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calcium hopantothenate (Hopate / hopantenate calcium)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · 小分子 · 小分子

什么是 calcium hopantothenate？

calcium hopantothenate 是一种小分子，由Mitsubishi Tanabe Pharma Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Hopate, hopantenate calcium
公司Mitsubishi Tanabe Pharma Corporation
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

治疗适应症

calcium hopantothenate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersAttention deficit hyperactivity disorder✓ Approved

相关研究文献

PubMedJournal of neurogastroenterology and motility2026-07-27

Advances in Understanding Calcium Sensitization in Gastrointestinal Smooth Muscles: Pathways, Interstitial Cells, and Disease.

Perrino Brian A BA, Lee Ji Yeon JY, Koh Sang Don SD

Contractile activity of gastrointestinal smooth muscles is triggered by increased intracellular Ca2+, which activates myosin light chain kinase (MLCK) and leads to phosphorylation of myosin regulatory light chain (RLC), enabling contraction. Myosin light chain phosphatase (MLCP) dephosphorylates RLC for relaxation. The balance between MLCK and MLCP determines the relationship between calcium levels and contractile force. Shifting the balance between MLCK and MLCP in favor of MLCK by inhibiting MLCP allows MLCK to phosphorylate more RLC and generate increased force at any given Ca2+ concentration. Thus, when MLCP is inhibited, the myofilaments are more sensitive to calcium, allowing greater force at any given Ca2+ concentration. Major mechanisms for calcium sensitization in GI smooth muscle include protein kinase C-mediated phosphorylation of protein phosphatase 1 regulatory subunit 14A (CPI-17) and Rho-associated coiled-coil kinase 2 (ROCK2)-mediated phosphorylation of myosin phosphatase targeting subunit 1. Calcium sensitization is crucial for sphincter tone, sustained contraction, peristalsis, energy conservation, and coordinated motility. Smooth muscle cells, interstitial cells of Cajal, and platelet-derived growth factor alpha positive (PDGFRα+) cells form the SIP syncytium, which regulates excitability and calcium sensitization. This review updates our current understanding of the regulatory mechanisms of calcium sensitization with the recent findings from genetically engineered mice with deficiencies in protein kinase C and ROCK2 calcium sensitization pathways, and the involvement of interstitial cells in regulating GI smooth muscle cell excitability. Dysregulated calcium sensitization pathways in motility disorders are summarized, to potentially aid in the development of new pharmacological strategies to prevent and treat GI motility disorders.

PMID 42504649
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PubMedCureus2026-07-27

A Case of Severe Hypercalcemia in a Patient Taking Tirzepatide: Potential Risk Factors.

Iqbal Safiah S, Javed Faiza F, Oyibo Samson O SO

Hypercalcemia is commonly caused by hyperparathyroidism and malignancy. Medication-induced hypercalcemia is less common. Tirzepatide is a dual glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor agonist (GLP-1/GIP RA) used to aid weight loss and glycemic control. It is associated with gastrointestinal side effects, but its effect on calcium homeostasis has not been well reported. We report the case of a 75-year-old woman with a history of type 2 diabetes, hypertension, obesity, chronic kidney disease, and post-surgical hypothyroidism and hypoparathyroidism, who presented with severe symptomatic hypercalcemia one month after starting tirzepatide while taking bendroflumethiazide, calcium carbonate, and alfacalcidol. Her serum calcium levels had been in the normal treatment range before the initiation of tirzepatide. All other possible causes of hypercalcemia were ruled out. Her calcium levels returned to normal after intravenous fluid therapy and withholding tirzepatide, bendroflumethiazide, and calcium carbonate. This case highlights the potential occurrence of severe hypercalcemia during the concurrent use of tirzepatide with bendroflumethiazide, a calcium supplement, and vitamin D in the context of chronic kidney disease. With the increasing use of tirzepatide, healthcare workers need to be mindful of the interaction between tirzepatide and these potential risk factors. While further research is required, we suggest serum calcium monitoring during similar clinical scenarios.

PMID 42504310
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PubMedJournal of biomedical materials research. Part B, Applied biomaterials2026-07-27

Pilot Histomorphometric Study of Combined Use of Poly-L-Lactic Acid and Calcium Hydroxyapatite to Improve Dermis Remodeling.

Gonçalves Pedro Ivo Romani de Oliveira PIRO, Pedrini Flavia F, Barros Isabela Rodrigues de Souza IRS, Ruiz Rogério de Oliveira RO et al.

Injectable collagen biostimulators such as Calcium Hydroxyapatite and Poly-L-Lactic Acid are well-established in regenerative dermatology for their ability to induce neocollagenesis and improve skin quality. Despite their proven individual efficacy, the combined use of these biomaterials remains underexplored. This study aimed to evaluate the histological and stereological effects of Calcium Hydroxyapatite, Poly-L-Lactic Acid, and their combination on dermal remodeling and connective tissue deposition. A pilot histomorphometric study was conducted in patients undergoing abdominoplasty, allowing access to treated and untreated tissue. Injections of Calcium Hydroxyapatite, Poly-L-Lactic Acid, their combination (Composite), or saline were administered in infraumbilical areas, using intradermal and deep dermal planes according to the material. Tissue samples were collected at D-30 (before intervention), and at 60 and 120 days for analysis. Histological assessment included fiber density, organization, and inflammatory infiltrates. Stereological analysis was performed using the point-counting method to quantify extracellular matrix (ECM) content. Results showed that all active treatments induced significant dermal remodeling compared with controls. Calcium Hydroxyapatite and Poly-L-Lactic Acid individually led to increased fiber bundle thickness and reduced interstitial spaces. The Composite group demonstrated the most pronounced effects, with fiber compaction and enhanced ECM remodeling. The ECM content increased up to 1000% by 60 days, with slower gains between 60 and 120 days, suggesting early peak stimulation followed by stabilization. In conclusion, the combination of Calcium Hydroxyapatite and Poly-L-Lactic Acid resulted in superior histological outcomes compared with isolated applications. These findings support the potential of a dual-modality dermis biostimulation as a promising strategy for treating skin laxity.

PMID 42504042
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PubMedFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026-07-27

Time-Restricted Feeding With High-Fat Diet Slows Weight Gain and Reduces Renal Calcium Oxalate Crystal Formation Without Reducing Energy Intake.

Xiao Yunfei Y, Wang Jiahao J, Cui Jianwei J, Yin Shan S et al.

Renal calcium oxalate stones are closely linked to lipid metabolism disorders. A long-term high-fat diet (HFD) can lead to obesity and other metabolic disorders, which significantly contribute to stone formation. Recent studies indicate that time-restricted feeding (TRF) plays a crucial role in improving metabolic homeostasis and preventing metabolic diseases. However, its impact on kidney stone formation has yet to be investigated. We examined differences in calcium oxalate crystal formation in mouse kidneys using glyoxylic acid (Gly) modeling in HFD mouse models subjected to either ad libitum (Ad) feeding or TRF. TRF mitigated weight gain, improved blood lipid metabolism disorders, and reduced lipid deposition in the liver and kidneys, alleviating pathological damage. Compared with the Ad group, the TRF group exhibited lower urinary concentrations of oxalate and calcium ions, which corresponded with reduced expression of OPN and CD44, leading to decreased oxalate crystal formation. Gly intervention in the Ad group increased the expression of TNF-α and IL-6 in the kidneys, leading to an imbalance between oxidative stress and antioxidant responses. In contrast, TRF showed significant improvement, potentially linked to activation of the PI3K-AKT pathway. Nighttime TRF, which more closely aligns with the natural work and rest rhythms of mice, produced more pronounced effects than daytime TRF. NR1D1 expression in the kidneys was closely associated with stone formation. TRF can improve lipid metabolism and inhibit the formation of renal calcium oxalate stones, and dietary preventive strategies that align with biological rhythms demonstrate particularly significant effects.

PMID 42504853
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PubMedJournal of functional biomaterials2026-07-27

Mesoporous Bioactive Glass Nanoparticle-Reinforced Calcium Silicate Sealer for Reduced Microleakage and Enhanced Antibacterial Performance.

Zhang Zun Z, Zhang Qianqian Q, Sun Ying Y, Sui Baiyan B et al.

Long-term success of root canal therapy depends not only on effective disinfection but also on durable sealing of the obturated canal system. However, currently available sealers still face persistent challenges in balancing handling, interfacial stability, bioactivity, and antibacterial performance. Here, we developed an injectable calcium silicate-based root canal sealer reinforced with mesoporous bioactive glass nanoparticles (MBGN) to improve sealing-related performance. The formulation integrated a hydration-active calcium silicate matrix with a mesoporous bioactive component while maintaining practical handling characteristics. MBGN incorporation enhanced dentin-associated mineralization, promoted intratubular crystal deposition, reduced apical microleakage, and decreased internal porosity after obturation. The 5% MBG formulation showed the most favorable sealing profile, reducing the dye penetration depth from 2.68 ± 0.41 mm in the 0% MBG group to 1.87 ± 0.32 mm, together with decreased open and closed pore parameters in the apical region. In parallel, the MBGN-reinforced sealer preserved acceptable cytocompatibility and exhibited stronger antibacterial activity against Streptococcus mutans than the reference formulations. The improved performance may be associated with effective initial adaptation and bioactive interfacial densification. Together, these findings suggest that MBGN incorporation may be a promising route for engineering more bioactive calcium silicate sealers with improved sealing stability and antibacterial function for endodontic applications.

PMID 42506564
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PubMedGels (Basel, Switzerland)2026-07-27

Calcium Alginate-Based Hydrogel-Encapsulated Nutrients and Nucleic Acid Delivery for Ameliorating Saline-Alkali Stress in Plants.

Riaz Muhammad M, Li Lixia L, He Ping P, Jiang Rong R et al.

Calcium alginate is an anionic polysaccharide that forms an ionically crosslinked hydrogel network with encapsulation properties to nucleic acids and nutrients for the amelioration of osmotic stress, ion toxicity and nutrient imbalance in saline-alkali soils. Traditional soil reclamation methods, including salt leaching, incorporation of organic matter, and gypsum application, are water-intensive under a changing climate, ultimately necessitating transformative bio-based solutions for food security. Calcium alginate-based biohydrogel represents a versatile platform with a tunable macromolecular architecture, ionic crosslinking via an "egg box" mechanism and potentially promising to deliver engineered co-encapsulated nutrients and genetically modified cargoes. The mannuronic (M) and guluronic (G) acid (M/G) ratios govern ion exchange capacity, rheological behavior and release kinetics in saline- and alkali-stressed environments. Recent studies on alginate-based nutrient encapsulation showed reduced oxidative damage and a 15-50% increase in plant-available water. The irrigation intervals extended from 7 to 14 days and yield gains by 24% in wheat, with comparable improvements in maize, tomato, rice and cotton. Calcium alginate hydrogels encapsulated salt tolerance genes (HKT1, SOS1, AVP1) encoding proteins mainly involved in Na+ retrieval from xylem, Na+ extrusion from root cells and vacuolar Na+ sequestration, which have achieved yield gains of 40 to 75% across wheat, rice and maize. Future research should focus on optimizing mechanical strength, crosslinking chemistry and smart bioencapsulation strategies for sustainable development so that crops are capable of withstanding variable climate stresses.

PMID 42505273
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