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filgrastim (long-acting)

✓ Approved

Win Medica · CSF3R · 重组蛋白

什么是 filgrastim (long-acting)？

filgrastim (long-acting) 是一种重组蛋白，由Win Medica研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Win Medica
药物类别重组蛋白
分子靶点CSF3R
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Win Medica

作用机制

分子靶点

filgrastim (long-acting) 作用于 1 个分子靶点：

CSF3Rcolony stimulating factor 3 receptor (CD114, GCSFR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

filgrastim (long-acting) 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersBone marrow disorder✓ Approved

相关研究文献

PubMedAdvances in respiratory medicine2026-10-26

Deciphering the Benefits and Risks of Single-Inhaler Triple Therapy in COPD.

Kopitovic Ivan I, Dimic-Janjic Sanja S, Stjepanovic Mihailo M, Hromis Sanja S et al.

Single-inhaler triple therapy (SITT) combines an inhaled corticosteroid (ICS; for example, fluticasone furoate, budesonide, or beclometasone dipropionate), a long-acting β2-agonist (LABA; for example, vilanterol or formoterol fumarate), and a long-acting muscarinic antagonist (LAMA; for example, umeclidinium or glycopyrronium bromide) in one device. Triple pharmacological therapy reduces exacerbations in selected patients with chronic obstructive pulmonary disease (COPD), but its effects on mortality and cardiovascular outcomes remain uncertain. This structured narrative review summarizes randomized trials, observational comparative-effectiveness studies, target trial emulations, systematic reviews, and health technology assessments published between 2015 and 2026. We grouped the evidence by comparator: LABA/LAMA, ICS/LABA, multiple-inhaler triple therapy (MITT), and ICS continuation versus withdrawal, because each comparison addresses a different clinical question. Pivotal trials and evidence syntheses consistently showed fewer moderate-to-severe exacerbations with triple therapy, with reported rate ratios of approximately 0.69-0.93. Mortality signals from IMPACT and ETHOS are clinically important, but previous ICS use and ICS withdrawal among participants assigned to ICS-free comparators make these findings difficult to interpret. Observational cardiovascular findings are also uncertain because residual confounding, treatment selection, exposure misclassification, outcome misclassification, and differences in baseline disease severity limit causal interpretation. Compared with MITT, the main advantages of SITT are simpler treatment and possible improvements in adherence and persistence, not greater pharmacological potency. Treatment decisions should consider exacerbation history, repeated blood eosinophil counts, pneumonia risk, cardiovascular disease, previous ICS exposure and response, inhaler technique, device suitability, and patient preference. Trials in patients with documented absence of previous ICS use and well-designed target trial emulations are needed to determine whether the observed mortality and cardiovascular associations are causal.

PMID 42930048
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PubMedPsychopharmacology2026-10-26

Evaluating whether a therapeutic dose of ketamine exposure during adolescence influences adult vulnerability in rats to commonly abused drugs.

Jornet-Plaza Jordi J, Colom-Rocha Carles C, García-Fuster M Julia MJ

Rationale Ketamine has emerged as a rapid-acting antidepressant drug for treatment-resistant depression in adults and is currently evaluated for adolescent depression. However, the long-term effects of ketamine exposure during this period of brain development remain unclear, particularly regarding addiction liability. Objectives To investigate whether repeated ketamine exposure during adolescence may influence the long-term risk of addiction following subsequent exposure to commonly abused drugs (alcohol and cocaine) in adulthood. Methods Male and female Sprague-Dawley rats received daily i.p. injections of ketamine (10 mg/kg) or saline for 7 consecutive days during mid adolescence. The dose paradigm of ketamine administered was selected based on its antidepressant-like properties in adolescent rats. In adulthood, addiction liability was measured by voluntary ethanol consumption, using a two-bottle choice paradigm, and by assessing cocaine reward using a single-exposure place preference protocol. Results The main results suggested that a therapeutic dose of ketamine exposure during adolescence did not enhance addictive liability in adulthood as measured by voluntary ethanol consumption or cocaine reward in rats of both sexes. Conclusions Ketamine, administered during adolescence at a dose known to induce antidepressant-like effects did not impact the long-term risk of addiction caused by exposure to commonly abused drugs (i.e., alcohol and cocaine). These results suggested a good long-term safety profile following the therapeutic use of ketamine in adolescence.

PMID 42928272
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PubMedAIDS research and treatment2026-10-26

A Highly Sensitive and Specific Rapid Lateral Flow Assay for the HIV Integrase Strand Transfer Inhibitors Bictegravir, Cabotegravir, and Dolutegravir.

Wei Xierong X, Youngpairoj Ae S AS, Haaland Richard R, Dinh Chuong C et al.

Second-generation HIV-1 integrase strand transfer inhibitors (INSTIs)-bictegravir (BIC), cabotegravir (CAB), and dolutegravir (DTG)-are leading components of highly potent antiretroviral therapy, and CAB is also used for long-acting chemoprevention. Rapid detection of clinically relevant INSTI concentrations could support point-of-care assessment and real-time clinical decision-making. We developed a lateral flow assay (LFA) that detects BIC, CAB, and DTG in whole blood and plasma and evaluated its performance against predefined concentration thresholds and high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). A single LFA cassette design was developed using a monoclonal antibody to distinguish BIC, CAB, and DTG concentrations below trough, at minimal-to-moderate trough, and at ideal concentrations. LFA results were read visually at 20 min and were compared with LC-MS/MS-quantified INSTI concentrations for 124 clinical plasma specimens. For 24 plasma samples from US participants receiving treatment involving one of the three INSTIs, the LFA interpretations matched all LC-MS/MS results except for one DTG specimen, which was interpreted by LFA as 1.0-1.6 μg/mL but measured 2.1 μg/mL by LC-MS/MS. Among 100 plasma remnants from routine national surveillance in Eswatini, the LFA correctly interpreted DTG concentrations in 95 specimens. Four specimens had DTG LC-MS/MS concentrations slightly above the LFA-determined range, differing by ≤ 0.1 μg/mL, and one specimen measured at 1.20 μg/mL by LC-MS/MS was interpreted as ≥ 1.6 μg/mL by LFA. In total, 6 of 124 specimens (4.8%) had LFA-interpreted INSTI concentrations that varied slightly from the LC-MS/MS results, with no statistically significant difference in overall performance by Wilcoxon signed-rank test (W = 8.00, p = 0.94, one-tailed). The LFA design successfully provided clinically useful interpretations of BIC, CAB, and DTG concentrations with minor discrepancies in < 5% of samples. Importantly, all low-concentration samples of < 1 μg/mL were correctly interpreted by LFA. The assay shows promise as a point-of-care tool for assessing clinically relevant INSTI concentrations.

PMID 42928809
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PubMedNature communications2026-10-26

Long-read RNA sequencing identifies non-coding isoform switching as a regulator of cell fate.

Fort Victoire V, Khelifi Gabriel G, He Ruicen R, Watters Valérie V et al.

Development of long-read RNA sequencing technologies has paved the way to the exploration of RNA isoform diversity and its relevance in regulating cell fate. However, identifying new functional isoforms is still very difficult. Here, we leverage long-read RNA sequencing to study changes in isoforms during somatic cell reprogramming and identify novel isoforms occurring throughout cell state transitions. We demonstrate tight regulation of non-coding isoforms and show that isoform switching plays previously overlooked functional roles and outcomes in gene regulation and cell fate changes. We uncover a novel long non-coding RNA, Snhg26, that undergoes isoform switching during reprogramming to enhance the conversion of differentiated cells towards the pluripotent state. Knock-down of Snhg26 in mouse and human pluripotency models reveals that it is important for pluripotency acquisition. Together, our study provides a resource to study full-length isoform usage during cell fate change. It also demonstrates the power of long-read sequencing to identify functionally relevant gene isoforms in the context of cell plasticity.

PMID 42928361
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PubMedCureus2026-10-26

Long-Term Cardiovascular, Thromboembolic, and Malignancy Safety of Janus Kinase (JAK) Inhibitors in Dermatologic and Rheumatologic Populations: A Narrative Comparative Review.

Bou Rolon Shakira S, Ortiz Echevarria Andrea N AN, Burgos Claudio Monica M, Solis Esquilin Edgar A EA et al.

Janus kinase inhibitors are increasingly used in dermatology and rheumatology, but concerns about cardiovascular events, thromboembolism, and malignancy continue to influence long-term treatment decisions. This narrative comparative review examines evidence from randomized trials, integrated safety analyses, long-term extensions, selected observational studies, and regulatory sources, focusing on rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, and alopecia areata. Topical agents and selective tyrosine kinase 2 inhibition are considered separately because of important differences in systemic exposure and pharmacology. The original, informally assembled evidence base was supplemented by a targeted literature update. ORAL Surveillance identified an important safety signal for tofacitinib compared with tumor necrosis factor inhibitors in patients with rheumatoid arthritis and cardiovascular risk factors. Long-term dermatology studies have generally reported low absolute event rates, although younger study populations, restrictive eligibility criteria, limited long-term comparator data, and treatment discontinuation affect how these findings should be interpreted. Observational studies in dermatology have produced mixed results, including thromboembolic associations that warrant further investigation. Psoriatic arthritis provides additional evidence across the clinical boundaries of both specialties. Differences in patient populations, study design, outcome definitions, and statistical measures limit direct comparisons across studies. Treatment decisions should follow indication-specific prescribing requirements and consider cardiovascular disease, prior thrombosis, smoking, age, malignancy history, and available alternatives. Additional long-term comparative studies are needed to better distinguish patient-, disease-, and treatment-related risks.

PMID 42928856
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PubMedBMC ecology and evolution2026-10-26

Acute heat stress induces short- and long-term epigenetic changes in the buff-tailed bumblebee (Bombus terrestris).

Renard Thibaut T, Boseret Morgane M, Aron Serge S

Global warming and the increasing frequency of extreme weather events threaten organisms worldwide, with cold-adapted species like bumblebees being especially vulnerable. Although heat stress has been shown to affect bumblebee physiology and behaviour, whether it also impacts their epigenome remains unknown. In this study, we addressed this gap by investigating the short- and long-term effects of acute heat stress experienced early in adult life on DNA methylation profiles in the buff-tailed bumblebee (Bombus terrestris). The DNA methylomes of males exposed either to control conditions (25°C) or to acute heat stress (42 °C for 60 min) were sequenced 1 day and 15 days after exposure to disentangle the short- and long-term effects of thermal stress. Heat stress induced differential methylation at hundreds to thousands of sites in both the short- and long-term, yet these signatures were largely distinct across time points. Accordingly, random forest classification failed to identify a persistent long-term DNA methylation signature of heat stress, indicating that heat-induced DNA methylation patterns change over time. Similarly, epigenetic clock analyses revealed that epigenetic age was transiently increased in the short-term, but not in the long-term. By uncovering the temporal dynamics of DNA methylation profiles following heat stress inB. terrestrismales, our findings suggest that DNA methylation is actively regulated rather than passively maintaining environmentally induced alterations. These results shed new light on how environmental signals may dynamically shape the insect epigenome.

PMID 42928104
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