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Uralyt-K

✓ Approved

Rottapharm Madaus · 小分子 · 小分子

什么是 Uralyt-K？

Uralyt-K 是一种小分子，由Rottapharm Madaus研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

公司Rottapharm Madaus
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Rottapharm Madaus

治疗适应症

Uralyt-K 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Renal and urinary disordersCalculus urinary✓ Approved

相关研究文献

PubMedPolymers2026-10-27

Architecture-Specific Performance of Silica and MWCNT Modified Hybrid Epoxy Laminates Under Mechanical Loading and Fracture.

Bashir Muhammad Tariq MT, Naseem Khawaja Atif KA, Khan Atif A, Sadiq Muhammad Rehan MR et al.

Hybrid fiber-reinforced epoxy laminates integrate macroscale fiber architecture with nanoscale matrix modification. The effects of nanofillers cannot be isolated from laminate architecture when both variables are altered simultaneously. This study independently evaluated silica-modified Kevlar/basalt/alkali-resistant glass (K/B/ARG), silica-modified Kevlar/carbon/alkali-resistant glass (K/C/ARG), and multi-walled carbon nanotube (MWCNT)-modified Kevlar/glass/carbon (K/G/C) laminates. Each laminate family incorporated 0, 1.5, 3.0, 4.5, or 6.0 wt.% nanofiller. Mechanical performance was assessed using tensile, flexural, interlaminar-shear, quasi-static puncture, punch-shear, impact, and energy-absorption tests. Scanning electron microscopy (SEM) was employed to examine fracture morphology, and selected K/C/ARG laminates underwent thermogravimetric analysis (TGA/DTG). For each architecture, 4.5 wt.% nanofiller yielded the highest mean values for most measured responses. At this concentration, K/B/ARG achieved 167.93 ± 5.71 MPa tensile strength, 112.09 ± 3.70 MPa puncture strength, and 1598.1 ± 73.5 J/m Izod impact strength. K/C/ARG achieved 171.95 ± 5.50 MPa tensile strength, 7710 ± 285.3 N puncture load, and 1813.6 ± 79.8 J/m Izod impact strength. K/G/C achieved 215.58 ± 7.76 MPa tensile strength, 28.49 ± 1.20 MPa interlaminar-shear strength, 110.80 ± 5.54 MPa punch-shear strength, and 15.45 ± 0.77 J net energy absorption. Several matrix-sensitive responses declined at 6.0 wt.%, while K/G/C flexural strength remained nearly constant. SEM revealed greater matrix retention and more uniform damage distribution at intermediate nanofiller loading but clustered weak regions at 6.0 wt.%. Single-run TGA indicated a higher principal DTG temperature and greater residue for the 4.5 wt.% K/C/ARG formulation; however, replication is necessary. The convolutional neural network (CNN) analysis was constrained by the limited number of formulation levels, target leakage, and the absence of independent validation. Consequently, 4.5 wt.% is identified as the best-performing tested concentration within each architecture, rather than a universal optimum. Additional durability, fire, and structural-scale testing is required before these laminates can be considered for building design, resilient infrastructure, or sustainable construction.

PMID 42942585
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PubMedMicroorganisms2026-10-27

Phenotypic and Molecular Characterization of Klebsiella pneumoniae Species Complex Isolates from Clinically Healthy Poultry, with Identification of Novel K. quasipneumoniae ST9812.

Karacan Sever Nurdan N, Şahan Yapıcıer Özlem Ö, Sarıçam İnce Seyyide S

This cross-sectional, culture-based study aimed to recover Klebsiella pneumoniae species complex (KpSC) isolates from fecal samples collected from clinically healthy chicken and turkey flocks in Diyarbakır, Türkiye, and to characterize the sequence-confirmed isolates. A total of 419 fecal samples from small-scale, family-operated farms were examined. Presumptive isolates were screened by MALDI-TOF MS and confirmed by 16S rRNA and rpoB gene sequencing. Antimicrobial susceptibility testing, phenotypic ESBL and carbapenemase assays, targeted PCR detection of resistance- and virulence-associated genes, multilocus sequence typing (MLST), and phylogenetic analyses were performed. Six KpSC isolates were confirmed from the 419 samples examined (6/419, 1.43%): K. pneumoniae (n = 4), K. quasipneumoniae (n = 1), and K. variicola (n = 1). All six were resistant to ampicillin, amoxicillin, and enrofloxacin; two were multidrug-resistant, and one showed an ESBL phenotype. No carbapenemase phenotype or targeted carbapenemase genes were detected. intI1 and blaSHV were each detected in four isolates, while wabG and entB were present in all isolates. MLST identified six distinct sequence types, one of which, K. quasipneumoniae ST9812, was novel and associated with the novel rpoB allele 593, while one turkey-origin K. pneumoniae isolate belonged to ST15. These findings demonstrate phenotypic and molecular diversity among poultry-origin KpSC isolates and provide a basis for broader genomic investigation of their epidemiological significance.

PMID 42943379
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PubMedNeurological research and practice2026-10-27

Sequential decision-making in endovascular stroke therapy: benefit and harm of the next retrieval attempt after failed reperfusion.

Meucci Luca L, Meyer Lukas L, Broocks Gabriel G, Bechstein Matthias M et al.

After failed reperfusion in endovascular thrombectomy (EVT), interventionalists must outweigh the expected benefit of an additional retrieval attempt with the outcome of the current angiographic result. Framing EVT as an infinite-horizon optimal stopping problem, the present study provides a per-pass evaluation of the expected benefit of EVT continuation versus procedural termination after unsuccessful reperfusion, based on large-scale real-world registry data. Patients from the German Stroke Registry - Endovascular Treatment (GSR-ET) between 2015 and 2023 were screened. Inclusion criteria were (1) age ≥ 18 years, (2) anterior circulation LVO, (3) 1-15 retrieval attempts and (4) availability of relevant clinical data. Primary endpoint was the rate of good functional outcome, defined as modified Rankin Scale (mRS) score 0-2 at 90 days. For each retrieval attempt, patients were stratified into successful reperfusion (mTICI 2b-3) and persistent occlusion (mTICI 0-2a). The net expected benefit of EVT continuation, Δ(k), was defined as the difference between the mRS 0-2 rate at pass k + 1, and the mRS 0-2 rate for unsuccessful reperfusion at pass k. A positive Δ(k) indicates that continuation is favored at that decision node k. The pass at which Δ(k) first becomes non-significant identifies the empirical, optimal stopping threshold. Among 9,495 included patients, successful reperfusion (mTICI 2b-3) was achieved in 8,405 (89%), and 3,428 (36%) achieved good functional outcome at 90 days. Up to six retrieval attempts, Δ(k) was positive and statistically significant (p < 0.05), indicating that continuation of EVT was associated with superior expected outcome at each of these decision points. At pass seven, Δ(k) became negative and lost statistical significance (p = 0.53), identifying this as the empirical optimal stopping threshold. Continuation of EVT up to six retrieval attempts confers a significant functional benefit over termination after unsuccessful reperfusion. These findings provide a decision-theoretic basis for individualized intraprocedural decision-making and suggest that functional independence can be achieved beyond conventionally assumed pass thresholds.

PMID 42934769
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PubMedDiagnostics (Basel, Switzerland)2026-10-27

Quadrilateral Segmental Analysis (QSA): A Calibration-Free Geometric Method for Detecting Lumbar Spondylolisthesis.

Szczepański Tomasz T, Jasiński Michał M, Koźba-Gosztyła Marta M, Więcław Jakub J et al.

Background/Objectives: On standing lateral radiographs, millimetre measurements of vertebral slip depend on magnification and calibration; slip percentage is scale-free but is usually reported in coarse Meyerding grades. In this exploratory derivation study, we introduce quadrilateral segmental analysis (QSA), a calibration-free geometric method for detecting anterolisthesis. Methods: In 50 patients with degenerative spondylolisthesis from the PROGRES cohort, a blinded observer drew the L1-S1 superior endplate lines on standing radiographs; an automated pipeline computed the diagonal ratio K and the posterior angles of each quadrilateral formed by adjacent lines. The annotation was performed by a single observer; its reproducibility was not assessed, and its sensitivity to annotation error was simulated. The reference standard was an adjudicated two-radiologist classification (κ = 0.916). Segments outside the anterior-translation domain (negative shear; n = 90) were not graded further; the remaining 160 were analysed with patient-cluster bootstrap and leave-one-patient-out validation. Results: Anterolisthesis was present in 54 of 160 segments (33.8%). K discriminated well (area under the curve [AUC] 0.892, 95% CI 0.841-0.937): K ≤ 0.85 supported a slip (specificity 99.1%), and K > 0.95 argued against it (sensitivity 100%; smallest reference-positive slip 9%). Rounded to one decimal, K assigned 46.9% of segments to extreme tiers without observed misclassification. With the lower posterior angle N ≤ 93° in the intermediate tier, the two-step rule reached 94.4% sensitivity and 95.3% specificity, unchanged under nested leave-one-patient-out validation. Simulated endpoint errors of 0.5-1.0 mm changed the two-step classification in 5-13% of segments (ICC 0.74-0.92 for K and 0.85-0.96 for N). Conclusions: Calibration-free QSA parameters discriminated reference-positive from reference-negative segments in patients with degenerative spondylolisthesis. K (the diagonal ratio) translates the radiologist's assessment of anterolisthesis into a single number. These exploratory findings, which do not establish performance for small or borderline slips, require replication in independent cohorts and by other observers before the thresholds can be applied clinically.

PMID 42938131
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PubMedVeterinary sciences2026-10-27

Temperature Distribution and Vertical Stratification near Side-Wall Inlets of Stacked Cage Broiler Houses in Winter.

Wei Yongxiang Y, Li Wenjia W, Sun Quanyou Q, Li Shaoyu S et al.

Inlet design assumes that supply air from side-wall inlets mixes with house air over several metres, but whether this holds in a densely caged multi-tier house, where cages and birds obstruct the jet, is untested. The bird-zone environment of a commercial stacked-cage house was measured with 24 in-cage sensors at three distances and two tiers over ten winter days. Three of four groups showed no resolvable cooling gradient at 1.5 m; only one north-side group cooled with distance, strengthening with ventilation (0.30 K per percent, R2 = 0.39), while another showed the opposite sign. Every fitted decay coefficient (αdh=0 to 0.004) lay below the free-jet design range (0.01-0.03), by five or more times over the window. Vertical stratification of 0.78 K dominated (side × tier p<0.001): the upper tier was up to 2.4 K warmer on the north side, while the south-side tiers differed by under 0.5 K. Shading nets lowered north-side inlet temperature by 0.80 K but warmed the south side. The practical consequence is that the thermal environment is organised by tier and side rather than by near-inlet distance, so monitoring, control and welfare-oriented assessment should target tiers and sides.

PMID 42944197
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PubMedJournal of the American Chemical Society2026-10-27

Covalency-Driven Framework Contraction Weakens the Coupling Between Charge and Phonon Transport in Tunnel-Type TlCu5Se3.

Wu Yi Y, Lin Chen-Sheng CS, Li Ying-Qi YQ, Yang Shun-Da SD et al.

Framework thermoelectrics are promising for decoupling charge and phonon transport, yet a general structural strategy for simultaneously enhancing carrier mobility and suppressing lattice thermal conductivity (κL) remains unclear. Here, a comparative survey of representative layered, tunnel-type, and cage-like framework thermoelectrics reveals an empirical trend within an isomorphic family: reduced unit-cell volume is generally accompanied by enhanced apparent weighted mobility (μw) and power factor (PF), whereas κL shows no corresponding dependence on unit-cell volume. This weakened coupling suggests that framework contraction is a promising method for achieving excellent thermoelectric performance. Among tunnel-type thermoelectric materials MCu5Se3 (M = Tl, K, Cs), TlCu5Se3 with the smallest volume is selected to verify this strategy. Owing to the enhanced covalent character of Tl-Se interactions relative to nearly ionic K-Se and Cs-Se bonds, TlCu5Se3 exhibits an anomalously contracted Cu-Se framework despite the larger ionic radius of Tl+ than K+. This relative Tl-Se covalency contracts and moderately reinforces the Cu-Se framework, modifies Cu-Se orbital overlap and the valence-band-edge structure, and thereby provides a structural contribution favorable to carrier transport. Meanwhile, because the Tl-Se interaction remains weak and soft in absolute strength, heavy Tl+ cations with stereochemically active 6s2 lone pairs generate low-frequency localized vibrations and strong anharmonicity, efficiently scattering heat-carrying phonons. Consequently, TlCu5Se3 achieves an ultralow κL of 0.27 W m-1 K-1 and a PF of 9 μW cm-1 K-2 at 750 K, yielding ZT ≈ 1.9. These findings establish covalency-driven framework contraction combined with lone-pair-induced phonon scattering as an effective route for high-performance framework thermoelectrics.

PMID 42937986
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