北京若生智能科技有限公司
Drug Database
DO

doxorubicin (doxorubicin, Nanox / Doxonax)

✓ Approved

Nanox · TOP2A · 小分子

什么是 doxorubicin？

doxorubicin 是一种小分子，由Nanox研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名doxorubicin, Nanox, Doxonax
公司Nanox
药物类别小分子
分子靶点TOP2A
给药途径Injectable (Others)
状态Approved
来源： ClinicalTrials.gov, Nanox

作用机制

分子靶点

doxorubicin 作用于 1 个分子靶点：

TOP2ADNA topoisomerase II alpha (TOP2alpha, TOPIIA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

doxorubicin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Kaposi's sarcoma✓ Approved

相关研究文献

PubMedJournal of materials chemistry. B2026-10-26

Alpha-mangostin combined with doxorubicin-loaded hydrogel for the treatment of ovarian cancer.

Liu Xia X, Zhou Wenjie W, Chen Lezong L, Wang Yue Y et al.

Ovarian cancer is one of the most prevalent malignancies of the female reproductive system and a gynecological malignancy with a high mortality rate. Alpha-mangostin is a xanthone derivative with anticancer activity that can increase the sensitivity of ovarian cancer cells to doxorubicin, and the combination of the two drugs exerts a synergistic therapeutic effect. However, the poor solubility of α-mangostin limits its application. To solve this problem, we prepared an α-mangostin nanoformulation via self-assembly using the film dispersion method. The formulation had a uniform particle size of approximately 58 nm, a stable nanostructure and good water solubility. Hydrogels, as good thermosensitive drug delivery systems, enable sustained and controlled release of drugs. Accordingly, we utilized the synergistic efficacy of the α-mangostin nanoformulation combined with doxorubicin and used a thermosensitive hydrogel carrier to jointly treat ovarian cancer. In vitro, the combined treatment achieved better effects than either drug alone in inducing ovarian cancer cell apoptosis, inhibiting ovarian cancer cell proliferation, and inducing cell cycle arrest. In vivo, this composite formulation effectively inhibited tumor growth by inducing ovarian cancer cell apoptosis, inhibiting tumor cell proliferation, and suppressing tumor angiogenesis, and effectively inhibited ascites formation, achieving a better antitumor effect than either drug alone. In summary, the composite hydrogel co-loaded with α-mangostin nanoformulation and doxorubicin represents a promising and effective strategy for the treatment of ovarian cancer.

PMID 42929270
阅读全文 →
PubMedBiosensors2026-10-26

A Phytol-Modified Carbon Veil Paste DNA Sensor for Anticancer Drug Detection.

Karaguzina Kamila K, Stoikov Dmitry D, Ivanov Alexey A, Kappo Dominika D et al.

Electrochemical DNA sensors offer a rapid and miniaturizable approach to monitoring drugs that interact with nucleic acids, but their performance depends on the electrode matrix and DNA immobilization strategy. Here, a renewable bulk-modified carbon veil paste DNA sensor was developed by synergistically combining a custom 3D-printed screw-driven housing and a phytol-derived dicationic amphiphile to retain DNA within a conductive fibrous matrix. Carbon veil paste electrode composition and interfacial properties were studied by voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy, and analytical performance was evaluated for doxorubicin and dacarbazine in buffer, synthetic plasma, and synthetic urine. The carbon veil matrix provided an effective electroactive area 5.06 times greater than its geometric area. Among the tested modifiers, the phytol-derived amphiphile produced the highest and most stable marker currents. Doxorubicin decreased, whereas dacarbazine increased, the ferrocyanide marker current. Responses were linear over the tested concentration ranges of 1 pM-0.1 µM for doxorubicin and 8 nM-1 µM for dacarbazine, and the determined detection limits were 19 fM and 8.0 nM, respectively. Recoveries in synthetic matrices were 94-99%. The platform provides a renewable DNA-containing electrode architecture for sensitive analysis of individual DNA-interacting drugs in model samples.

PMID 42930095
阅读全文 →
PubMedChembiochem : a European journal of chemical biology2026-10-26

Vitamin B12-Functionalized Nanogels for pH-, and Redox-Responsive Doxorubicin Delivery.

Dagdelen Serife S, Mestizo Paula D PD, Mackiewicz Marcin M, Kurdyn Agnieszka A et al.

Rapidly proliferating cancer cells display an elevated demand for vitamin B12, rendering this bacterial-derived cofactor an attractive targeting motif for nanotherapeutic drug delivery. Herein, we report a concise two-step synthesis of a polymerizable 5'-modified vitamin B12 -monomer that enables the covalent integration of B12 into pH- and redox-responsive nanogels. The resulting nanogels efficiently encapsulate doxorubicin through electrostatic interactions between the cationic drug and the anionic nanogel network, while enabling stimuli-responsive drug release under tumor-relevant conditions. In vitro studies revealed that DOX@B12-nanogels retain potent antiproliferative activity against HT-29 colorectal cancer cells (IC50 = 0.878 ± 0.102 μM), while decreasing cytotoxicity toward healthy CCD 841 CoN cells by 34-fold relative to non-B12-functionalized control nanogels. These findings establish covalently engineered vitamin B12-nanogels as a promising platform for selective and stimuli-responsive anticancer drug delivery.

PMID 42929280
阅读全文 →
PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Bioengineered Stroma-Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity.

Zhang Ziqi Z, Luo Jing J, Zhang Mengdi M, Zhuang Jingying J et al.

The cooperative upregulation of IDO1 and the immune checkpoint CD276 in solid tumors establishes a dual immunosuppressive circuit that depletes tryptophan, accumulates kynurenines, and silences T-cells. We engineered fibroblast-mimetic nanovesicles (AM@UIO-BMS/DOX) that uniquely integrate stromal-camouflaged tumor accumulation, CD276 checkpoint blockade, and co-delivery of doxorubicin with the clinical IDO1 inhibitor BMS-986205. The fibroblast-derived membrane coating promotes accumulation in fibroblast-rich tumor regions, while surface-anchored anti-CD276 scFv enables precision tumor specific targeting and concurrent checkpoint neutralization. Within the tumor microenvironment, doxorubicin elicits immunogenic cell death, and BMS-986205 metabolically recalibrates the tryptophan-kynurenine equilibrium, relieving the metabolic suppression that otherwise blunts T-cell priming. In syngeneic tumor models, this bioengineered platform profoundly remodeled the immune microenvironment, as evidenced by a tripartite shift: enhanced dendritic cell maturation and cross-presentation, expansion of Granzyme B+ cytotoxic CD8+ T lymphocytes, and selective depletion of CD25+FoxP3+ regulatory T cells. This concerted action effectively converted immunologically "cold" tumors into an inflamed phenotype, overcoming intrinsic chemoresistance and adaptive immune evasion. Collectively, our findings establish that bioengineered stroma-camouflaged nanovesicles disrupt the dual IDO1/CD276 immunosuppressive circuit, enhancing antitumor immunity and offering a promising strategy to surmount chemo-immunotherapy resistance in advanced solid tumors.

PMID 42928435
阅读全文 →
PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion.

Ping Jieming J, Wang Wenliang W, Xu Jinnuo J, Yang Mengyun M et al.

Plasma membrane (PM) phospholipid asymmetry is a fundamental feature of eukaryotic cells that regulates signaling, trafficking, and cell fate. Whether it also controls passive diffusion across the PM remains unknown. Here, we show that phospholipid asymmetry is a critical determinant of PM permeability to hydrophobic molecules. Using genetic and biochemical approaches, we demonstrate that disruption of lipid asymmetry by the Ca2 +-activated scramblase TMEM16F or apoptotic scramblase XKR8 profoundly alters the permeation and intracellular accumulation of diverse hydrophobic compounds, including widely used fluorescent probes, while preserving the barrier to membrane-impermeable molecules. Lipid scrambling is sufficient to remodel membrane permeability to lipophilic molecules, alter membrane biophysical properties, and differentially affect their intracellular accumulation, suggesting selective regulation of passive diffusion rather than nonspecific membrane leakage. Physiological lipid scrambling during T cell activation was also accompanied by altered membrane permeability. Moreover, lipid asymmetry regulates the cellular entry of doxorubicin, 17β-estradiol, and all-trans retinoic acid. Together, our findings identify PM lipid asymmetry as a previously unrecognized regulator of membrane permeability and establish a link between membrane organization and molecular transport.

PMID 42928505
阅读全文 →
PubMedCureus2026-10-26

CD20-Positive B-Cell Non-Hodgkin Lymphoma Associated With Recurrent Acute Pancreatitis, Bilateral Renal Lesions, and Retroperitoneal Lymphadenopathy.

Sarfraz Rehan R, Ledesma Leon Magnie L ML, Nabi Dunia D, Hernandez Carratala Laura L et al.

Acute pancreatitis is most often caused by gallstones, alcohol use, or hypertriglyceridemia, whereas malignancy is an uncommon association. We report a case of a 29-year-old woman with recurrent acute pancreatitis without a clearly dominant, identifiable cause. Although she reported intermittent heavy weekend alcohol use, recurrence after initial improvement, increasing lactate dehydrogenase (LDH), bilateral renal cortical lesions, and progressive retroperitoneal lymphadenopathy suggested a systemic process. Core biopsy of a retroperitoneal lymph node demonstrated a CD20-positive B-cell non-Hodgkin lymphoma with a Ki-67 proliferation index of up to 80%. Limited tissue and nondiagnostic flow cytometry prevented definitive subclassification; diffuse large B-cell lymphoma (DLBCL) remained in the differential diagnosis. One documented cycle of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was administered during a subsequent hospitalization, with short-term symptomatic, pancreatic enzyme, and renal improvement. The patient was subsequently lost to follow-up. This case emphasizes the importance of considering lymphoproliferative disease when recurrent pancreatitis is accompanied by progressive systemic imaging abnormalities.

PMID 42928836
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多doxorubicin