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albumin (albumin, Qiombiotec)

✓ Approved

Quimbiotec · 细胞治疗 · 细胞治疗

什么是 albumin？

albumin 是一种细胞治疗，由Quimbiotec研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名albumin, Qiombiotec
公司Quimbiotec
药物类别细胞治疗
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Quimbiotec

治疗适应症

albumin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersHypoalbuminaemia✓ Approved

相关研究文献

PubMedF1000Research2026-09-11

Dynamics of Body Mass Index and Serum Albumin Levels Before and After the Intensive Phase of Tuberculosis Treatment.

Agaus Lisna Rosalia LR, Ilyas Muh M, Sudarso Agus A, Bakri Syakib S et al.

Tuberculosis remains a major global health problem and is frequently associated with malnutrition, which can negatively affect treatment outcomes. This study aimed to evaluate changes in body mass index (BMI) and serum albumin levels before and after the intensive phase of tuberculosis treatment. An observational analytic study with a prospective cohort design was conducted at Dr. Wahidin Sudirohusodo Hospital, Makassar. A total of 175 newly diagnosed tuberculosis patients were enrolled. BMI and serum albumin levels were measured at baseline and after completion of the two-month intensive treatment phase. Paired sample t-tests were used to assess differences between pre- and post-treatment values. BMI increased significantly from 19.21 ± 3.55 kg/m 2 to 19.78 ± 3.50 kg/m 2 ( p < 0.0001), corresponding to a 2.96% improvement. Serum albumin levels also increased significantly from 3.06 ± 0.62 g/dL to 3.25 ± 0.64 g/dL ( p < 0.0001), with an average improvement of 6.17%. Additionally, the proportion of patients with normal nutritional status increased, while the proportion of underweight patients decreased significantly after treatment ( p = 0.002). Intensive-phase anti-tuberculosis therapy is associated with significant improvements in both anthropometric and biochemical nutritional parameters. Routine monitoring of BMI and serum albumin may serve as practical indicators for assessing treatment response and guiding nutritional interventions in tuberculosis patients.

PMID 42723639
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PubMedNarra J2026-09-11

Correlation of nutritional status and anxiety with quality of life among ovarian cancer patients undergoing chemotherapy: A cross-sectional study at a provincial referral hospital in Indonesia.

Meutia Inong I II, Munizar Munizar M, Indirayani Ima I, Hasanuddin Hasanuddin H et al.

Ovarian cancer and its treatment are associated with substantial physical and psychological burden, which may adversely affect patients' quality of life (QoL). While nutritional status and psychological factors are both considered important determinants of QoL, their contributions in patients undergoing chemotherapy remain unclear. This study aimed to evaluate the correlation between nutritional status and anxiety level with QoL among patients with ovarian cancer undergoing chemotherapy. A cross-sectional study was conducted at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia, in 2025. Nutritional status was assessed using body mass index (BMI) and serum albumin levels; anxiety was measured using the Zung Self-Rating Anxiety Scale (SAS); and QoL was evaluated using the EORTC QLQ-C30 questionnaire. Data were analyzed using Pearson correlation tests followed with multivariate linear regression test. A total of 101 patients with ovarian cancer undergoing chemotherapy were included in this study. Nutritional status indicators, BMI and serum albumin, were not significantly correlated with QoL across all domains, with very weak correlation coefficients (r=-0.165 to 0.097). In contrast, anxiety level demonstrated significant negative correlations with global health status (r=-0.426), physical function (r=-0.449), emotional function (r=-0.427), cognitive function (r=-0.337), and social function (r=-0.466) (all p<0.05), but not with role function. Multivariate analysis confirmed that anxiety was the only independent predictor of QoL across these domains, whereas BMI and serum albumin showed no significant association. These findings indicate that anxiety plays a more prominent role than nutritional status in determining QoL among patients with ovarian cancer undergoing chemotherapy. Routine screening and management of anxiety could be beneficial to be integrated into oncologic care to improve patient outcomes.

PMID 42724217
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PubMedPhotochemistry and photobiology2026-09-11

The effect of light source and fluence on the photodynamic response of RAW 264.7 macrophages containing indocyanine green-bovine serum albumin complexes.

Szpunar Magdalena M, Mytych Wiktoria W, Tabarkiewicz Jacek J, Czuba Zenon Z et al.

Photodynamic therapy (PDT) efficacy depends on both the photophysical properties of the photosensitizer and the spectral characteristics of the irradiation source. In this study, the photodynamic response of RAW 264.7 macrophages incubated with an indocyanine green-bovine serum albumin (ICG-BSA) complex was evaluated using three irradiation sources: an 820 nm diode laser (emission maximum ~790 nm), a 660 nm diode laser, and a broadband tungsten-halogen OSL2 illuminator. The photophysical stability of the ICG-BSA complex was assessed by UV-Vis spectroscopy, while PDT activity was evaluated by cell viability and fluorescence measurements. The ICG-BSA complex exhibited good spectral stability and maintained characteristic absorption bands associated with monomeric and dimeric forms of ICG. Irradiation induced a fluence-dependent decrease in cell viability and fluorescence intensity, indicating effective photodynamic activation and photobleaching of the photosensitizer. The strongest photodynamic response was observed for the 820 nm laser, followed by the OSL2 illuminator, whereas the 660 nm laser produced the weakest effect. Increasing ICG concentration further enhanced photodynamic cytotoxicity under constant irradiation conditions. The results demonstrate that PDT efficiency is strongly influenced by spectral overlap between the irradiation source and the absorption characteristics of the ICG-BSA complex, highlighting the importance of excitation conditions in determining photodynamic activity.

PMID 42723266
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PubMedFrontiers in cardiovascular medicine2026-09-11

A composite model incorporating systemic inflammatory burden and GRACE score for enhanced identification of elevated myocardial stress in acute myocardial infarction: an exploratory analysis.

Libao Peng P, Wenji Lin L, Mengjiao Wang W, Jiali Zou Z

Acute myocardial infarction (AMI) remains a leading cause of mortality and heart failure worldwide. Early identification of patients with elevated myocardial stress, a key driver of adverse outcomes, is clinically important. However, the utility of a composite inflammatory burden score for this purpose remains unclear. This retrospective study enrolled 302 consecutive patients hospitalized for AMI at Shenzhen Qianhai Shekou Hospital between January 2023 and December 2024, with 50 healthy controls for descriptive purposes only. Patients were stratified into three groups based on their systemic inflammatory burden score (SIBS): low (score 0), intermediate (score 1), and high (score 2) inflammatory burden. Clinical characteristics, laboratory parameters, and in-hospital outcomes were compared across groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminatory ability of SIBS, GRACE score, hs-CRP, albumin, C-reactive protein-to-albumin ratio (CAR), and a composite logistic regression model combining SIBS ≥ 1, GRACE score, and hs-CRP for identifying elevated myocardial stress, defined as NT-proBNP >75th percentile (647 pg/mL) as an exploratory surrogate endpoint. Areas under the curve (AUC) were compared using the DeLong test. Internal validation was performed using 10-fold cross-validation and bootstrap optimism correction on the final model. The SIBS was significantly correlated with heart rate, Killip class, GRACE score, left ventricular ejection fraction (LVEF), prevalence of multi-vessel coronary disease, and length of hospital stay in AMI patients (P < 0.05). The high inflammatory burden group (SIBS = 2) exhibited more severe cardiac dysfunction and extensive coronary artery disease. For identifying elevated myocardial stress, the GRACE score yielded the highest AUC among individual markers (0.766), followed by albumin (0.707) and hs-CRP (0.671). The composite model incorporating SIBS ≥ 1, GRACE score, and hs-CRP significantly improved discriminatory capacity, achieving an apparent AUC of 0.815 (95% CI: 0.737-0.888), which was superior to any single marker alone (P < 0.05). After bootstrap optimism correction, the corrected AUC was 0.798, and the Hosmer-Lemeshow test indicated good calibration (P = 0.32). The model also showed a Brier score of 0.168, a calibration slope of 0.94 (95% CI: 0.82-1.06), and a calibration intercept of -0.12 (95% CI: -0.45 to 0.21). In this exploratory analysis, SIBS is associated with clinical severity and myocardial stress in AMI patients. A composite model combining SIBS, GRACE score, and hs-CRP improves identification of elevated myocardial stress compared with single biomarkers in this exploratory analysis. External validation is needed before clinical application.

PMID 42724051
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PubMedWater environment research : a research publication of the Water Environment Federation2026-09-11

Phosphoric Acid-Modified TiO2 Nanoparticles as Functional Additives for High-Performance Polyethersulfone Ultrafiltration Membranes.

Al-Jubouri Assala M AM, Shabeeb Kadhum M KM, Alsalhy Qusay F QF, Al-Saadi Saad S et al.

Polyethersulfone (PES) ultrafiltration membranes were modified with phosphoric acid-functionalized TiO2 nanoparticles (0-1 wt%) via phase inversion to enhance permeability, antifouling performance, and dye removal for wastewater treatment. Structural and morphological analyses confirmed the successful modification and uniform incorporation of TiO2 within the PES matrix. The membrane containing 0.5 wt% TiO2 exhibited optimal performance, achieving the lowest contact angle (~39°), highest porosity (~65.5%), and maximum pure water flux (~292 L·m-2·h-1), compared to 204 L·m-2·h-1 for pristine PES. Rhodamine B rejection exceeded 85%, driven by electrostatic interactions between phosphate groups and cationic dye molecules. Fouling tests using bovine serum albumin revealed a high FRR (~92%) and reduced irreversible fouling. Excessive TiO2 loading led to nanoparticle agglomeration and reduced permeability.

PMID 42723184
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PubMedJournal of thoracic disease2026-09-11

Day-7 lactate-to-albumin ratio as a prognostic marker in sepsis patients requiring prolonged mechanical ventilation: a multicenter retrospective landmark analysis of the Korean Sepsis Alliance registry.

Jang Hyojin H, Yoo Wanho W, Rhee Harin H, Ko Ryoung-Eun RE et al.

Prognostication in patients with sepsis requiring prolonged mechanical ventilation (MV) is challenging. While the lactate-to-albumin ratio (LAR) predicts early sepsis outcomes, its value during prolonged MV remains undefined. We evaluated the prognostic performance of the MV day-7 LAR in this population. This multicenter study retrospectively analyzed prospectively collected data [2019-2023] from the Korean Sepsis Alliance (KSA) registry. By a pre-specified day-7 landmark design, the analysis was restricted to adult sepsis patients who survived on MV to day 7 (requiring MV for ≥7 days). We compared the prognostic accuracy of day-7 LAR with days 1-3 LARs using receiver operating characteristic (ROC) curve analysis. Independent predictors of in-hospital mortality were assessed using multivariable logistic regression. We also evaluated the day-7 LAR's added value to the Sequential Organ Failure Assessment (SOFA) score. Among 1,128 patients, survivors showed a significant LAR reduction by day 7 compared with non-survivors. The day-7 LAR demonstrated higher discriminative ability [area under the curve (AUC) 0.714] for in-hospital mortality than days 1, 2, and 3 LARs (AUC 0.600, 0.646, and 0.674). It also showed higher discrimination than procalcitonin and comparable discrimination to C-reactive protein (CRP). The day-7 LAR was an independent predictor of mortality [adjusted odds ratio 2.191, 95% confidence interval (CI): 1.626-2.952]. Adding the day-7 LAR to the day-7 SOFA score significantly improved predictive performance compared with the SOFA score alone. Furthermore, patients with a day-7 LAR ≥0.81 exhibited significantly lower survival rates and required more frequent organ-support therapies. In sepsis patients requiring prolonged MV, the day-7 LAR serves as a potential marker of the transition to non-resolving organ dysfunction and provides incremental prognostic value to the SOFA score. The day-7 LAR may offer a reproducible anchor for risk stratification and structured reassessment of therapeutic goals in this high-mortality population. These findings apply to patients surviving to the day-7 landmark and may not generalize to unselected ventilated sepsis populations.

PMID 42724331
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