北京若生智能科技有限公司
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AD-201 (AD 201 / AD201)

✓ Approved

Addpharma · 小分子 · 小分子

什么是 AD-201？

AD-201 是一种小分子，由Addpharma研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名AD 201, AD201
公司Addpharma
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Addpharma

治疗适应症

AD-201 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersHypertension✓ Approved
Metabolism and nutrition disordersHyperlipidaemia✓ Approved

相关研究文献

PubMedInternational journal of molecular sciences2026-10-27

HDL Functionality, Cholesterol-Related Biomarkers and Incidence of Dementia: A Case-Cohort Study in Older Adults at High Cardiovascular Risk.

Malcampo Mireia M, Hernáez Álvaro Á, Hernando-Redondo Javier J, Ros Emilio E et al.

Associations of lipid profiles, including qualitative and functional high-density lipoprotein (HDL) traits, and cholesterol-related biomarkers with incident dementia and Alzheimer's disease (AD), remain unclear. In this regard, older adults at high cardiovascular risk are at particularly high risk of developing dementia. The aim is to evaluate whether these biomarkers are associated with the incidence of dementia and AD in older adults at high cardiovascular (CV) risk. In a case-cohort study, we selected 106 incident dementia cases (82 AD) and a random subcohort of 201 non-cases. We quantified (baseline and at one-year), lipid profile; HDL-mediate cholesterol efflux capacity in a model of human neurons; HDL-mediated anti-inflammatory protection in a model of brain endothelial cells; 24S-hydroxycholesterol and apolipoprotein E. Multivariable-adjusted Cox models were addressed. HDL cholesterol was inversely associated, whereas triglycerides directly associated, with dementia and AD incidence. Higher HDL-mediated cholesterol efflux was inversely associated with dementia (HR 0.64, 95% confidence interval (CI) 0.45-0.91) and AD (HR 0.52, 0.35-0.76). Greater HDL-mediated endothelial protection was associated with lower dementia and AD incidence (HR 0.68, 95% CI 0.47 to 0.99 and HR 0.61, 95% CI 0.41 to 0.91, respectively). A one-year increase in 24S-hydroxycholesterol was associated with a higher incidence of any dementia (HR 2.38, 1.33-4.27) and AD (HR 2.24, 1.11-4.53). Enhanced HDL functional properties ex vivo, in preclinical models using human brain cells, together with lower levels of 24S-hydroxycholesterol, are inversely associated with the incidence of dementia and AD, highlighting these factors as promising prognostic targets in older adults at high CV risk.

PMID 42941970
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PubMedDiagnostics (Basel, Switzerland)2026-10-27

Agreement Between Venous and Capillary Haemoglobin Concentrations in a High-Burden Urban Indian Setting: A Cross-Sectional Analysis.

Sharma Nandini N, Basu Saurav S, Singh Mongjam Meghachandra MM, Zode Mrunali M et al.

Background: Anaemia is a major public health issue in India, where point-of-care testing is central to national control strategies. This study evaluated the diagnostic accuracy of the HemoCue® Hb 201+ for haemoglobin (Hb) estimation from capillary blood compared to the gold-standard venous blood analysis. Methods: In a cross-sectional study of 748 participants in a low-resource urban Delhi setting, Hb levels from single-drop capillary samples (HemoCue® Hb 201+) were compared to those from venous samples (automated autoanalyzer). Agreement was assessed using Bland-Altman analysis, Passing-Bablok regression, and standard diagnostic accuracy metrics. Results: The mean (SD) haemoglobin concentration was lower in capillary samples (11.83 [1.95] g/dL) than in venous samples (12.56 [1.89] g/dL). Capillary Hb was, on average, 0.73 g/dL lower than venous Hb (95% limits of agreement: -3.11 to 1.65 g/dL). Consequently, the HemoCue® Hb 201+ significantly overestimated anaemia prevalence (54.4% vs. 35.0%). The capillary method demonstrated high sensitivity (92.4%) for detecting anaemia but only moderate specificity (66.1%), indicating a tendency for false positives. Conclusions: Although the HemoCue® Hb 201+ is a sensitive tool for anaemia screening in field settings, the moderate specificity and the significant negative bias can lead to overestimation of prevalence and potential misclassification of individuals. However, the limitation of single-drop capillary sampling warrant cautious interpretation of results, particularly for clinical decision-making and precise prevalence estimation.

PMID 42938258
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PubMedCurrent issues in molecular biology2026-10-27

Integrative Single-Cell Transcriptomic Analysis Identifies Candidate Endothelial Activation Signatures in Atopic Dermatitis.

Cao Fang F, Zhang Hui H, Guo Cui C, Guo Jing J

Background: Endothelial activation is a recognized histological feature of atopic dermatitis (AD), but its transcriptional programs remain incompletely characterized. Methods: We reanalyzed public single-cell RNA-seq data from the skin of five patients with AD and four healthy donors using AD-associated gene set scoring, CellChat, endothelial hdWGCNA and pseudotime ordering, and examined candidate genes with eight machine learning classifiers and SHAP in public bulk transcriptomes of lesional and non-lesional AD skin. Results: Inferred intercellular interactions were more numerous in AD (1348 vs. 1111), with COLLAGEN, CD99 and MIF showing the largest gains in communication strength. Differences in AD-associated gene set scores between AD and healthy endothelial cells were small and inconsistent between scoring approaches. Among seven endothelial modules, Endo7, an NF-κB-responsive immediate-early module containing SELE, ICAM1, IRF1 and NFKBIA, overlapped most strongly with the AD gene set (10 genes; approximately 30-fold enrichment). AD endothelial cells were concentrated at intermediate pseudotime positions (Cohen's d = 0.334). In bulk skin, classifiers based on 14 LASSO-selected genes separated lesional from non-lesional AD skin in a small test set (AUC 0.70-0.98; likely optimistic estimates, as feature selection preceded the training-test split and paired samples from the same patients may span both partitions), with SELE, TOP2A and IRF1 ranked highest by SHAP. Conclusions: This hypothesis-generating analysis identifies AD-associated endothelial activation signatures and candidate genes that require confirmation in independent, clinically characterized cohorts and experimental studies.

PMID 42939577
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PubMedBiomolecules2026-10-27

Integrated Multi-Omics Analysis Reveals ACO2 as an Oxidative-Stress-Related Biomarker in Alzheimer's Disease.

Dou Wenbo W, Chen Xue X, Hong Hang H, Liu Qiong Q et al.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment. Oxidative stress plays an important role in disease progression in AD. However, the molecular mechanisms underlying oxidative stress in AD remain unclear and reliable biomarkers for its detection have not been identified. In this study, bioinformatics analyses integrating differential expression analysis and weighted gene co-expression network analysis were performed to identify oxidative-stress-related differentially expressed genes. Using machine learning algorithms, ACO2 was identified as a significantly downregulated hub gene associated with AD. Single-cell transcriptomic analysis further showed markedly reduced ACO2 expression levels in hippocampal neurons of patients with AD. To validate these findings, proteomic analysis, quantitative real-time polymerase chain reaction (qPCR), and Western blotting were performed in a mouse model of AD. These results confirmed decreased ACO2 mRNA and protein expression levels in the hippocampus. Consistently, qPCR analysis of peripheral blood samples from patients with AD revealed significantly reduced ACO2 expression levels compared to those in healthy controls. Collectively, these findings identified ACO2 as an oxidative-stress-related biomarker associated with AD and suggested its potential value as an AD-related candidate biomarker.

PMID 42939687
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PubMedGenes2026-10-27

Multi-Cohort Transcriptomic Integration Identifies Overlapping Immune and Antigen-Presentation Features in Alzheimer's Disease and Hashimoto's Thyroiditis.

Zhong Shuting S, Xie Guanfeng G, Zhang Zhaohui Z

Thyroid disorders and Alzheimer's disease (AD) have been linked epidemiologically, but whether AD brain tissue and thyroid tissue affected by Hashimoto's thyroiditis (HT) share molecular features remains unclear. Differential expression was estimated in AD (GSE122063) and HT (GSE138198) discovery cohorts using limma, with donor-level blocking and adjustment for age, sex and post-mortem interval where available. Shared genes were tested against chance within the genes measured in both cohorts, separately for each direction of change; characterized by enrichment analysis; related to marker-based cell-state scores; and evaluated in two AD cohorts, three thyroid cohorts including one with concurrently collected normal thyroid (GSE165724), and a single-nucleus AD dataset (GSE138852). The discovery analyses identified 3593 AD- and 3806 HT-associated genes. The overlap was direction-specific: genes upregulated in both diseases exceeded chance (117 vs. 83.2 expected; p = 8.9 × 10-5), whereas the other direction combinations did not. Co-upregulated genes were enriched for MHC class II antigen presentation (FDR = 0.004), complement (FDR = 0.002), microglial activation (FDR = 0.017) and T-cell activation (FDR = 1.7 × 10-4), and recurred in two independent thyroid datasets and the within-study LT+ versus LT- comparison, with less consistent, region-dependent recurrence in AD cohorts. This shared component tracked immune cell-state signals-glial/myeloid activation in AD and lymphocytic infiltration in HT. Fourteen co-upregulated genes, including ITGAX, CD22 and BST2, met prespecified recurrence and detectability criteria. AD brain tissue and thyroid tissue affected by HT exhibit a co-upregulated immune and antigen-presentation transcriptional program that reflects immune activation in both tissues. These overlapping features are associative and do not establish a causal relationship between AD and HT.

PMID 42938377
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PubMedBiomolecules2026-10-27

Deubiquitinating Enzymes in Alzheimer's Disease: From Protein Homeostasis to Diverse Pathological Processes.

Shi Xueying X, Chen Guilin G, Wang Xiufeng X, Ma Rong R et al.

Alzheimer's disease (AD) is a neurodegenerative disorder involving multiple pathological processes, including amyloid-β (Aβ) accumulation, tau pathology, impaired autophagy, mitochondrial dysfunction, neuroinflammation, and synaptic dysfunction. Deubiquitinating enzymes (DUBs) reverse ubiquitination and regulate protein stability, degradation, and cellular signaling. Although studies of DUBs in AD have largely focused on Aβ metabolism and tau homeostasis, accumulating evidence implicates DUBs in a broader range of AD-related processes, including autophagy, neuroinflammation, mitochondrial function, and synaptic function. Several DUBs have also been implicated in more than one of these processes, although these effects have often been identified in different experimental models. In this review, we summarize current knowledge of DUBs in major AD-related pathological processes and discuss the mechanisms through which individual DUBs may influence different aspects of AD pathology. We also discuss the limitations of current studies and the potential and challenges of targeting DUBs in AD.

PMID 42939748
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