doxycycline hyclate (Targadox)

A journey mapping study of healthcare professionals' involvement in fertility preservation for cancer patients.

Xue Di D, Zhu Aijun A, Song Hongyuan H, Cheng Meijuan M et al.

Based on journey mapping, this study aimed to identify the main tasks, key pain points, and emotional experiences of healthcare professionals throughout their involvement in fertility preservation for cancer patients, and to provide evidence for designing targeted interventions and optimizing fertility preservation services. This qualitative study adopted purposive sampling to recruit 24 healthcare professionals from the departments of breast and thyroid surgery, oncology, and related departments at Yichang Central People's Hospital between June and August 2025. Semi-structured interviews were conducted, and thematic analysis guided data coding and analysis. A journey map was then constructed. The journey map of healthcare professionals' engagement in cancer patients' fertility preservation consisted of four stages: needs identification and topic communication, option assessment and referral, intervention and treatment, and long-term follow-up. Analysis of the interview data yielded 14 themes. The key pain points included insufficient knowledge, ambiguous role perception, the sensitivity of reproductive discussions, constrained medical resources, inadequate multidisciplinary collaboration, and gaps in follow-up care. Healthcare professionals acknowledge the importance of fertility preservation for cancer patients, yet they encounter multiple obstacles in clinical practice, such as deficiencies in professional knowledge and skills, weak interdisciplinary collaboration, and limitations in resources and policies. A multilevel intervention strategy should be developed through measures such as creating standardized assessment tools, building regional collaborative networks, strengthening knowledge and skill training with clear role definitions, improving cross-departmental information sharing, and prioritizing follow-up care. These efforts can enhance healthcare professionals' engagement in fertility preservation and improve the quality of survival for cancer patients.

Correction: Exploring genetic diversity and selective signatures, a journey through Colombian cassava's landscape.

Mora Moreno Rubén Eduardo RE, Sánchez Ferro Juan Sebastián JS, Garcia Emili Ishikawa EI, Jiménez Maldonado Andrés David AD et al.

Attitudes, knowledge, facilitators, and barriers to doxycycline post-exposure prophylaxis for sexually transmitted infections among gay and bisexual men who have sex with men and trans-gender women: A mixed-methods scoping review.

Fouhy Fergal F, Budden George G, Pool Erica E, Kohli Manik M

BackgroundAs doxycycline post-exposure prophylaxis (doxyPEP) implementation for bacterial STI prevention expands among gay, bisexual and other men who have sex with men (GBMSM) and transgender women (TGW), this scoping review synthesised community knowledge, attitudes, barriers, facilitators and practices to inform guidelines and support uptake.MethodsThis scoping review followed JBI methodology and was reported per PRISMA-ScR. Three databases (Embase, Medline/PubMed, Web of Science) were searched for articles on community perspectives of doxyPEP among GBMSM and TGW published from 2013 to 2025. Included studies were screened, data extracted using inductive coding, and analysed thematically. Factors were mapped onto the Knowledge, Attitudes, and Practices (KAP) Model.Results24 studies (18,428 participants) met inclusion criteria, (North America (n = 12), Europe (n = 6), Asia (n = 3), Oceania (n = 3)). Most were quantitative (n = 20), with two qualitative and two mixed-methods studies, recruiting primarily via online/app-based surveys or from sexual health clinics. Five coding categories emerged: awareness and knowledge; previous use; willingness to try; barriers and concerns; and facilitators and predictors. Awareness and prior use were low and heterogenous (ranging from 17 to 67%), yet willingness was moderate to high (12% to 90%), particularly after brief education and when free of charge. Prior use remained limited (2.5-36%). Predictors of interest included prior STI diagnosis, HIV PrEP use, living with HIV, multiple sexual partners, condomless sex, and higher educational attainment. Side effects and antimicrobial resistance (AMR) were the primary concerns.ConclusionsClinicians and sexual health services should prioritise opportunistic doxyPEP offers to those with recent STIs, HIV PrEP use, or HIV, embedding education and low/no-cost access within routine care to close the awareness-uptake gap. Public health bodies should invest in robust AMR surveillance alongside implementation, and community-based education should directly address side-effect concerns. Extending research and delivery models to under-represented groups is also needed to ensure equitable, evidence-based uptake.

At the Interface of Urban Exposure and Infection: A Classical Case of Leptospirosis in New York City.

Lopez Priscila P, De Oliveira Cox Bruna B, Schliep Tjark T

Leptospirosis is a zoonotic spirochetal infection transmitted through exposure to water or soil contaminated with animal urine, often associated with unsanitary living conditions and environmental exposure. Early recognition and prompt initiation of appropriate antimicrobial therapy are critical to prevent severe complications, including multiorgan failure and death. We present a case of a 43-year-old man from New York City (NYC) with alcohol use disorder who was experiencing homelessness and presented with bilateral lower extremity myalgias after sleeping outdoors on a soccer field while intoxicated several days prior. He was initially managed for sepsis of unknown origin with broad-spectrum antibiotics. Subsequent diagnostic testing confirmed leptospirosis, prompting de-escalation to targeted therapy with ceftriaxone. The patient improved clinically despite developing severe acute kidney injury and hyperbilirubinemia and was discharged to complete a course of doxycycline, with a favorable outcome.