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doxycycline hyclate (Targadox)

✓ Approved

Fortress Biotech, Inc. · 小分子 · 小分子

什么是 doxycycline hyclate？

doxycycline hyclate 是一种小分子，由Fortress Biotech, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Targadox
公司Fortress Biotech, Inc.
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Fortress Biotech, Inc.

治疗适应症

doxycycline hyclate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersAcne✓ Approved

相关研究文献

PubMedJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2026-07-27

Effect and length of doxycycline administration in elderly patients with bullous pemphigoid.

Merkel-Ropele Alena A, Salmhofer Wolfgang W, Wolf Peter P

Bullous pemphigoid (BP) is the most common autoimmune blistering disease and primarily affects the elderly. Systemic corticosteroids and immunosuppressive drugs are the standard treatment, but side effects often restrict their use. Doxycycline has been proposed as an alternative, but there is limited long-term, real-world data on its efficacy and tolerability. We aimed to evaluate the effectiveness and length of doxycycline treatment in BP patients. This retrospective, single-center study analyzed data from patients with a confirmed BP diagnosis treated with doxycycline. The comprehensive dataset included information on disease severity, concomitant therapies, and treatment response. Treatment duration was analyzed using the Kaplan-Meier method. The cohort comprised 102 patients with a mean age of 79 (range 51-95) years. A clinical response (an improvement of 1 or 2 on the PGA score, which ranges from 2 to -2) was observed in 85 patients (83.3 %), many of whom received combination therapy with other drugs (67.7 %). The median length of doxycycline treatment was 122.7 weeks. Adverse events, mainly of gastrointestinal origin, were rare, non-serious and manageable. Doxycycline proved to be an effective and well-tolerated long-term treatment for elderly patients with BP, when used either as monotherapy or in combination.

PMID 42504029
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PubMedJournal of interpersonal violence2026-07-27

Coping With Gender-Based Violence Across the Migration Journey: Strategies of Urban Refugee Women in Nairobi, Kenya.

Obara Lena Moraa LM, Winter Samantha C SC, John Rachel R, Shin Gi Un GU et al.

This study examines the coping strategies used by refugee women who have survived gender-based violence (GBV) across multiple stages of migration. Drawing on interviews with 50 urban refugee women in Nairobi, Kenya, the study explores how coping processes shift or remain consistent throughout the migration trajectory using the migration process framework. Although GBV is widespread among forcibly displaced women globally, limited research has investigated how survivors appraise and manage the stress of these experiences over time and within changing displacement contexts. Guided by Lazarus and Folkman's transactional theory of stress and coping, the analysis identifies a wide range of strategies. Emotion-focused approaches include caring for children, acceptance, crying, religiosity, silence, avoidance, and self-care. Problem-focused strategies encompass social and community support; reliance on marital or partner relationships; access to medical and mental health services; participation in skills training; support from host communities; and efforts to adapt economically and culturally. Data were collected through quota and snowball sampling and analyzed using thematic analysis. Findings show that coping is a dynamic, context-dependent process shaped by women's agency alongside the social and structural resources available at each displacement phase. Survivors continuously recalibrated their coping approaches in response to evolving risks, opportunities, and support systems. The study underscores the need for culturally grounded, phase-specific interventions that strengthen emotional resilience while expanding practical support for refugee women affected by GBV. Such interventions should address both immediate psychosocial needs and the broader structural conditions that shape women's capacity to cope throughout their displacement journeys.

PMID 42505081
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PubMedMarine drugs2026-07-27

A Structure-Activity Relationship Study of Trypargine and Opacaline β-Carbolines.

Chen Dan D, Rouvier Florent F, Brunel Jean Michel JM, Copp Brent R BR et al.

The marine environment represents a rich source of novel antimicrobial compounds. This study investigated the isolation and synthesis of antimicrobial agents from the New Zealand ascidian Pseudodistoma opacum to identify natural products and derivatives with potential pharmacological applications. Screening of a marine natural product library and related synthetic analogues revealed several compounds exhibiting antibiotic-potentiating activity in combination with doxycycline against Pseudomonas aeruginosa. To further explore these findings, the most active natural product, opacaline A (1), was synthesized, and a structure-activity relationship (SAR) study was conducted to identify key structural features required for activity. This work reports the first total synthesis of opacaline A (1) and racemic 7-bromohomotrypargine (3). Biological evaluation demonstrated that the presence of a bromine substituent and a free amine or guanidine group is essential for both intrinsic antimicrobial activity and antibiotic potentiation. Additionally, both oxidation states of the β-carboline ring (aromatic and tetrahydro-) were found to retain activity. These findings provide insight into the structural requirements for activity and support further development of these compounds as antimicrobial adjuvants.

PMID 42505988
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PubMedTropical medicine and infectious disease2026-07-27

A Rare Cause of Folliculitis by Dermatophilus congolensis in a Tropical Martial Arts Fighter.

Martínez-Carrión Guillermo G, Fernández-Ciriza Leire L, Razquin Iosu I, Río-Poza María Ángeles Del MÁD et al.

Dermatophilus congolensis, a Gram-positive actinomycete, is a well-known animal pathogen but a rare cause of human skin infections. Human dermatophilosis is an infection associated with tropical environments and animal contact that remains frequently underdiagnosed. We report a case of recurrent folliculitis in a 34-year-old male Muay Thai fighter returning from Thailand to Spain. The patient presented with pustular lesions on his lower limbs following frequent leg shaving and close physical contact during training. Microbiological culture from skin swabs yielded beta-hemolytic colonies, identified as D. congolensis by MALDI-TOF MS. Identification was confirmed through Whole-Genome Sequencing (WGS), which also revealed an absence of antimicrobial resistance genes. Despite the lack of established EUCAST breakpoints, the isolate showed low MICs for most tested antibiotics. The patient was treated with doxycycline, although clinical follow-up was not possible due to travel. This case highlights D. congolensis as an emerging differential diagnosis for persistent folliculitis in travelers and athletes. Our findings suggest a potential horizontal transmission route through contact sports and fomites (e.g., mats) in high-humidity settings.

PMID 42506766
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PubMedThe American psychologist2026-07-27

From first-generation Asian American college student to the American Psychological Association presidency: A developmental journey of identity, leadership, and collective purpose.

Kawahara Debra M DM

This presidential reflection traces a developmental pathway from a culturally grounded upbringing in Gardena, California, to the unexpected role of serving as president of the American Psychological Association. Integrating a personal narrative with scholarly literature on leadership development, cultural humility, identity formation, and first-generation educational experiences, this article examines how values and lived experience shaped my professional trajectory. Themes of transformative and relational leadership and culturally responsive practice are woven throughout the narrative to illuminate the ways in which community, mentorship, and structural opportunity inform leadership emergence. It provides insights into navigating an unprecedented presidential year, where leadership required drawing upon cultural grounding, crisis expertise, and a deep commitment to collective care. The article concludes with reflections on the developmental trajectory toward the American Psychological Association presidency and the culmination of the various individual and contextual experiences leading to it. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

PMID 42507377
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PubMedAnalytical methods : advancing methods and applications2026-07-27

Smartphone-based fluorescence sensing platform for tetracycline determination based on a high quantum yield europium metal-organic framework with a dual-ligand strategy.

Cheng Shuang S, Song Jintian J, Wen Yue Y, Xu Yijia Y et al.

Ultrasensitive and visual detection of tetracyclines (TCs) is of great significance to public health and environmental safety. Herein, we synthesized a dual-ligand europium metal-organic framework (Eu-phen-MOF) via a one-step solvothermal method for the fluorescence detection of TCs. Compared with the Eu-MOF without 1,10-phenanthroline, Eu-phen-MOF exhibits superior stability, lower LOD and higher quantum yield. It delivers superior TC sensing performance and anti-interference, enabling high-accuracy detection with limits of 152.0 nmol L-1, 249.4 nmol L-1, 171.0 nmol L-1 and 277.7 nmol L-1 for tetracycline (TC), oxytetracycline (OTC), doxycycline hydrochloride (DOX), and chlortetracycline (CTC), respectively. Eu-phen-MOF was used for the quantitative detection of TC, OTC, DOX, and CTC in real samples (milk, eggs, and river water) and recoveries ranging from 94.64% to 105.37% were achieved. Finally, a portable fluorescence sensing platform integrating a smartphone and the Eu-phen-MOF fluorescent hydrogel was constructed, enabling convenient, rapid, and low-cost detection of TCs. This work not only highlights the significance of the dual-ligand strategy for fabricating an efficient TC sensor, but also develops a rapid and visual method for TC detection.

PMID 42504902
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