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MV

MV-130 (Bactek / MV130)

✓ Approved

Inmunotek · 细胞治疗 · 细胞治疗

什么是 MV-130？

MV-130 是一种细胞治疗，由Inmunotek研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Sublingual (SL)/Oral Transmucosal。

药物档案

商品名Bactek, MV130
公司Inmunotek
药物类别细胞治疗, 疫苗
给药途径Oral (PO), Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, Inmunotek

治疗适应症

MV-130 针对 11 个适应症，涉及 4 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsViral upper respiratory tract infection✓ Approved
Infections and infestationsLower respiratory tract infectionPhase III
Infections and infestationsOtitis mediaPhase II
Infections and infestationsPneumoniaPhase II
Infections and infestationsSinusitisPhase II

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相关研究文献

PubMedChemical communications (Cambridge, England)2026-10-26

Ir-modified Co3O4 nanowire arrays for efficient and ultrastable bifunctional seawater electrolysis.

Yang Guangzhao G, Zhuo Yuling Y, Wang Lei L, Wang Zhenbo Z et al.

An Ir-modification strategy alters the surface chemical states and oxygen coordination environment of Co3O4 nanowire arrays. The resulting Ir/Co3O4-x achieves 90 mV (HER) and 219 mV (OER) at 10 mA cm-2, with >900 h durability at 200 mA cm-2 in alkaline seawater. This approach enables highly efficient, stable bifunctional seawater electrolysis.

PMID 42929682
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PubMedBioinformatics (Oxford, England)2026-10-26

Multi-View State-Space Modeling for Zero-Shot circRNA-miRNA Interaction Prediction.

Wei Meng-Meng MM, Wang Lei L, Huang Yu-An YA, Huang Zhi-An ZA et al.

CircRNA-miRNA interactions (CMIs) play regulatory roles in human diseases and provide clues for therapeutic target discovery. However, most existing prediction methods rely on circRNA-miRNA pairs and overlook disease-level regulatory contexts, which limits their ability to characterize cross-pathway dependencies in zero-shot inference. We propose MV-S2M, a multi-view state-space modeling framework that integrates molecular attributes to enhance relational reasoning, enabling zero-shot CMI prediction. Specifically, MV-S2M performs structure-aware diffusion to enrich molecular priors and constructs disease-mediated semantic subgraphs. It then incorporates state-space modeling to capture long-range dependencies and view-specific regulatory patterns. The learned multi-view representations are fused through a linear projection and fed into an MLP for CMI prediction. Extensive experiments on multiple benchmark datasets demonstrate that MV-S2M achieves state-of-the-art performance under both zero-shot and conventional settings. Cold-start evaluations reveal distinct generalization behavior across different unseen-entity settings. Case studies illustrate the contribution of meta-path-guided semantic subgraphs to CMI prediction. The code and data are publicly available at https://github.com/591286260/MV and https://doi.org/10.5281/zenodo.22858403.

PMID 42929772
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PubMedInorganic chemistry2026-10-26

Phase-Transition-Induced Co-Fe2O3 Nanosheets from Upcycling Spent LiFePO4 for Oxygen Evolution.

Wang Chang C, Zha Liuyang L, Liu Qiangchun Q, Kong Xiangkai X

Spent LiFePO4 (LFP) batteries were upcycled into Co-modified Fe2O3 nanosheets (sFe2O3@Co) through an oxidative reconstruction, selective acid leaching, and Co incorporation. Phase-transition-induced confined growth generated defect-rich ultrathin Fe2O3 nanosheets, while Co doping reconstructed the local electronic structure and accelerated the charge transfer. As a result, sFe2O3@Co exhibited excellent OER activity, requiring only 265 mV at 10 mA cm-2 with a Tafel slope of 28.6 mV dec-1 and maintaining 72.6% activity after 350 h. An AEM electrolyzer achieved 100 mA cm-2 at 1.62 V. A techno-economic analysis further demonstrated the superior value of this upcycling strategy over conventional recycling routes.

PMID 42929622
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PubMedInorganic chemistry2026-10-26

Dual-Functional Interface Molecular Engineering of Conductive MOF Nanoarrays for Oxygen Evolution Reaction.

Lin Chong C, Luo Xinyi X, Zhang Xuetong X, Zeng Cuiping C et al.

Drawing conceptual inspiration from the inorganic-organic hybrid architecture of natural Photosystem II, this work presents a dual-functional interface molecular engineering strategy. A Ni(TCNQ)2-FcDA nanoarrays (NAs) composite catalysts were constructed by anchoring ferrocene dicarboxylic acid (FcDA), featuring both proton-relay and redox activities, onto conductive Ni(TCNQ)2 nanoarrays (Ni(TCNQ)2 NAs). Structural characterizations indicate that carboxyl groups in FcDA participate in interfacial proton transport, while Ni-Fe coupling synergistically modulates the electronic structure of the active Ni centers. Theoretical calculations indicate that this interfacial engineering induces a significant downshift in the Ni 3d orbital d-band center, effectively lowering the energy barrier for the OH to O conversion step. Consequently, the catalyst achieves a current density of 10 mA cm-2 at an overpotential of only 226 mV in 1.0 mol L-1 KOH, with a low Tafel slope of 30.4 mV dec-1 and stability exceeding 24 h. Kinetic analysis further reveals a concerted proton-coupled electron transfer (PCET) mechanism. This work presents a strategy for synergistically addressing mass transport bottlenecks and electronic structure mismatches in conductive MOFs via dual-functional molecular interface engineering.

PMID 42929641
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Donor-Cell Senescence Redirects PINK1-Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3-Stabilized HSPA9.

Ou Zixuan Z, Zhao Mingke M, Ling Zhiwei Z, Peng Lianqi L et al.

Extracellular vesicle therapies have been developed for tissue repair, but how donor-cell senescence reshapes vesicle-mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose-derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro-degenerative carriers. Senescent ADSC-derived MVs are enriched in PINK1-marked, oxidatively damaged mitochondrial cargo. After transfer to nucleus pulposus cells (NPCs), this cargo disrupts recipient mitochondrial homeostasis, activates the cGAS-STING-NLRP3 inflammatory axis, and aggravates intervertebral disc degeneration. Proteomic and functional analyses identify HSPA9 as a mitochondrial cargo-sorting adaptor. Senescent stress induces SUMO3 conjugation of HSPA9 at K612, stabilizing HSPA9 by limiting ubiquitin-proteasomal degradation. Stabilized HSPA9 uses its peptide-binding domain to engage the kinase domain of activated PINK1 and links PINK1-positive damaged mitochondria to Annexin A1-associated MV structures. This SUMO3-HSPA9-PINK1 module diverts damaged mitochondria from PINK1-Parkin mitophagy toward MV-mediated mitochondrial transfer. Donor-cell reprogramming that restrains the release of damaged mitochondria and reinforces mitophagic clearance restores the in vivo therapeutic efficacy of senescent ADSC-derived MVs. These findings identify mitochondrial cargo fate as a switch between vesicle-mediated repair and degeneration.

PMID 42928447
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-10-26

Engineering Thermoelectric-Electrocatalytic Coupling in RuO2/PrCoO3 Heterointerface for Efficient Oxygen Evolution.

Yu Yue Y, Zhang Guikai G, Wang Ruqi R, Wang Yueshuai Y et al.

The oxygen evolution reaction (OER) is pivotal for diverse electrochemical energy conversion systems; however, it has so far been plagued by sluggish kinetics and excessive energy consumption. In this study, we proposed an innovative thermoelectric-electrocatalytic coupling strategy to enhance OER efficiency by constructing an Ohmic heterointerface through uniform integration of RuO2 with thermoelectric oxide (PrCoO3). Combined experimental and theoretical analyses revealed that the thermoelectric potential generated by PrCoO3 selectively activates the intrinsically inert (101) facet of RuO2 by lowering *OOH formation barrier, thereby substantially boosting the overall OER performance. Consequently, the RuO2/PrCoO3 heterointerface delivered exceptional OER performance under a mild temperature gradient (ΔT) of 175°C, achieving dramatic reduction in overpotential at 10 mA cm-2 from 300 mV (ΔT = 0°C) to 178 mV, 4 300% increase in current density, and negligible potential loss over 1,000 h. When the catalyst was assembled into an anion exchange membrane water electrolyzer, the cell driven by spontaneous heating reached a low voltage of 2.18 V at a current density of 2.0 A cm-2, with stable operation for 600 h. These insights into harnessing thermal gradient via integrated electrocatalytic system are crucial for the recovery of industrial waste heat and its conversion into high-value chemicals.

PMID 42928654
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