however, when mixed with a binder, monomeric species were formed, and the intensity of dimers decreased with the aging period, leading to the formation of only monomeric species with a color change. Scanning electron microscopy (SEM) analysis showed that the paint layers remained uniform even after the studied aging period. μ-Raman showed signals below 500 cm-1, which are attributed to Cu-O vibrational modes of new structures formed during the aging process of the paints. The chemical transformations do not lead to color changes in the pigments of malachite and azurite, so the results suggest that soybean oil-based alkyd resin could be a viable and cost-effective alternative to be used in the formulation with copper pigments. Furthermore, the data present can help understand the behavior of alkyd paints in the presence of copper pigments, assisting in the advancement of materials for use in painting materials.

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Extrauterine Adenomyoma of the Lung: A Rare Case Report.

Zhou Minhua M, Liu Zhongda Z, Ye Yiping Y, Liu Xiaojing X et al.

Extrauterine adenomyomas (EAs) are rare benign lesions that arise outside the uterus and only rarely involve the lung. We describe a 34-year-old woman with a history of multiple gynecological surgeries who was diagnosed with a pulmonary benign uterine adenomyoma. Chest CT, pelvic MRI, and ultrasound revealed pulmonary masses, uterine adenomyosis with fibroids, and an adnexal cystic mass. A CT-guided lung biopsy confirmed benign uterine adenomyoma; the diagnosis was supported by histopathological and immunohistochemical findings. The patient received goserelin acetate and letrozole, and serial follow-up chest CT through November 2024 showed stable pulmonary lesions without respiratory symptoms. This case highlights the importance of considering EAs in the differential diagnosis of pulmonary masses, particularly in individuals with uterine adenomyosis. It demonstrates that endocrine therapy can be an effective option for managing benign adenomyomas in patients who are inoperable or prefer non-surgical management.

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