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testosterone enanthate (Vibex QS T / QS T / Xyosted)

✓ Approved

Antares Pharma, Inc. · AR · 类固醇

什么是 testosterone enanthate？

testosterone enanthate 是一种类固醇，由Antares Pharma, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Vibex QS T, QS T, Xyosted
公司Antares Pharma, Inc.
药物类别类固醇, 小分子
分子靶点AR
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Antares Pharma, Inc.

作用机制

分子靶点

testosterone enanthate 作用于 1 个分子靶点：

ARandrogen receptor (DHTR, AR8)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

testosterone enanthate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersHypogonadism✓ Approved

相关研究文献

PubMedCurrent issues in molecular biology2026-10-27

Testosterone Impairs Endometrial Receptivity Markers and Trophoblast Spheroid Attachment In Vitro: Reversal by Flutamide in a Model of Polyendocrine Metabolic Ovarian Syndrome.

Harper Claire V CV, Reeves Beth J BJ, Elliott Chloe S CS, Sidat Raabiah R et al.

Polyendocrine metabolic ovarian syndrome (PMOS; previously termed polycystic ovary syndrome, PCOS) is a multi-faceted reproductive and endocrinological condition that affects approximately 10% of women of reproductive age. It is typically characterised by chronic anovulation and elevated levels of the androgen testosterone, which have been linked to reduced implantation rates and fertility outcomes. In this study, we investigated whether increased testosterone treatment affected attachment of trophoblast spheroids to an endometrial cell monolayer and the expression of genes known to be involved in the attachment process. Attachment of BeWo spheroids to Ishikawa endometrial cells was significantly reduced when Ishikawa cells were pre-treated for 24 h with pathological and suprapathological doses of testosterone compared to the results for the untreated control, with no significant effect measured following treatment with a physiological testosterone dose (1 nM). Expression of the transcription factor gene HOXA10; integrin β3 (a component of the αVβ3 molecule) and SPP1 (the gene expressing the ligand osteopontin), were significantly decreased in Ishikawa cells following treatment with 10 nM testosterone, along with αVβ3 protein. Treatment with the nonsteroidal antiandrogen flutamide (1 µM) rescued the testosterone-induced decrease in BeWo spheroid-endometrial cell attachment and associated decreases in gene expression. These results suggest that increased levels of testosterone decrease endometrial receptivity and downstream embryo attachment through negatively affecting the expression of genes required for the success of these processes. This testosterone-induced decrease can be reversed in vitro with flutamide treatment. These results highlight the importance of considering endometrial receptivity in the treatment of PMOS-induced infertility.

PMID 42939628
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PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Codeine and Testosterone Concentration Patterns During Co-Administration of Codeine and Testosterone Undecanoate in Male Wistar Rats.

Ünalmış Murat M, Karakükçü Çiğdem Ç, Yerer Mükerrem Betül MB, Saraçoğlu Hatice Duman HD

Background: Three widely separated sampling days cannot establish conventional pharmacokinetic parameters. We therefore examined exploratory whole-blood codeine and plasma total-testosterone concentration patterns during co-administration of codeine and testosterone undecanoate in male Wistar rats. Methods: Thirty-two rats were allocated to saline (S), codeine (C), testosterone undecanoate (T), or combined codeine plus testosterone undecanoate (CT) groups (eight animals per group). Codeine (10 mg/kg by oral gavage) was administered once daily from Day 0 through Day 5 (six total doses) and testosterone undecanoate (100 mg/kg intramuscularly) on Day 3. On Day 0, whole blood was collected two hours after codeine administration; therefore, Day 0 was a post-dose sampling point rather than a pre-dose baseline. No codeine was administered on Day 6; the Day 6 sample was collected after completion of the six-dose treatment schedule. Codeine dose volumes were adjusted according to each rat's baseline body weight. Measurements unavailable because of insufficient sample volume were treated as missing without imputation. Codeine was quantified only in C and CT; the corresponding model therefore estimated the association of adding testosterone undecanoate among codeine-treated animals rather than a full factorial drug-drug interaction. Results: All 14 available Day 0 samples had instrument-reported whole-blood codeine concentrations (range, 0.339-4.705 ng/mL), consistent with their post-dose status. The C-versus-CT group-by-day test using all instrument-reported values yielded Wald chi-square = 8.487 (df = 2, p = 0.014). With the verified LOQ of 0.25 ng/mL, only CT7 Day 14 (0.08 ng/mL) was below the LOQ while remaining above the LOD of 0.07 ng/mL; excluding this observation yielded Wald chi-square = 7.856 (df = 2, p = 0.020). Plasma testosterone availability varied by group and day (n = 3-8); the raw-scale group-by-day test was p = 0.0076, whereas the log-scale sensitivity test was p = 0.052. Conclusions: The observed numerical patterns are exploratory. Sparse sampling, one below-LOQ codeine value, an influential CT7 observation, unequal plasma-testosterone availability, and sensitivity to analytical and modeling choices prevent causal, pharmacokinetic, metabolic, endocrine-mechanistic, or clinical conclusions.

PMID 42943350
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PubMedInternational journal of molecular sciences2026-10-27

The Impact of Vitamin E Intake on Cardiometabolic Outcomes of Testosterone Replacement Therapy in Men with Late-Onset Hypogonadism.

Krysiak Robert R, Szkróbka Witold W, Kowalcze Karolina K, Machnik Grzegorz G et al.

Androgen deficiency is associated with an increased risk of cardiometabolic complications, whereas vitamin E may exert protective effects against cardiovascular and metabolic diseases. This pilot prospective cohort study examined whether cardiometabolic outcomes observed during exogenous testosterone therapy differed according to vitamin E intake in men with insufficient endogenous testosterone production. Three cohorts of men with late-onset hypogonadism (LOH) (n = 29 per group), matched for age, smoking status, body mass index, and baseline testosterone concentration, were classified according to vitamin E intake as low, adequate, or high; 29 men without LOH served as controls. Men with LOH received intramuscular testosterone injections every three weeks for six months. Cardiometabolic parameters were assessed before and after treatment, including biochemical markers, carotid intima-media thickness, retinal vascular sclerotic changes, and estimated 10-year cardiovascular risk. Compared with controls, men with LOH had higher HOMA-IR, LDL cholesterol, uric acid, fibrinogen, homocysteine, high-sensitivity C-reactive protein (hsCRP), urinary albumin-to-creatinine ratio (UACR), carotid intima-media thickness, and estimated 10-year cardiovascular risk. Elevations in homocysteine, hsCRP, and UACR were more pronounced in men with low or high vitamin E intake than in those with adequate intake. Testosterone levels increased during treatment in all groups. Improvements were observed in most cardiometabolic parameters in men with adequate vitamin E intake, whereas changes were limited to HOMA-IR in those with low intake. In men with high intake, no significant changes were observed except for a decrease in HDL cholesterol. At study completion, carotid intima-media thickness and retinal vascular sclerotic changes in men with adequate vitamin E intake did not differ significantly from those in controls. Changes in assessed risk factors correlated with increases in testosterone levels and mean daily vitamin E intake. These findings suggest an association between vitamin E intake and cardiometabolic outcomes observed during testosterone therapy in men with testosterone deficiency.

PMID 42941730
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PubMedVeterinary sciences2026-10-27

Clinical Diagnostic Assessment of Serum Testosterone in Intact and Castrated Tomcats.

Tekin Koray K, Pereira Maria M, Pimazzoni Laura L, Bonsembiante Federico F et al.

Basal serum testosterone may help determine reproductive status in tomcats with an uncertain surgical history, but interpretation of a single result is limited by episodic secretion and reduced analytical precision at very low concentrations. We evaluated the analytical performance and diagnostic accuracy of an automated fluorescence enzyme immunoassay (FEIA) in 80 male cats (40 intact and 40 castrated). Within-run and between-day precision and dilutional recovery were assessed using pooled feline serum, and diagnostic performance was evaluated by receiver operating characteristic analysis. Testosterone concentrations were significantly higher in intact than castrated cats (p < 0.001), although overlap occurred at low concentrations. ROC analysis yielded an AUC of 0.773 (95% CI, 0.665-0.859). The Youden-derived threshold > 0.124 ng/mL had 60.0% sensitivity (95% CI, 43.3-75.1%) and 90.0% specificity (95% CI, 76.3-97.2%). No castrated cat had a concentration > 0.271 ng/mL; this cohort-specific rule-in threshold had 47.5% sensitivity (95% CI, 31.5-63.9%) and 100% observed specificity (95% CI, 91.2-100.0%). Therefore, clearly elevated basal testosterone can support the presence of functional testicular tissue, but concentrations ≤ 0.271 ng/mL cannot exclude intact status. Low or equivocal results require integration with clinical examination and, when indicated, GnRH stimulation and/or anti-Müllerian hormone measurement. Independent validation is required before broad clinical application.

PMID 42944175
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PubMedReproduction (Cambridge, England)2026-10-27

Long-term sildenafil attenuates age-associated functional and reproductive decline in male rats.

Sokanovic Srdjan S, Keselj Isidora I, Medar Marija M, Baburski Aleksandar A et al.

Aging in males is accompanied by a progressive decline in physical activity, androgen status, and reproductive function. We investigated whether long-term treatment with the phosphodiesterase type 5 inhibitor sildenafil attenuates these changes and is accompanied by remodeling of mitochondrial homeostasis in the testis. Male rats were treated with low-dose sildenafil from 12 to 18 months of age, with age-matched untreated rats serving as controls and young adult rats providing a reference for the age-associated phenotype. Aging markedly reduced voluntary locomotor activity, circulating testosterone, and sperm production, while increasing circulating corticosterone. Long-term sildenafil treatment increased locomotor activity, testosterone, and sperm number, while corticosterone tended to decrease. Sildenafil-associated body weight changes were observed in animals with access to voluntary running. Treatment was also accompanied by pronounced changes in mitochondrial homeostasis-related gene expression in Leydig cells and spermatozoa. These transcriptional responses differed between cell types, particularly for genes regulating mitochondrial dynamics and quality control. Expression of mitochondrial homeostasis-related genes was more closely associated with circulating testosterone than with corticosterone and showed distinct testosterone-associated patterns in Leydig cells and spermatozoa. Recovery toward young levels differed among parameters, being more pronounced for reproductive and endocrine measures than for locomotor activity. These findings indicate that long-term low-dose sildenafil attenuates age-associated functional and reproductive decline and promotes a partial shift toward a younger male phenotype, accompanied by cell-specific mitochondrial transcriptional remodeling.

PMID 42937178
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PubMedPlants (Basel, Switzerland)2026-10-27

Effects of Lindera aggregata Linderae Radix on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats.

Kang Sehwang S, An Sueyoung S, Yoo Mi-Hyang MH, Gao Enmei E et al.

Linderae Radix, the root of Lindera aggregata, has shown beneficial effects on bladder function in experimental studies, but whether it can attenuate benign prostatic hyperplasia (BPH) remains unknown. This study evaluated an ethanol extract of L. aggregata roots (LAE) in a testosterone propionate (TP)-induced rat model of prostatic hyperplasia. Castrated male Sprague-Dawley rats received TP (3 mg/kg/day, subcutaneously) and LAE (200 mg/kg/day) or finasteride (1 mg/kg/day) orally for 14 days. LAE significantly reduced total and ventral prostate weights and indices, together with ventral prostate histological scores and epithelial thickness. The serum dihydrotestosterone/testosterone ratio was significantly lower in the LAE group than in the control group. In the ventral prostate, aromatase protein expression was significantly reduced by LAE treatment. Significant changes in apoptosis-related proteins included increased Bax and cleaved caspase-3 levels, decreased procaspase-9 levels, and higher cleaved/procaspase ratios of both caspases. These findings demonstrate that LAE attenuated TP-induced prostatic hyperplasia in rats. The accompanying hormonal and protein expression changes provide a basis for further mechanistic investigation. Further evaluation of LAE as a potential therapeutic option for BPH is warranted.

PMID 42943155
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