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fluvoxamine (Favoxil CR / Favoxile CR / fluvoxamine CR)

✓ Approved

Astellas Pharma · SLC6A4 · 小分子

什么是 fluvoxamine？

fluvoxamine 是一种小分子，由Astellas Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Favoxil CR, Favoxile CR, fluvoxamine CR
公司Astellas Pharma
药物类别小分子
分子靶点SLC6A4
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Astellas Pharma

作用机制

分子靶点

fluvoxamine 作用于 1 个分子靶点：

SLC6A4solute carrier family 6 member 4 (5HTT, 5-HTT)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

fluvoxamine 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersObsessive-compulsive disorder✓ Approved
Psychiatric disordersSocial anxiety disorder✓ Approved

相关研究文献

PubMedBiology of reproduction2026-09-10

Mechanisms of Hexavalent Chromium-Induced Reproductive Toxicity: A Focus on the Ovary and Placenta.

Kluaiphanngam S S, Saravanan I P IP, Kolla V S V VSV, Krothapalli S S et al.

Hexavalent Chromium (Cr(VI)) is a Group A carcinogen, mutagen, and teratogen. Cr(VI) has been used by more than 50 industries, and its contamination of drinking water is widespread across the United States (U.S.). Epidemiological data of women who lived in Willits, California, U.S., indicate that environmental exposure to Cr(VI) adversely affects pregnancy outcomes and the health of their immediate offspring, resulting in a low birth rate, pregnancy loss, and spontaneous abortion, and their children (F1 offspring) experienced birth defects. However, the molecular mechanisms behind Cr(VI)-induced reproductive and developmental toxicity are poorly understood. Cr(VI) enters cells through anion transporters and is rapidly reduced to Cr(III) by endogenous antioxidants within the cell. Cr(III) forms adducts with DNA, which can block DNA replication and transcription; abnormal repair can lead to DNA double-strand breaks, mutations, micronucleus formation, chromosomal abnormalities, and increased genomic instability. Cr(VI) induces oxidative stress via the Fenton reaction, generating free radicals, and depleting antioxidants, thereby promoting apoptosis via p53-dependent and independent pathways, resulting in follicular atresia and accelerated reproductive aging. Antioxidant supplementation with resveratrol, vitamin C, and edaravone mitigates Cr(VI) toxicity in the ovary. Cr(VI) disrupts meiosis in metaphase II oocytes by causing DNA strand breaks, altering F-actin dynamics, disturbing microtubules, and leading to chromosome missegregation. Gestational exposure to Cr(VI) also disrupts placental function through multiple mechanisms by targeting trophoblast lineages. The current review focuses on genotoxicity, oxidative stress, and other mechanisms by which Cr(VI) disrupts the female reproductive and endocrine systems, with particular emphasis on the ovary and placenta.

PMID 42720308
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PubMedJournal of the International Society of Sports Nutrition2026-09-10

Creatine formulations and repeated sprint training: effects on physical and physiological adaptations in soccer players during the short-term preparation phase.

Duan Changyuan C, Wang Zaitao Z, Wang Qianjin Q

This research examined the impact of various creatine (Cr) supplementation formulations during a 4-week preparatory phase on the efficacy of repeated sprint training (RST) and on improvements in physical and physiological performance in male soccer athletes. A total of forty collegiate young soccer players volunteered for the study. They were randomly divided into four groups: creatine monohydrate (Cr-Mon, n = 10), creatine ethyl ester (Cr-Ee, n = 10), creatine hydrochloride (Cr-Hcl, n = 10), and placebo (PL, n = 10). All athletes engaged in a 4-week training intervention, three times a week (i.e. 12 sessions), and physical (countermovement vertical jump [CMVJ], 20-m sprint, and L-run) and physiological (Wingate anaerobic power and incremental exercise tests) performance were assessed both before and after the training period. All training groups improved physical and physiological performance following the 4-week intervention period (p < 0.05). Additionally, the groups receiving the Cr supplement exhibited significantly greater changes (p = 0.001) in physical performance, peak power output, and fatigue index compared to the PL group. However, no significant differences were found among the groups regarding mean power output and VO2max. Notably, the Ee and Hcl forms of Cr showed superior gains (p < 0.05) in physical performance and peak power compared to the Mon form after the 4-week intervention. The results underscore the importance of Cr ingestion in enhancing adaptations for short-term physical performance tasks, highlighting the effectiveness of the Ee and Hcl forms in further improving the CMVJ, 20-m sprint, L-run, and peak power among soccer players during the short-term preparation phase.

PMID 42720250
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-09-10

OsCPK12-OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice.

Wang Beifang B, Chan Aaron A, Fan Yongyi Y, Wang Yanwu Y et al.

The synergy between light and dark reactions is the key to photosynthesis. This synergy not only helps plants achieve maximum photosynthetic efficiency but also plays a crucial role in photosynthetic protection. However, the mechanisms through which plants regulate this process remain unclear. In this study, we demonstrated that the calcium-dependent protein kinase OsCPK12 is essential for mediating rice's responses to light intensity. The oscpk12-cr mutant displayed light-sensitive premature senescence. Specifically, light-induced OsCPK12 expression targeted Ser8 on the chloroplast transit peptide of OsAtpD1, a subunit of ATP synthase, thereby promoting its transport into chloroplasts. OsAtpD1S8D overexpression in oscpk12-cr rescued its premature senescence. ATPase activity and electron transport rate (ETR) were decreased in oscpk12-cr, oscpk12-cr/OE-OsAtpD1S8A, and RNAi-OsAtpD1 plants. In contrast, OsCPK12 overexpression in rice resulted in higher ATPase activity and ETR than in ZH8015. Overall, OsCPK12 phosphorylated OsAtpD1 to promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress. Our findings reveal the intrinsic mechanism by which the OsCPK12-OsATPD1 module regulates ATP synthase activity and ETR efficiency, fine-tuning photosynthetic acclimation to prevent light damage.

PMID 42720038
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PubMedFrontiers in endocrinology2026-09-10

Longitudinal evaluation of glomerular filtration rate across adolescence and early adulthood in youth with type 1 diabetes: associations with clinical and social risk factors.

Clarke Antoine B M ABM, Curtis Jacqueline R JR, Elia Yesmino T YT, Benitez-Aguirre Paul P et al.

The continuous evaluation of GFR among youth with T1D has traditionally been difficult during the transition to adult care given distinct pediatric & adult estimated GFR (eGFR) formulas recommended by clinical practice guidelines. We aimed to assess longitudinal trends in kidney function in type 1 diabetes from adolescence to early adulthood using updated eGFR formulae and to examine associations between eGFR and clinical as well as social factors over time in this population. Clinical factors including age, sex, diabetes duration, insulin therapy, BMI and HbA1c in addition to social factors including ethnicity & material deprivation (MD) were collected alongside creatinine (Cr) and cystatin c (CysC) from Canadian participants in the AdDIT & CanSOLVE CKD-SPOR studies (2009-2023). Estimated glomerular filtration rates (eGFR) derived using updated Chronic Kidney Disease in Children under 25 (CKiD U25) Cr, CysC & combined Cr-CysC formulas were evaluated longitudinally using linear mixed effects regression, as were urine albumin-creatinine ratios (uACR). Youth with type 1 diabetes ages 10 to <25 years were evaluated (N = 137) at a median 5 timepoints (IQR: 4-6) over 9.8 ± 1.3 years. As age increased, eGFRCr increased mildly (β:+1.0 ml/min/1.73m2/year; P<0.0001), whereas eGFRCysC decreased until the age of 18 (β:-3.3 ml/min/1.73m2/year; P<0.0001) and stabilized thereafter (β: +0.1 ml/min/1.73m2/year; P = 0.433). These trends nullified one another across the age range using the combined eGFRCr-CysC, which remained stable (β:-0.1 ml/min/1.73m2/year) from ages 10-25 years (P = 0.452). Sex, BMI, insulin therapy, HbA1c and MD were associated with eGFRCr-CysC over time with a large difference of +6.5 ml/min/1.73m2 seen in high relative to low MD groups (P = 0.0025). Log-transformed uACR was negatively associated with male sex (P = 0.017) and baseline diabetes duration (P = 0.049) yet positively associated with HbA1c (P = 0.021). Different eGFR trends were observed using Cr- vs. CysC-derived estimates in youth with diabetes using updated eGFR formulae. Elevations in eGFR, alongside alterations in markers of albuminuria, were associated with increased glycemia and marginalization, providing insights into key clinical and social risk factors for kidney disease monitoring in this population. (NCT01581476).

PMID 42718842
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PubMedJournal of spine surgery (Hong Kong)2026-09-10

Incidence of asymptomatic early postoperative epidural hematoma in minimally invasive lumbar fusions: an exploratory prospective observational study.

Kaufmann Ascher B AB, Lytle Evan J EJ, Griepp Daniel W DW, Claus Chad F CF et al.

The incidence of all postoperative spinal epidural hematomas (SEH) following open lumbar decompression and fusions reportedly ranges from 58% to 89%. However, the incidence of asymptomatic SEH and the radiographic parameters predicting symptomatic SEH have not been established. The objective was to determine the incidence of SEH and the radiologic parameters that predict SEH becoming symptomatic following minimally invasive transforaminal lumbar interbody fusions (MiTLIF). Between January 2017 and January 2018, we prospectively studied a series of consecutive patients without new neurologic symptoms following MiTLIFs. The enrolled patients underwent gratis magnetic resonance imaging (MRI) of the lumbar spine. An additional consecutive series of patients who developed symptomatic SEH, confirmed on MRI, were retrospectively analyzed as a control. Using Merge, we measured the level of maximal compression (MC): dural sac-to-spinal canal diameter, length of MC, the volume of the thecal sac, and the ratio of preoperative/postoperative dural-sac cross-sectional area [critical ratio (CR)]. Univariate analyses compared patient hematoma risk factors between asymptomatic and symptomatic patients, radiographic parameters between asymptomatic and symptomatic compressions, and between symptomatic and asymptomatic hematomas. P<0.05 was considered significant. Twelve patients developed symptomatic SEH, while 4 demonstrated asymptomatic SEH, and 26 were without hematoma. The incidence of asymptomatic SEH rate was 13.3% [95% confidence interval (CI): 3.8-30.7%] for MiTLIFs. SEH cross-sectional area was significantly larger in symptomatic than asymptomatic SEH (1.88±0.70 vs. 1.04±0.19, P=0.002). Between the cohorts, post-operative thecal sac cross-sectional area was significantly larger in the no hematoma group than asymptomatic or symptomatic groups (1.22±0.6 vs. 0.80±0.22 vs. 0.62±0.28, P=0.008), and CR was greatest (1.24±0.55 vs. 0.70±0.13 vs. 0.57±0.20, P<0.001), respectively. The incidence of SEH in asymptomatic patients following MiTLIF was lower than previously described for open surgeries. The CR may aid in determining if compression is causing symptoms.

PMID 42718891
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PubMedPediatric blood & cancer2026-09-10

ENCERT: A Multisite Phase 1 Trial Using Everolimus in Combination With Nelarabine, Cyclophosphamide, and Etoposide in Relapsed T-Cell Lymphoblastic Leukemia/Lymphoma.

Sabnis Himalee S HS, Pauly Melinda M, Schafer Eric S ES, Norris Robin E RE et al.

Relapsed and refractory (R/R) T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/T-LL) remains a therapeutic challenge. Allogeneic hematopoietic stem cell transplantation (HSCT) after achieving complete remission (CR) offers the only chance of cure, but effective modalities to achieve CR are limited. Activation of mTOR and PI3K pathways has been well described in T-ALL and monotherapy with mTOR inhibitors has shown efficacy signals used in relapsed disease. This multisite Phase 1 study evaluated the safety, tolerability, and anti-leukemic activity of everolimus with NEC chemotherapy (nelarabine, etoposide, and cyclophosphamide) among children and young adults with relapsed/refractory T-ALL/T-LL. Eight patients were enrolled to two dose levels (DLs) on this study and no dose-limiting toxicities were reported. Most adverse events related to therapy were expected and hematological. DL2 (n = 5) of everolimus at 5 mg/m2/day was the highest dose tested. The overall response rate (complete response + complete response with incomplete platelet recovery + partial response) was 75% (6/8) with 100% (5/5) responses in the T-ALL cohort and 33% (1/3) responses in T-LL cohort. All six patients who obtained a PR or greater proceeded to receive HSCT as consolidation therapy. Two of the six patients transplanted are alive today with two deaths related to progressive disease and two related to veno-occlusive disease post transplantation. This study demonstrates safety with a combination of everolimus and NEC chemotherapy. Given the observed tolerability and efficacy of everolimus with NEC in this small cohort of patients, this combination should be further evaluated in larger phase 2/3 clinical trials. ClinicalTrials.gov identifier: NCT03328104.

PMID 42720434
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