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calcium hopantothenate (Hopate / hopantenate calcium)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · 小分子 · 小分子

什么是 calcium hopantothenate？

calcium hopantothenate 是一种小分子，由Mitsubishi Tanabe Pharma Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Hopate, hopantenate calcium
公司Mitsubishi Tanabe Pharma Corporation
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

治疗适应症

calcium hopantothenate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersAttention deficit hyperactivity disorder✓ Approved

相关研究文献

PubMedInternational journal of dentistry2026-09-11

Evaluation of the Effect of Adding Various Polymeric Rheological Agents on the Physical and Mechanical Properties of Calcium Silicate Cement.

Zadsirjan Saeede S, Feli Mojgan M, Zargar Nazanin N, Tayebi Golnaz G et al.

The effect of polymer addition on the properties of calcium silicate cement (CSC) was evaluated. The powder component was based on calcium silicate. The liquid component contained distilled water (control group) and distilled water with polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), and polycarboxylate ether (PCE) polymers separately or in combination (PVA + PCE, PVP + PCE) at concentrations of 1 and 3 wt%. In addition to the evaluation of handling properties, some analyses were performed, including setting time, compressive strength, flowability, and injectability. The best-performing groups were selected as the final groups. The specimens were immersed in distilled water and simulated body fluid (SBF) for 1 and 7 days to evaluate the amount of calcium ion release, weight changes, and hydroxyapatite formation. One-way ANOVA, repeated measures ANOVA, and Tukey tests were used for statistical analysis (α = 0.05). Based on the handling evaluation and the results of the setting time, compressive strength, flowability, and injectability analyses, the PVA 3% and PVP 3% groups were selected as the optimal groups and subjected to further analysis. The PVA 3% group showed the highest calcium ion release after 1 day of immersion, while no significant difference was observed among the groups on the seventh day. All three groups (PVA 3 wt%, PVP 3 wt%, and control) showed the formation of calcium phosphate deposits after immersion in SBF. The use of PVA 3% and PVP 3% polymers separately in the liquid component of CSC improved the properties of this cement.

PMID 42724287
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PubMedPlastic and reconstructive surgery. Global open2026-09-11

Limb Salvage Using Local Antibiotic Beads for Calcaneal Osteomyelitis With Multidrug-resistant Infection and Chronic Limb-threatening Ischemia.

Alhunayan Danah D, Alsaleh Ahmed A, Makhdoomi Mahmood M, Khuraibet Salma S et al.

Calcaneal osteomyelitis in diabetic patients with chronic limb-threatening ischemia (CLTI) and multidrug-resistant (MDR) infection poses a significant reconstructive challenge. Limited perfusion, high plantar loading, and constrained antimicrobial delivery often narrow salvage options and increase the risk of major amputation. We report a case of recurrent calcaneal osteomyelitis in a 53-year-old man with type 2 diabetes, chronic kidney disease, peripheral vascular disease, CLTI, and polymicrobial MDR infection. Management included revascularization, serial debridement, culture-directed systemic therapy, negative-pressure wound therapy, hyperbaric oxygen therapy, structured offloading, and adjunctive local antibiotic delivery using calcium sulfate beads. Following recurrence, repeat calcaneal debridement and saucerization were performed, and vancomycin- and gentamicin-loaded calcium sulfate beads were placed individually into the calcaneal defect. The wound progressed with no recurrent infection or exposed bone. Complete epithelialization was achieved at 14 months, and the patient remained pain-free and independently ambulatory in offloading footwear. In recurrent calcaneal osteomyelitis complicated by CLTI and MDR infection, calcium sulfate antibiotic carriers may serve as a useful adjunct to staged multimodal limb salvage. By combining dead-space management with high local antibiotic delivery after repeat debridement, this approach may be considered in selected ischemic, infection-resistant presentations.

PMID 42724855
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PubMedJournal of thoracic disease2026-09-11

Factors associated with postoperative respiratory failure in hospitalized patients with thoracolumbar fractures: a retrospective cross-sectional study based on the MIMIC-IV database.

Zhou Jingjing J, Weng Lili L, Ni Yan Y, Jin Ling L

Postoperative respiratory failure is a serious complication following thoracolumbar fracture surgery, yet research in this specific population remains scarce. This retrospective cross-sectional study used the Medical Information Mart for Intensive Care IV (MIMIC-IV) database to identify factors associated with postoperative respiratory failure in hospitalized patients with thoracolumbar fractures. Postoperative respiratory failure was identified using diagnosis codes recorded during hospitalization. The variance inflation factor (VIF) test was used to assess collinearity among the collected variables. Least absolute shrinkage and selection operator (LASSO), random forest, and Adaptive Boosting (AdaBoost) regression analyses were used to rank variable importance. A Venn chart was used to determine the common variables identified by the three screening methods. Univariate and multivariate logistic regression were used to determine the factors associated with postoperative respiratory failure. The receiver operating characteristic (ROC) curve and nomogram analysis were used to evaluate discriminative performance. All statistical tests were two-sided. A total of 726 patients were included in this study, and 110 patients experienced respiratory failure. Among 25 candidate variables, 10 were identified as key candidates for respiratory failure according to their importance. On univariate analysis, pneumonia [odds ratio (OR) =11.489, 95% confidence interval (CI): 7.173-18.401; P<0.001], white blood cell (WBC) count (OR =1.086, 95% CI: 1.050-1.123; P<0.001), bicarbonate (OR =0.899, 95% CI: 0.854-0.946; P<0.001), calcium (OR =0.602, 95% CI: 0.463-0.782; P<0.001), potassium (OR =1.501, 95% CI: 1.164-1.935; P=0.002), and age (OR =1.013, 95% CI: 1.002-1.023; P=0.01) were associated with respiratory failure. In multivariate analyses, pneumonia and calcium remained independently associated with respiratory failure in all three models [for model 3, OR =7.532, 95% CI: 4.447-12.758, P<0.001; and OR =0.610, 95% CI: 0.443-0.841, P=0.003, respectively], whereas WBC count and potassium remained associated in most models. The area under the ROC curve (AUC) of the comprehensive model combining pneumonia, calcium, WBC count, and potassium was 0.798 (95% CI: 0.746-0.845). Pneumonia, calcium, WBC count, and potassium were factors associated with postoperative respiratory failure in patients with thoracolumbar fractures. The combined model based on these factors showed acceptable discrimination.

PMID 42724579
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PubMedNature communications2026-09-11

InsP3R signaling and actomyosin-dependent mitochondrial dynamics play essential roles in mitochondrial stress-induced longevity.

Feng Gaomin G, Ruark Elizabeth M EM, Mulligan Alexandra G AG, Donahue Eric K F EKF et al.

Certain forms of mitochondrial impairment confer longevity, while disease-associated mitochondrial dysfunction triggers pathogenesis. The adaptive pathways that distinguish benefit from pathology remain unclear. Here we reveal that longevity induced by mitochondrial Complex I/nuo-6 mutation in C. elegans is dependent on the endoplasmic reticulum (ER) Ca2+ channel, InsP3R. To explain this connection, we test multiple candidate links between Ca2+ and mitochondrial homeostasis previously established in vitro, including mitochondrial calcium uniporter (MCU)-dependent stimulation of respiration and cytosolic pathways regulating mitochondrial dynamics. We find that MCU is dispensable for both respiration and longevity in Complex I mutants. Conversely, transcriptomic profiling and imaging reveal InsP3R impairment results in maladaptive expansion of compromised mitochondrial networks. We provide evidence that this aberrant mitochondrial expansion results from disruption of a conserved, InsP3R-dependent actin remodeling network centered on Arp2/3. Disruption of actin remodeling or autophagy mimics the mitochondrial expansion and longevity suppression of InsP3R mutants. Conversely, driving mitochondrial fragmentation ameliorates mitochondrial expansion and rescues longevity in InsP3R mutants, supporting a model in which InsP3R-dependent actin remodeling is required for segregation and clearance of mitochondria. These findings identify an inter-organelle signaling axis linking ER calcium release and cytoskeletal remodeling to adaptive mitochondrial responses associated with longevity.

PMID 42722646
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PubMedFrontiers in microbiology2026-09-11

Microbially induced calcite precipitation (MICP): mechanisms, engineering applications, and pathway to field-scale deployment - a comprehensive review.

He Tao T, Chen Jiaxing J, Lou Xiyan X

Over the last twenty years, there has been a great amount of multidisciplinary interest in Microbially Induced Calcite Precipitation (MICP) as a truly sustainable solution to ground treatment using Portland cement. The process utilizes the urease activity of ureolytic bacteria, most commonly Sporosarcina pasteurii to convert soluble urea and calcium to solid calcite in the pore space of granular media, providing cementation, impermeability reduction and contaminant sequestration without excavation or heat. This review compiles over sixty publications covering all aspects of MICP research, ranging from the enzymological chemistry of urease to the documented field trials of over 100 m3 of treated volume, to the thermodynamics of calcium carbonate polymorphism. Unconfined compressive strengths of over 10 MPa have been reached in laboratory columns and wind erosion reduction of 95% has been observed in field tests, while the efficiency of heavy metal removal can reach up to 99% for lead in aqueous laboratory systems, though removal efficiencies in soil matrices are typically lower and highly dependent on metal concentration, soil type, and treatment conditions. The self healing concrete application is the most advanced toward commercial maturity, and there are products available from Basilisk, Evonik and BioMason. Ground improvement, liquefaction mitigation, and coastal erosion control are other geotechnical applications at Technology Readiness Levels 5 to 7, with the challenges of uniformity of treatment in heterogeneous soils, management of the by-product of ammonium, bacterial transport at depth, and competitiveness with conventional grouting. New developments such as non-ureolytic microbial pathways, fiber and biochar reinforced hybrid biocementation, 3D bio-printing of living mineral structures, and process optimization via machine learning with R2 > 0,95, are also being explored. The review closes with a candid critique of the gaps in the research, especially long-term durability information, scale-specific cost analyses, and standardized monitoring protocols, which will decide whether or not MICP becomes a successful laboratory-based concept that moves into a common engineering tool.

PMID 42724962
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PubMedAngewandte Chemie (International ed. in English)2026-09-11

Structure and Function of a Multi-Megadalton Virus-Like Proteolytic Dodecahedron.

Madej Mariusz M, Rodríguez-Banqueri Arturo A, Mizgalska Danuta D, Szmigielski Borys B et al.

Natural pentamer dodecahedra (Ddhs) span six orders of magnitude in diameter. Among proteins, only two catalytic Ddhs have been structurally characterized: lumazine synthase (LS) and the core of pyruvate dehydrogenase (PDH). Zuzalysin (ZUZ) is a ≈95-kDa metallopeptidase secreted for virulence by Porphyromonas gingivalis. Calcium converts latent flexible monomers into active ≈0.5-MDa pentamers that further assemble hierarchically into bipentamers, tripentamers, and a ≈5.6-MDa, ≈355-Å virus-like dodecahedron (DdhZUZ). Experimental structures (1.8-3.6 Å) across these states reveal the molecular basis of activation, association, and catalysis, culminating in DdhZUZ, which is physiologic, exceeds small viral capsids, and has 20 main entry pores and 60 lumen-facing active sites. ZUZ represents the largest catalytic protein assembly resolved at high resolution, exceeding LS, PDH, and major peptidase complexes in size and/or resolution.

PMID 42723362
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