Drug Database
ES

estrogens (Cenestin / Bijuva, Barr)

✓ Approved

Teva Pharmaceutical Industries Ltd. · ESR1

什么是 estrogens?

estrogens 是一种治疗药物,由Teva Pharmaceutical Industries Ltd.研发。该药已获批,用于治疗相关适应症,给药途径:Intravaginal、Oral (PO)。

药物档案

商品名Cenestin, Bijuva, Barr
公司Teva Pharmaceutical Industries Ltd.
分子靶点ESR1
给药途径Intravaginal, Oral (PO)
状态Approved

作用机制

分子靶点

estrogens 作用于 1 个分子靶点:

ESR1estrogen receptor 1 (ER, ESR)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

estrogens 针对 3 个适应症,涉及 2 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersAtrophic vulvovaginitis✓ Approved
Surgical and medical proceduresHormone replacement therapy✓ Approved
Reproductive system and breast disordersMenopausal symptoms✓ Approved

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PubMedChemical communications (Cambridge, England)2026-09-10

In vivo targeted fluorescence imaging and magnetic resonance imaging of E. coli bacterial infection using polymyxin B-conjugated and polyacrylic acid-grafted GdEuO3 nanoparticles.

Liu Ying Y, Tegafaw Tirusew T, Zhao Dejun D, Yue Huan H et al.

Lanthanide oxide nanoparticles are ideal systems for highly sensitive diagnosis of infectious diseases because of their excellent optical, magnetic, and physicochemical properties. In this study, polymyxin B (PMB), serving as an E. coli-targeting ligand, was conjugated with polyacrylic acid (PAA)-grafted GdEuO3 nanoparticles, used as Eu-based fluorescence imaging (FI) and Gd-based magnetic resonance imaging (MRI) agents. The PMB-PAA-GdEuO3 nanoparticles were further conjugated with the organic photosensitizer 2,6-pyridinedicarboxylic acid (PDA) to enhance their Eu photoluminescence in the visible region (i.e., red color). The performance of (PMB-PAA)/PDA-GdEuO3 nanoparticles as E. coli-targeting and detection agents was demonstrated in vivo on an E. coli-infected mouse model using FI and MRI.

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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Direct Growth of BODIPY-Based Conjugated Porous Polymer Shell on Upconversion Nanoparticles for NIR-Driven Photocatalysis.

Naranjo Teresa T, Francés-Soriano Laura L, Bellezza Delia D, Pérez-Prieto Julia J et al.

The great applications of upconversion nanoparticles (UCNPs) can be further extended by their encapsulation within conjugated porous polymers (CPPs). However, the synthesis of monodisperse core@shell based CPPs upconversion nanohybrids remains a challenge. Herein, we report a simple, general strategy that combines (i) prefunctionalization of UCNPs with polymerizable units, (ii) monomer-feed control, and (iii) a centrifugation-based work-up to ensure anchoring to the inorganic core. This approach enables covalent growth of CPP shells with tunable thickness and low polydispersity. Thus, a BODIPY-based CPP shell was grown over both core (NaYF4: Yb3+ (20%), Er3+ (2%)) and core-shell (NaYF4: Yb3+ (20%), Er3+ (2%)@NaYF4) UCNPs, yielding UCC@CPP and UCCS@CPP nanohybrids. Under near-infrared (NIR) excitation, the UCNP core upconverts light to activate the surrounding CPP shell leading to photocatalytic activity. UCCS@CPP exhibits a twofold higher photocatalytic activity than UCC@CPP highlighting the critical role of the NaYF4 passivation layer in preserving upconversion efficiency. Our approach overcomes key limitations of previous designs achieving improved photooxidation yields (i.e., 42%) and excellent recyclability. This modular platform provides a robust and versatile route to UC@CPP hybrids for designing NIR-driven, reactive oxygen species (ROS)-generating photocatalysts.

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PubMedF1000Research2026-09-10

In-house designed Multiplex Real-Time PCR Assay Developed for Epstein - Barr virus and Cytomegalovirus DNA detection in Pooled Blood Samples from Iraqi blood donors.

Majid Ghinwa S GS, Abdulamir Ahmed S AS, Aufi Iman M IM

The problem of transmissible human herpesvirus infections through blood donation has not been completely resolved by serological testing due to issues such as delayed in seroconversion or false-negative results. This study aimed to develop a cost-effective, In-house designed multiplex real-time PCR assay for the simultaneous detection of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) DNA in pooled blood donor samples. A total of 1000 whole-blood samples were collected from apparently healthy Iraqi blood donors and pooled into mini pools 10(MP10) i.e. 100 MP10 tested by a commercial CMV and EBV multiplex- qPCR detection kit; then retested by In-house designed multiplex qPCR. Fifteen patients who were positive for CMV and fifteen for EBV were considered as positive groups and fifteen healthy individuals as negative groups used to estimate the validity and feasibility of the In-house designed kit. Blood donors who tested by the commercial kit were 42% MP10 positive for EBV and 4% positive for CMV while the In-house designed multiplex qPCR results were 40% and 6% for EBV and CMV, respectively. The specificity and sensitivity of the In-house designed kit for the detection of CMV were 97.92% (95% CI 92.6 to 99.7), 100% (95% CI 39.7 to 100), for EBV were 100% (95% CI 93.84 to100.00) and 95.24 % (95% CI 83.84 to 99.42), respectively. The rate of EBV was high within Iraqi blood donors while the CMV was moderately low and the In-house designed multiplex qPCR was sensitive and specific for CMV and EBV DNA detection at a much lower cost than that of the commercial, about 10% of the commercial cost. Such a cost-effective and sensitive test is crucial in reducing blood transfusion-associated diseases.

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PubMedAngewandte Chemie (International ed. in English)2026-09-10

The Multi-Scale Paradigm: An Integrated Design Logic for Nonlinear Optical Crystals.

Cao Xiangqing X, Qiu Haotian H, Lu Juanjuan J, Yang Yun Y et al.

Nonlinear optical (NLO) crystals are essential for laser frequency conversion, yet rational crystal design remains challenging due to intrinsic trade-offs among key performance parameters. This review establishes a multi-scale design paradigm to unify fragmented knowledge of NLO materials by correlating microscopic, mesoscopic, and macroscopic structural features, delivering a chemistry-based framework to recognize cross-scale constraints and direct NLO crystal exploration. At the microscopic level, the intrinsic optical responses of planar π-conjugated units, non-π-conjugated tetrahedral motifs, and distorted polyhedra are systematically analyzed at the atomic scale, with emphasis on the chemical substitution, functional-group modification, and multi-unit assembly strategies that directly manipulate the microscopic electronic structures of these functional building blocks. At the mesoscopic scale, cation-regulated coordination, dimensionality engineering, hydrogen bonding, domain manipulation, and interfacial coupling are discussed for ordered functional unit arrangement and constructive polarization accumulation. At the macroscopic scale, we discuss converting small-scale designs into usable bulk crystals, focusing on mitigating layered growth via strengthened interlayer interactions to improve crystal dimension, quality, and device compatibility. Representative NLO crystal examples validate this coherent logic. This framework clarifies structure-property correlations and supplies guidelines for new NLO materials, advancing this field from empirical screening toward rational, application-driven design.

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PubMedJournal of medicinal chemistry2026-09-10

Homocamptothecin Payloads with Enhanced Potency for Antibody-Drug Conjugates.

Xie Jiajun J, Li Yalong Y, Pan Fengyuan F, Wang Yifan Y et al.

Camptothecin derivatives, exemplified by DXd, are a dominant class of payloads for antibody-drug conjugates (ADCs). Herein, we describe the design and synthesis of H2, a novel homocamptothecin featuring a simplified hydroxybutyl structure that circumvents the complex assembly of the F-ring. H2 exhibits superior hydrolytic stability, while maintaining potent intrinsic cytotoxicity. In vitro, the H2-conjugated ADC candidates, Tras-L-H2 and Tras-TL-H2, demonstrated robust bystander killing effect and potent antiproliferative activity, similar to that observed with T-DXd. Importantly, these candidates exhibited noninferior antitumor efficacy to that of T-DXd in JIMT-1 xenograft model. These findings demonstrate the therapeutic utility of the seven-membered homocamptothecin scaffold and identify H2 as a promising candidate for next-generation ADC payloads.

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PubMedPediatric transplantation2026-09-10

The IPTA Nashville Consensus Conference on Post-Transplant Lymphoproliferative Disorders After Solid Organ Transplantation in Children: Updates on Classification and Prevention-2026.

Green Michael M, Michaels Marian G MG, Gross Thomas T, Allen Upton U et al.

The 2019 International Pediatric Transplant Association (IPTA) consensus conference assessed available evidence and developed recommendations for various aspects of care relating to post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation in children. Because of the key role Epstein-Barr Virus (EBV) plays in the pathogenesis of many PTLD cases, it was addressed in many recommendations from the Consensus Conference. Working groups addressed and published three separate manuscripts providing recommendations and identifying key knowledge gaps relating to the diagnosis, prevention, and management of PTLD and EBV infection in this setting. The definition and classification of PTLD were actively discussed, but recommendations were not addressed in these publications. In 2025, a working group of experts in EBV and PTLD initiated an effort to review, describe, and consider the impact of newer data published since the consensus conference on the appropriateness of recommendations made and the status of knowledge gaps identified through the 2019 consensus conference's efforts. This manuscript addresses the results of this work relating to the classification and prevention of PTLD and EBV in pediatric SOT. Trial Registration: ClinicalTrials.gov identifier: NCT05164094; ID NCT06741072.

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