北京若生智能科技有限公司
Drug Database
PO

polyvalent human immunoglobulin (liquid) (Clairyg)

✓ Approved

LFB · 多克隆抗体 · 多克隆抗体

什么是 polyvalent human immunoglobulin (liquid)？

polyvalent human immunoglobulin (liquid) 是一种多克隆抗体，由LFB研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Clairyg
公司LFB
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, LFB

治疗适应症

polyvalent human immunoglobulin (liquid) 针对 7 个适应症，涉及 5 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersGuillain-Barre syndrome✓ Approved
Skin and subcutaneous tissue disordersPurpura✓ Approved
Congenital, familial and genetic disordersWiskott-Aldrich syndrome✓ Approved
Immune system disordersSelective IgG subclass deficiency✓ Approved
Congenital, familial and genetic disordersBruton's agammaglobulinaemia✓ Approved

注册免费账户还可查看另外 2 个适应症

免费注册查看全部适应症 →

相关研究文献

PubMedOne health (Amsterdam, Netherlands)2026-10-27

Epidemiology of animal bites and post-exposure vaccination coverage in Davao City, Philippines: A five-year retrospective cohort study, 2019-2023.

Hinay Alfredo A AA, Parilla-Sarabia April Joy AJ, Reyes Jennifer Ashley H JAH, Lopez Mariel Phoebe M MPM et al.

Rabies remains a major public health threat in the Philippines, particularly in urban areas such as Davao City, where frequent animal bites from domestic reservoirs increase the transmission risk at the human-animal-environment interface. Detailed epidemiological data on animal bites and post-exposure prophylaxis (PEP) coverage are limited. This One Health-framed retrospective cohort study describes trends in bite incidents, assesses PEP coverage, and identifies gaps in rabies prevention efforts from 2019 to 2023. Surveillance data from the Davao City Animal Bite Treatment Centers captured 98,442 cases. Dogs caused 63.5% of bites, with a significant upward trend (p = 0.027; τ = 1.0, 95% CI 0.200-1.800); cat bites (36.4%) rose sharply, indicating an emerging reservoir challenge. Children ≤15 years of age showed a significant increase (p = 0.027). The 3rd congressional district had the most pronounced rise across demographics and exposure categories. Tissue culture vaccine coverage remained at 100%, equine rabies immunoglobulin rose from 18.5% to 85.9%, whereas human rabies immunoglobulin remained low post-COVID. Despite universal TCV access, immunoglobulin gaps limit its control. Rising cat bites and severe exposures demand integrated One Health strategies, enhanced surveillance, animal vaccination, and supply chain strengthening, to achieve zero human rabies deaths by 2030.

PMID 42935849
阅读全文 →
PubMedFrontiers in public health2026-10-27

From environmental occurrence to human exposure: multisystem toxicity, immune-relevant mechanisms, and gaps in health-risk assessment of liquid crystal monomers.

Zhang Hongchi H, Qiu Jingle J, Lu Zhenyu Z, Zheng Xiangbin X et al.

Liquid crystal monomers (LCMs), functional constituents of liquid crystal displays, are emerging contaminants increasingly detected in environmental and human matrices, yet the implications of these exposures for human health remain uncertain. This review critically synthesizes current evidence on environmental occurrence and potential exposure pathways, human biomonitoring, toxicokinetics, multisystem toxicity, immune-relevant mechanisms, and health-risk assessment gaps. PubMed, Web of Science Core Collection, and Scopus were searched from database inception to 22 July 2026. Forty-one primary studies met the predefined eligibility criteria, while additional environmental-occurrence studies were used to contextualize sources, release processes, and potential exposure pathways. LCMs have been reported in dust, airborne particulate matter, soils, sediments, and landfill leachate, indicating several plausible exposure pathways, including dust ingestion, inhalation, dermal contact, and dietary intake. LCMs have been detected in urine, serum, human milk, maternal serum, and cord serum, indicating exposure in the general population and during sensitive life stages. Experimental studies report neurological, hepatic, renal, intestinal, respiratory, cutaneous, endocrine, reproductive, developmental, and metabolic effects. Oxidative stress, inflammatory signaling, nuclear receptor perturbation, metabolic dysregulation, and gut microbiota disruption provide biological plausibility for immune-related effects, although direct evidence of classical immunotoxicity remains limited. Major uncertainties include heterogeneous analyte coverage, insufficient human toxicokinetic data, limited chronic low-dose and mixture studies, and the absence of congener-specific reference values. Future research should prioritize harmonized biomonitoring, environmentally relevant mixture testing, prospective studies in susceptible populations, and integrated risk-assessment frameworks for this emerging class of contaminants.

PMID 42935800
阅读全文 →
PubMedLife (Basel, Switzerland)2026-10-27

Gamma-Glutamyl Transferase and Cognitive Outcomes: A Cross-Species Analysis and Hepatic Transcriptomic Signature.

Zhang Rongjiang R, Yu Tianhao T, Hao Kai K, Lu Hui H et al.

Cognitive impairment is a major public health concern, and the liver-brain axis has attracted growing interest. Gamma-glutamyl transferase (GGT) is a serum marker of liver function, but its association with cognitive outcomes remains uncertain. We conducted a cross-species analysis. In 5xFAD mice (n = 52), we examined serum liver markers and spatial cognition using the Morris water maze. In NHANES 2011-2014 (n = 3181, aged ≥60 years), we evaluated liver markers and low cognitive performance (LCP) using multivariable logistic regression. We also performed virtual hepatic GGT1 knockout in a human liver single-cell atlas and integrated GTEx liver co-expression, transcription factor enrichment, and WGCNA analyses. In mice, GGT-cognition associations largely attenuated after strain adjustment, but a positive association with platform crossings emerged (r = 0.321, p = 0.02). In NHANES, serum GGT was inversely associated with LCP (Q4 vs. Q1 OR = 0.54, p < 0.001), with a nonlinear association and an inflection point near 19 U/L. Virtual hepatic GGT1 knockout identified eight immunoglobulin-related genes associated with SPI1 and oxidative stress-related pathways. These parallel findings are hypothesis-generating. A testable hypothesis is that lower hepatic GGT1 activity or serum GGT is associated with upregulated cholangiocyte immunoglobulin-related programs and poorer cognition.

PMID 42942321
阅读全文 →
PubMedJournal of molecular and cellular cardiology plus2026-10-27

Myocardial lipid remodeling in patients with myocardial infarction undergoing cardiac surgery.

Shiozawa Tomoyuki T, Kadoguchi Tomoyasu T, Lee-Okada Hyeon-Cheol HC, Shimada Kazunori K et al.

Myocardial lipid remodeling in myocardial infarction (MI) remains insufficiently characterized in human myocardium. Using liquid chromatography-mass spectrometry, we analyzed left atrial appendage tissue from patients with and without MI undergoing cardiac surgery. MI was characterized by reduced phospholipid species containing omega-3 polyunsaturated fatty acids (PUFAs) and myristic acid, together with reduced diacylglycerol species containing omega-3 PUFAs. Reduced phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and plasmalogens were observed, whereas triacylglycerols were enriched. Loss of polyunsaturated phospholipids and accumulation of relatively saturated triacylglycerols indicate a shift toward neutral lipid storage in human MI myocardium.

PMID 42935987
阅读全文 →
PubMedGenes2026-10-27

Study of Population-Differentiated Single-Nucleotide Variants in Human Immunoglobulin Loci Using Short-Read Sequencing Data.

Zhang Qi Q, Chen Xudong X, Li Qiang Q

Population differences in immunoglobulin (IG) variation offer a starting point for studying inherited antibody diversity. We screened reference-based single-nucleotide variants for population differentiation and linked the resulting candidates to expression and trait annotations. The primary analysis included 2488 participants from five 1000 Genomes Project groups after pruning documented pedigree relationships and incorporated reference-risk filtering, genotype-quality sensitivity, two FST estimators, linkage disequilibrium and resampling. A separate descriptive extension included 255 Simons Genome Diversity Project participants but did not constitute independent replication. The four-estimate screening rule retained 231 conditional candidates: 49 in IGH and 182 in IGL, with none in IGK. Of these, 177 matched GTEx significant-eQTL catalogs, and seven coordinates overlapped 18 GWAS Catalog records. At rs2856876, the observed alternate-allele frequency was 70.04% in East Asian and 13.65% in European samples; annotations included an IGLV4-69 expression association and a protein-level trait with the same gene label. This correspondence identifies a question for molecular follow-up, not cross-assay validation. High-FST candidates were not consistently more likely to appear in GTEx catalogs than variants in supported local backgrounds. Local assembly-call disagreement, LD dependence and SGDP population composition further constrained interpretation. The resource connects conditional population differences with specific expression and molecular-trait records for follow-up studies of antibody variation.

PMID 42938332
阅读全文 →
PubMedBiomedicines2026-10-27

Thermal Analysis in the Diagnostics of Inflammatory and Septic Conditions.

Lőrinczy Dénes D, Bogdán László L, Pillér Árpád Á, Dandé Árpád Á et al.

Background/Objectives: Differentiating between inflammatory and septic purulent processes in the human body remains difficult today. A number of research techniques have emerged recently, and calorimetric investigations have shown promise in the study of malignancies and inflammatory and septic diseases. The purpose of our review article is to present and summarize the potential applications of calorimetric measurements in the study of human inflammatory and septic disorders. Methods: For calorimetric measurements, a small volume of liquid (blood plasma, synovial fluid) or tissue sample is sufficient. The thermal data and denaturation curve obtained during the calorimetric procedure performed by a differential scanning calorimeter (DSC) show the structural changes in the proteins of the examined sample. The thermograms and the calculated thermal values (∆Hcal, calorimetric enthalpy, Tm melting or denaturation temperature) can demonstrate the unique variation and characteristics of the studied pathologies. These calorimetric procedures have recently been referred to as thermal liquid biopsy (TLB). Results: With the help of proliferation thermograms provided by isothermal calorimetric measurements (IMCs), it is also possible to detect bacteria present in low concentrations in different samples. Based on the literature and on our workgroup's data, calorimetric analyses have been successfully applied in the differential diagnosis of numerous human inflammatory diseases (psoriasis, systemic lupus erythematosus, synovitis) and septic conditions (septic arthritis, periprosthetic joint infection, fracture related joint infection). Conclusions: Considering the advantages of the technique, calorimetric analyses could serve as a complementary method in the clinical diagnostics of septic conditions in the future.

PMID 42940096
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多polyvalent human immunoglobulin (liquid)