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Hoe-285 (Hoe 285 / Brainorm / Albex 285)

✓ Approved

Sanofi S.A · 小分子 · 小分子

什么是 Hoe-285？

Hoe-285 是一种小分子，由Sanofi S.A研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)、Oral (PO)。

药物档案

商品名Hoe 285, Brainorm, Albex 285
公司Sanofi S.A
药物类别小分子
给药途径Injectable (Others), Intravenous (IV), Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Sanofi S.A

治疗适应症

Hoe-285 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersDelayed ischaemic neurological deficit✓ Approved

相关研究文献

PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Molecularly Engineered Nitrate Double Perovskites with Elevated Ferroelectric Phase Transition Temperature and Large Piezoelectric Response.

Ye Le L, Hu Guang-Yuan GY, Duan Yarou Y, Lin Yutong Y et al.

Conventional ABX3 perovskites place organic species at A-sites or as X-site linkers, where the B-site is reserved for metals. Molecular double perovskites with a general formula A2BIBIIIX6 possess higher tunability and distinct BI-sites that can accommodate small cations, further regulating lattice connectivity and physical properties. Here, we introduce a new family of BI-site-organic nitrate double perovskites, (RM3HQ)2BIEu(NO3)6 (RM3HQ = (R)-N-methyl-3-hydroxyquinuclidinium), forming compounds 1-4 with BI = ammonium, methylammonium, formamidinium, and dimethylammonium, respectively. Compounds 1 and 2 adopt mixed corner-/face-sharing non-perovskite structures, whereas 3 and 4 form double perovskites. This structural variation raises the ferroelectric phase-transition temperature to 349 K in 4 and 414 K in 3, much higher than that of the inorganic analogue (Tc = 285 K). This further widens the temperature margin for stable room-temperature piezoelectric responses, as demonstrated in 3 by ferroelectric hysteresis loops, ferroelastic domains, and a large piezoelectric coefficient (|d33| ≈ 56 pC N-1). During these phase transitions, the Eu3+ photoluminescence intensity ratio (616 nm/ 592 nm) increases from 0.32 to 2.92 in 3 and from 0.37 to 4.59 in 4, reflecting transition-related changes in the ligand field. This work highlights the BI-site as an effective handle for tuning ferroelectric phase-transition temperatures and tunable Eu3+ photoluminescence.

PMID 42929189
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PubMedEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2026-10-25

Endoscopic and histopathologic findings in adults with iron deficiency anemia: the role of age.

Karabulut Ümit Ü, Ökmen Tekeş Şerbet Ş, Eser Mehmet M, Çelik Mehmet Ali MA et al.

Iron deficiency anemia may signal underlying gastrointestinal pathology in adults. This study aimed to evaluate endoscopic and histopathological findings in adults undergoing upper gastrointestinal endoscopy and colonoscopy for iron deficiency anemia and to compare selected lesion frequencies between age groups. This retrospective study included 328 adult patients who underwent upper gastrointestinal endoscopy for iron deficiency anemia between January 2024 and December 2025; 285 also underwent colonoscopy. The mean age was 61.2 ± 14.8 years, and 62.5% of patients were male; 64.3% were older than 50 years. Pangastritis (30.5%) and antral gastritis (23.8%) were the most common upper gastrointestinal findings. Among biopsied patients, Helicobacter pylori positivity was 54.2%, intestinal metaplasia 14.6%, and atrophic gastritis 7.5%. On colonoscopy, hemorrhoids were most common (32.3%), followed by colonic polyps (24.6%); colorectal adenocarcinoma was found in eight patients (2.8%), all older than 50 years. Tubular adenoma with low-grade dysplasia was the most frequent polyp histopathology. Gastric polyps (P = 0.013) and colonic polyps (P = 0.041), which were not uniformly subclassified histologically, were significantly more frequent after age 50, whereas intestinal metaplasia (P = 0.051) and colorectal cancer (8/190 vs. 0/95; P = 0.055) did not differ significantly between age groups. In this descriptive, single-group cohort, bidirectional endoscopy identified premalignant and malignant lesions in adults with iron deficiency anemia. As no nonanemic control group was included, these findings describe the diagnostic yield within this population and do not establish the clinical benefit of combined endoscopic evaluation.

PMID 42924863
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PubMedEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2026-10-25

Minimised SARS-CoV-2 transmission during Tokyo 2020 Olympic and Paralympic Games: insights from enhanced integrated surveillance, Japan, July to September 2021.

Fukusumi Munehisa M, Tsukada Keiko K, Otani Kanako K, Yamauchi Masato M et al.

BACKGROUNDAmid the COVID-19 pandemic, stringent public health measures were taken during the Tokyo 2020 Olympic and Paralympic Games (Tokyo 2020).AIMWe describe SARS-CoV-2 transmission among Games participants and in-person contributors (GPIPC)s.METHODSTokyo 2020-related SARS-CoV-2 infection cases were individuals linked to the event, testing positive for the virus between 1 July-19 September 2021, reported to the Tokyo Metropolitan Government. Attack rates among athletes and team officials were determined. Enhanced case-based surveillance integrating genomic sequencing data supported viral spread investigations among various GPIPC groups.RESULTSA total 804 cases (median age: 35 years, interquartile range (IQR): 27-45; 194 female/610 male) were reported. Among athletes and team officials, attack rates were 0.6% (65/11,400) in Olympic Games and 0.6% (30/4,800) in Paralympic Games. These 95 infections concerned mainly overseas travellers (n = 92), 85 of whom were diagnosed within 14 days of arrival in Japan. Among the 804 cases, whole-genome sequencing data were obtained for 304 (median age: 38 years, IQR: 29-47; 67 female/237 male) with sufficient viral load (as indicated by RT-PCR Cq ≤ 32), including 79% (75/95) of athletes and team officials cases, 74% (131/176) of Games' organisers and media cases, and ˂ 20% (98/533) of remaining cases. Delta variants dominated (94%; 285/304), with domestic (AY.29 lineage) Delta strains prominent among Delta-variant-affected resident cases (96%; 104/108) and Games' organisers and media cases diagnosed ≥ 15 days after entering Japan (97%; 63/65). Overseas Delta strains mostly affected travellers within 14 days of entry, particularly athletes and team officials (97%; 66/68) and Games' organisers and media (29/34).CONCLUSIONMultilayered-risk-reduction measures likely minimised SARS-CoV-2 transmission to athletes.

PMID 42921684
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PubMedPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026-10-25

The vitality infant algorithm: A validated tool to classify food allergy outcomes in research studies.

Odoi Alexsandria A, Koplin Jennifer J JJ, Soriano Victoria X VX, Parker Kayla M KM et al.

Food allergy algorithms provide a systematic approach to assigning food allergy outcomes in research studies when oral food challenges (OFC) are not performed. Currently no such algorithms validated for infants exist. We aimed to develop and validate a research algorithm for classifying infant food allergies. An algorithm incorporating skin prick test (SPT), allergen ingestion, and reaction data was developed and validated by comparing peanut, cashew, egg, and cow's milk algorithm outcomes to OFC outcomes in infants from the Vitality (n = 285) (NCT02112734), EarlyNuts (n = 111) (ACTRN12618001990213), and HealthNuts (n = 191) studies. Validation included 740 OFCs from 587 infants (191 SPT-negative [0 mm] and 396 SPT-positive [≥1 mm] infants; first-OFC median age: 14.4 months). The algorithm assigned all SPT-negative infants as tolerant, achieving 99.5% agreement with OFCs (peanut 100% [n = 135/135]; egg 98.2% [n = 55/56]). The algorithm assigned an allergic or tolerant outcome to 65% (93/144) of peanut SPT-positive, 38% (41/108) cashew SPT-positive, 81% (n = 209/258) egg SPT-positive, and 90% (n = 35/39) milk SPT-positive infants. Agreement with OFC was 81% (n = 75/93) for peanut, 88% (n = 36/41) for cashew, 88% (n = 184/209) for egg, and 97% (n = 34/35) for milk. Accuracy and areas under the curve (AUCs) were fair-to-excellent: peanut (AUC = 0.79 [95% confidence interval [CI]: 0.71-0.88]; sensitivity = 87% [95% CI: 75-95]; specificity = 72% [95% CI: 55-85]), cashew (AUC = 0.88 [95% CI: 0.77-0.98]; sensitivity = 84% [95% CI: 60-97]; specificity = 91% [95% CI: 71-99]); egg (AUC = 0.88 [95% CI: 0.81-0.94]; sensitivity = 88% [95% CI: 83-93]; specificity = 87% [95% CI: 70-96]); milk (AUC = 0.98 [95% CI: 0.94-1]; sensitivity = 96% [95% CI: 80-100]; specificity = 100% [95% CI: 69-100]). Using routinely collected data, this validated infant-focused food allergy algorithm performed well in classifying peanut, cashew, egg, and cow's milk allergies, offering applicability in research settings.

PMID 42922290
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PubMedZhonghua zhong liu za zhi [Chinese journal of oncology]2026-10-25

[Predictive value of dynamic contrast-enhanced magnetic resonance imaging features for the efficacy of neoadjuvant chemotherapy in breast cancer patients with non-mass enhancement].

Zhu Z J ZJ, Han Y Y, Yu H H, Sun L N LN

Objective: To analyze the potential predictive value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features for the efficacy of neoadjuvant chemotherapy in breast cancer patients with non-mass enhancement on MRI, and to analyze their correlation with patient prognosis. Methods: A total of 285 breast cancer patients with non-mass enhancement on MRI admitted to Shengjing Hospital of China Medical University between January 2021 and December 2023 were retrospectively included. All patients underwent neoadjuvant chemotherapy, and were divided into a pathologic complete response (pCR) group (n=132) and a non-pCR group (n=153) based on whether they achieved pCR after neoadjuvant chemotherapy. Differences in DCE-MRI features and other clinicopathological characteristics between the two groups were analyzed. Receiver operating characteristic (ROC) curves were used to determine the optimal cutoff values for different DCE-MRI feature parameters. Multivariate logistic regression models were employed to analyze factors influencing pCR after neoadjuvant chemotherapy in breast cancer patients, and multivariate Cox regression models were used to analyze factors influencing disease-free survival (DFS). Followed-up continued until November 2025, with a median follow-up duration of 41 months. Results: The ROC curves showed that the areas under the curve for the apparent diffusion coefficient (ADC) and rate constant (Kep) in predicting pCR in breast cancer patients with non-mass enhancement on MRI after neoadjuvant chemotherapy were 0.813 (95% CI: 0.765-0.860, P＜0.001) and 0.756 (95% CI: 0.702-0.811, P＜0.001), respectively. The optimal cutoff values were 0.895×10-3 mm2/s and 1.305 min-1, respectively. Lymph node metastasis (OR=0.382), triple-negative breast cancer (OR=0.396), ADC＜0.895×10-3 mm2/s (OR=0.189), and Kep＞1.305 min-1 (OR=0.281) were identified as adverse factors for pCR in breast cancer patients with non-mass enhancement on MRI after neoadjuvant chemotherapy (all P＜0.05). Multivariate Cox regression analysis revealed that an ADC＜0.895×10-3 mm2/s and Kep＞1.305 min-1 were independent risk factors for disease progression after neoadjuvant chemotherapy in breast cancer patients with non-mass enhancement. Patients with these DCE-MRI characteristics had significantly shorter disease-free survival (DFS), with hazard ratios (HRs) of 2.659 and 2.759, respectively (both P＜0.001). Conclusion: ADC and Kep are potential biomarkers for the efficacy and prognosis of neoadjuvant chemotherapy in breast cancer patients with non-mass enhancement.

PMID 42927952
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PubMedInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026-10-23

Respectful maternity care: A multinational survey of maternity care providers by the World Association of Trainees in Obstetrics and Gynecology.

Ubom Akaninyene Eseme AE, Mughal Mawrah M, Portilla Francisco Javier Ruiloba FJR, Ohachenu Chidinma Peace CP et al.

This study evaluates maternity care providers' knowledge, practice, and perspectives on respectful maternity care (RMC). A global cross-sectional online survey on RMC was conducted by the World Association of Trainees in Obstetrics and Gynecology (WATOG). A total of 458 maternity care providers from 48 countries across six global regions participated in the study. One in five providers (93, 20.3%) had never heard of RMC, and nearly half (223, 48.7%) had received no formal RMC training. Only 74 (16.2%) demonstrated good knowledge of the seven categories of maternal disrespect and abuse. There was no association between RMC knowledge and practice (P = 0.066). Despite 429 (93.7%) of respondents agreeing that RMC could improve feto-maternal outcomes, self-reported practices inconsistent with RMC were common, including verbal abuse (285, 62.2%), detention for unpaid bills and non-confidential care (262, 57.2%), discrimination (203, 44.3%), abandonment/denial of care (187, 40.8%), and physical abuse (119, 26.0%). The most frequently reported barriers to RMC implementation were time constraints owing to staff and resource shortages (361, 78.8%), inadequate training (356, 77.7%), lack of sanctions for disrespectful care (239, 52.2%), and restrictive cultural and religious norms (203, 44.3%). There are critical gaps in maternity care providers' knowledge and practice of RMC, despite widespread recognition of its importance for good feto-maternal outcomes. Institutionalized RMC education, adequate staffing and resources, strengthened institutional accountability and reporting mechanisms, and workplace cultures that prioritize patient dignity and autonomy are critical steps toward ensuring RMC for all women.

PMID 42908965
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