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polyvalent human immunoglobulin (liquid) (Clairyg)

✓ Approved

LFB · 多克隆抗体 · 多克隆抗体

什么是 polyvalent human immunoglobulin (liquid)？

polyvalent human immunoglobulin (liquid) 是一种多克隆抗体，由LFB研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Clairyg
公司LFB
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, LFB

治疗适应症

polyvalent human immunoglobulin (liquid) 针对 7 个适应症，涉及 5 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersGuillain-Barre syndrome✓ Approved
Skin and subcutaneous tissue disordersPurpura✓ Approved
Congenital, familial and genetic disordersWiskott-Aldrich syndrome✓ Approved
Immune system disordersSelective IgG subclass deficiency✓ Approved
Congenital, familial and genetic disordersBruton's agammaglobulinaemia✓ Approved

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相关研究文献

PubMedJournal of medical virology2026-09-10

Molecular Evidence of Human T‑Cell Leukemia Virus Type 1 Transmission by Needlestick Injury in Healthcare Workers.

Tokunaga Masahito M, Kuramitsu Madoka M, Saito Masumichi M, Yoshimori Miyuki M et al.

Human T‑cell leukemia virus type 1 (HTLV‑1) is a retrovirus that spreads primarily through cell-to-cell transmission. Occupational transmission of HTLV-1 by needlestick injury is considered exceedingly rare, with no reported molecularly confirmed cases. We report two healthcare workers who experienced accidental needlestick injuries while caring for patients seropositive for HTLV‑1 and subsequently seroconverted. Full‑length HTLV‑1 proviral sequencing revealed complete nucleotide identity between source patients and infected nurses. These strains belonged to the HTLV-1 subtype 1a Japanese subgroup but were distinct from 315 previously registered strains. Proviral integration site analysis demonstrated nonoverlapping integration profiles between source patients and healthcare workers, providing direct evidence of de novo HTLV‑1 infection rather than expansion of transferred infected cells. Longitudinal analysis in one case showed dynamic clonal turnover between 5 and 14 months after transmission; > 90% of infected-cell clones were replaced, although the proviral load remained stable and low. Serological profiling revealed transiently elevated immunoglobulin M responses to Gag p19 peptides during early infection, followed by gradual immunoglobulin G maturation. These findings provide the first molecular confirmation of HTLV‑1 transmission via needlestick injury resulting in de novo infection, revealing an under-recognized occupational exposure route and supporting reconsideration of post-exposure testing strategies, particularly in endemic regions.

PMID 42720182
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PubMedSoft matter2026-09-10

Photo-controlled soft robots based on liquid crystal elastomer tubular actuators.

Lin Shaopeng S, Tang Yuanxin Y, Liu Jianan J, Wang Xiuxiu X et al.

Soft tubular actuators can be widely found in nature and engineering fields. To demonstrate the advantages of soft tubular actuators in potential applications and exploit the unique actuation properties of liquid crystal elastomer (LCE) materials, we fabricated LCE tubular actuators with multiple photo-controlled and programmable actuation modes by using the centrifugal synthesis process. Controlled by the applied light irradiation stimulus, the LCE tubular actuators can exhibit omnidirectional bending motion, large radial contraction/elongation or clockwise/anticlockwise rotation. Using multiple LCE tubular actuators, we built multi-functional non-tethered soft robots, including a two-leg walking robot, cargo-transporting robot, and manipulator-robots. Under moderate photo guides, the two-leg walking robot can realistically simulate human-walking and direction-turning motion, the cargo-transporting robot can efficiently transport cargoes in a forward way, backward way or rotation way, and the manipulator-robots can effectively grasp, lift, install or disassemble objects. Our study provides insights into the development of LCE actuators for constructing compact and multifunctional smart machines.

PMID 42719937
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PubMedACS applied materials & interfaces2026-09-10

Water Vapor-Assisted Electrospinning Construction of a Double-Reentrant-Analogous Surface Topography for a Durable, Fluorine-Free Superomniphobic PS/OTS Fibrous Membrane.

Fang Xinrui X, Xu Yuxin Y, Zhang Zhong Z, Xun Huayang H et al.

Fluorine-containing chemicals have been extensively utilized for fabrication of liquid-repellent, in particular oil-repellent, surfaces. However, such chemicals pose significant risk to both environment and human health. The development of fibrous materials with fluorine-free super-oil-repellent surfaces remains a considerable challenge. Herein, we propose an innovative water vapor-assisted electrospinning strategy for an in-situ construction of fluorine-free superomniphobic ultrathin fibers. This approach synergistically integrates electrostatic force-driven stretching, vapor-induced phase separation (VIPS) of polystyrene (PS)/octadecyltrichlorosilane (OTS)/tetrahydrofuran (THF) solution jets, and hydrolytic condensation of OTS, yielding a vesicular porous fiber surface topography characterized by a double-reentrant-analogous structure and a substantially reduced surface energy. The synergistic combination of fibrous architecture and low surface energy endows the PS/OTS membranes with superomniphobicity, exhibiting super-liquid-repellent behavior toward water and a series of polar and nonpolar liquids having surface tension ranging from 28.4 to 72.8 mN/m. Benefiting from the hierarchical roughness-induced nonwetting properties, the membrane shows fluffy morphology and thermal insulation performance with a thermal conductivity of 0.018 W/m·K at a loading weight of ∼12 g/m2. Moreover, the PS/OTS membrane demonstrates excellent chemical and physical durability, maintaining structural integrity and liquid repellent property under severe conditions, such as chemical corrosion, UV irradiation, and ultrasonication.

PMID 42720034
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PubMedCureus2026-09-10

Paraplegia Caused by IgG4-Related Hypertrophic Pachymeningitis With an Elevated Cerebrospinal Fluid Immunoglobulin G4 Concentration.

Doyama Hisaki H, Matsumoto Yasuko Y, Kurosaka Akiho A, Kobayashi Motoya M et al.

Immunoglobulin G4-related hypertrophic pachymeningitis (IgG4-RP) is a rare manifestation of immunoglobulin G4 (IgG4)-related disease and an uncommon cause of hypertrophic pachymeningitis (HP). Because serum IgG4 concentration is not necessarily elevated, the diagnosis of IgG4-RP is often challenging. We report a rare case of IgG4-RP in a 78-year-old woman presenting with complete paraplegia, sensory loss in the lower extremities, and bladder and rectal dysfunction. Gadolinium-enhanced magnetic resonance imaging showed enhancing spinal epidural lesions. A histopathological examination revealed dense lymphocyte and plasma-cell infiltration with fibrosis and increased IgG4-positive plasma cells, leading to the diagnosis of IgG4-RP. Although the serum IgG4 concentration was within the reference range, retrospective analysis of cerebrospinal fluid (CSF) showed a markedly elevated IgG4 concentration, with an increased IgG4 index and IgG4Loc. Glucocorticoid therapy resulted in radiological and neurological improvement. This case highlights the importance of considering IgG4-RP in patients with spinal HP even if serum IgG4 concentration is not elevated. Furthermore, CSF IgG4 measurement may contribute to the diagnosis of IgG4-RP, although further studies are required to establish its clinical utility.

PMID 42719365
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PubMedFrontiers in medicine2026-09-10

Case Report: Balancing immunosuppression and infection-intravenous immunoglobulin in anti-HMGCR immune-mediated necrotizing myopathy complicated by severe pneumonia.

Fu Jing J, Zhao Qiong Q, Lou Jing-Bo JB, Tang Gui-Hua GH et al.

A 65-year-old male with a 3-year history of atorvastatin use presented with progressive proximal muscle weakness, dysphagia, and markedly elevated creatine kinase (2,277 U/L). Initially misdiagnosed with polymyositis, he deteriorated with severe pneumonia, septicemia, and type I respiratory failure requiring mechanical ventilation. Interleukin-6 rose from 12.83 to 610.9 pg/mL during sepsis. After confirmation of anti-HMGCR antibody positivity (18 arbitrary units [AU], cutoff >10 AU) via line blot assay, we discontinued methotrexate, maintained methylprednisolone at 40 mg, and initiated intravenous immunoglobulin (IVIG) 0.4 g/kg/day for 5 days with broad-spectrum antibiotics. Within two weeks, proximal muscle strength (MRC scale) improved from 2/5 to 4/5, IL-6 normalized to 8.56 pg/mL, and respiratory failure resolved. This case suggests that IVIG may serve as a safe immunomodulatory bridge in critically ill IMNM patients with severe infections.

PMID 42718719
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PubMedACS chemical biology2026-09-10

An Automated Scalable Chemoproteomics Workflow that Recovers Known Serine Hydrolase Target Profiles of Clinically Used Drugs.

Ter Brake Franciscus H G FHG, Gagestein Berend B, van der Stelt Mario M, Janssen Antonius P A APA

Activity-based protein profiling has established itself as a powerful technology with demonstrated use in on- and off-target profiling. However, determining the off-target profile of many drugs using the unbiased mass spectrometry-based chemoproteomics approach remains time- and cost-intensive. In this study, we implemented an SP3-based, high-throughput, plate-based chemoproteomic workflow compatible with liquid-handling robotics. We then profiled a library of 40 marketed drugs targeting the serine hydrolases or containing potentially reactive electrophiles against the human serine hydrolase proteome in HT29 cell lysate. We included two additional well-studied literature compounds as controls to benchmark our workflow. Our results validated 16 out of 20 intended human targets and found 5 previously described off-targets for the compounds tested. Additionally, we discovered six unknown off-targets that could warrant future follow-up research. In all, our approach demonstrates how automated chemoproteomics can be used to accelerate the identification of clinically relevant off-targets, providing a scalable blueprint for rational drug repurposing.

PMID 42717654
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