北京若生智能科技有限公司
Drug Database
QL

QL-1209 (QL1209 / QL 1209)

✓ Approved

Qilu Pharmaceutical · ERBB2 · 单克隆抗体

什么是 QL-1209？

QL-1209 是一种单克隆抗体，由Qilu Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名QL1209, QL 1209
公司Qilu Pharmaceutical
药物类别单克隆抗体, 抗体
分子靶点ERBB2
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Qilu Pharmaceutical

作用机制

分子靶点

QL-1209 作用于 1 个分子靶点：

ERBB2erb-b2 receptor tyrosine kinase 2 (NEU, CD340)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

QL-1209 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Breast cancer✓ Approved

相关研究文献

PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-11

In-Situ Preparation of Nano-Si Embedded in Porous Carbon From Liquid Silicon Precursors in Molten Salt for High-Performance Lithium-Ion Battery Anodes.

Wang Yida Y, Cui Xiaoyan X, Liao Renwei R, Xia Yun Y et al.

The structures of silicon‑embedded porous carbon feature unique pore‑confinement effects and serve as highly promising configurations for silicon‑carbon anodes. However, conventional preparation technologies based on silicon sources have obvious technical shortcomings that limit the fabrication and industrial application of such composite anodes. Among them, the CVD process using silane as a precursor carries high safety risks and can easily lead to pore clogging of carbon matrices and aggregation of silicon particles. This work employs chemically stable and highly wettable polydimethylsiloxane (PDMS) as the liquid silicon source, employs biomass-derived porous carbon as a host matrix, and synthesizes silicon-embedded porous carbon anode materials through in situ low-temperature molten salt reduction (denoted as SiNPs@PC). SiNPs@PC exhibits a reversible capacity of up to 1209 mAh g-1 after 100 cycles at 0.1 A g-1. Subsequently, coating SiNPs@PC with an ionic-liquid-derived carbon layer yields SiNPs@PC1_ILs3, which delivers enhanced cycling stability and retains 82.7% of its initial capacity after 2000 long-term cycles at 5 A g-1. The in situ preparation strategy using liquid silicon source offers comprehensive advantages over CVD method in the safety, operability and cost of process.

PMID 42723401
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PubMedAdvanced healthcare materials2026-09-08

Dual‑Channel Hypoxia Detection Using PET-Based Water-Soluble Cyanine Probes to Suppress False Negatives in Image‑Guided Pancreatic Cancer Resection.

Huang Huiling H, Jiang Shihao S, Zhang Zhipengjun Z, Chen Ye Y et al.

Fluorescence‑guided surgery using activatable probes is promising, but single‑channel probes often give false negatives-especially in pancreatic cancer due to tumor heterogeneity and limited imaging depth. Here, we built a universal charge-switching gated PET platform based on cyanine dyes bearing a meso-quinolinium moiety. This platform-by decoupling quenching from the recognition group-enabled the construction of two structurally analogous, hypoxia-activatable near-infrared (NIR) probes (Cy5-Ql-NTR and Cy7-Ql-NTR), which have comparable responsive kinetics (sensitive, fast-responding, and low-background), good water solubility and favorable renal clearance, but differ in tissue imaging depth: the former generates brighter signals in superficial regions, while the latter enables deeper tissue penetration and serves as a self-calibration reference. Notably, compared to a single probe, the combined metabolic distribution of the two probes covers a broader range of tumor target tissues. Through their dual-channel imaging, depth-dependent signal attenuation is corrected, and blind spots during probe delivery are reduced. Compared to single-channel fluorescence-guided surgery in subcutaneous pancreatic cancer and orthotopic pancreatic tumor, the dual-channel approach yielded clean margins, preserved significantly more normal tissue, and left no residual tumor on histology. This self-referenced detection strategy suppresses false negatives in single-channel detection, offering a practical and optimized solution for intraoperative guidance in pancreatic cancer.

PMID 42706780
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PubMedPLoS genetics2026-09-08

EFN-4/Ephrin converges with SAX-3/Robo, UNC-6/Netrin, and Heparan Sulfate Proteoglycan signaling to control MAB-5/Hox-dependent posterior Q neuroblast migration in Caenorhabditis elegans.

Jain Vedant D VD, Johannesen Andrew M AM, Teixeira Felipe L FL, Lundquist Erik A EA

Hox genes have been broadly implicated in nervous system development, but the molecular and genetic mechanisms that act downstream of Hox factors remain to be identified. The MAB-5 antennapedia-like Hox transcription factor is both necessary and sufficient to cause posterior migration of the Q neuroblast descendants in Caenorhabditis elegans. In response to MAB-5, the left-side QL descendants QL.a and QL.ap undergo a three-stage migration process, with each stage characterized by a posterior lamellipodial protrusion followed by cell body migration. The QL.ap cell differentiates into the PQR neuron posterior to the anus. Previous studies showed that the MAB-5-regulated gene efn-4/Ephrin was required for the third and final stage of QL.ap migration, with efn-4 mutation resulting in placement of PQR immediately anterior to the anus. This subtle and previously-undescribed phenotype opens the possibility that other known neuronal development genes could be involved. In this work, we screened known signaling mutants for third-stage PQR migration defects. We found that mutations in SAX-3/Robo signaling, UNC-6/Netrin signaling, and heparan sulfate proteoglycans (HSPGs) all displayed third-stage PQR migration defects. The effects in single mutants were weak compared to efn-4, and double mutant analysis revealed lack of genetic synergy, consistent with all of these molecules converging on a common pathway. This genetic analysis is consistent with physical interaction studies in vitro from another group that suggest that these molecules form connected communities of interacting extracellular domains, raising the possibility that they are all components of a large extracellular signaling complex required for posterior QL.ap migration. In this model, we envision that MAB-5/Hox drives EFN-4/Ephrin expression in QL.ap, which then seeds the formation of an extracellular signaling complex containing SAX-3/Robo signaling, UNC-6/Netrin signaling, and HSPGs that drives posterior lamellipodial formation and posterior migration.

PMID 42709880
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PubMedBioinformation2026-09-06

Ultrasound-guided quadratus lumborum block versus caudal block for post-operative analgesia in childrens.

Gandhi Monika M, Sharma Nidhi N, Rana Divya D, Jain Shalini S

Post-operative pain control in children undergoing lower abdominal surgery remains a concern because single-shot caudal analgesia has limited duration. Therefore, it is of interest to compare ultrasound-guided quadratus lumborum block and caudal block in 70 children, with 35 patients each in Group-QL and Group-C. Baseline age and gender distribution were comparable between the groups, with p = 0.580 and p = 0.550 respectively, while time to first rescue analgesia was significantly longer in Group-QL than Group-C (9.60 ± 0.59 h versus 3.37 ± 0.49 h, p = 0.001). Thus, ultrasound-guided quadratus lumborum block provided longer overall Post-operative analgesia, with significant difference in FLACC score at selected Post-operative time points.

PMID 42701700
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PubMedMolecular psychiatry2026-09-03

Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.

Sun Yunkai Y, Fang Yehong Y, Peng Pu P, Wu Qiuxia Q et al.

Marked interindividual heterogeneity in substance use disorder (SUD) impedes the identification of consistent neuroanatomical alterations, limiting the development of robust markers for clinical risk stratification. We applied a normative modeling framework to explore individual neuroanatomical deviations in individuals with SUD across two distinct substance classes, and assessed their potential for classification and risk prediction. We established a developmental normative model of gray matter volume (GMV) using T1-weighted images from 1209 healthy individuals aged 18-65 years. Deviations from this normative model were then estimated for 184 individuals with methamphetamine use disorder (MUD), 94 with ketamine use disorder (KUD), and 220 healthy controls (HC) collected from two independent sites. Based on these individual deviation scores, a machine learning model was constructed to identify individuals at risk for SUD. The normative model revealed high interindividual heterogeneity in GMV deviations among individuals with MUD and KUD. Cross-substance extreme negative deviations were primarily located in regions of the default mode network (DMN). Notably, individual-level deviations could successfully distinguish both MUD and KUD from HC, and replicated in an external dataset. We further identified significant associations between abnormal GMV trajectories and neurobiological features, particularly myelination and neurotransmitter systems. These findings enhance our understanding of the heterogeneous neurobiology underlying SUD, providing potential neurobiological biomarkers for clinical diagnosis, risk stratification, and prevention.

PMID 42686998
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PubMedACS sensors2026-09-03

Boosting Sensitivity of a Microwave Gas Sensor via Electrically Tunable Frequency.

Yang Xianwang X, Liu Yong Y, Wang Xiaolong X, Wang Renshuo R et al.

In this study, a tunable microwave gas sensor (T-MGS) is proposed and demonstrated. By cascading a pair of varactor diodes at the terminal of the coupled line (CL) resonator and adjusting the direct current (DC) bias voltage, the capacitance of varactor diodes and the surface current distribution of the resonator can be effectively modified, thereby synchronously regulating the equivalent capacitance and inductance of the resonator. This enables significant enhancement of both the electric field (E-field) and magnetic field (H-field) inside the resonator, which effectively compensates for the loaded quality factor (QL) and unloaded quality factor (QU), and further improves the sensing performance of the sensor. To systematically demonstrate the material-agnostic nature of the proposed sensitization strategy, experiments were conducted employing a diverse panel of sensing materials (SMs) spanning the full conductivity range from insulating to highly conductive, and their performance was characterized against reducing NH3 and oxidizing NO2 analytes, representing two fundamentally distinct redox-based sensing mechanisms. Experimental results show that after tuning, the minimum limit of detection (LOD) of the NO2 sensor can reach 0.7 ppb, with a peak sensitivity of 9.779 dB/ppm (1.7 times higher); the minimum LOD of the NH3 sensor can reach 2.3 ppb, with a peak sensitivity of 1.279 dB/ppm (7.6 times higher). Validated in all experimental systems, this sensitization method can significantly improve the sensor sensitivity by 1.7-16 times and greatly reduce the LOD, showing great application potential in the field of high-performance microwave gas sensing.

PMID 42687313
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