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Hoe-285 (Hoe 285 / Brainorm / Albex 285)

✓ Approved

Sanofi S.A · 小分子 · 小分子

什么是 Hoe-285？

Hoe-285 是一种小分子，由Sanofi S.A研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)、Oral (PO)。

药物档案

商品名Hoe 285, Brainorm, Albex 285
公司Sanofi S.A
药物类别小分子
给药途径Injectable (Others), Intravenous (IV), Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Sanofi S.A

治疗适应症

Hoe-285 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersDelayed ischaemic neurological deficit✓ Approved

相关研究文献

PubMedJapanese journal of ophthalmology2026-07-27

Microbial contamination of donor corneoscleral rims and storage medium in keratoplasty.

Fukuto Atsuhiko A, Deie Suzu S, Shimizu Yurie Y, Sakaguchi Hirokazu H et al.

To investigate the prevalence and spectrum of microbial contamination of donor corneoscleral rims and storage medium in keratoplasty and to report a case of donor-derived fungal keratitis. Single-center, retrospective study. We reviewed 285 eyes that underwent keratoplasty at Hiroshima University Hospital between October 2022 and January 2025. Donor corneas were preserved using Optisol®-GS. The donor rim and storage medium were separately cultured intraoperatively, and the minimum inhibitory concentrations (MICs) were determined. Culture positivity was identified in 10 of the 285 eyes (3.5%): six from donor rims and four from storage media, with no eye yielding positive results in both. All tested bacterial isolates were Gram-positive; three of six tested were not susceptible to levofloxacin and gatifloxacin (MIC ≥4 μg/mL), including methicillin-resistant Staphylococcus aureus, but retained susceptibility to vancomycin and meropenem. All fungal isolates were Candida with low MICs for voriconazole and micafungin. C. albicans and C. glabrata were recovered from the mate corneas of a single donor; the recipient of the cornea contaminated with C. albicans developed keratitis requiring repeat penetrating keratoplasty, whereas the recipient of the C. glabrata-contaminated cornea did not. Adding storage medium to the rim culture improved the detection of donor-associated microorganisms. When donor-derived C. albicans keratitis developed, susceptibility data from contemporaneous cultures enabled prompt targeted antifungal therapy and globe preservation, although repeated penetrating keratoplasty was ultimately required.

PMID 42507299
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PubMedGels (Basel, Switzerland)2026-07-27

Construction of PEGMC Copolymerized Modified Hydrogel and Its Mechanism for Salt Retardation and Nutrient Immobilization in Dryland Soil.

Cheng Jianwei J, Xiang Rui R, Liu Jingcai J, Yang Baocun B et al.

Aiming at severe soil secondary salinization, poor water retention and insufficient salt tolerance of conventional acrylic-based modifiers in arid and semi-arid regions of China, a poly(ethylene glycol) maleate citrate (PEGMC) crosslinking monomer was synthesized through esterification, and a dual covalent-hydrogen crosslinked P(PEGMC/AA) hydrogel was fabricated via free radical copolymerization with acrylic acid (AA). The hydrogel was characterized by NMR, FTIR, SEM, TGA and elemental mapping, while its binding mechanism with saline-alkali ions was elucidated through DFT calculations and molecular dynamics simulations. Its amelioration performance was evaluated through swelling, soil water retention, desalination and pot germination experiments. The hydrogel exhibited outstanding water absorbency, salt resistance and dry-wet cycling stability, with swelling ratios of 712 g/g in deionized water and 285 g/g in 0.9% NaCl solution, and remained 200 g/g after four dry-wet cycles. It enhanced soil water retention remarkably (over 93% after 72 h). At 0.30% dosage, soil salt content declined from 7.1 g/kg to 1.3 g/kg with desalination efficiency exceeding 80%, owing to porous physical adsorption and chemical chelation toward Na+, Ca2+ and Mg2+, with a binding energy of -136.936 kJ/mol. Pot tests revealed that crop germination rate rose from 19% (blank) to 75% under severe saline-alkali stress. Meanwhile, the hydrogel inhibited nutrient leaching and favored soil-water conservation. This work first incorporated PEGMC monomer into agricultural hydrogels to construct a stable dual crosslinked network, clarifying its synergistic mechanisms for salt fixation and water retention macroscopically and microscopically. It provides a promising functional material and theoretical basis for green, efficient in situ amelioration of dryland saline-alkali soil.

PMID 42505278
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PubMedDentistry journal2026-07-27

Socio-Economic Determinants of Access to Orthodontic Treatment: A Cross-Sectional Study in the Romanian Population.

Bunta Olimpia O, Jizdan Doina D, Chiciudean Gabriela Ofelia GO, Chiciudean Daniel Ioan DI et al.

Background: Malocclusion has important functional, esthetic, and psychosocial consequences; however, access to orthodontic treatment remains uneven and strongly influenced by socio-economic factors. While these disparities are well documented internationally, evidence from Romania remains limited. This study aimed to evaluate the influence of socio-economic factors on orthodontic treatment initiation within the Romanian population. Methods: A cross-sectional questionnaire-based study was conducted in 2025 using an online survey distributed through social media and community networks. A total of 285 adults were included. Data were analyzed using descriptive statistics, chi-square tests, and multivariable logistic regression. Results: Overall, 56.5% of respondents reported having undergone orthodontic treatment. Age and self-perceived information level were significantly associated with treatment initiation in the multivariable model. Participants older than 30 years were significantly less likely to have undergone orthodontic treatment compared with those aged 18-30 years (OR = 0.28, 95% CI: 0.12-0.62, p = 0.002). Higher levels of self-perceived information were associated with a greater likelihood of having undergone orthodontic treatment (OR = 0.75, 95% CI: 0.59-0.96, p = 0.020). Income and area of residence were not significantly associated with treatment initiation. However, respondents with lower income levels were significantly more likely to perceive treatment cost as a barrier to orthodontic care. Conclusions: Within this surveyed sample, age and self-perceived information level were independently associated with orthodontic treatment initiation. Although income was not associated with treatment uptake, financial cost remained an important perceived barrier, particularly among lower-income respondents. Given the convenience sampling strategy and limited representativeness of the sample, the findings should be interpreted as exploratory and require confirmation in larger population-based studies.

PMID 42505712
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PubMedThe Journal of dermatology2026-07-27

Assessment of Major Adverse Cardiovascular Event Across Diverse Racial Groups of Psoriasis Patients on Biologic Therapy: A Retrospective Cohort Study.

Ro Chunghwan C, Ormaza Vera Ana A, Adawi Waleed W, Enos Clinton W CW

Psoriasis is associated with an increased risk of major adverse cardiovascular events (MACE), and biologic therapy may reduce this risk by targeting systemic inflammation. However, limited data exist on whether long term MACE risk differs by biologic class or across racial groups. We conducted a retrospective cohort study to assess the risk of primary MACE in psoriasis patients receiving biological therapies, stratified by biological class, compared with biologic-naïve psoriasis patients. Whether MACE risk among biologic-treated patients varied by race was further examined. After 1:1 propensity score matching, 36 330 biologic-treated patients were compared with 36 330 non-biologic-treated patients. Incident MACE was assessed over 10 years. Class-specific analyses evaluated mutually exclusive biologic exposure groups, including TNF inhibitors (TNFi), IL-17 inhibitors (IL-17i), IL-12/23 inhibitors (IL-12/23i), and IL-23 inhibitors (IL-23i), each compared with an independently matched nonbiologic psoriasis comparator cohort. Race stratified analyses were restricted to biologic-treated patients, with White patients serving as the reference group. Psoriasis patients treated with biologics exhibited a 37% lower hazard of MACE compared with non-biologic users over the 10-year follow-up period [2160 vs. 3294; HR 0.63 (0.60-0.67)]. Class-specific analyses revealed reductions in MACE risk for TNFi [1403 vs. 1844; HR: 0.74 (0.69-0.80)], IL-17i [285 vs. 450; HR: 0.61 (0.53-0.72)], IL-12/23i [280 vs. 374; HR: 0.73 (0.62-0.86)], and IL-23i [238 vs. 363; HR: 0.64 (0.54-0.76)]. Race stratified analyses showed broadly similar MACE risk across racial groups; although, patients identifying as Non-White treated with TNFi did experience a reduced MACE risk compared to White patients [127 vs. 162; HR: 0.79 (0.62-0.99)]. This isolated finding should be interpreted cautiously given multiple race stratified comparisons. Overall, biologic therapy is associated with lower 10-year MACE risk among patients with psoriasis, with findings observed across biologic classes and largely consistent across racial strata.

PMID 42504065
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PubMedPediatric emergency care2026-07-27

Caregiver Health Information-Seeking Behavior During Pandemics, Disasters, and Emergencies Within Pediatric Advocacy and Health Care Networks.

Hong Eury E, Auerbach Marc M, Lee Danielle D, Talley Jennifer J et al.

Many caregivers of children face significant challenges accessing reliable health information during pandemics, disasters, and emergencies, which exacerbates health disparities. This study aimed to understand caregivers' information-seeking behaviors during emergencies, pandemics/disasters and explore their preferences to improve information dissemination during such events. An explanatory sequential mixed-methods approach was used to examine caregivers' information-seeking behaviors during pandemics, large-scale disasters, and/or individual medical emergencies. Recruitment (1/1/24 to 6/30/24) was through the Pediatric Pandemic Network (PPN), EMSC Family Advocacy Network (FAN), and Family Voices Affiliate Organizations (FVAOs). A 21-item survey assessed time spent seeking information, sources used, preferred sources, and barriers during past disasters and emergencies. A subset of respondents were invited to complete a qualitative phase involving semistructured interviews exploring caregivers' personal experiences navigating emergency situations and experience during COVID involving the children in their care. Interviews were recorded, transcribed, and inductive qualitative coding processes were followed iteratively until no new emerging themes, codes, nor discrepancies arose. A total of 285 responses where received to the quantitative survey (144 male, 138 female; 48 rural; 33 states; 88% with at least one child with special health care needs) with 73 screened and 40 completing interviews. Caregivers spent an average of 3.38 hours/week seeking health information. The most common sources were professional and institutional sources (relational) (30.2%) and personal and social networks (relational) (29.6%). A significant gap exists between current usage and preferred sources, particularly for professional and institutional sources (asynchronous) (+45.7%) and media and online learning sources (online relational) (+55.4%). Availability (13.0%, 10.8%) and cost (14.5%, 10.6%) were primary barriers for personal and professional relational sources, respectively. In contrast, those using the most preferred resources report fewer barriers: availability (4.9%), cost (5.6%), time (4.0%), and internet access (2.3%). During emergencies, pandemic, and disasters caregivers from established networks with a high representation of children with special health care needs often depend on real time, relational support for immediate needs. These caregivers strongly prefer professional and institutional sources (asynchronous) and media and online learning sources (online relational) for flexibility and reliability. A hybrid approach combining real-time professional access with asynchronous resources can more effectively meet these caregivers' diverse needs.

PMID 42504117
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PubMedNeurology international2026-07-27

Route-Specific Meningo-Ophthalmic and Orbitomeningeal Communications Relevant to Middle Meningeal Artery Embolization: A Systematic Review and Meta-Analysis.

Bruna-Mejias Alejandro A, Paez-Allendes Loreto L, Perez-Lira Valentina V, Santander-Chavez Diego D et al.

Meningo-ophthalmic and orbitomeningeal arterial communications comprise route-specific relationships between the middle meningeal artery (MMA) and the ophthalmic or orbital arterial system. Their recognition is relevant to middle meningeal artery embolization because orbital or ophthalmic collateral pathways may create routes for non-target embolization. This systematic review aimed to synthesize the prevalence and anatomical patterns of these communications, using quantitative pooling only where the anatomical definition and denominator were sufficiently coherent. This systematic review and meta-analysis were conducted according to PRISMA 2020 principles and registered in PROSPERO (CRD420261361050). Eligible studies were original human cadaveric anatomical, angiographic, or radiological investigations reporting MMA-ophthalmic or MMA-orbital arterial relationships. After the closure of the full-text retrieval audit, studies and extracted rows were audited by anatomical family, unit of analysis, numerator, denominator, and independence. No global pooled prevalence was calculated across anatomical families. When family-specific pooling was methodologically defensible, proportions were synthesized using logit transformation, restricted maximum likelihood random-effects models, and Hartung-Knapp confidence intervals. Database searches identified 558 records. After removal of 228 duplicates, 330 records were screened, and 285 were excluded by title and abstract. Forty-five reports were sought for retrieval; 10 were not retrieved or were not available as assessable full-text reports after retrieval auditing. Thirty-five full-text reports were assessed; thirteen were excluded for reasons, and three were duplicate reports at the full-text stage. Nineteen studies were included in the qualitative synthesis, and 12 contributed independent data to the final R-ready matrix. MMA arising from the ophthalmic artery was uncommon, with a pooled prevalence of 0.03 (95% CI 0.01 to 0.13; I2 = 75.9%). After excluding the clinically selected chronic subdural hematoma subgroup, the estimate was 0.02 (95% CI 0.01 to 0.06; I2 = 7.7%). The meningolacrimal/lacrimal-MMA route yielded an exploratory pooled proportion of 0.45 (95% CI 0.09 to 0.86; I2 = 95.9%), with substantial anatomical and methodological heterogeneity. The available evidence supports route-specific synthesis rather than a single global prevalence estimate. MMA arising from the ophthalmic artery appears uncommon but procedurally important; however, this estimate should be interpreted as a route-specific estimate across eligible angiographic/anatomical series rather than as a universal anatomical prevalence. Meningolacrimal and lacrimal-MMA routes are frequently described, but their prevalence remains difficult to generalize because detection methods, populations, and denominators differ across studies. Future anatomical and angiographic reports should standardize route definitions, laterality, unit of analysis, and denominator reporting to improve prevalence estimation and procedural safety interpretation.

PMID 42506050
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