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Uralyt-K

✓ Approved

Rottapharm Madaus · 小分子 · 小分子

什么是 Uralyt-K？

Uralyt-K 是一种小分子，由Rottapharm Madaus研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

公司Rottapharm Madaus
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Rottapharm Madaus

治疗适应症

Uralyt-K 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Renal and urinary disordersCalculus urinary✓ Approved

相关研究文献

PubMedMaterials horizons2026-09-10

Tunable A-site crystal-field modulation enables ultra-sensitive, multi-channel lanthanide thermometry in low-phonon halide lattices.

Xin Yuxiang Y, Wang Jianru J, Xiao Xiachu X, Yang Yutao Y et al.

The development of high-performance lanthanide-based fluorescence-intensity-ratio (FIR) thermometers is limited by the lack of a continuously tunable, qualitative guided crystal-field design principle. Most systems still rely on empirical host-dopant screening, and the correlation among lattice geometry, crystal-field strength, energy gap (ΔE), and thermometric sensitivity (Sr) remains unclear. Here, we establish an A-site lattice-site engineering strategy in APb2Cl5 (A = Na, K, Rb, Cs and solid solutions), where the A-site ionic radius acts as a single tunable parameter to regulate local geometry, crystal-field strength, and ΔE. Mapping from Na+ to Cs+ identifies an optimal K-Rb-Cs regime enabling linear tuning of ΔE and Sr, while excessive lattice contraction near the Na boundary suppresses luminescence and disrupts thermal coupling, revealing that ΔE enhances Sr only within a finite, lattice-defined window. Owing to the ultra-low phonon energy of the Pb-Cl lattice, Er3+/Yb3+-doped KPb2Cl5 nanoparticles (NPs) exhibit strong upconversion (UC), including the 490 nm 4F7/2 band, and achieve record Sr values of 33.6% K-1 at 78 K and 2.3% K-1 at 298 K, enabling cross-validated thermometry from 78-418 K. Extending this framework to Nd3+ enables 808 nm excitation and visible/near infrared (NIR) dual-mode thermometry with Sr up to 21.7% K-1. This work establishes a general route for high-performance optical nanothermometers.

PMID 42720040
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PubMedThe Plant cell2026-09-10

MdKIM1-MdMYB306 enhances apple resistance to Cytospora mali via brassinosteroid biosynthesis under sufficient potassium status.

Wang Yan Y, Du Youwei Y, Qi Hua H, Zhang Shuang S et al.

Potassium (K) supplementation enhances apple (Malus ×domestica) resistance to Cytospora mali, thereby reducing apple Cytospora canker occurrence in the field. Nevertheless, the molecular mechanisms underlying this K-enhanced resistance remain largely unelucidated. Here, we found that brassinosteroid (BR) biosynthesis was active in apple tissues under sufficient K (SK) conditions, resulting in an elevation of brassinolide (BL), the bioactive BR. Exogenous BL application under low K (LK) conditions restored apple resistance in both detached branches and field-grown trees, while the BR inhibitor brassinazole (BRZ) attenuated SK-dependent resistance. Notably, BR biosynthetic gene MdBR6ox2 was upregulated under SK conditions. Silencing of MdBR6ox2 reduced BL content and consequently compromised resistance to C. mali in SK apple calli. Furthermore, we identified that MdMYB306 is responsible for transactivating MdBR6ox2 expression via binding to the MBS cis-element in its promoter. Gene function analysis confirmed the positive role of MdMYB306 in regulating BR biosynthesis. Importantly, K supplementation facilitated the recruitment of MdKIM1, which interacts with MdMYB306 and induces conformational changes in MdMYB306, and enhances its transactivation capacity toward MdBR6ox2. Genetic evidence confirmed the importance of the MdKIM1-MdMYB306 module in initiating BR biosynthesis and increasing resistance in apple under SK status. Collectively, our findings uncovered a MdKIM1-MdMYB306-MdBR6ox2 module that promotes BR accumulation under SK conditions, providing a promising strategy for managing Cytospora canker via combined application K and BR.

PMID 42717807
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PubMedCureus2026-09-10

Histomorphological and Immunohistochemical Subtyping of Ampullary Adenocarcinoma and Its Association With Survival Status: An Ambispective Observational Study.

Goyal Namisha N, Giri Ranjana R, Pradhan Prita P, Sahu Subrat S

Periampullary adenocarcinoma (PAC) is a rare and unique malignancy arising from structures around the ampulla. Based on the histomorphology, two common subtypes include pancreatobiliary (PB) and intestinal (INT), which have therapeutic and prognostic significance. There are limited studies that highlighted the magnitude of interobserver variability in subtyping. The aims of the study were primarily to assess the morphologic and IHC expression of CK7, CK20, and CDX2 to differentiate between pancreatobiliary and intestinal types of PAC and secondarily to compare the subtype with pathological grade, stage, lymph node status, lymphovascular invasion, and survival status. This was an ambispective study of six years' duration, including prospective cases from June 2022 to May 2024 (two years) and retrospective cases from January 2018 to May 2022 (four years) in the Department of Pathology, Kalinga Institute of Medical Sciences (KIMS) and Pradyumna Bal Memorial Hospital (PBMH), Bhubaneswar. All pancreaticoduodenectomy specimens received for adenocarcinoma were included in the study. The histomorphologic features were studied and documented. The cases were sub-classified as PB and INT based on standard criteria. Discrepant cases were reviewed for consensus morphology (CM). CK7 was used as a marker for PB type, while CK20 and CDX2 were used for INT type. The CM and immunomorphologic subtype (IMS) were studied and documented. Statistical tools like correlation analysis and comparative analysis were used in the study. A total of 33 pancreaticoduodenectomy specimens were received during this period. Our study comprised subjects belonging to 32 to 74 years with a mean age of 55.9 years, including 19 males (57.6%) and 14 females (42.4%). Histomorphological subtyping was done by two different observers as per the criteria, which showed slight agreement in architecture (k = 0.2), desmoplastic stroma (k = 0.1), luminal necrosis (k = 0.2), and presence of goblet cells (k = 0.1); however, no agreement was observed in cytomorphology (k = -0.2) and nuclear features (k = -0.2). Interobserver variation was noted in 51.5% cases (17/33) with no agreement between the observers (k = 0.1, p = 0.6). IMS showed a significant moderate degree of agreement with the diagnosis made on CM (k = 0.6, p ≤ 0.001). With optimal sampling, the use of CM along with adjunct immunohistochemistry to recognize the IMS, accurate classification of PAC is possible in most cases, which has therapeutic and prognostic significance.

PMID 42719869
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PubMedFrontiers in aging neuroscience2026-09-10

Two serial MoCA assessments may support biomarker-sparing triage between Parkinson's disease/Lewy body dementia and frontotemporal dementia: a progressive inclusion analysis of 1,129 participants.

Lin Wei W, Grewal Sanjeet S SS, Byrne Richard W RW

Reliable differentiation of Parkinson's disease/Lewy body dementia (PD/LBD) from frontotemporal dementia (FTD) affects treatment strategy and clinical trial eligibility, yet confirmatory biomarker testing remains costly and unevenly available. Whether routine cognitive trajectories can support testing prioritization has not been systematically quantified. We performed a progressive inclusion analysis of 1,129 National Alzheimer's Coordinating Center participants with PD/LBD (n = 385) or FTD (n = 744) to determine the minimum number of serial Montreal Cognitive Assessment (MoCA) administrations required for diagnostic separation. Random forest classifiers used seven MoCA subdomain slopes from the first k chronological assessments (k = 2 through k = 8), with five-fold stratified cross-validation and 500-iteration bootstrap confidence intervals. In the primary full-cohort analysis, two assessments yielded AUC = 0.785 (95% CI 0.757-0.814; sensitivity = 0.922; specificity = 0.525). The interval-restricted 6-12 month subset yielded AUC = 0.837 (95% CI 0.787-0.885), near the lower edge of published biomarker-panel ranges in an indirect comparison, although its lower confidence bound remained below 0.85. Discrimination persisted after age matching (AUC = 0.794, 95% CI 0.761-0.826; residual age gap = -0.3 years) and age restriction to 55-75 years (AUC = 0.777, 95% CI 0.741-0.814). Age alone yielded lower discrimination (AUC = 0.721, 95% CI 0.691-0.751) than MoCA slopes, while slopes plus age yielded AUC = 0.867 (95% CI 0.845-0.888). Four-assessment performance was AUC = 0.831 (95% CI 0.791-0.873), consistent with an apparent sample-size-limited plateau as eligible N contracted from 391 at k = 4 to 98 at k = 6. These findings support serial MoCA trajectory analysis as an exploratory tool for prioritizing confirmatory diagnostic testing, with age sensitivity, subtype sensitivity, and operating-point performance quantified.

PMID 42718894
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PubMedActa physiologica (Oxford, England)2026-09-10

Impaired Hepatic Glucose Metabolism Is Associated With Glucose Intolerance in Mice Carrying α2 Isoform Na,K-ATPase Mutation.

Staehr Christian C, Nguyen Tue Duy TD, Pedersen Tina Myhre TM, Vendelbo Mikkel M et al.

The Na,K-ATPase is important for energy demanding cellular processes, including essential components of substrate metabolism and metabolic flexibility. Mice heterozygous for the hemiplegic migraine-related mutation, G301R, of the Na,K-ATPase α2 isoform (α2 +/G301R) demonstrated altered metabolism in the heart. We hypothesized that mitochondrial dysfunction in α2 +/G301R mice is associated with abnormal systemic glucose metabolism. 3- and 8-month-old α2 +/G301R and wild type (WT) mice of both sexes were metabolically phenotyped. Glucose uptake in peripheral tissues was assessed by [18F]-2-fluoro-2-deoxyglucose (FDG) MRI. Mitochondrial function in liver was assessed with high-resolution respirometry. Protein expression was assessed by proteomics and Western blot. Glycated hemoglobin (HbA1c) was measured with immunoassay. The 3-month-old α2 +/G301R mice had normal responses to glucose tolerance test, but males showed a reduced insulin response. The 8-month-old α2 +/G301R mice exhibited glucose intolerance associated with impaired glucose uptake in the liver while unaltered in skeletal muscle associated with unchanged GLUT-4 and insulin receptor levels. Insulin secretion and insulin sensitivity were similar between 8-month-old genotypes. In the liver, 8-month-old α2 +/G301R mice of both sexes showed reduced expression of the α2 Na,K-ATPase and several key mitochondrial proteins from the electron transport chain. Accordingly, mitochondrial oxygen consumption was reduced in 8-month-old α2 +/G301R males, and 8-month-old α2 +/G301R females showed a complex I-mediated dysfunction in the liver mitochondria. Migraine-associated mutation of the Na,K-ATPase α2 isoform was associated with impaired mitochondrial respiratory capacity in the liver. Hence, α2 +/G301R mice exhibited reduced capacity of ATP-demanding metabolic pathways in the liver resulting in age-dependent impaired glucose homeostasis.

PMID 42717423
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PubMedPhysical chemistry chemical physics : PCCP2026-09-10

Spin states of myoglobin heme iron in aqueous solutions at room temperature probed from porphyrins using nitrogen K-edge X-ray absorption spectroscopy.

Sugimoto Yasunobu Y, Tsuru Shota S, Nagasaka Masanari M

The porphyrin CN π* peaks of myoglobin heme iron in aqueous solutions at room temperature were observed using nitrogen K-edge X-ray absorption spectroscopy (XAS), which enabled separation from the protein polypeptide peaks. The spin states of the heme iron were investigated by interpreting the CN π* peaks through inner-shell calculations. Oxymyoglobin, in which an Fe2+ ion is connected to an oxygen molecule, is in the S = 0 state. By contrast, deoxymyoglobin with an Fe2+ ion shows spin equilibrium between the S = 2 and 1 states, while metmyoglobin with an Fe3+ ion coordinated to a water molecule shows spin equilibrium between the S = 5/2 and 3/2 states. This study proposes that N K-edge XAS measurements of porphyrins are effective for determining the spin equilibrium of heme proteins, which is influenced by liquid temperature and protein structure.

PMID 42720097
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