Inmunotek · 细胞治疗 · 细胞治疗
MV-130 是一种细胞治疗，由Inmunotek研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Sublingual (SL)/Oral Transmucosal。
| 商品名 | Bactek, MV130 |
| 公司 | Inmunotek |
| 药物类别 | 细胞治疗, 疫苗 |
| 给药途径 | Oral (PO), Sublingual (SL)/Oral Transmucosal |
| 状态 | Approved |
MV-130 针对 11 个适应症，涉及 4 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Infections and infestations | Viral upper respiratory tract infection | ✓ Approved |
| Infections and infestations | Lower respiratory tract infection | Phase III |
| Infections and infestations | Otitis media | Phase II |
| Infections and infestations | Pneumonia | Phase II |
| Infections and infestations | Sinusitis | Phase II |
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Kaaki Suha S, Aldayel Aya K AK, Hajjar Waseem M WM, Hajjar Ahmad W AW et al.
Cervical spinal cord injury (SCI) carries a significant burden in Saudi Arabia, frequently resulting in permanent ventilator dependence and high morbidity. While laparoscopic diaphragmatic pacing (DP) has emerged as an alternative to long-term mechanical ventilation (MV) globally, regional evidence regarding its application within the Middle East remains limited. This study evaluates a single-center cohort of ventilator-dependent cervical SCI patients undergoing laparoscopic DP. We conducted a retrospective analysis of all ventilator-dependent patients with cervical SCI admitted to a tertiary hospital in Riyadh between 2012 and 2024 who underwent laparoscopic DP after failing traditional weaning attempts. Inclusion criteria required at least 3 months of MV dependence, intraoperative diaphragmatic stimulability and a minimum one-year follow-up post-implantation. Across the entire cohort, the long-term follow-up duration reached a median of 60.0 months (interquartile range [IQR]: 36.0-84.0 months; range: 12.0-120.0 months). Out of 30 initial candidates with cervical SCI, 28 patients (22 males, 6 females; median age 24.0 years (interquartile range [IQR]: 15.0-33.0 years)) were included. Patients had been on MV for a median of 13.0 months (IQR: 10.5-16.0 months) prior to the procedure. Utilizing a combined weaning success rate (complete or partial weaning), 26 patients (92.86%; 95% CI: 77.42-98.01%) were successfully transitioned to the pacing protocol, while 2 patients (7.14%) experienced DP failure. Complete (24 h) daily MV independence was achieved by 18 patients (64.29%), and partial weaning (≥4 h/day of MV-free time) was achieved by 8 patients (28.57%). Age at the time of injury ranged from 5 to 62 years. No major intraoperative or postoperative complications occurred. Minor exit-site skin irritation was observed in 3 patients (10.71%), all of which resolved completely with conservative local care alone without requiring antibiotic therapy. In this selected single-center Saudi cohort of ventilator-dependent cervical SCI patients, laparoscopic DP was feasible and was associated with high rates of partial or complete ventilator-free breathing. Larger prospective multicenter studies with standardized selection criteria, safety reporting, respiratory outcomes, quality-of-life measures, and longer follow-up are needed.
Serrano-Cañadillas Carmen C, Jiménez-Lozano Manuel M, Alonso-Escribano María M, Sánchez-Medina Luis L et al.
Serrano-Cañadillas, C, Jiménez-Lozano, M, Alonso-Escribano, M, Sánchez-Medina, L, González-Badillo, JJ, and Rodríguez-Rosell, D. Analysis of the load-velocity relationship in the full squat exercise in female soccer players of different ages. J Strength Cond Res XX(X): 000-000, 2026-The aims of this study were twofold: to compare the load-velocity relationship in the full squat (FS) exercise in young female soccer players, and to examine the effect of chronological age on this relationship. Eighty-five female soccer players from the same club voluntarily participated in this study. Players were recruited from 3 age categories: Senior, Under-18, and Under-16. All subjects had at least 6 months of resistance training experience, including the FS, performed twice per week. The load-velocity relationship was determined using a progressive loading test up to the one-repetition maximum (1RM). Lifting velocity was measured using a linear velocity transducer. For each repetition, 3 velocity variables were obtained during the concentric phase: mean propulsive velocity (MPV), mean velocity (MV), and peak velocity (PV). Significant relationships (p < 0.001) were found between relative load (%1RM) and MPV (R2 = 0.961; SEE = 0.069), MV (R2 = 0.958; SEE = 0.062), and PV (R2 = 0.795; SEE = 0.132). Importantly, no statistically significant between-group differences were observed in MPV, MV, or PV at any relative load across age categories. In addition, mixed-effects polynomial models revealed no consistent effect of age on the overall level of the load-velocity relationship. These findings provide insights for optimizing resistance training load prescription in female soccer players. Based on our results, MPV and MV seem to be more valid than PV and may be preferable for prescribing and monitoring relative load during the FS exercise in female soccer players.
Yu Mei-Ching MC, Chung Tzu-Wei TW, Lin Wei-Cheng WC, Liao Chien-Hung CH
Trimethylamine N-oxide (TMAO) has recently emerged as a clinically relevant biomarker for the early diagnosis and risk stratification of chronic diabetic nephropathy and cardiovascular disease. Here, we report an electric-field-driven pixel array urine biosensor for the assessment of diabetic nephropathy and for elucidating the relationship among urine TMAO, glucose, and urine microalbumin-to-creatinine ratio (UACR). The purified trimethylamine N-oxide reductase (torA) enzyme catalyzes the reduction of TMAO to trimethylamine (TMA) and H2O, during which generated H+ ions modulate the local ionic environment and attenuate the device electric field. The proposed pixel array biosensor, integrated with a dedicated readout circuit, enables quantitative TMAO detection over a broad UACR range, exhibiting a sensitivity of 8.2 mV/(mg/g) over a dynamic range up to 1200 mg/g. In contrast, glucose shows an initial increase at low UACR but becomes highly variable above 30 mg/g, indicating poor correlation with progressive albuminuria due to preserved tubular reabsorption at early stages of glomerular injury. The device further achieves a sensitivity of 2.5 mV/μM, a response time of 10 s, a reproducibility of 98%, and a low long-term offset drift of 0.3 mV. Only 5 μL of urine is required for simultaneous quantification of TMAO and glucose. Overall, the proposed system provides a rapid, sensitive, and user-friendly point-of-care platform for early risk assessment of chronic kidney disease in diabetic populations, enabling improved accessibility for home-based monitoring.
Liu Yuanxin Y, Qi Longbin L, Qin Wei W
The lifetime of polymeric membrane ion-selective microelectrodes is one of the key factors limiting their practical applications. Herein, we report a simple strategy for the fabrication of liquid-contact ion-selective microelectrodes with a long lifetime by increasing the thickness of the polymeric sensing membrane via filling the membrane solution from the back of the micropipette tip. A lead ion-selective microelectrode (Pb2+-ISμE) was used as a model sensor. The geometry of the electrode tip and the amount of membrane solution were optimized. The microelectrode exhibited a Nernstian response slope of 27.4 ± 0.7 mV decade-1 over the concentration range from 1.0 × 10-7 to 1.0 × 10-3 M with a detection limit of 4.2 × 10-8 M. Notably, the response slope of the microelectrode decreased by only 2.2% in 30 days.
Vigil S Avery SA, Yuan Yong Y, Zagalskaya Alexandra A, Calegari Andrade Marcos F MF et al.
Noble metal oxides such as RuO2 are the state-of-the-art electrocatalysts for anodic reactions in acidic electrolytes, but their scarcity and moderate activity greatly limit emerging renewable energy technologies. Here, we show that oxidized overlayers of ruthenium on earth-abundant manganese oxide (MnO2/o-RuOx) nanocrystal supports exhibit Ru chemical states associated with reduced Ru-O-Ru coordination that enable dynamic switching of hydrogen bonding, with *OH intermediates hydrogen bonding to surface O and *OOH intermediates bonding to protruding RuOx clusters. The resulting electrocatalysts exhibit an overpotential of 218.9 ± 0.3 mV at 10 mA cm-2 for the oxygen evolution reaction in acid, corresponding to a 2425% increase in Ru mass activity compared to RuO2, enabling the construction of electrolyzers that achieved 3 A cm-2 at 1.646 V, 5.54 A cm-2 at 1.8 V, and exhibited over 3000-h stability at 100 mA cm-2. These findings motivate further efforts to develop nanomaterials that harness reduced Ru-O-Ru coordination to enable emerging renewable energy technologies.
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