Drug Database
CL

clomipramine hydrochloride + sildenafil citrate (Gusejeong / DKB22002 / DKB 22002)

✓ Approved

DongKoo Bio & Pharma · PDE5A · 小分子

什么是 clomipramine hydrochloride + sildenafil citrate?

clomipramine hydrochloride + sildenafil citrate 是一种小分子,由DongKoo Bio & Pharma研发。该药已获批,用于治疗相关适应症,给药途径:Oral (PO)。

药物档案

商品名Gusejeong, DKB22002, DKB 22002
公司DongKoo Bio & Pharma
药物类别小分子
分子靶点PDE5A
给药途径Oral (PO)
状态Approved

作用机制

分子靶点

clomipramine hydrochloride + sildenafil citrate 作用于 1 个分子靶点:

PDE5Aphosphodiesterase 5A (PDE5, CGB-PDE)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

clomipramine hydrochloride + sildenafil citrate 针对 2 个适应症,涉及 2 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersPremature ejaculation✓ Approved
Reproductive system and breast disordersErectile dysfunction✓ Approved

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Transporter Engineering for Enhancing Citric Acid Production in Aspergillus niger.

Li Jie J, Li Mingyang M, Song Yan Y, Xu Zeyu Z et al.

The efficient industrial production of citric acid by A. niger requires overcoming the limitations of substrate uptake and citrate export on the citrate synthesis efficiency. This study addresses these obstacles using a transporter engineering strategy, modifying the endogenous high-affinity glucose transporter MstF and citrate exporter CexA. The "push-pull" strategy was used to improve citric acid production by increasing glucose import and citrate export. A single overexpression of mstF improved citric acid production, reaching 179.35 g/L in the H7 strain. However, cexA high expression impaired dense mycelium pellet formation and affected the expression of key genes, resulting in reduced citric acid production. For balancing intracellular accumulation and secretion of citrate, simultaneous overexpression of mstF and cexA increased citric acid production and efficiency. In a 30 L fermenter, strain A5 achieved a citric acid titer of 185.91 g/L, a productivity of 3.21 g/h/L, and a shortened fermentation cycle. Collectively, these results provide a reference for the industrial production of citric acid and other organic acids.

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Structure and Compressional Behavior of Sillén-Type (BiO)2(CO3) Bismutite Carbonate.

Chuliá-Jordán Raquel R, Santamaría-Pérez David D, Botan-Neto Benedito Donizeti BD, Bera Ganesh G et al.

In this joint experimental/computational work, we study the ambient-conditions structure of bismutite (BiO)2(CO3) and its evolution under high pressure by means of a combination of in situ synchrotron X-ray diffraction (XRD) measurements, Raman spectroscopy, and density-functional theory (DFT) calculations. Using single-crystal XRD, (BiO)2(CO3) is determined to be an orthorhombic Cmcm phase with disorder arising from carbonate rotations at ambient-conditions and DFT confirms the stability of the structure. In situ high-pressure synchrotron powder XRD measurements showed that the Cmcm ambient-pressure structure adequately accounts for the observed diffraction patterns up to 17.7 GPa. The compressibility was determined, obtaining an experimental bulk modulus of 67.2(11) GPa and significant anisotropy in the axial compressibilities: the a and c axes, parallel to the (BiO)22+ layers, are less compressible than the b direction perpendicular to those layers, which we justify on the basis of the bismuth lone electron pair compressibility and the slight reorientation of the carbonate groups. Raman spectroscopy measurements at ambient conditions and under pressure were used to characterize the vibrational properties of this carbonate, unvealing a differentiated behavior of the nonequivalent carbonate units.

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