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clomipramine hydrochloride + sildenafil citrate (Gusejeong / DKB22002 / DKB 22002)

✓ Approved

DongKoo Bio & Pharma · PDE5A · 小分子

什么是 clomipramine hydrochloride + sildenafil citrate？

clomipramine hydrochloride + sildenafil citrate 是一种小分子，由DongKoo Bio & Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Gusejeong, DKB22002, DKB 22002
公司DongKoo Bio & Pharma
药物类别小分子
分子靶点PDE5A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, DongKoo Bio & Pharma

作用机制

分子靶点

clomipramine hydrochloride + sildenafil citrate 作用于 1 个分子靶点：

PDE5Aphosphodiesterase 5A (PDE5, CGB-PDE)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

clomipramine hydrochloride + sildenafil citrate 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersPremature ejaculation✓ Approved
Reproductive system and breast disordersErectile dysfunction✓ Approved

相关研究文献

PubMedSexual medicine2026-10-27

Understanding patient perspectives and preferences on sildenafil orodispersible formulation: a survey-based evaluation of men using erectile dysfunction medications.

Sansone Andrea A, Mondello Malvestiti Franco M P FMP, Mantegazza Raffaella R, Vignesh Shivani Ohri SO et al.

Erectile dysfunction (ED) is a common disease condition with major psychosocial and clinical consequences. Over 50% of men aged 40 years and above are estimated to experience some level of ED. Phosphodiesterase type 5 inhibitors (PDE5Is) remain the mainstay of ED treatment. Sildenafil citrate orodispersible film (ODF) is a novel formulation designed to improve convenience and patient satisfaction. This study explored real-world perspectives and patient preferences regarding the use of sildenafil citrate ODF. A cross-sectional, web-based survey was conducted in Italy (September-November 2024) in adult men using prescription ED medications. Data on demographics, lifestyle, clinical condition, treatment experiences, and patient perceptions about PDE5Is with a focus on sildenafil ODF were collected. The survey included 276 men (mean age 47 years; 43.5% Viagra users, 25% Cialis users, 13.4% other branded ED medication users, and 18.1% generic ED medication users). Most were married (51%), employed (78%), and reported at least one comorbidity (75%), predominantly cardiovascular (53%). Film-coated tablets of PDE5 inhibitors were the most used formulation (72%), while 5% reported sildenafil ODF use.Awareness of sildenafil ODF was high, with valued attributes including water-free administration, portability, discretion, and faster perceived onset of action. Among overall ED medication users, 79% expressed willingness to adopt sildenafil ODF with 33% citing liking of the formulation and 28% citing perceived difference from already using medication. The main barrier to adoption was high cost compared to other ED medications, cited by 37% of the 21% participants who did not express willingness to adopt sildenafil ODF. Sildenafil ODF was widely perceived by patients as a discreet and practical alternative to conventional film-coated tablets, with high willingness for adoption. Aligning treatment choices with patient preferences may enhance adherence, satisfaction, and overall quality of life in ED management.

PMID 42936858
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PubMedInternational journal of molecular sciences2026-10-27

Influence of UV Irradiation Source and of Carboxylic Acid Additives on the Kinetics of Photodegradation of Five Tricyclic Antidepressant Drugs in Aqueous Medium.

Ciuca Maria D MD, Racovita Radu C RC

Use of antidepressant medication has increased substantially nowadays. Investigations of their photostability in aqueous environment are therefore needed both for shelf life assessment of liquid pharmaceutical formulations and for development of wastewater remediation technologies. In this work, the comparative kinetics of photodegradation of five tricyclic antidepressants (TCAs) in aqueous solution was studied under direct photolysis using UVA, UVB, and UVC sources, respectively. A gas chromatography-mass spectrometry (GC-MS) method was developed and validated intra-laboratory for accurate quantification of the five TCAs (amitriptyline hydrochloride AMI, doxepin hydrochloride DOX, imipramine hydrochloride IMI, clomipramine hydrochloride CLO, trimipramine maleate TRI) in the course of photodegradation. UVC photolysis yielded the highest rates of photodegradation, followed by UVB and then UVA. The molecular structure and UV absorption characteristics of individual TCAs were shown to influence photodegradation rates as well. Specifically, heteroatoms (N, O, Cl) present in the molecule and redshifted UV absorption bands increased photosensitivity typically in the order: AMI < IMI < TRI < CLO < DOX. The effect that some mono- and polycarboxylic acids dissolved in the aqueous solutions had on TCA photodegradation kinetics under UVC was also investigated and, for most TCAs, rates were faster and durations required for their complete photodegradation decreased generally in the order: citric > oxalic > maleic > benzoic acid. Furthermore, citric acid was reused for a second round of TCA photodegradation and showed rate enhancement effects very close to those exhibited in the first round.

PMID 42941717
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PubMedReproduction (Cambridge, England)2026-10-27

Long-term sildenafil attenuates age-associated functional and reproductive decline in male rats.

Sokanovic Srdjan S, Keselj Isidora I, Medar Marija M, Baburski Aleksandar A et al.

Aging in males is accompanied by a progressive decline in physical activity, androgen status, and reproductive function. We investigated whether long-term treatment with the phosphodiesterase type 5 inhibitor sildenafil attenuates these changes and is accompanied by remodeling of mitochondrial homeostasis in the testis. Male rats were treated with low-dose sildenafil from 12 to 18 months of age, with age-matched untreated rats serving as controls and young adult rats providing a reference for the age-associated phenotype. Aging markedly reduced voluntary locomotor activity, circulating testosterone, and sperm production, while increasing circulating corticosterone. Long-term sildenafil treatment increased locomotor activity, testosterone, and sperm number, while corticosterone tended to decrease. Sildenafil-associated body weight changes were observed in animals with access to voluntary running. Treatment was also accompanied by pronounced changes in mitochondrial homeostasis-related gene expression in Leydig cells and spermatozoa. These transcriptional responses differed between cell types, particularly for genes regulating mitochondrial dynamics and quality control. Expression of mitochondrial homeostasis-related genes was more closely associated with circulating testosterone than with corticosterone and showed distinct testosterone-associated patterns in Leydig cells and spermatozoa. Recovery toward young levels differed among parameters, being more pronounced for reproductive and endocrine measures than for locomotor activity. These findings indicate that long-term low-dose sildenafil attenuates age-associated functional and reproductive decline and promotes a partial shift toward a younger male phenotype, accompanied by cell-specific mitochondrial transcriptional remodeling.

PMID 42937178
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PubMedInternational journal of molecular sciences2026-10-27

Profiling of Bioactive Metabolites and In Vitro Multifunctional Properties of Postbiotic Cell-Free Supernatant Derived from Probiotic Lactic Acid Bacteria Isolated from Fermented Olives.

Abouloifa Houssam H, Maiouet Imane I, Bouqafa Asma A, Mouhtadi Nada N et al.

This work aims to characterize the bioactive metabolite profile and in vitro multifunctional properties of postbiotic cell-free supernatants (Postbiotic-CFSs) derived from three lactic acid bacteria (Levilactobacillus brevis S27, Lactiplantibacillus pentosus S42, and Lactiplantibacillus plantarum S62) isolated from fermented green olives. The postbiotic-CFSs were analyzed for their bioactive metabolites, emulsification index E24%, and antimicrobial, antioxidant, anti-inflammatory, and antidiabetic activities. The bioactive metabolites identified in all postbiotics included organic acids (lactate, citrate, and oxalate), SCFAs (acetate), hydrogen peroxide, diacetyl, exopolysaccharides (EPSs), proteins, biosurfactants, polyphenols, and flavonoids. The postbiotic-CFSs exhibited emulsification index (E24%) values ranging from 21.5% to 38.2%. Furthermore, they demonstrated antimicrobial properties with inhibition diameters ranging from 14.10 to 16.9 mm against pathogenic bacteria and from 15.8 to 23.50 mm against yeast, while fungal mycelial growth was inhibited by 35.77 to 45.09%. All postbiotics demonstrated antioxidant activities of DPPH from 65.91 to 68.55% and FRAP values from 1707.31 to 1765 µg AAE/mL, as well as anti-inflammatory activity (11.83-12.88%) and antidiabetic activity (34.38-93.75%). These findings highlight the significant potential of postbiotic-CFSs as natural bio-preservative agents in food products and as a source of bioactive metabolites with multifunctional health benefits for consumers.

PMID 42941905
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PubMedPolymers2026-10-27

Sustainable Approach to Thermoplastic Polyurethanes Stabilization: Vanillin as a Natural Additive in Melt-Processing.

Smorawska-Kliza Joanna J, Jażdżewska Anna A, Głowińska Ewa E

Thermo-oxidative degradation during high-temperature processing remains a major challenge limiting the performance of thermoplastic polyurethanes (TPUs). This study evaluated vanillin (4-hydroxy-3-methoxybenzaldehyde), a bio-based phenolic compound, as a primary thermo-oxidative stabilizer acting as a free-radical scavenger. Bio-based TPU (bio-TPU) was synthesized via a two-step method using a commercial bio-based polyol, a bio-based chain extender, and a mixture of diisocyanates. During processing in an internal mixer, vanillin was incorporated into both bio-TPU and a commercial TPU at concentrations of 0.03, 0.165, and 0.3 wt%. Changes in chemical structure were assessed by Fourier-transform infrared spectroscopy (FTIR), thermal properties were evaluated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), including oxidation onset temperature (OOT) measurements, and dynamic mechanical analysis (DMA). Mechanical properties were assessed by tensile test and hardness. FTIR analysis revealed no significant structural changes after vanillin addition. However, changes in thermal properties were observed, including an increase in the OOT for materials containing the highest vanillin content. TGA results also showed a generally improved thermal stability at higher vanillin concentrations, approaching reference-material values at the highest concentration in the commercial TPU. A slight decrease in mechanical properties was observed. These findings demonstrate a pronounced stabilizing effect of 0.3 wt% vanillin on both bio-TPU and commercial TPU, providing new insights into the potential reuse and further recycling of TPU materials stabilized with bio-based additives.

PMID 42942660
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PubMedMicromachines2026-10-27

Protein-Based Biomaterials for Bio-Optoelectronics: A Review of Bio-Integrated and Biodegradable Optodevices.

Merlo Anna A, Conti Fosca F

Growing development of biomaterials has stimulated the biomedical sector to seek innovative alternatives to conventional medical technologies. Bio-optoelectronic devices are emerging as promising tools, integrating biologically derived components, biodegradable end-of-life approaches, and highly biocompatible materials with optoelectronic systems. The devices combine optical and electronic properties with biological interfaces, enabling more effective interaction with tissues and cellular systems. Applied research is motivated by the need to improve the efficacy and biocompatibility of medical devices while reducing invasiveness and adverse effects. Wearable devices and implants based on flexible, biodegradable, or bioinspired materials allow better adaptation to biological tissues and real-time monitoring or modulation of physiological processes. Proteins are attracting increasing attention due to their biocompatibility, biodegradability, mechanical flexibility, and ability to respond to optical and electrical stimuli. Furthermore, the combination of proteins with synthetic materials and nanomaterials in biohybrid platforms offers new opportunities for advanced bio-optoelectronic systems. This review summarizes key developments in bio-optoelectronic devices, focusing on protein-based materials; their roles in sensing, imaging, and neuromodulation; and their use in wearable, implantable, and biotech systems. Crucial challenges, including long-term stability and integration with biological systems, are also discussed, together with future perspectives for diagnostic and therapeutic applications.

PMID 42943875
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