若生智能
Drug Database
TH

thiamine-cobaltichlorophyllate (Midoriamin)

✓ Approved

Nisshin Pharma · 小分子 · 小分子

什么是 thiamine-cobaltichlorophyllate？

thiamine-cobaltichlorophyllate 是一种小分子，由Nisshin Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Midoriamin
公司Nisshin Pharma
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Nisshin Pharma

治疗适应症

thiamine-cobaltichlorophyllate 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersDuodenal ulcer✓ Approved
Gastrointestinal disordersGastric ulcer✓ Approved

相关研究文献

PubMedZhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi2026-07-27

[Trends in dietary structure and patterns in urban and rural residents in Guangdong Province, 2002-2022].

Zhang S J SJ, Hong X M XM, Fang Y T YT, Meng X X et al.

Objective: To analyze the patterns of dietary structure and nutritional status of urban and rural residents in Guangdong Province from 2002 to 2022, and provide evidence for the development of targeted nutritional intervention strategies. Methods: Data from three rounds of Guangdong Provincial Residents' Nutrition and Health Survey (2002, 2009-2012, and 2022) collected from multistage cluster random sampling were used. Dietary surveys were conducted by using 3-day 24-hour recall method combined with household seasoning weighing. After sampling and post-stratification weighting, the trends in food consumption, nutrient intake, and macronutrient energy contribution ratios were analyzed. Results: The study included 7 726, 5 073, and 4 073 participants in 2002, 2009-2012, and 2022, respectively. Compared with 2002, the average daily intakes of vegetables, animal-based foods, and dairy products increased by 39.8 g, 96.4 g, and 21.6 g, respectively in 2022. The daily average grains intake decreased by 93.2 g, and the fruits intake also showed a downward trend (all P<0.001). The daily standardized protein and fat intakes significantly increased from 79.6 g to 83.0 g and from 82.1 g to 98.4 g respectively. The dietary structure had a marked change: the fat energy contribution increased from 32.1% to 44.2%, animal source protein accounted for 73.7% of protein intake, and animal fat provided 55.7% of total energy. The intakes of calcium, thiamine and riboflavin remained at relatively low levels. Conclusions: From 2002 to 2022, the dietary structure of residents in Guangdong had a profound change from traditional pattern to "high-fat, high-protein, low-carbohydrate" pattern, highlighting the typical dietary transformation characteristics in area with rapid economy development. Despite adequate energy and protein intakes, severe macronutrient imbalances coexist with insufficient calcium and B-vitamin intakes, presenting new challenges for chronic disease prevention and control.

PMID 42503959
阅读全文 →
PubMedFood science & nutrition2026-07-26

Effect of Chitooligosaccharides-Combination Fortified Noodles Intervention on Visceral Adiposity and Serum Metabolites in a High-Risk Occupational Cohort of Young Seafarers.

Bian Zhongbo Z, Wang Jiaming J, Lu Yi Y, Yao YanYing Y et al.

Offshore seafarers face a unique "metabolically obesogenic" environment, predisposing them to an elevated risk of central obesity and metabolic disorders, even at a young age, creating a critical need for feasible, on-board nutritional interventions. This study aimed to evaluate the effects of Chitooligosaccharides-combination fortified noodles on body composition in young male seafarers and to elucidate the underlying systemic metabolic mechanisms. A self-controlled trial was conducted with 73 participants, who underwent a 4-week placebo phase followed, after a washout, by a 4-week intervention phase consuming functional noodles every other day. Clinical assessments included body weight, waist circumference, body composition indices, and serum lipid profiles, and untargeted metabolomics was performed on a subset of 38 participants. Compared with the placebo phase, oligosaccharide intervention significantly reduced waist circumference (WC), visceral fat area (VFA), serum leptin and LDL-cholesterol (LDL-C) levels, and increased skeletal muscle mass index, with no significant change in body weight. Linear mixed models confirmed significant net reductions in VFA (β = -18.36 cm2, 95% CI: -31.56 to -5.16; p < 0.05), WC (β = -7.51 cm, 95% CI: -10.78 to -4.23; p < 0.001), and LDL-C (β = -0.33 mmol/L, 95% CI: -0.55 to -0.11; p < 0.005) following the intervention. Untargeted metabolomics revealed profound perturbations in the serum metabolome, with glycerophospholipid and thiamine metabolism identified as the most significantly dysregulated pathways. Key metabolites in these pathways exhibited marked alterations: phosphatidylethanolamine PE(18:3/12:0) and thiamine triphosphate (ThTP) were upregulated, while lysophosphatidylserine LysoPS(19:0/0:0) was downregulated. These metabolic changes were strongly associated with clinical improvements, with elevations in PE(18:3/12:0) and ThTP being inversely correlated with reductions in VFA, WC, and LDL-C, and the decrease in LysoPS(19:0/0:0) positively correlated with these same clinical changes. Subgroup analysis indicated that seafarers with elevated central adiposity at baseline had a deficient metabolic state with lower levels of PE(18:3/12:0) and ThTP, and these participants derived greater corrective benefits in these metabolites and VFA reduction from the intervention; notably, baseline LysoPS(19:0/0:0) levels were comparable between subgroups, but its downregulation in response to the intervention was more pronounced in non-centrally obese individuals. A four-week dietary intervention with Chitooligosaccharides-combination fortified noodles effectively reduced visceral adiposity and improved body composition in young seafarers, with benefits associated with targeted remodeling of glycerophospholipid and thiamine metabolism. The greater corrective response in individuals with pre-existing central obesity highlights the potential of this strategy for precision nutrition in high-risk occupational groups.

PMID 42502802
阅读全文 →
PubMedEuropean journal of internal medicine2026-07-26

Alcohol withdrawal syndrome in hospitalized patients: a practical review.

Caputo Fabio F, Lungaro Lisa L, Costanzini Anna A, De Giorgio Roberto R et al.

Alcohol withdrawal syndrome (AWS) develops in patients with alcohol use disorder (AUD) and physical dependence after abrupt cessation or substantial reduction of sustained heavy alcohol use. It is common and potentially life-threatening in general medical practice. Characteristic features include tremor, autonomic activation, anxiety, insomnia, perceptual disturbances, seizures, and delirium tremens. This practical review aims to guide internists in early recognition, risk stratification, monitoring, pharmacological treatment, and transition to longitudinal AUD care. Most hospitalized patients can be managed effectively when physicians identify early high-risk features, select an appropriate level of monitoring, and use approved first-line therapy. Supportive care, including thiamine, hydration, electrolyte correction, and reassessment for differential diagnoses, is essential. Benzodiazepines remain the standard of care for moderate to severe withdrawal, but decisions should reflect withdrawal history, current severity, comorbidity, and symptom-scale limitations in medically complex patients. Benzodiazepine-based protocols include symptom-triggered therapy, fixed-dose therapy, and front loading; choosing among them should depend on the patient's risk profile, ability to participate in symptom scoring, and monitoring environment. Phenobarbital is increasingly used within standardized, closely monitored hospital protocols with appropriate expertise, whereas clomethiazole and sodium oxybate remain region-specific alternatives in some European countries. This review also emphasizes delirium tremens and refractory withdrawal, including when higher-acuity care and adjunctive sedatives should be considered. Hospitalization should be used to initiate treatment for AUD and reduce recurrent withdrawal, readmission, and mortality.

PMID 42502044
阅读全文 →
PubMedCase reports in neurology2026-07-25

Korsakoff Syndrome in a Late Adolescent with Wernicke Encephalopathy: A Case Report.

Bourcier Dax D, Holland Joanna J, Veysey Andrew A, Khan Naeem N et al.

Wernicke encephalopathy (WE) is a neurological emergency characterized by acute encephalopathy, oculomotor dysfunction, and ataxia, and may progress to Korsakoff syndrome - a disorder characterized by irreversible global episodic amnesia. Although classically linked to alcohol misuse, WE also arises in medical and psychiatric conditions associated with nutritional deficiency. We report an 18-year-old male with schizophrenia, non-adherent to antipsychotic treatment, who was admitted with disorganization, catatonia, and dehydration. After several days of minimal nutrition (including dextrose-containing fluids), oral lorazepam, and intramuscular olanzapine, he developed acute WE with worsening catatonia. Intravenous thiamine and continued lorazepam rapidly improved his level of consciousness. Laboratory testing revealed undetectable thiamine, and MRI findings were consistent with WE. Despite oral multivitamin supplementation, catatonia improved only after escalation to intravenous lorazepam and electroconvulsive therapy. As catatonia improved, symptomatology of schizophrenia emerged and improved significantly with paliperidone therapy. As schizophrenia symptoms improved, complete anterograde and partial retrograde amnesia, apathy, and anosognosia emerged, consistent with Korsakoff syndrome. He continued to meet diagnostic criteria at 3-year follow-up. This complex case demonstrates the importance of maintaining a suspicion of thiamine deficiency in patients with a history of nutritional depletion of greater or equal to 2 weeks. Prompt initiation and continuation of thiamine therapy while investigating and treating concurrent diagnoses can reduce the risk of WE and Korsakoff syndrome.

PMID 42499986
阅读全文 →
PubMedFrontiers in pharmacology2026-07-24

Protection against cisplatin-induced acute kidney injury by hellgrammite extract: insights from comprehensive metabolomics.

Lin Kexin K, Lu Guangling G, Liu Rui R, He Yanmei Y et al.

Cisplatin (CP), a highly potent antineoplastic agent, is severely limited in clinical use by dose-limiting toxicities, particularly acute kidney injury (AKI). The hellgrammite (Hel), a kind of rare edible and medicinal insect, is known in Traditional Chinese Medicine (TCM) for its ability to tonify the qi and kidneys. However, its potential to ameliorate CP-induced AKI remains unexplored. We first evaluated the nutritional profile of Hel using high-performance liquid chromatography (HPLC) for amino acid composition analysis. Subsequently, a mouse model of CP-induced AKI was treated with different doses of Hel by gavage, then traditional pharmacology, and metabolomics were used to elucidate the effects and mechanism of Hel on CP-induced AKI mice. Hel effectively ameliorated CP-induced alterations in biochemical indicators and alleviated kidney pathological changes. Hel administration rectified the kidney metabolic disturbances induced by CP, involving alterations in 38 differential metabolites associated with glycerophospholipid metabolism, purine metabolism, nicotinate and nicotinamide metabolism, and thiamine metabolism. Hel confers renoprotection by reversing metabolic disorders in CP-induced AKI, revealing actionable targets for AKI intervention.

PMID 42494521
阅读全文 →
PubMedChronic diseases and translational medicine2026-07-24

Plasma Exosome Metabolomics Reveal Stage-Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome.

Qian Mengtao M, Nie Dan D, Gao Qianyi Q, Mo Xingbo X et al.

Metabolic syndrome (MetS) is a chronic disorder that poses a major threat to global health. Exosomes have emerged as promising biomarkers for diagnosing and monitoring chronic diseases. However, stage-specific alterations in the exosomal metabolome during MetS development remain poorly understood. This study aimed to characterize the plasma exosomal metabolome and explore candidate exosomal biomarkers in individuals with MetS. This study included 20 patients with MetS, 23 individuals with pre-MetS, and 45 healthy controls. Plasma exosomes were isolated and analyzed using untargeted liquid chromatography-mass spectrometry-based metabolomics. Differential metabolites were defined by a dual-threshold, that is, p < 0.05 from t-test and variable importance in projection > 1 from partial least squares discriminant analysis, with fold change indicating their expression changes. Further, we employed machine learning algorithms to predict MetS status. We identified 27 differential metabolites between the pre-MetS and control groups, mainly enriched in histidine metabolism and the tricarboxylic acid cycle. Of these, 12 metabolites were upregulated, and 15 were downregulated, with 1-methylhistidine and isocitrate playing central regulatory roles. Comparison between the MetS and control groups revealed 45 differentially expressed metabolites, mainly enriched in thiamine metabolism, including 13 upregulated and 32 downregulated. In the pre-MetS group, cladribine showed the highest area under the curve (AUC) (0.743, p < 0.05), whereas 3-methylxanthine yielded the largest AUC (0.714, p < 0.05) in the MetS group. Our study characterized stage-dependent alterations in the plasma exosome-derived metabolome in MetS and suggests that exosomal metabolomics may provide complementary molecular information on early MetS metabolic perturbations.

PMID 42494944
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多thiamine-cobaltichlorophyllate