calcitonin (Fortical Injection / Forcaltonin)

An Injectable, Self-Healing Hydrogel Based on G-Quadruplexes/Phenylboronic Acid Composites with Antibacterial Activity.

Yang Hongyi H, Jiang Hui H

Injectable and self-healing hydrogels hold tremendous promise for biomedical applications; however, synchronously integrating robust mechanical adaptability, excellent cytocompatibility, and intrinsic antibacterial capabilities within a single matrix remains a significant challenge. In this study, we engineered an injectable, self-healing hydrogel based on dynamic cross-linking using guanosine-derived G-quadruplex supramolecular self-assembly and 3-aminophenylboronic acid (3-APBA)-mediated dynamic boronate ester. Systematic evaluation of various phenylboronic acid derivatives, GMP concentrations, K+ sources, and 3-APBA levels on gelation behavior yielded an optimized formulation. Scanning electron microscopy revealed that the optimized hydrogel exhibits a continuous, interconnected porous network structure after lyophilization. Thioflavin T fluorescence enhancement assays and circular dichroism spectroscopy further verify the formation of G-quadruplex-related ordered assemblies within the system. Rheological assessments demonstrate elasticity-dominated gel behavior, pronounced shear-thinning characteristics, and reversible structural breakdown and recovery under high and low strain cycles, indicating excellent injectability and self-healing properties. In vitro cytocompatibility evaluations show that the hydrogel possesses favorable cellular compatibility. Further antimicrobial studies reveal excellent in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli. In summary, the injectable, self-healing G-quadruplex hydrogel constructed in this study integrates a porous architecture, dynamic reversibility, and robust biological functionality, highlighting its promising potential in antibacterial applications.

Juxtamembrane mimic peptide loaded injectable sodium alginate/bioglass bioactive hydrogel for suppressing tumor recurrence in post-breast conserving surgery treatment.

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Correction: Chen et al. A dZnONPs Enhanced Hybrid Injectable Photocrosslinked Hydrogel for Infected Wounds Treatment. Gels 2022, 8, 463.

Chen Yao Y, Xiang Yu Y, Zhu Tonghe T, Chen Sihao S et al.

In the original publication [...].

From ECM Aging to Mechanobiological Restoration: Injectable Fillers and Dermal Fibroblast Mechanotransduction-A Narrative Review.

Marchetti Francesco F, Habib Mahmoud M Fahmy MMF, Basso Matteo M

Skin aging reflects the accumulation of molecular damage and a progressive disruption of dermal mechanical homeostasis. Fragmentation and disorganization of the dermal extracellular matrix (ECM) impair force transmission to resident fibroblasts. Reduced cell spreading and mechanical force generation are associated with increased matrix metalloproteinase expression and reduced collagen synthesis, partly through c-Jun/AP-1 activation and attenuation of TGF-β/TβRII signaling. Reduced YAP/TAZ mechanosignaling has also been linked to cGAS-STING-dependent senescence in experimental models. However, its causal role in aging human dermis remains unresolved. This narrative review considers dermal mechanobiology as an integrative framework alongside ultraviolet exposure, oxidative stress, glycation, and cellular senescence. It examines how injectable fillers may influence the dermal mechanical microenvironment. A filler's material properties may constitute a mechanical exposure, although bulk rheological measurements do not define force transmission at the cellular scale. Human in vivo studies of cross-linked hyaluronic acid provide the most direct evidence that enhanced structural support is associated with fibroblast spreading, activation of TGF-β-related signaling, and increased type I collagen deposition. Evidence for calcium hydroxylapatite and other biostimulatory fillers is complementary but more heterogeneous. A composite of PEGDE-cross-linked hyaluronic acid and calcium hydroxylapatite microspheres is considered as an explicitly preliminary example. This review defines the current evidence, its key limitations, and the mechanistically informed studies needed to determine whether, and which, fillers can meaningfully modify dermal mechanobiology.