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fluvoxamine (Favoxil CR / Favoxile CR / fluvoxamine CR)

✓ Approved

Astellas Pharma · SLC6A4 · 小分子

什么是 fluvoxamine？

fluvoxamine 是一种小分子，由Astellas Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Favoxil CR, Favoxile CR, fluvoxamine CR
公司Astellas Pharma
药物类别小分子
分子靶点SLC6A4
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Astellas Pharma

作用机制

分子靶点

fluvoxamine 作用于 1 个分子靶点：

SLC6A4solute carrier family 6 member 4 (5HTT, 5-HTT)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

fluvoxamine 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersObsessive-compulsive disorder✓ Approved
Psychiatric disordersSocial anxiety disorder✓ Approved

相关研究文献

PubMedMolecules (Basel, Switzerland)2026-10-27

Phosphoric Acid-Modified Wood Biochar for Cr(VI) Retention in Aqueous Systems and Sustained Mobility Control Under Dynamic Soil Conditions.

Su Zihan Z, Li Sitong S, Tang Junfeng J, Tu Zipeng Z et al.

Effective remediation of hexavalent chromium [Cr(VI)] requires materials that perform well not only in aqueous systems but also in heterogeneous soils exposed to fluctuating water flow and environmental disturbance. Here, phosphoric acid-modified wood biochar (P-BC) was evaluated against pristine biochar (BC) through physicochemical characterization, pH-dependent aqueous retention tests, soil water-retention measurements, repeated-infiltration leaching experiments, and accelerated drying-rehumidification cycles. Across the tested pH range (pH 2.0-4.0), P-BC showed slightly higher mean apparent Cr(VI) retention than BC at each tested pH. Batch experiments showed higher measured apparent Cr(VI)-derived retention for P-BC under the tested conditions: at 25 °C and an initial Cr(VI) concentration of 106.06 mg L-1, the 360-min mean apparent retention values were 8.46 ± 0.03 mg g-1 for BC and 10.10 ± 0.10 mg g-1 for P-BC. At 55 °C, the model-derived Langmuir qmax values were 18.08 and 28.18 mg g-1 for BC and P-BC, respectively. P-BC showed higher late-stage water-retention values, while a 3.5% layered application reduced cumulative Cr(VI) leaching by 82.9% relative to the unamended control. Under the accelerated drying-rehumidification protocol, low mean water-extractable Cr(VI) endpoints were observed at the higher P-BC application rates, with the 2.5% P-BC treatment yielding the lowest mean cycle-12 concentration among the tested P-BC treatments. Taken together, these findings show that phosphoric acid modification was associated with modestly higher aqueous Cr(VI)-derived retention and lower measured Cr(VI) mobility under several dynamic soil conditions. The results further indicate that amendment rate and spatial configuration are important determinants of remediation performance, supporting further evaluation of P-BC as an engineered amendment for aqueous Cr(VI) treatment and soil mobility control.

PMID 42943682
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PubMedMicroorganisms2026-10-27

Emergence of NDM-5-Positive Salmonella enterica Serovar Typhimurium Monophasic Variant ST34 in Hong Kong During 2020-2025.

Tse Atalie Ching-Yee AC, Choi Garnet Kwan-Yue GK, Luk Hayes Kam-Hei HK, Yip Eric Kam-Tong EK et al.

The emergence of carbapenem-resistant non-typhoidal Salmonella species (CR-NTS) has been observed in recent years, causing increasing challenges in the clinical management and control of Salmonella infections. However, CR-NTS had not been comprehensively studied in Hong Kong previously. We retrieved archived non-typhoidal Salmonella isolates demonstrating carbapenem resistance from five public hospitals in Hong Kong during January 2020-June 2025. The isolates were characterised by NG-TEST CARBA-5 and subjected to whole-genome sequencing (WGS) and phylogenetic analysis. Clinical information of CR-NTS cases was also reviewed. Fourteen CR-NTS isolates (0.3%, 14/4404) were identified during the study period. All 13 CR-NTS isolates (one isolate could not be recovered) were NDM (New Delhi metallo-β-lactamase)-positive, with the first case identified in March 2023. WGS revealed six Group B Salmonella monophasic variants of Salmonella enterica serovar Typhimurium ST34 harbouring the blaNDM-5 gene. The most common plasmid replicon co-present among blaNDM-5-positive isolates was IncHI2-IncHI2A (63.6%, 7/11). Among cases of CR-NTS in our study, self-limiting gastroenteritis was the most common presentation (84.6%, 11/13); none presented with invasive infections; travel history was present in 7.7% (1/13). Phylogenetic analysis showed the genotypic relatedness of the ST34 isolates identified in Hong Kong to those on the Chinese mainland, with the possibility of local CR-NTS acquisition via imported food sources. Our findings highlighted the importance of a One Health approach to the control of CR-NTS and the need for continuous antimicrobial resistance surveillance of Salmonella spp. in Hong Kong.

PMID 42943528
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PubMedMaterials (Basel, Switzerland)2026-10-27

Study on the Rheological Properties of Aged SBS-Modified Asphalt Rejuvenated with Soybean Oil and Crumb Rubber.

Chen Yang Y, Sun Chen C, Ji Qinghao Q, Zhang Yujuan Y

To address the issue that a single soybean oil rejuvenator weakens the high-temperature performance of aged SBS-modified asphalt, soybean oil and crumb rubber (CR) were used to construct a synergistic composite rejuvenation system for long-term aged SBS-modified asphalt (ASMA). Conventional property tests, dynamic shear rheometer (DSR) tests, bending beam rheometer (BBR) tests, and microstructural characterization were performed to investigate the macroscopic rheological properties and microscopic mechanisms of rejuvenated asphalt. The results indicate that soybean oil can restore the low-temperature performance of ASMA, yet it weakens its high-temperature deformation resistance. Incorporating CR into the 5 wt% soybean oil rejuvenated system effectively compensates for this drawback. As the CR content increases, the high-temperature deformation resistance, low-temperature crack resistance, fatigue life, and thixotropy of the rejuvenated asphalt improve significantly. Specifically, as the CR content increases from 0 wt% to 25 wt%, the rutting factor at 64 °C increases 14.7-fold, the fatigue life at 5% strain increases 13.7-fold, the low-temperature creep stiffness at -24 °C decreases by 17.1%, and the creep rate increases by 51.8%. The balanced optimization of high- and low-temperature rheological performance of the rejuvenated asphalt can be interpreted from multi-scale characterization results. On the one hand, weak interfacial chemical reactions occur during soybean oil rejuvenation, while CR mainly exerts physical swelling and filling effects. On the other hand, the system gradually evolves from dispersed-phase filling to a continuous network as the CR content increases. In addition, the likely competitive adsorption of soybean oil between CR and residual SBS modifiers promotes the formation of the continuous phase. This study provides a feasible technical reference for the synergistic rejuvenation of aged SBS-modified asphalt using bio-oil and CR.

PMID 42941015
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PubMedBrain sciences2026-10-27

Fronto-Parietal Brain Metabolites Following Traumatic Brain Injury-A Proton MR Spectroscopy Study.

Yeh Ping-Hong PH, Yeh Chen-Haur CH, Oakes Terrence R TR, Ollinger John J et al.

Background: Conventional structural CT and MRI may be normal after mild traumatic brain injury (mTBI), while magnetic resonance spectroscopic imaging (1H-MRSI) can provide regional measures of brain metabolites. We examined supracallosal fronto-parietal metabolite ratios in active-duty service members with military-related TBI and non-TBI military controls, including comparisons by injury mechanism and exploratory clinical associations. Methods: The study used a retrospective cross-sectional cohort. Participants underwent 3T 2D multivoxel 1H-MRSI covering a 6 × 8 × 1 cm3 supracallosal fronto-parietal PRESS/CSI volume of interest. Regional N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine/phosphocreatine (Cr) measures were processed with SIVIC and summarized as NAA/Cr and Cho/Cr ratios. Linear mixed-effects models were adjusted for age and sex, with Bonferroni correction for regional group comparisons. Male-only analyses were performed as a sensitivity analysis. Associations with clinical and neurocognitive measures were exploratory. Results: The final analytic cohort reported in the manuscript comprised 741 service members with TBI (34.3 ± 8.1 years old; M/F = 711/30; mean 327.4 ± 226.8 days post-injury) and 75 non-TBI controls (M/F = 53/22; mean age: 33.1 ± 10.0 years). TBI participants showed lower Cho/Cr area ratios in multiple fronto-parietal regions, including right precuneus (estimate = -0.0781, SE = 0.0176, t = -4.43, pBonf < 0.0001, Cohen's d = -0.36, 95% CI [-0.1127, -0.0435]), left superior frontal gyrus (estimate = -0.0715, SE = 0.0163, t = -4.38, pBonf < 0.0001, Cohen's d = -0.36, 95% CI [-0.1035, -0.0394], and bilateral fronto-parietal WM (right: estimate = -0.0741, SE = 0.0169, t = -4.39, pBonf < 0.0001, Cohen's d = -0.35, 95% CI [-0.1072, -0.0410]; left: estimate = -0.0656, SE = 0.0161, t = -4.08, Cohen's d = -0.33, pBonf = 0.0011, 95% CI [-0.0971, -0.0340]). Injury mechanism stratification revealed a widespread reduction in Cho/Cr area in individuals with blast-related TBI relative to unexposed non-TBI controls over the left superior frontal gyrus (estimate = -0.0941, SE = 0.0176, t = -5.35, pBonf < 0.0001, Cohen's d = -0.44, 95% CI [-0.1287, -0.0596]), right precuneus (estimate = -0.0900, SE = 0.0193, t = -4.66, Cohen's d = -0.38, pBonf = 0.0010, 95% CI [-0.1279, -0.0521]), and right fronto-parietal WM (estimate = -0.0895, SE = 0.0182, t = -4.91, Cohen's d = -0.39, pBonf < 0.0001, 95% CI [-0.1253, -0.0537]). Twelve regional differences remained significant in the primary analysis, and the principal pattern was substantially preserved in the male-only sensitivity analysis. Blast-related and multiple-blast comparisons also showed regional Cho/Cr differences; individuals with multiple blast exposures mainly drove Cho/Cr reduction. Exploratory clinical analyses found inverse associations between Cho/Cr and Post-Traumatic Stress Checklist-Civilian version (PCL-C) and Neurobehavioral Symptom Inventory (NSI) scores, and positive associations between selected NAA/Cr measures and cognitive performance. Specifically, higher NAA/Cr area over the left caudal anterior cingulate correlates positively with verbal fluency performance (r = 0.358, p < 0.0001). Higher NAA/Cr peak heights in the left caudal middle frontal cortex correlated with better response inhibition accuracy (r = 0.278, p = 0.0003). Concurrently, lower Cho/Cr values over default mode network hubs-specifically the left caudal anterior cingulate gyrus (estimate = -0.00144, t = -4.02, uncorrected p < 0.0001, 95% CI [-0.00215, -0.00074]), left posterior cingulate gyrus (estimate = -0.00115, t = -3.76, uncorrected p = 0.00019, 95% CI [-0.00175, -0.00055], and the left precuneus gyrus (estimate = -0.00120, t = -3.62, p = 0.00033, 95% CI [-0.00186, -0.00055])-associated significantly with greater self-reported post-traumatic stress severity on the PCL-C. In addition, Cho/Cr in the left fronto-parietal WM was inversely associated with PCL-C (estimate = -0.00115, t = -3.87, p = 0.00012, 95% CI [-0.00174, -0.00057]) and NSI (estimate = -0.00117, SE = 0.00030, t = -3.92, p < 0.0001, 95% CI [-0.00176, -0.00058]). Injury chronicity did not correlate with metabolic alterations. Conclusions: 1H-MRSI identified regional metabolite-ratio differences in this military TBI cohort. The findings support further investigation of regional Cho/Cr and NAA/Cr measures as correlates of clinical heterogeneity after TBI. The widespread depression of Cho/Cr suggests persistent membrane depletion and/or chronic axonal degeneration, particularly in TBI individuals with multiple blast exposures. Although the cross-sectional design does not establish causality, diagnostic sensitivity, biomechanical strain patterns, or longitudinal recovery, the results imply the utility of MRSI as a robust translational tool for phenotyping chronic military brain injury and objectively monitoring long-term neural recovery.

PMID 42939341
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PubMedInternational journal of molecular sciences2026-10-27

Prediction of Tumor Complete Response Using Genomic and Clinical Data in Solid Cancer Undergoing Definitive Radiation Therapy.

Chang Jun Young JY, Jung Seung-Hyun SH, Lee Dong Soo DS

In this retrospective, single-center observational study, targeted next-generation sequencing (NGS) was performed on pre-radiation therapy (RT) tumor specimens to identify genomic features associated with RT response and clinical outcomes. This study included 77 eligible patients with esophageal squamous cell carcinoma (ESCC, n = 23), non-human papilloma virus-related head and neck squamous cell carcinoma (HNSCC, n = 24), and rectal adenocarcinoma (RAC, n = 30) treated between 2014 and 2020. Treatment was employed for definitive aim (chemoradiotherapy or pre-operative chemoradiotherapy followed by radical surgery). Treatment response was assessed using clinical and pathological criteria and was dichotomized as complete response (CR) versus non-CR. Targeted NGS was performed using a customized panel composing 161 genes. A total of 1263 nonsynonymous somatic variants were identified across 153 genes. The most commonly altered genes were TP53 (70.1%), APC (41.6%), NOTCH1 (41.6%), KMT2C (39.0%), NOTCH3 (36.4%), and NOTCH2 (35.1%). Overall, 25 (32.5%) and 52 patients (67.5%) were classified as CR and non-CR, respectively. APC (P = 0.008), KMT2C (P = 0.018), and KRAS (P = 0.012) alterations were associated with non-CR, whereas CD274 (P = 0.003), MSH3 (P = 0.011), and NOTCH3 (P = 0.048) alterations were associated with CR. KRAS alterations occurred exclusively in RAC, and most concurrent APC-KMT2C alterations in non-CR tumors were also observed in RAC, suggesting that these associations may partly reflect tumor type-specific genomic backgrounds. An exploratory pooled model incorporating age and six candidate genomic variables achieved a cross-validated area under the curve of 0.867 for CR prediction. In survival analysis, alterations in CCND1, CXCL9, ERCC6, LIF, and RAD51B were independently associated with poor recurrence-free survival. Pre-RT tumor genomic profiling identified candidate features associated with RT response and recurrence-free survival in this heterogeneous cohort. The pooled genomic associations and prediction model should not be interpreted as pan-cancer biomarkers or predictors and require validation in larger, independent, cancer-specific cohort.

PMID 42941765
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PubMedAntibiotics (Basel, Switzerland)2026-10-27

In Vitro Activity of Imipenem/Relebactam and Ceftolozane/Tazobactam Against Multidrug-Resistant Klebsiella pneumoniae: A Retrospective Single-Center Study in China.

Yi Juan J, Liu Chao C, Yang Ping P, Wang Bowen B et al.

Multidrug-resistant Klebsiella pneumoniae (MDR-KP) is a global health threat with limited treatment options. Comparative in vitro data for imipenem-relebactam (I/R) and ceftolozane-tazobactam (C/T) across diverse MDR-KP clinical populations remain limited. Susceptibility to I/R and C/T was determined by Etest. Whole-genome sequencing was used to identify sequence types, resistance genes, and virulence genes, with hypervirulent K. pneumoniae (hvKP) defined by genomic criteria. A total of 312 nonduplicate MDR-KP clinical isolates, including 70.8% carbapenem-resistant K. pneumoniae (CR-KP), 56.7% difficult-to-treat resistant K. pneumoniae (DTR-KP), and 28.2% carbapenem-resistant hvKP (CR-hvKP), were retrospectively analyzed. I/R resistance was low across all subgroups (overall 3.8%, CR-KP 5.0%, DTR-KP 6.2%, CR-hvKP 2.3%) and across specimen types (0-9.6%; blood 3.8%). In contrast, C/T resistance was higher (overall 57.7%, CR-KP 79.2%, DTR-KP 91.0%, CR-hvKP 84.1%), with the highest rate in respiratory isolates (63.0%), followed by blood (57.7%) and urine (50.0%). Among extended-spectrum β-lactamase (ESBL)-producing isolates, I/R and C/T resistance rates were 2.1% and 12.4%, respectively. Although C/T resistance was higher in hvKP than in classic K. pneumoniae in unadjusted analysis, hvKP was not independently associated with increased C/T resistance after adjustment. Instead, ST11, ST15, ST307, blaKPC-2, and blaNDM-1 were independently associated with C/T resistance. For I/R, blaNDM-1 was associated with resistance. I/R was active across MDR-KP subgroups including CR-hvKP and DTR-KP. C/T worked mainly against ESBL-producers. These findings highlight the importance of resistance genotyping when interpreting susceptibility to these agents.

PMID 42938688
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