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doxycycline hyclate (Targadox)

✓ Approved

Fortress Biotech, Inc. · 小分子 · 小分子

什么是 doxycycline hyclate？

doxycycline hyclate 是一种小分子，由Fortress Biotech, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Targadox
公司Fortress Biotech, Inc.
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Fortress Biotech, Inc.

治疗适应症

doxycycline hyclate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersAcne✓ Approved

相关研究文献

PubMedHealthcare (Basel, Switzerland)2026-10-27

Addressing Scanxiety Throughout the Cancer Surveillance Journey: A Co-Design Study.

Vanpoecke Hannes H, De Pourcq Kaat K, Gemmel Paul P, Meijboom Bert R BR et al.

Background/Objectives: Scanxiety, the distress associated with cancer surveillance imaging, is a common concern among cancer survivors. Although most research has focused on the imaging event itself, less is known about how scanxiety unfolds throughout the broader cancer surveillance journey. This study aimed to map the cancer surveillance journey of cancer survivors and identify patient-centred intervention opportunities to reduce scanxiety. Methods: We used a qualitative participatory design involving cancer survivors, travelling companions, and healthcare professionals. Nine co-creation workshops were conducted; in six survivors and companions participated in journey-mapping exercises, while in three, healthcare professionals completed an immersive exercise. All groups subsequently engaged in structured brainstorming workshops to generate intervention opportunities. Data were analysed using abductive thematic analysis. Results: Scanxiety extended beyond the imaging procedure and unfolded throughout the cancer surveillance journey, spanning three phases and seven subphases. Participants identified opportunities to redesign the journey by enhancing existing touchpoints, augmenting the journey with additional touchpoints, and eliminating unnecessary or stress-inducing touchpoints. These opportunities targeted interpersonal, technical, environmental, and administrative dimensions of care. Administrative qualities, particularly timeliness and operational processes, emerged as important contributors to distress. Preferences for support and communication varied, underscoring the need for flexible supportive care during medical surveillance. Conclusions: Scanxiety is a journey-wide experience shaped by both individual and organisational factors. Opportunities to address scan-related distress may include not only psychosocial support, but also improvements in how surveillance care is organised and delivered. The findings provide a patient-centred approach for redesigning cancer surveillance services and identifying intervention opportunities for future evaluation.

PMID 42940581
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PubMedAntibiotics (Basel, Switzerland)2026-10-27

Therapeutic Outcomes of Oral Antibiotics for the Treatment of Methicillin-Resistant Staphylococcus aureus Urinary Tract Infections: A Multisite, Retrospective Cohort Study of Linezolid, Trimethoprim-Sulfamethoxazole and Doxycycline.

McCall Ryan R, Gatskevich Elena E, Fiester Steven E SE, Floren Michael M et al.

Methicillin-resistant Staphylococcus aureus (MRSA) urinary tract infections (UTIs), while relatively uncommon, pose a unique challenge in treatment as only specific intravenous (IV) options are typically utilized, with the efficacy of oral antimicrobials being poorly defined. The multi-site retrospective cohort study described herein therefore aims to characterize outcomes associated with oral administration of linezolid, trimethoprim-sulfamethoxazole (TMP-SMX), or doxycycline for the treatment of MRSA UTIs. Study participants were adults with culture-positive MRSA UTIs receiving one of the three oral therapies. Exclusion criteria included polymicrobial UTI, concomitant MRSA outside the urinary tract, receipt of non-study anti-MRSA agents for greater than or equal to 50% of treatment, less than 48 h of the oral study drug, and/or prostatitis. The primary outcome was clinical cure defined as a composite of symptom resolution, no readmission within 30 days of discharge attributable to UTI, and no change in therapy due to treatment failure. Secondary outcomes included antibiotic discontinuation because of adverse effects (AEs). Overall, patients attained a clinical cure rate from MRSA UTI of 78.8%, 80.0%, and 94.4% when treated with linezolid, TMP-SMX, or doxycycline, respectively. While there were no observed differences between the clinical cure rates of the three antimicrobials studied, the high clinical cure rate coupled with low rates of AEs may support these oral therapies for the treatment of MRSA UTIs, but further investigation is required.

PMID 42938697
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PubMedJournal of the Society for Cardiovascular Angiography & Interventions2026-10-27

Optimal Sheath for Single-Access Percutaneous Coronary Intervention With Impella CP Hemodynamic Support.

Thakker Ravi R, Khalif Adnan A, Xu Ying Y, Bilazarian Seth S et al.

Single-access percutaneous coronary intervention (PCI) with the Impella CP (Abiomed) has increased in prevalence. Despite this, the optimal PCI sheath remains unknown. We characterized the optimal 7F PCI sheath using the single-access technique. The outer diameter measurement of the sheaths was performed using a Keyence 2-axis laser micrometer (Keyence). The force needed to insert the sheath and the torqueability of the guide catheter were assessed using the Mark-10 M5i Advanced Digital Force/Torque Indicator (Mark-10 Corporation) on a simulated single-access setting in a simulated skin pad. The sample size was determined to be 5 sheaths for each test. The BRITE TIP 11 cm (Cordis), BRITE TIP 35 cm (Cordis), and Destination sheath (Terumo) had the largest outer diameters; the Prelude IDeal (Merit Medical) and Terumo Glidesheath (Terumo) had the smallest outer diameters. The Glidesheath was easiest for insertion/removal, followed by the Prelude IDeal and Impella Low Profile (LP) Companion sheath (Abiomed). The Impella LP Companion, Prelude Roadster (Merit Medical), and Destination sheaths allowed for the best torqueability and lowest force to remove the guide catheter. The longer Impella LP Companion sheath did not impact torqueability, but the removal force increased by 50% compared with the shorter Impella LP Companion sheath. The Impella LP Companion sheath demonstrated the best torqueability and least effort in advancing the guide catheters, while the Prelude Roadster and Destination also performed well on these metrics. The Prelude IDeal and Glidesheath were good options for single-access because of their smaller outer diameters and hydrophilic coating and were easiest for insertion/removal through the 14F LP sheath.

PMID 42936568
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PubMedAIDS (London, England)2026-10-27

Impact of doxycycline postexposure prophylaxis on sexually transmitted infections within a statewide community healthcare system.

Burch Sarah S, Alqahtani Zuhair Z, Brown Bethanne B

This study evaluated the impact of doxycycline postexposure prophylaxis (DoxyPEP) prescribing on sexually transmitted infection (STI) incidence proportion in an underserved population receiving care from a statewide community healthcare system. Retrospective cohort study was conducted using pharmacy and electronic health records data between 4 May 2021 and 1 April 2025. Primary outcome was the overall STI incidence proportion during 12 months prior to and following DoxyPEP initiation. Secondary outcomes included categorizing bacteria and site-specific STIs and exploring the association between DoxyPEP, preexposure prophylaxis (PrEP), and STI incidence proportion. Pharmacy dispensing reports and patient demographic information were combined with EHR laboratory-confirmed STI results for review and analysis. Patient data were included if the DoxyPEP prescription was written by an Equitas Health provider and dispensed by the in-house pharmacy, and at least one documented STI test during the 12 months before and after the DoxyPEP initiation. Data were excluded if the prescription originated from an outside provider or was sold after 1 April 2025. Overall STI incidence proportion decreased from 30.5% preintervention to 17.6% postintervention (P < 0.001) for the 1,111 included patients. Reductions were observed in chlamydia (17.3-3.1%, P < 0.001) and syphilis (3.5-0.6%, P < 0.001), while gonorrhea incidence decreased slightly (16.9-15.2%, P = 0.24). Rectal and urine chlamydia infections experienced the largest decline, and no association was found with PrEP use. DoxyPEP use was associated with a significant reduction in overall STI incidence proportion in a high-risk population, supporting this prevention strategy.

PMID 42937323
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PubMedJournal of shoulder and elbow arthroplasty2026-10-27

The hospital cost of primary reverse total shoulder arthroplasty performed with traditional instrumentation: a Time-Driven Activity-Based Costing (TDABC) benchmark analysis in the era of digital enabling technology.

Barret Hugo H, Vazquez Amanda A, Dholakia Ruchita R, Borah Bijan J BJ et al.

There is increasing interest in the use of digital enabling technology, and particularly robotic-assisted surgery, to perform reverse total shoulder arthroplasty (rTSA). However, a major concern with the adoption of digital enabling technology is the potential for increased cost, related not only to the capital cost of acquisition and disposables but also to longer procedure times. Time-Driven Activity-Based Costing (TDABC) was developed to calculate the true cost of healthcare by meticulously tracking the resources and time consumed during each step of a patient's hospital journey. The purpose of this study was to apply TDABC and traditional costing to analyze the costs of rTSA performed with traditional instrumentation in order to establish a benchmark for future comparison with new technologies. Twenty-five primary rTSA performed at a single high-volume institution in the United States in 2025 were included in this prospective TDABC study. A detailed process map of all pre-operative, intraoperative, and post-operative activities patients underwent from hospital admission to same-day hospital discharge was created. A single observer followed all 25 patients and used a chronometer to accurately record the time spent in each activity mapped. Costs generated through TDABC were combined with the cost of supplies, equipment, medications, and other direct and indirect operational activities to obtain the total cost. The cost of drugs, durable medical equipment, and supplies was obtained using the traditional costing method for the TDABC group as well. The results of both costing methods were then compared by 2 independent financial analysts. The average standardized hospital cost of the 25 primary rTSAs included in the study was estimated to be $21,579 using traditional costing and $16,547 using TDABC. Medical devices represented the largest cost using both methods (39% of the total cost for traditional costing and 51% for TDABC). Traditional costing overestimated personnel cost and fixed direct costs compared to TDABC. On average, surgeons spent an average of 47 minutes to perform the critical portion of the rTSA procedure. The average per minute salary cost for all personnel categories was $24. In a high-volume institution, there was an average $5,000 difference in estimated costs using traditional costing vs. TDABC. This methodology and results represent a benchmark that can be used to understand the potential added cost of digital enabling technology, and particularly robotic-assisted rTSA, as widespread adoption increases over time.

PMID 42936368
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PubMedCureus2026-10-27

Acoustic and Ultrasonic Energy Devices for Soft Tissue Dissection in General Surgery: Current Evidence and Future Directions.

Arragan Lezama Carlos Alejandro CA, Tandayamo Sisalima Luis Fernando LF, Posada Manjarrez Álvaro de Jesús ÁJ, Arguello Hernández José Luis de Jesús JLJ et al.

Acoustic and ultrasonic energy instruments have paved the way for revolutionizing soft tissue dissection, leading to the development of energy instruments in general surgery. These devices, such as the Harmonic® ultrasonic surgical system (Ethicon, Johnson & Johnson), Sonicision (Covidien/Medtronic), Thunderbeat® (Olympus Corporation), and high-intensity focused ultrasound (HIFU) devices, are high-frequency mechanical vibrating tools that can cut and coagulate tissue simultaneously with minimal thermal spread compared to traditional electrosurgery. This literature review aims to present evidence (2020-2026) published in PubMed, including mechanisms of action, clinical effectiveness, safety, comparisons of systems with varying devices, and new and potential applications of ultrasonic and acoustic energy in general surgery (both open and minimally invasive). Systematic reviews, meta-analyses, and clinical trials have demonstrated a step-by-step buildup of evidence indicating that ultrasonic devices lead to fewer inflammatory tissue responses, less blood loss, a shorter postoperative hospital length of stay, and faster surgery times than traditional electrocautery. However, there are also clinical concerns, such as the possibility of overheating the blades, the risk of thermal residues, and the cost of the devices. Future trends involve incorporating artificial intelligence (AI) and smart energy delivery into the platform, adding AI to an ultrasonic (robotic-compatible) platform with wristed articulation, and expanding the clinical uses of AI in non-invasive tissue ablation.

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