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clomipramine hydrochloride + sildenafil citrate (Gusejeong / DKB22002 / DKB 22002)

✓ Approved

DongKoo Bio & Pharma · PDE5A · 小分子

什么是 clomipramine hydrochloride + sildenafil citrate？

clomipramine hydrochloride + sildenafil citrate 是一种小分子，由DongKoo Bio & Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Gusejeong, DKB22002, DKB 22002
公司DongKoo Bio & Pharma
药物类别小分子
分子靶点PDE5A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, DongKoo Bio & Pharma

作用机制

分子靶点

clomipramine hydrochloride + sildenafil citrate 作用于 1 个分子靶点：

PDE5Aphosphodiesterase 5A (PDE5, CGB-PDE)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

clomipramine hydrochloride + sildenafil citrate 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersPremature ejaculation✓ Approved
Reproductive system and breast disordersErectile dysfunction✓ Approved

相关研究文献

PubMedFrontiers in oncology2026-09-10

A two-phase low-dose ACD-A strategy overcomes hypocalcemia during peripheral blood stem cell collection: a randomized controlled study.

Long Zhangbiao Z, Jin Yutong Y, Zhao Dinghui D, Li Yuxin Y et al.

Citrate anticoagulation during peripheral blood stem cell (PBSC) collection frequently causes hypocalcemia. Conventional fixed-ratio protocols frequently employ prophylactic calcium supplementation in many centers; however, they are associated with a high citrate burden and have been linked to platelet aggregation in some reports. This randomized controlled study evaluated a two-phase low-dose Acid Citrate Dextrose formula A (ACD-A) strategy designed to reduce hypocalcemia without compromising collection efficiency. Consecutive donors undergoing PBSC collection were randomly assigned to two groups. The Control group (n=22) received a blood-to-ACD-A ratio of 10-12:1 with prophylactic intravenous calcium. The Low ACD-A group (n=21) received initial loading phase at a ratio of 10-12:1 until 1 mL/kg of ACD-A was infused, followed by maintenance at 25:1 without prophylactic calcium. The primary outcome was the incidence of hypocalcemia-related symptoms. Secondary outcomes included collection time, ACD-A intake, CD34+ cell yield, and platelet aggregation. The incidence of hypocalcemia-related symptoms was significantly lower in the Low ACD-A group than in the Control group (14% vs. 73%, P = 0.0002). Collection time was shorter (170.8 vs. 199.3 min, P = 0.0029), and ACD-A intake was substantially reduced (6.10 vs. 12.96 mL/kg, P < 0.0001). No significant differences were observed in CD34+ cell yield, enrichment ratio, yield per liter processed, or changes in ionized calcium levels between groups. Mild platelet aggregation occurred less frequently in the Low ACD-A group (9.5% vs. 41%, P = 0.0339). A two-phase low-dose ACD-A strategy significantly reduces hypocalcemia-related symptoms, shortens collection time, and decreases platelet aggregation without compromising stem cell yield or product quality. This simple modification represents a meaningful improvement over conventional citrate protocols for PBSC collection.

PMID 42718461
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PubMedBiopolymers2026-09-10

Pre-Esterification Dry Heat Treatment Enhances the Functional Properties of Starch Citrate: Enzyme Resistance and Water Absorption.

Dogadina Anna A, Tryakhov Denis D, Grishkova Svetlana S, Maslennikov Daniel D

This study investigates how pre-esterification dry heat treatment (DHT) of corn starch at 170°C, 180°C, and 200°C influences the functional properties of subsequently synthesized starch citrates. Structural and morphological changes induced by DHT and esterification were analyzed using scanning electron microscopy, X-ray diffractometry, and Fourier-Transform Infrared spectroscopy. Starch citrates were characterized for their resistance to pancreatic α-amylase and amyloglucosidase, as well as their water absorption capacity (WAC) at 37°C. Results demonstrated a strong correlation between DHT temperature and the functional properties of the final citrate. Increasing the DHT temperature significantly increased the resistant starch fraction and WAC. Specifically, citrates from native starch had a resistant starch (RS) fraction of 91%, while citrates from starch pre-treated at 200°C exhibited a markedly increased RS fraction of 98% and a 64% increase in WAC. These findings indicate that DHT is an effective pre-treatment for enhancing the dietary fiber potential and hydration properties of starch citrates.

PMID 42717628
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Manipulating the Buried Interfacial Dipole: The Role of Pyridine Acetate-Hydrochloride Isomers in Carbon-Based Perovskite Solar Cells Prepared in Air.

Shi Yifei Y, Gong Jianwen J, Wang Xu X, Hu Shuming S et al.

The buried interface between tin oxide and perovskite is the key factor for non-radiative recombination and energy level mismatch, which limits the performance and stability of perovskite solar cells. This work explores a simple interfacial dipole engineering strategy, where three pyridine acetate-hydrochloride (PAH) isomer molecules (2-PAH, 3-PAH, and 4-PAH) are used to modify the SnO2 electron transport layer. The 3-PAH-modified layer can control the work function of tin oxide, achieve the best energy level alignment, and improve the crystallization quality of the perovskite film, thereby effectively suppressing interface recombination and promoting electron extraction. All the devices are prepared in air, and the device optimized by 3-PAH achieved a champion energy conversion efficiency of 14.31% and demonstrated stability. Subsequent to an 800 h placement in an N2 glove box or a 340 h exposure to an air environment, the unencapsulated target devices that were modified by 3-PAH maintained 80.7% and 81.3% of their initial efficiency.

PMID 42717680
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-09-10

Bio-Inspired Calorimetric Flow Sensor With Hierarchical Microfluidic Design For Flow-Acoustic Fusion Sensing.

Cao Yudong Y, Ye Hong H, Gong Zheng Z, Zhou Weitai W et al.

High-sensitive flow and acoustic sensors with wide detection range are essential for the intelligence of underwater robotics. To tackle the challenge of limited detection range of flow sensors, here we present a bio-inspired calorimetric flow sensor (BioCFS) with hierarchical microfluidic design, mimicking the graded neuromast location of fish lateral line. The BioCFS achieves a high velocity resolution of 20 µm·s-1 and a wide dynamic range of 0-3 m·s-1. The high-sensitive and wide-range BioCFS enables the functions of yaw angle and velocity estimation, obstacle recognition, and vortex source localization. Moreover, the BioCFS can perceive low-frequency underwater acoustic signals, demonstrating a benchmark acoustic sensitivity of 1.31 V·Pa-1. By integrating flow-acoustic fusion perception with deep-learning models, the sensor achieves an accuracy of 99.6% in classifying 12 types of underwater scenarios. The excellent sensor performance and flow-acoustic fusion sensing function of the BioCFS offer significant potential for environmental perception and intelligent navigation in underwater robotics.

PMID 42717516
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PubMedAAPS PharmSciTech2026-09-10

Ethosomal Gel-Based Topical Delivery of Albendazole Hydrochloride for Psoriasis: In Vitro and In Vivo Evaluation.

Rençber Seda S, Karpuz Merve M, Ünlü Çakıcı Büşra B, Karayıldırım Çinel Köksal ÇK et al.

This study aimed to develop an albendazole hydrochloride (ALB)-loaded ethosomal gel for topical psoriasis treatment. ALB-loaded ethosomes were prepared and characterized to select the optimal formulation, which was subsequently incorporated into an HPMC-based hydrogel. The ethosomal gel was evaluated through physicochemical, in vitro and in vivo studies. The optimized ethosomal formulation prepared by the film hydration method exhibited a mean vesicle size of 490.00 ± 0.14 nm, polydispersity index of 0.31 ± 0.14, zeta potential of -22.85 ± 2.28 mV and encapsulation efficiency of 23.90 ± 1.43%. After incorporation into the hydrogel matrix, the Gel4-E3/ALB formulation demonstrated appropriate mechanical properties (hardness 8.42 ± 0.70 mN, adhesiveness - 16.85 ± 1.50 mN·s, elasticity 0.89 ± 0.07, cohesiveness 1.14 ± 0.09) and shear-thinning behavior, ensuring ease of application and skin retention. A controlled release pattern was observed, consistent with the controlled-release behavior expected from ethosomal hydrogel systems. Radiolabeling studies demonstrated high labeling efficiency (> 95%). In vitro cytotoxicity evaluation indicated that the optimized ethosomal gel formulation was non-toxic. In vivo studies performed in an imiquimod (IMQ)-induced psoriatic mouse model revealed significant therapeutic improvement in the Gel4-E3/ALB-treated group compared with the IMQ control, with visible reduction in erythema, scaling, and skin thickening after the fifth day of treatment. Hematological analysis showed no adverse effects associated with the formulation. Histopathological evaluation confirmed the reduction in epidermal hyperplasia and inflammatory cell infiltration in the treated group. The developed ALB-loaded ethosomal gel represents a safe and promising topical therapeutic system for psoriasis management.

PMID 42717176
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PubMedFrontiers in pediatrics2026-09-10

Association of caffeine citrate plus vitamin A/D drops with bronchopulmonary dysplasia and respiratory outcomes in preterm infants born at <32 weeks' gestation: a 72-h landmark retrospective cohort study.

Su Rongying R, Pei Yaohua Y

The aim of this work is to examine whether the early addition of vitamin A/D drops to caffeine citrate was associated with bronchopulmonary dysplasia (BPD) and short-term respiratory outcomes in preterm infants born at <32 weeks' gestation. This single-center, 72-h landmark retrospective cohort study included 126 infants admitted to the hospital between October 2022 and November 2024 with a gestational age <32 weeks and birth weight ≤1.5 kg. Exposure was determined at 72 h as either caffeine alone or caffeine plus vitamin A/D drops. Complete-case analyses were performed. Among the 119 infants who survived to 36 weeks' postmenstrual age, BPD, longitudinal outcomes, and clinical course were evaluated. Multivariable regression and stabilized inverse probability of treatment weighting (IPTW) were applied. BPD occurred in 20 of 55 survivors (36.4%) receiving caffeine alone and 11 of 64 (17.2%) receiving combination therapy. After adjustment for gestational age, birth weight, and grade III-IV respiratory distress syndrome, combination therapy was associated with a lower risk of BPD [adjusted odds ratio (aOR), 0.36; 95% confidence interval (CI), 0.14-0.90]. The composite outcome of death or BPD occurred in 25 of 60 infants (41.7%) in the caffeine group and 13 of 66 (19.7%) in the combination group (extended-model aOR, 0.33; 95% CI, 0.14-0.80); IPTW results were consistent. Combination therapy was also associated with more favorable changes in blood gas and inflammatory markers, along with shorter durations of respiratory support and hospitalization. No serious adverse event required permanent treatment discontinuation. Among infants who survived to 72 h, early initiation of vitamin A/D drops as an adjunct to caffeine was associated with lower risks of BPD and death or BPD, as well as more favorable short-term respiratory outcomes. Non-randomized treatment allocation, complete-case selection, and residual confounding preclude causal inference.

PMID 42718862
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