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fluvoxamine (Favoxil CR / Favoxile CR / fluvoxamine CR)

✓ Approved

Astellas Pharma · SLC6A4 · 小分子

什么是 fluvoxamine？

fluvoxamine 是一种小分子，由Astellas Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Favoxil CR, Favoxile CR, fluvoxamine CR
公司Astellas Pharma
药物类别小分子
分子靶点SLC6A4
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Astellas Pharma

作用机制

分子靶点

fluvoxamine 作用于 1 个分子靶点：

SLC6A4solute carrier family 6 member 4 (5HTT, 5-HTT)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

fluvoxamine 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersObsessive-compulsive disorder✓ Approved
Psychiatric disordersSocial anxiety disorder✓ Approved

相关研究文献

PubMedAnalytical chemistry2026-07-27

Rational Design of a Fluorogenic Probe for Sphingosine Based on Precisely Controlled Intramolecular Spirocyclization of Coumarin-Rhodamine Hybrid Dye.

Wang Junjie J, Zhang Nayan N, Yun Rong R, Wu Lei L et al.

We synthesized a series of coumarin-rhodamine (CR) derivatives with near-infrared fluorescence (NIRF) properties, and found their intramolecular spirocyclization equilibrium strongly depends on the hydrophilicity/hydrophobicity of their 5'-substituent: the hydrophobic substituent favors a closed spirolactone form (NIRF OFF), whereas the hydrophilic one prefers an open form (NIRF ON). On the basis of these findings, we developed a new design strategy to develop fluorogenic probes based on hydrophilicity-regulated ring-opening of CR scaffold. Based on this mechanism, a fluorogenic probe (CR-SE2) for sphingosine (Sph) was developed. CR-SE2 can react with Sph to afford the ligation product CR-Sph, which leads to the replacement of its salicylaldehyde ester recognition moiety by a less hydrophobic Sph, thereby shifting the equilibrium of CR platform toward the open form and thus resulting in a large turn-on fluorescence readout in the NIR region. CR-SE2 features fast response, high sensitivity, and high selectivity toward Sph, and has been applied to monitor Sph levels in senescent cells, mice, and their tissue slices, revealing a close correlation between aging and Sph levels in biological specimens. The present study provides a more generalizable design strategy for developing fluorogenic probes to study various pathological and biological processes.

PMID 42504604
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PubMedNanomaterials (Basel, Switzerland)2026-07-27

First-Principles Study on the Magnetic Properties of Monolayer MOCl (M = Ti, V, Cr, Mo).

Pan Yu Y, Wang Yanjie Y

Two-dimensional (2D) intrinsic ferromagnets with perpendicular magnetic anisotropy (PMA) have been experimentally verified as promising candidates for nanoscale spintronic devices and magnetic random-access memories. In this work, we systematically investigate the stability, electronic structure, and magnetic properties of monolayer MOCl (M = Ti, V, Cr, Mo) via first-principles calculations. The results demonstrate that allshi ciju monolayers MOCl (M = Ti, V, Cr, Mo) are intrinsic ferromagnetic semiconductors, with magnetic moments of 1.0 μB/Ti atom, 2.0 μB/V atom, 2.5 μB/Cr atom and 3.0 μB/Mo atom, respectively. Notably, both monolayers TiOCl and CrOCl exhibit perpendicular magnetic anisotropic energy (MAE), which is mainly contributed by metal atoms Ti and Cr, respectively. Drawing on the second-order perturbation theory, we conduct an analysis of the density of states and the magnetic anisotropy energy (MAE) resolved by d orbitals for Ti and Cr atoms. Our analysis shows that in monolayer TiOCl, the MAE of Ti atoms mainly stems from the disparities in matrix elements between the dyz and dx2-y2 (dxz) orbitals. Conversely, in monolayer CrOCl, the MAE of Cr atoms is largely due to the differences in matrix elements between the dxy (dyz) and dx2-y2 (dz2) orbitals. Biaxial strain can efficiently regulate the MAE of monolayer CrOCl. Specifically, when under tensile strain, the MAE of monolayer CrOCl experiences a substantial increase. Our research results indicate that both monolayers TiOCl and CrOCl have significant potential for use in spintronic devices and high-density data storage systems.

PMID 42506499
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PubMedClinical oral investigations2026-07-27

Evaluation of serum chromium, nickel, and magnesium levels in patients with type 2 diabetes mellitus and periodontitis: A cross-sectional study.

Bozkurt Esra E, Özdemir Eda Çetin EÇ, Gül Kamile K, Kılınç Metin M et al.

The aim of this study was to evaluate serum chromium (Cr), magnesium (Mg), and nickel (Ni) levels in periodontitis and type 2 diabetes mellitus (T2DM) and to examine the relationship of these elements with periodontal clinical parameters and glycemic control. A total of 74 individuals were included in this cross-sectional study and participants were divided into four groups: periodontally and systemically healthy control group (n = 18), periodontitis group (n = 19), controlled T2DM+periodontitis group (n = 18), and uncontrolled T2DM+periodontitis group (n = 19). Clinical periodontal parameters, plaque index (PI), gingival index (GI), bleeding on probing index (BOP), probing pocket depth (PPD), and clinical attachment level (CAL), were recorded in all patients. Serum HbA1c, Cr, Mg, and Ni levels were measured using atomic absorption spectrometry. Serum Cr levels were significantly lower in the periodontitis group compared to the control group. Serum Cr and Mg levels were significantly lower in both the controlled and uncontrolled T2DM+ periodontitis groups compared to the healthy control group. Significant correlations were found between serum Cr and Mg levels and periodontal clinical parameters and HbA1c. Serum Ni levels did not differ between groups but showed significant correlations with periodontal parameters and HbA1c. The decrease in serum Cr and Mg levels in individuals with periodontitis associated with T2DM suggests that metabolic and inflammatory load may affect mineral homeostasis. Serum Ni levels did not differ significantly between the groups. The combination of periodontitis and uncontrolled T2DM may exert a synergistic effect on mineral homeostasis. Future longitudinal or interventional studies should assess whether monitoring chromium and nickel adds clinical value in understanding periodontal-systemic interactions and periodontal treatment response. Retrospectively registered at ClinicalTrials.gov (Identifier: NCT07327086.; First submitted: 2025-12-24).

PMID 42507181
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PubMedJournal of the American Chemical Society2026-07-27

Noninnocent Ligands as a Design Strategy for Fully Compensated Ferrimagnetism in Two-Dimensional Metal-Organic Frameworks.

Li Yuxuan Y, Che Yixuan Y, Lv Haifeng H, Wu Xiaojun X et al.

Fully compensated ferrimagnets (fFiMs), which combine vanishing macroscopic magnetization with spin-split electronic states, are attractive for stray-field-free spintronics. However, achieving exact moment cancellation typically requires fine control over inequivalent magnetic sublattices, making the rational design of fFiMs a fundamental challenge. Here, we propose a general design strategy for two-dimensional (2D) fFiMs by integrating redox-active noninnocent ligands (NILs) into metal-organic frameworks (MOFs). First-principles calculations demonstrate that fractional metal-to-ligand charge transfer converts NILs from closed-shell linkers into a spin-bearing ligand sublattice that aligns antiparallel to the metal centers, enabling stoichiometric moment compensation. We validated this concept in a family of trigonal 2D chromium MOFs. While the prototype Cr(BTT)2 confirms fully compensated ferrimagnetism, it exhibits intrinsic thermal instability. The modular nature of the NIL strategy allows for chemical refinement, and ligand fluorination (Cr(F-BTT)2) or heavy-chalcogen substitution (Cr(BSeT)2) stabilizes the 2D lattice without disrupting the fFiM ground state. The chemically optimized Cr(F-BTT)2 retains fully compensated ferrimagnetism and exhibits a near-Fermi quasi-Dirac-like band feature with an estimated magnetic transition temperature of 132 K. Extended studies of nitrogen- and phosphorus-based ligands further support the generality and boundary of this approach. These findings establish NIL-directed charge transfer as a chemically programmable handle for engineering 2D-compensated magnets.

PMID 42503666
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PubMedNanomaterials (Basel, Switzerland)2026-07-27

Pack-Boriding of Fe-20Cr-5Al Alloy: Nanostructured Boride Layer Formation, Mechanical Performance, and Paradoxical Passivation Loss via Micro-Galvanic Interactions.

Temiz Cengiz C, Öztürk Uğur U, Çağlar Seyit S, Yılmaz Fikret F

This study investigates the microstructural evolution, mechanical performance, and electrochemical corrosion behavior of nanocrystalline boride layers formed on an Fe-20Cr-5Al ferritic alloy by pack boriding at 950 °C for 4 h. X-ray diffraction (XRD) and scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDS) analyses confirmed the formation of a hierarchical boride layer approximately 80-85 μm in thickness, consisting of orthorhombic (Fe,Cr)B and tetragonal (Fe,Cr)2B phases at the surface and (Fe,Cr)23(C,B)6 carboboride phases in the diffusion zone, the latter attributed to the carbon push-ahead mechanism. Rietveld refinement yielded a quantitative phase fraction of 51.9 wt.%. (Fe,Cr)B, 46.1 wt.% Fe2B, and 2.0 wt.% (Fe,Cr)23(C,B)6, with a theoretical boride layer density of 7.40 g cm-3. Williamson-Hall analysis yielded an average crystallite size of 50.7 nm and a microstrain of 1.686 × 10-3, confirming the nanocrystalline character of the boride phases. Mechanical evaluation revealed a ~9-fold increase in surface hardness in Fe20Cr5Al-B relative to Fe20Cr5Al, reaching 1854 HV (18.18 GPa). Tribological testing demonstrated an ~18-fold reduction in wear rate (from 3.29 × 10-4 to 1.82 × 10-5 mm3/m) and a 14.5% reduction in the coefficient of friction (0.76→0.65), confirming the effectiveness of the boride layer as a tribological barrier. However, electrochemical analyses in 5 wt.% H2SO4 revealed a paradoxical deterioration in corrosion resistance: despite a noble shift in Ecorr from -0.459 to -0.295 V, the corrosion rate increased ~4-fold (from 9.67 × 10-3 to 3.83 × 10-2 mm/year), driven by Al-repulsion-induced passive film loss and micro-galvanic cell formation through micro-crack and porosity networks. These findings emphasize that while pack-boriding is highly effective for tribological enhancement of FeCrAl alloys, minimizing boride layer defects is essential to achieve concurrent corrosion protection in acidic environments.

PMID 42506504
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PubMedInternational urology and nephrology2026-07-27

Impact of creatine supplementation on kidney health: a systematic review and meta-analysis.

de Souza Almeida Artur A, da Silva Leonardo Olimpio Dias LOD, Takahasi Bianca Namie Abe BNA, Terada Bruno Damico BD et al.

To evaluate the safety of creatine supplementation on kidney health in healthy individuals and patients with CKD. The MEDLINE, Embase, Cochrane Library, and Google Scholar databases were systematically searched for RCTs from inception to March 2025. Studies comparing creatine supplementation with placebo in human subjects that assessed kidney health parameters were selected by 2 independent reviewers following PRISMA guidelines. A random-effects model was used to pool mean differences with 95% CI. The primary outcome was serum creatinine level. Secondary outcomes included GFR assessed by creatinine-based methods and by Cr-EDTA, serum urea, albuminuria, proteinuria, and urinary creatinine. Twenty-six studies (1036 participants) were included. Creatine supplementation was associated with a significant increase in serum creatinine levels (MD, 0.14 mg/dL; 95% CI 0.05-0.22; P = .002; I2 = 93.9%) and a reduction in GFR assessed by creatinine-based methods (MD, -10.75 mL/min; 95% CI -17.48 to -4.02; P = .002; I2 = 0%). No significant differences were observed when assessed by Cr-EDTA (MD, 5.89 mL/min; 95% CI -0.30 to 12.08; P = .06; I2 = 6.3%) or in serum urea, albuminuria, proteinuria, and urinary creatinine. In the hemodialysis subgroup, creatine supplementation was associated with a significant increase in serum creatinine; conversely, serum urea levels were significantly reduced. Creatine supplementation is associated with increased serum creatinine levels and reduced glomerular filtration rate estimated by creatinine-based methods in healthy individuals and patients with chronic kidney disease. These findings likely reflect altered creatinine metabolism rather than kidney injury, given the absence of changes when assessed using Cr-EDTA. CRD420251015042.

PMID 42507286
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