北京若生智能科技有限公司
Drug Database
TE

teriparatide (Xinfutai Pro)

✓ Approved

Shenzhen Salubris Pharmaceuticals Co., Ltd. · PTH1R · 重组蛋白

什么是 teriparatide？

teriparatide 是一种重组蛋白，由Shenzhen Salubris Pharmaceuticals Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名Xinfutai Pro
公司Shenzhen Salubris Pharmaceuticals Co., Ltd.
药物类别重组蛋白
分子靶点PTH1R
给药途径Injectable (Others)
状态Approved
来源： ClinicalTrials.gov, Shenzhen Salubris Pharmaceuticals Co., Ltd.

作用机制

分子靶点

teriparatide 作用于 1 个分子靶点：

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

teriparatide 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedBMC geriatrics2026-10-26

Long-term trends, age-period-cohort patterns, and future projections of incident stroke with comorbid hypertension and diabetes among older adults in Shenzhen, China: a population-based surveillance study.

Xu Ping P, Li Zhixue Z, Xu Ying Y, Hou Yunfeng Y et al.

Older adults with stroke frequently have coexisting hypertension and diabetes, a high-risk cardiometabolic profile that complicates prevention, long-term management, and health service planning. However, population-based evidence on the long-term incidence trajectory of stroke occurring with both conditions remains limited, particularly in rapidly urbanizing settings undergoing population ageing. This study examined long-term trends, age-period-cohort patterns, and future projections of incident stroke with comorbid hypertension and diabetes among older adults in Shenzhen, China. This population-based retrospective surveillance study used data from the Shenzhen Cardiovascular and Cerebrovascular Disease Registry System. Incident stroke events registered between 1 January 2004 and 31 December 2023 among adults aged ≥ 60 years were identified, and 40,128 events with comorbid hypertension and diabetes were included. Crude incidence rates (CIRs) and age-standardized incidence rates (ASIRs) were calculated. Joinpoint regression, age-period-cohort analysis, and Bayesian age-period-cohort modeling were used to assess temporal trends, estimate age, period, and cohort effects, and project incidence trends from 2024 to 2033. From 2004 to 2023, the number of incident stroke events with comorbid hypertension and diabetes increased from 314 to 3,336, and the ASIR rose from 141.12 per 100,000 in 2004 to 414.78 per 100,000 in 2023. Joinpoint regression showed overall increasing trends in CIR and ASIR across the study period, with average annual percent changes of 5.44% and 6.14%, respectively, while identifying a late-period decline after 2017. Incidence levels were generally higher in males than in females. Age-period-cohort analysis showed marked age effects, elevated period-related risks in recent periods, and increasing cohort effects across successive birth cohorts. Bayesian projections suggested that both CIR and ASIR may increase from 2024 to 2033, with larger projected increases in males. Among older adults in Shenzhen, the burden of stroke with comorbid hypertension and diabetes showed a long-term upward trajectory over the study period. Model-based projections suggested that the burden may increase from 2024 to 2033, particularly among males and older age groups. These findings provide population-level descriptive and projection evidence that may inform risk stratification and health service planning for ageing urban populations.

PMID 42928102
阅读全文 →
PubMedBiotech (Basel (Switzerland))2026-10-26

Pharmaceutical Residues in Human Urine from Patients Under Antiretroviral Regimens and Self-Reported Healthy Individuals Before and After Three Months' Storage: Implication for Agricultural Reuse in Pretoria, South Africa.

Lizbelt Mugivhisa Liziwe ML, Faith Baloyi Khanyi BK, Oladeji Oluwaseun Mary OM, Olatunji Olatunde Stephen OS et al.

Background/Objectives: Pharmaceutical residues in human urine have raised serious concerns about the safe reuse of urine in agriculture. The current study investigates and compares the concentrations of pharmaceuticals in urine samples collected from male patients undergoing active antiretroviral regimens and self-reported "healthy individuals" at a government hospital in Pretoria, South Africa, and determines how the residues changed during three months of ambient storage, which is the usual recommendation before use in agriculture. Methods: The urine samples were collected in a plastic bottle to prevent fecal contamination, and 15 targeted compounds were analyzed using solid-phase extraction and liquid chromatography-mass spectrometry. The linearity ranged from 0.9910 to 0.9999, 75.5% to 99.1% for recovery, and intra-day and inter-day precision were below 6%. The urine from each group was collected into one pooled sample and then analyzed both pre- and post-storage. Results: Thirteen pharmaceuticals were detected in urine from patients on regular medication before storage; in "healthy individuals", detections rose from eight to twelve after storage. Concentrations in the composite samples after storage were higher for some of the compounds but lower for others, including caffeine, nevirapine, prednisolone and 17α-ethinylestradiol. Metformin was highest overall at 1186.25 µg/L and remained at 806.68 µg/L after storage. The highest concentration for all the pharmaceuticals was reported for metformin, with a value of 1186.25 µg/L, occurring in the group of patients on a regular regimen. There could be a possibility that the rise can be attributed to the hydrolysis of conjugated metabolites during storage; however, no analysis of conjugates was carried out. Conclusions: This study shows the need for appropriate treatment of human urine prior to its reuse as fertilizer and echoes the importance of further research into human exposure pathways and effective pharmaceutical removal strategies.

PMID 42930069
阅读全文 →
PubMedACS applied materials & interfaces2026-10-26

Biomimetic Liquid Diodes Across Materials and Scales for Directional Liquid Transfer.

Sun Yanbo Y, Yang Ling L, Xu Boyuan B, Li Xing X et al.

The last decade has witnessed remarkable advancements in liquid diode, evolving from fundamental research to cutting-edge applications such as microfluidics, thermal management, and wearable electronics. However, how material characteristics and structural scales mediate liquid transport on liquid diodes has yet to be fully clarified to date. In this study, we develop a Crassula muscosa inspired liquid diode (CMLD) with superior material adaptability and structural scale adaptability spanning three orders of magnitude. Such a liquid diode endows a cross-material, and cross-scale unidirectional liquid transfer from microscale to macroscale. The mechanisms underlying the role of the wettability, viscosity and structure scale in regulating the liquid transfer kinetics including transfer distance, transfer velocity and liquid rectification, are clearly demonstrated. By combining experimental observation, numerical simulation, and building a theoretical retention force model, the liquid transfer and pinning mechanisms governed by asymmetric reentrant structures are systematically elucidated, which enables superior robustness for unidirectional liquid transfer of continuous flows with various flow rates. These results provide a robust framework for coupling material characteristics and structural scales to achieve controllable unidirectional liquid transfer, laying a solid foundation for the practical implementation of liquid diode-based technologies.

PMID 42929223
阅读全文 →
PubMedGels (Basel, Switzerland)2026-10-26

Development and Evaluation of a Novel Zwitterionic Surfactant-Based Foaming Formulation for Gas Well Deliquification.

Dong Sanbao S, Yan Yao Y, Liu Haifeng H, Chen Jiakui J et al.

A novel zwitterionic surfactant (HAPB) was synthesized and combined with lauramidopropyl trimethylammonium chloride (LATC) and alpha olefin sulfonate (AOS) to form a high-performance foaming formulation for gas well deliquification. The optimized LATC/AOS/HAPB formulation (15 mmol/L, molar ratio of 16/4/5) achieved a foaming volume and half-life of 400 mL and 9.46 min, respectively. Adding 0.2% sodium alginate (SA), a green polymer, the LATC/AOS/HAPB/SA foam's volume dropped to 350 mL; however, its half-life ramped to 55.47 min. With 0.1 SA and 0.01% calcium lactate (CL), the LATC/AOS/HAPB/SA/CL system exhibited excellent foaming and liquid-carrying performance. At 50% methanol, its liquid-carrying rate reached its maximum (57.44%), while the foaming rate remained 100%. Condensate oil slightly reduced the LATC/AOS/HAPB/SA/CL mixture's liquid-carrying performance, but did not affect its foaming ability, which was maintained at 100% below 50% condensate oil content. The foaming formulation demonstrated outstanding salt resistance, producing a liquid-carrying rate of 26.40% and a foaming rate of 90% at an extremely high salinity of 410 g/L, which was the highest level reported in the literature to date. Furthermore, surface tension tests and the foam's morphological analysis verified the presence of synergy among the LATC/AOS/HAPB/SA/CL system, which effectively enhanced its foaming capability, foam stability, and liquid-carrying ability.

PMID 42929938
阅读全文 →
PubMedBiosensors2026-10-26

Porous Transducers and Hybrid Recognition for Bulky Nitrosamine Impurities: Toward 3D-MXene-Aptamer Detection of Tricyclic NDSRIs.

Shah Tirath T, Patel Ankur A, Shah Jignesh J, Shah Darshil D

Pharmaceutical quality control faces an emerging problem with Tricyclic nitrosamine drug substance-related impurities (NDSRIs), for example, N-nitroso clozapine. The impurities preserve the compl ete structure of their parent active pharmaceutical ingredients, which consist of bulky lipophilic molecules with restricted conformational flexibility. The retention of bulky lipophilic structures from the parent active pharmaceutical ingredients in these impurities results in their complete overlap with other substances, which causes matrix ion suppression and weak ionization and unstable mass-spectrometric responses. The LC-MS/MS method functions as the official standard but its workflow requires excessive solvent use and produces complicated equipment systems, which prevent its use for routine ultra-trace monitoring. This narrative review analyzes hybrid electrochemical sensing technology to determine if it can solve the current problem by using tricyclic NDSRIs steric complexity as a functional benefit for detection purposes. The research combines data from nitrosamine detection with studies on porous 3D-printed electrodes, MXene electrochemistry, molecularly imprinted polymers, aptamer engineering and the computational systematic evolution of ligands by exponential enrichment (SELEX), molecularly imprinted polymer (MIP) and signal-off aptasensing. This review presents that planar electrodes create an unfavorable structure for bulky tricyclic analytes because they lead to surface obstruction and increased resistance during charge transfer. This review demonstrates that gyroid and TPMS-type porous scaffolds with a Ti3C2Tx MXene coating offer superior internal surface area, enhanced diffusion channels and accelerated electron movement. The dual MIP-aptamer system enables selective recognition by using MIP to perform shape-based target capture and specimen protection and aptamer to recognize specific molecular targets. The design process for aptamers includes E/Z nitrosamine isomer modeling, docking and molecular dynamics, and AI-based sequence selection methods, which form the core approach to targeting N-nitroso clozapine (N-CZN)-like proteins. This research outlines a new technique, which uses steric hindrance to block redox-probe entry, thus generating an electrical signal through current reduction. This review presents a fundamental operational model which supports the development of eco-friendly portable electrochemical devices to detect tricyclic NDSRIs with maximum sensitivity.

PMID 42930082
阅读全文 →
PubMedNanoscale2026-10-26

Liquid-phase exfoliation and thickness-selective separation of quasi-1D Ta2Pt3S8 nanowires via liquid cascade centrifugation for high-performance field-effect transistors.

Kang Jinsu J, Kim Jeong Tae JT, Cho Sooheon S, Kim Dahoon D et al.

Quasi-one-dimensional van der Waals Ta2Pt3S8 is a sulfide-based semiconductor with high carrier mobility and an anisotropic nanowire morphology, making it a promising building block for nanoelectronic devices. Although mechanically exfoliated Ta2Pt3S8 has demonstrated excellent device performance, its liquid-phase exfoliation (LPE) has not yet been reported. Herein, we establish an LPE process for Ta2Pt3S8 nanowires and demonstrate their integration into single-nanowire field-effect transistors (FETs). The solvent-dependent dispersion behavior was systematically investigated using eight solvents with different surface tension parameters, and NMP was identified as the optimal solvent because of its superior dispersion efficiency and stability. The LPE conditions were optimized by controlling the initial concentration, solvent volume, and sonication power, yielding an extinction coefficient of 14.39 mL mg-1 cm-1 at 855 nm. Liquid cascade centrifugation enabled thickness-selective fractionation of the exfoliated nanowires, with the 4.5-6 krpm fraction providing a suitable balance between reduced nanowire thickness and material availability for device fabrication. A representative single-nanowire FET fabricated from this fraction exhibited n-type behavior, an Ion/Ioff ratio of 28 770, and a two-terminal field-effect mobility of 66.38 cm2 V-1 s-1, demonstrating the feasibility of integrating LPE-processed Ta2Pt3S8 nanowires into field-effect devices.

PMID 42929352
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多teriparatide