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MV-130 (Bactek / MV130)

✓ Approved

Inmunotek · 细胞治疗 · 细胞治疗

什么是 MV-130？

MV-130 是一种细胞治疗，由Inmunotek研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Sublingual (SL)/Oral Transmucosal。

药物档案

商品名Bactek, MV130
公司Inmunotek
药物类别细胞治疗, 疫苗
给药途径Oral (PO), Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, Inmunotek

治疗适应症

MV-130 针对 11 个适应症，涉及 4 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsViral upper respiratory tract infection✓ Approved
Infections and infestationsLower respiratory tract infectionPhase III
Infections and infestationsOtitis mediaPhase II
Infections and infestationsPneumoniaPhase II
Infections and infestationsSinusitisPhase II

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相关研究文献

PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Tailoring Oxygen-Bridged Ru─Ti Asymmetric Pairs Enables Low-Overpotential Two-Electron Water Oxidation.

Liu Mingyu M, Mei Shaowei S, Khan Muhammad Afsar MA, Pei Wei W et al.

Electrochemical two-electron water oxidation (2e-WOR) offers a promising direct route to on-site hydrogen peroxide (H2O2) production, yet state-of-the-art catalysts still suffer from intrinsically low selectivity and large overpotentials, especially in near-neutral media. Equally unresolved is how the electrolyte composition steers the competition between 2e-WOR and the thermodynamically favored four-electron oxygen evolution reaction (OER). Here we employed a monolayer TiO2 nanosheet platform to anchor atomically dispersed 3d/4d transition-metal centers (Ru1, Cu1, Co1, and Fe1). Among them, Ru1-TiO2 delivers an optimal Faradaic efficiency (FE) of 60.8% at a low overpotential of 130 mV. Further analysis reveals that the oxygen-bridged Ru─Ti (Ru─O─Ti) asymmetric dimer establishes a gradient d-p-d orbital coupling. This electronic motif strengthens the adsorption of HCO3* while attenuating the over-binding of OH*, thereby switching the surface termination from OH* to HCO3*-rich. Consequently, a bicarbonate-mediated 2e-WOR pathway is selectively activated over the Ru─O─Ti sites, which is much more favorable than the conventional OH*-OH* coupling route. These findings underscore that gradient orbital coupling across asymmetric atomic pairs act as an electronic lever to redirect the catalytic trajectory, furnishing a general principle for pathway control in diverse electrosynthesis systems.

PMID 42717502
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PubMedThe journal of physical chemistry. B2026-09-10

Cryogenic Viscoelasticity of a C22-Tailed Amine Oxide across an Extremely Broad pH Range.

Chen Qiang Q, Xu Wei W, Liu Lulu L, Yin Hongyao H et al.

Sustaining viscoelasticity of surfactant solutions at subzero temperatures and across extreme pH regimes remains challenging, as freezing and harsh acidic or alkaline environments inhibit aggregate growth and retard structural relaxation. This study examines microstructural evolution and rheological response of C22-tailed amine oxide (C22AO) in a 50/50 (v/v) ethylene glycol-water mixture spanning pH 2.0-13.0 and 20 °C to -20 °C. Potentiometric titration identifies an apparent pKa at 6.8, with ζ-potential declining from +18.53 mV (pH 2.0) to +2.35 mV (pH 6.8) and -1.66 mV (pH 13.0). All formulations retain thermal stability, freezing near -42.0 °C. Microscopy and scattering confirm that pH dominates aggregate morphology in 0.5 wt % C22AO solutions. Acidic conditions (pH 2.0) yield heterogeneous lamellar domains with a 57.0 nm repeat distance at 20 °C, evolving into coexisting 62.8 and 48.3 nm spacings at -20 °C. Near neutrality (pH 6.8), compact lamellar bilayers shrink from 37.0 to 31.4 nm upon cooling, whereas alkaline conditions (pH 13.0) promote disordered, entangled wormlike micelles. All samples exhibit pronounced shear-thinning and elasticity-dominated rheology. At -20 °C across these three pH values, zero-shear viscosities reach 2.45 × 106, 1.96 × 106, and 1.10 × 106 mPa·s, with corresponding elastic moduli of 65, 10, and 28 Pa at 1 rad·s-1 and loss tangent values of 0.24, 0.40, and 0.75. These findings demonstrate that pH governs aggregate morphology, while subzero cooling strengthens molecular packing and decelerates structural relaxation, enabling robust thickening and marked viscoelasticity in cryogenic extreme-pH environments.

PMID 42720367
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PubMedDalton transactions (Cambridge, England : 2003)2026-09-10

Preparation of Pr2O3-Co3Fe7 dual-active components co-embedded in nitrogen-doped carbon and investigation of alkaline hydrogen evolution catalytic performance.

Song Jiahe J, Yu Di D, Li Yangyang Y, Zhang Chunlei C et al.

The hydrogen evolution reaction (HER) is a key half-reaction in electrocatalytic water splitting for hydrogen production that is limited by slow water dissociation kinetics in alkaline media. Therefore, developing high-performance nonprecious metal electrocatalysts for alkaline HER is crucial for sustainable energy conversion. In this study, a series of composite electrocatalysts with Pr2O3 and Co3Fe7 nanoparticles co-embedded in nitrogen-doped carbon (NC) were designed and synthesized via simple hydrothermal and pyrolysis processes. Among these catalysts, the 1.0Pr2O3/Co3Fe7/NC catalyst exhibits an overpotential of 198 mV and a Tafel slope of 95.17 mV dec-1 under alkaline conditions at a current density of -10 mA cm-2. Multiple characterization results indicate that the improvement in HER activity results from synergistic effects in the multicomponent system. An appropriate amount of the Pr2O3 phase provides abundant oxygen vacancies (Ov) for the catalyst and promotes the enrichment of Co2+/Fe2+ species, which are crucial for water dissociation during hydrogen evolution. This study clarifies the crucial role of rare-earth oxides in stabilizing the valence states of active metals and promoting synergistic catalysis among multiple components. It provides new insights into the design of advanced composite electrocatalysts.

PMID 42720062
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PubMedDalton transactions (Cambridge, England : 2003)2026-09-10

MOF-templated heterostructured CoS/NdS: driving interfacial charge transfer for efficient alkaline oxygen evolution reaction.

Ravi Barath B, Ravikumar Navaneeth Kumar NK, Perumal Panneerselvam P

Fabricating inexpensive and efficient electrocatalysts for the alkaline oxygen evolution reaction (OER) remains a critical challenge towards the practical implementation of renewable energy systems. Herein, we report a heterostructured CoS/NdS electrocatalyst obtained from a bimetallic Co/Nd-BDC MOF precursor. The uniform coverage of sulfur species over the Co and Nd regions is confirmed by morphological analysis, providing a strong interfacial interaction between CoS and NdS. The MOF-templated method enables the preparation of highly integrated nanoscale CoS/NdS heterointerfaces that favour interfacial charge redistribution and accelerate electron-transfer kinetics during anodic oxidation. In an alkaline electrolyte, the optimized CoS/NdS electrocatalyst demonstrates superior OER performance, requiring a low overpotential of 249 and 308 mV at current densities of 10 and 50 mA cm-2 and exhibiting a minimum Tafel slope of 51.37 mV dec-1. Chronoamperometry demonstrated the robust long-term electrochemical stability of CoS/NdS, which exhibited a high turnover frequency of 7.67 × 10-2 s-1 and an electrochemically active surface area of 918.25 cm2. Brunauer-Emmett-Teller (BET) analysis shows that the CoS/NdS composite has high specific surface area and a well-developed mesoporous structure with porous channels that further facilitate electrolyte penetration and charge transfer, thus improving the OER properties of the catalyst. Furthermore, analytical techniques confirm that the coexistence of sulphur and oxygen species in CoS/NdS catalyst plays a crucial role in enhancing its intrinsic OER catalytic activity.

PMID 42719945
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PubMedNpj Materials degradation2026-09-10

Materials Acceleration Platform for Electrochemistry: a Platform for Autonomous Electrochemistry.

Persaud Daniel D, Werezak Mike M, Xu Mark M, Zhou Melyne M et al.

Corrosion testing is slow, labor-intensive, and sensitive to operator technique, limiting the generation of large, high-quality datasets for data-driven materials discovery. The Materials Acceleration Platform for Electrochemistry (MAP-E) is an autonomous, high-throughput system, capable of performing parallel electrochemical experiments. It integrates robotic liquid handling and sample transfer with a multi-channel potentiostatic control to extract corrosion metrics without human intervention. Validation against an ASTM G61-analog benchmark demonstrates good reproducibility, with a standard deviation of 75 mV in pitting potential across 32 automated measurements. The platform was then employed to autonomously construct pH-chloride stability diagrams for 304 stainless steel using an uncertainty-driven sampling strategy on a Gaussian process surrogate model. This approach reduces operator involvement and accelerates the exploration of environmental spaces. The MAP-E establishes a framework for autonomous electrochemical experimentation, enabling generation of corrosion datasets that inform materials discovery, alloy design, and durability assessment in service environments.

PMID 42718626
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PubMedCommunications biology2026-09-10

Identifying causal genetic variants for high-altitude adaptation through blood eQTL analysis in plateau populations.

Zhao Chenghui C, Guan Jiawei J, Liu Junhua J, Zhang Zhe Z et al.

A substantial number of genetic variants have been associated with high-altitude adaptation (HAA), yet most of them are located in non-coding genomic regions, leaving their specific functions and underlying mechanisms largely unknown. In this study, we analyze whole-genome and transcriptome sequencing data from a self-established cohort comprising 61 native highlanders (NHs) and 164 acclimatized newcomers (ANs), identifying 6,586 cis- and 34,203 trans-expression quantitative trait loci (eQTLs), along with 130 cell type-specific eQTLs. By further combining these data with a large East Asia (~30% Tibetan) genome-wide association study (GWAS) cohort, we employ colocalization and causal inference analyses to prioritize 85 cis-eQTLs associated with HAA and identify several novel candidate causal genes, including EXOC8, which is experimentally confirmed to regulate erythroid differentiation. Additionally, network analysis of these causal genes uncovers multiple regulatory pathways, mainly involving energy metabolism, autophagy, ubiquitination and inflammation. Our study offers a comprehensive eQTL map and reveals causal chains of "variant-gene-phenotype" for HAA-related traits, which provides new insights into potential regulatory mechanisms and targets for prevention and treatment of altitude sickness.

PMID 42717232
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