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Factor VIII (ReFacto AF / Xyntha)

✓ Approved

Sobi · F8 · 重组蛋白

什么是 Factor VIII?

Factor VIII 是一种重组蛋白,由Sobi研发。该药已获批,用于治疗相关适应症,给药途径:Injectable (Others)、Intravenous (IV)。

药物档案

商品名ReFacto AF, Xyntha
公司Sobi
药物类别重组蛋白, 细胞治疗
分子靶点F8
给药途径Injectable (Others), Intravenous (IV)
状态Approved

作用机制

分子靶点

Factor VIII 作用于 1 个分子靶点:

F8coagulation factor VIII (AHF, FVIII)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Factor VIII 针对 1 个适应症,涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved

相关研究文献

PubMedEating disorders2026-09-10

Psychometric properties of a Greek translation of the intuitive eating Scale-3 (IES-3) in adults from Greece.

Argyrides Marios M, Maïano Christophe C, Tylka Tracy L TL, Reppa Glygeria G et al.

The Intuitive Eating Scale-3 (IES-3) is a new, 12-item measure of intuitive eating, which is recognised as a protective factor of disordered eating. Given its recency, there has been limited evaluation of the psychometric properties of the IES-3 in diverse national and linguistic contexts. Therefore, we report on the translation and psychometric evaluation of a novel Greek version of the IES-3 in Greek adults. A total of 1,138 women and 712 men completed the Greek IES-3 alongside additional measures selected to assess validity. Exploratory factor analysis with a first split-half subsample showed that the original 4-factor model fit the data well. In a second split-half subsample, a bifactor-exploratory structural equation model (B-ESEM) with a G-factor and four S-factors fit the data and demonstrated superior fit compared to alternative models. Across subsamples, the 4-factor and B-ESEM models demonstrated gender invariance and did not show measurement bias in terms of age and body mass index. Validity analyses revealed that intuitive eating was associated with higher positive body image and psychological well-being and lower disordered eating and psychological distress. These results indicate that the Greek IES-3 has robust psychometric properties.

PMID 42717485
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PubMedAnnals of thoracic surgery short reports2026-09-10

Surgical Interval as a Risk Factor for Postoperative Complications After Repeated Lung Cancer Resection: A Retrospective Cohort Study.

Kadomatsu Yuka Y, Nakanishi Keita K, Ueno Harushi H, Kato Taketo T et al.

With improved survival after initial surgery, repeated pulmonary resections are increasingly performed. However, the clinical effect of the interval between operations remains unclear. This study retrospectively analyzed data from patients who underwent only contralateral repeated pulmonary resection for lung cancer at a single institution between 2002 and 2024, assessing 30-day postoperative complications. Surgical interval was categorized as ≤3 months and >3 months. Multivariable logistic regression was employed to identify risk factors for morbidity. The final cohort comprised 246 contralateral second resections in 123 patients. The mean surgical interval was 40.2 months (median, 27 months). Approximately 40% of second resections occurred within 12 months of the first, half of which were within 3 months. Postoperative complications developed in 25 (20.3%; n = 25/123) patients who were frequently male, had a lower body mass index, and more commonly underwent anatomic resection. Multivariable analysis revealed age (odds ratio [OR], 1.15; 95% CI, 1.04-1.28), male sex (OR, 0.09; 95% CI, 0.02-0.40), anatomic resection (OR, 11.0; 95% CI, 2.08-58.3), and ≤3-month surgical interval (OR, 3.36; 95% CI, 1.01-11.3) as independently associated with postoperative complications. The overall morbidity rate was significantly higher in patients with a ≤3-month interval compared with longer intervals (36.0% [n = 9/25] vs 16.3% [n = 16/98]; P = .029). Contralateral repeated pulmonary resection is feasible, but a ≤3-month surgical interval is associated with greater postoperative morbidity. The surgical interval should be considered an important factor in operative planning.

PMID 42719611
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PubMedRegenerative biomaterials2026-09-10

Synergistic effects of berberine and adipose stem cells in a silk fibroin-PEG hydrogel for diabetic wound healing via macrophage polarization modulation.

Hu Xiaohao X, Xu Jia J, Zhong Yanping Y, Zheng Weihao W et al.

Diabetic wound repair remains a considerable clinical challenge, largely due to the limited efficacy of current therapies. Herein, we engineered a novel silk fibroin (SF)-polyethylene glycol (PEG) hydrogel (SPB) incorporated with berberine (BBR) and adipose-derived stem cells (ASCs) to synergistically promote diabetic wound healing. By optimizing the physicochemical properties of SPB, we found that a 7:3 SF:PEG ratio provided an ideal balance of pore size (25.83 ± 3.94 μm), mechanical strength (32.33 ± 4.07 kPa) and sustained BBR release. In vitro, SPB significantly enhanced ASC paracrine function, promoting the production of vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2), stromal cell-derived factor 1 (SDF-1), platelet-derived growth factor-BB (PDGF-BB), and transforming growth factor beta (TGF-β). Accordingly, SF-based hydrogel system (SPBA) markedly stimulated fibroblast proliferation and migration and enhanced endothelial cell angiogenesis. Moreover, SPBA effectively modulated macrophage repolarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype, thereby suppressing inflammation. In vivo, SPBA demonstrated remarkable therapeutic efficacy in diabetic rat full-thickness skin wounds, accelerating wound closure, promoting re-epithelialization, collagen deposition and neovascularization, while reducing local inflammation. These results highlight SPBA as a highly efficient and promising biomaterial strategy for diabetic wound treatment.

PMID 42719899
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PubMedmicroPublication biology2026-09-10

Gene model for the ortholog of Pi3K21B in Drosophila ananassae.

Backlund Anne E AE, Brigham Wyatt W, Dunne Clare C, Youngblom James J JJ et al.

Gene model for the ortholog of Phosphatidylinositol 3-kinase 21B ( Pi3K21B ) in the May 2011 (Agencourt dana_caf1/DanaCAF1) Genome Assembly (GenBank Accession: GCA_000005115.1 ) of Drosophila ananassae . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus Drosophila using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.

PMID 42719057
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Revealing the Impacts of Molecular Rigidity and Orientation on Interfacial Contact in Efficient Perovskite Solar Cell.

Xia Juan J, Zeng Yabing Y, Xing Zhou Z, Huang Yangkai Y et al.

Self-assembled monolayers (SAMs) are widely employed as hole transport layers in inverted perovskite solar cells (PSCs), but suffer from insufficient surface coverage and difficulties in spin-coating a perovskite film on top. Herein, we design and synthesize two novel corannulene derivatives, 3-(corannulen-1-yl)acrylic acid (CorAcA) and 3-(corannulen-1-yl)propionic acid (CorPrA), which successfully address the SAM/perovskite interfacial problems. Beyond achieving promising photovoltaic performance and operational stability in the PSCs, we provide deep insight into how molecular rigidity and orientation influence interfacial contact within the devices, thereby enabling us to identify the key factor responsible for the enhanced device performance and stability. We demonstrate that the more flexible linker (C-C) between the corannulene core and the anchoring group (-COOH) endows CorPrA with better orientational adaptability and interfacial contact compared to the rigid linker (C = C) of CorAcA. This not only generates a vertical interfacial dipole that facilitates efficient charge carrier dynamics but also distinctly improves the perovskite film quality, thus optimizing the fill factor and operational stability of the PSCs. This study underscores the importance of regulating molecular rigidity and orientation at device interfaces, providing a new paradigm for interfacial design toward highly efficient and stable PSCs.

PMID 42717691
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Manipulating the Buried Interfacial Dipole: The Role of Pyridine Acetate-Hydrochloride Isomers in Carbon-Based Perovskite Solar Cells Prepared in Air.

Shi Yifei Y, Gong Jianwen J, Wang Xu X, Hu Shuming S et al.

The buried interface between tin oxide and perovskite is the key factor for non-radiative recombination and energy level mismatch, which limits the performance and stability of perovskite solar cells. This work explores a simple interfacial dipole engineering strategy, where three pyridine acetate-hydrochloride (PAH) isomer molecules (2-PAH, 3-PAH, and 4-PAH) are used to modify the SnO2 electron transport layer. The 3-PAH-modified layer can control the work function of tin oxide, achieve the best energy level alignment, and improve the crystallization quality of the perovskite film, thereby effectively suppressing interface recombination and promoting electron extraction. All the devices are prepared in air, and the device optimized by 3-PAH achieved a champion energy conversion efficiency of 14.31% and demonstrated stability. Subsequent to an 800 h placement in an N2 glove box or a 340 h exposure to an air environment, the unencapsulated target devices that were modified by 3-PAH maintained 80.7% and 81.3% of their initial efficiency.

PMID 42717680
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