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thiamine-cobaltichlorophyllate (Midoriamin)

✓ Approved

Nisshin Pharma · 小分子 · 小分子

什么是 thiamine-cobaltichlorophyllate？

thiamine-cobaltichlorophyllate 是一种小分子，由Nisshin Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Midoriamin
公司Nisshin Pharma
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Nisshin Pharma

治疗适应症

thiamine-cobaltichlorophyllate 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersDuodenal ulcer✓ Approved
Gastrointestinal disordersGastric ulcer✓ Approved

相关研究文献

PubMedInternational journal of molecular sciences2026-10-27

Cerebral Metabolism Is More Susceptible to Oxythiamine Exposure Compared to Cardiac Metabolism.

Artiukhov Artem V AV, Graf Anastasia V AV, Chistyakov Dmitry V DV, Solovjeva Olga N ON et al.

Thiamine (vitamin B1) deficiency is known to cause predominantly neurological and cardiovascular symptoms due to the metabolic function of its diphosphate derivative as a coenzyme. A variety of natural and synthetic thiamine antimetabolites can simulate this deficiency. Oxythiamine may be spontaneously produced from thiamine itself and is known to accumulate in patients with kidney disorders. In this study, tissue specificity of chronic oxythiamine administration was investigated in male rats, focusing on changes in the physiology and thiamine-dependent enzyme activities of the cerebral cortex and heart. While oxythiamine treatment significantly reduced the pyruvate dehydrogenase activity in both tissues, its cerebral effects also included mild downregulation of another thiamine-dependent enzyme, 2-oxoglutarate dehydrogenase, indicating higher susceptibility of the cerebral metabolism to oxythiamine exposure. The oxythiamine neurological effects were also reflected in the rats' altered anxiety-like behavior and heart rate regulation. Further investigation of the cerebral effects of oxythiamine identified elevated 3-hydroxybutyrate and protein acetylation as indicators of perturbed acetyl-CoA utilization in the TCA cycle. Some heart-specific changes, such as decreased glutathione level, were also observed upon oxythiamine treatment. The present results highlight the consequences of chronic oxythiamine exposure. These finding are potentially relevant for understanding the metabolic changes in the brain and heart upon pathophysiological oxythiamine accumulation.

PMID 42941776
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PubMedRadiology2026-10-27

Case 351: Thalamic Dementia Secondary to Dural Arteriovenous Fistula.

Deen Surrin Shazam SS, Khalili Bobak B, Semalti Kapil K, Chen Michael M et al.

A 76-year-old man with a medical history of diabetes, hypertension, and dilated cardiomyopathy developed new symptoms of confusion, repeated falls, and urinary incontinence over the course of 3-4 months, which worsened over a 2-week period, leading to presentation at the emergency room. His partner reported that before this, he had no memory or movement disorders, but now he was experiencing memory lapses, such as forgetting his mother's recent death, and functional cognitive problems, including an inability to remember how to perform tasks that were previously simple for him, such as dosing his insulin with meals. At presentation, the patient was awake and alert, oriented to his name and location but not to the date. Full neurologic examinations, including of the motor and sensory systems and cranial nerves, were normal. There were no signs of meningism, no fever or leukocytosis, and no history of recent travel. Serum electrolyte panel and thiamine levels were normal, and he had no history of alcohol or drug abuse. Initial evaluation included noncontrast CT of the head, the results of which prompted multiphasic CT angiography of the head including parenchymal phase imaging and admission for observation and monitoring with serial noncontrast CT of the head. The patient's symptoms worsened during his hospital stay. He also developed facial twitching, increased drowsiness, and seizure episodes. He was therefore evaluated with noncontrast MRI of the brain and then digital subtraction angiography with external carotid artery and internal carotid artery contrast agent injections.

PMID 42937534
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PubMedMicroorganisms2026-10-27

Integrated Metagenomic and Metatranscriptomic Analysis Reveals Microbiome Differences Between Bisexual and Parthenogenetic Populations of Haemaphysalis longicornis.

Zhu Wen-Jie WJ, Zhang Yuchao Y, Mu Meiqi M, Pei Tingwei T et al.

The tick Haemaphysalis longicornis is an important vector of human and animal pathogens in East Asia that comprises both bisexual (Bis) and parthenogenetic (Par) populations. While previous studies have documented differences between these reproductive groups in genome ploidy, host transcription, and vector capacity, it remains unclear whether reproductive strategy is accompanied by systematic divergence in the tick-associated microbiome, including microbial community composition, transcriptional activities, and functional outputs. Here, we profiled laboratory-maintained Bis and Par populations using metagenomic (MG) and metatranscriptomic (MT) sequencing to integrate community composition, core taxa, functional potential, and RNA/DNA relative activity (RNA abundance normalized to corresponding DNA abundance). Par populations exhibited higher MG alpha diversity, whereas Bis populations showed higher MT alpha diversity, indicating a decoupling between the microbial DNA reservoir and the active RNA transcript community. MG functional analysis revealed that Par populations possessed a higher potential for environmental sensing, membrane transport, biofilm formation, porphyrin metabolism, and iron acquisition. Conversely, Bis populations exhibited enhanced potential in biotin metabolism, lipoic acid metabolism, and oxidative phosphorylation. MT analysis identified significant differences in a limited number of species and CAZy families, while selected KEGG pathways showed no significant variance, suggesting restricted rather than systemic transcriptional differentiation. By integrating DNA and RNA profiles, we classified 279 shared species into four activity states, revealing higher RNA/DNA relative activity ratios for thiamine metabolism in Par, and for biofilm formation, flagellar assembly, sulfur metabolism, and fatty acid degradation in Bis. Overall, Bis and Par populations exhibit distinct differences in their microbial reservoirs, transcript compositions, and relative transcriptional activities, providing critical microbiome insights into the symbiosis and vector adaptation associated with reproductive strategies in H. longicornis.

PMID 42943582
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PubMedReports (MDPI)2026-10-25

Beyond Ophthalmoplegia: Wernicke Encephalopathy with Anisocoria.

Ito Yoshihiro Y, Hayashi Koji K, Kurihara Haruka H, Nakaya Yuka Y et al.

A 69-year-old man with a history of heavy alcohol consumption and poor nutrition presented with disorientation and gait instability. The cognitive assessment was severely affected, with the Hasegawa Dementia Scale-Revised score was 4. Neurological examination revealed anisocoria (right 4.0 mm, left 2.0 mm) with sluggish light reflexes, gaze-evoked horizontal nystagmus, and vertical gaze restrictions. He exhibited disorientation and limb ataxia; deep tendon reflexes were normal. Brain MRI showed bilateral thalamic hyperintensities on diffusion-weighted imaging and periaqueductal high signal on T2 FLAIR. Laboratory testing confirmed a severely reduced serum thiamine level of 10.5 ng/mL, establishing Wernicke encephalopathy (WE) based on Caine's criteria. Immediately upon admission (Day 1), high-dose thiamine therapy was initiated at 700 mg/day (300 mg/day intravenous drip plus 400 mg/day oral) for 7 days, followed by 400 mg/day oral. Despite prompt, high-dose thiamine administration, the 2.0 mm anisocoria persisted consistently throughout the 19-day hospitalization, whereas cognitive function and ataxia partially improved. The 2.0 mm interocular difference confirmed pathologic anisocoria, indicating asymmetric autonomic disruption involving descending sympathetic pathways in the periaqueductal gray matter. While neuro-ophthalmic signs in WE are typically reversible, this case demonstrates that autonomic deficits may persist despite comprehensive thiamine therapy, highlighting WE as a critical metabolic mimic of life-threatening structural brainstem disorders.

PMID 42924793
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PubMedFood chemistry2026-10-25

Early-warning evaluation of pasteurized milk spoilage during storage and distribution.

Kang Min M, Liu Tong T, Wang Xiujuan X, Suo Ran R et al.

Hidden temperature deviations within the cold chain are a major contributor to global food waste, yet existing quality assurance methods predominantly rely on lagging indicators that fail to capture early-stage spoilage. Here, we integrate high-resolution foodomics with machine learning approaches to identify a biomarker for pasteurized milk freshness: N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamide (AMF). Through structural elucidation and isotope tracing, we revealed that AMF is formed via a specific hydrolytic ring-opening pathway of thiamine. Importantly, perturbation experiments using sterile UHT milk, NaOH, and formic acid further suggested that alkaline microenvironments and spoilage-associated biochemical activity may facilitate this transformation. Validated on datasets from diverse geographic regions and processing methods, we established a quantitative spoilage warning threshold at 1.7 ng/mL, and the early-warning sensitivity allows detection of transient high-temperature exposures as brief as 6 h. This promising molecular indicator enables a shift in milk quality control from retrospective rejection to prospective prevention, acting as an indicator of thermal history and allowing precise, early detection of temperature abuse in complex dairy supply chains.

PMID 42925602
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PubMedOrganic letters2026-10-23

Biocatalytic Synthesis of Substituted Cinnamaldehydes.

Salehi Ahmad Reza AR, Mustafa Farah M FM, Girier Rioual Terry T, Nakhleh Jonathan J et al.

Substituted cinnamaldehydes are valuable compounds, but current syntheses rely on expensive and toxic reagents. We report a biocatalytic synthesis of substituted cinnamaldehydes from the corresponding benzaldehydes via an aldolase, NahE, and benzoylformate decarboxylase. This is the first use of α,β-unsaturated 2-oxo acids as substrates for thiamine diphosphate-dependent 2-oxo acid decarboxylases. We found electron-donating substituents were better tolerated than electron-withdrawing substituents, but all showed good to excellent conversions. A preparative-scale reaction gave 4-methoxycinnamaldehyde in 77% isolated yield.

PMID 42917801
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