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miconazole + benzoyl peroxide (Acnidazil / Acne Creme Plus)

✓ Approved

Teva Pharmaceutical Industries Ltd. · 小分子 · 小分子

什么是 miconazole + benzoyl peroxide？

miconazole + benzoyl peroxide 是一种小分子，由Teva Pharmaceutical Industries Ltd.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名Acnidazil, Acne Creme Plus
公司Teva Pharmaceutical Industries Ltd.
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Teva Pharmaceutical Industries Ltd.

治疗适应症

miconazole + benzoyl peroxide 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersAcne✓ Approved

相关研究文献

PubMedInsects2026-10-27

Hydrogen Peroxide Regulates Butterfly Wing Eyespot Color Patterns.

Nakazato Yugo Y, Otaki Joji M JM

Butterfly wing color patterns are determined during the early pupal stage. It has been proposed that the interactions between wing epidermal cells and the facing inner cuticle surface may initiate signal transduction pathways that determine cell fate regarding presumptive scale colors. Here, we hypothesized that hydrogen peroxide plays a key role in color pattern determination. To examine this hypothesis, we pharmacologically treated fresh pupae of the Blue Pansy butterfly Junonia orithya using two application methods to experimentally manipulate the levels of hydrogen peroxide in pupal wing tissues. When systemically injected into pupae, hydrogen peroxide reduced eyespot size, and two scavengers of hydrogen peroxide, catalase and dimethylthiourea (DMTU), increased eyespot size. When topically applied to pupal wing tissues, hydrogen peroxide induced severe color pattern modifications, catalase increased eyespot size, and a cuticle inhibitor, fluorescent brightener 28 (FB28), reduced eyespot size. Mechanical load tests revealed that the level of hydrogen peroxide influences the cuticle hardness of the pupal body. These results suggest that hydrogen peroxide regulates eyespot color patterns in butterfly wings and that this regulation may be mediated by modulating the chemical and mechanical properties of the facing cuticle during the early pupal stage.

PMID 42940941
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PubMedJournal of conservative dentistry and endodontics2026-10-27

Efficacy and safety of internal bleaching agents for discolored endodontically treated teeth: A systematic review and network meta-analysis of in vitro and ex vivo studies.

Drouri Sofia S, Essanhajy Zohair Z, Jabri Mouna M

Discoloration of endodontically treated teeth is a common esthetic problem, and internal bleaching is its most conservative treatment. Laboratory evidence comparing agents and activation methods is fragmented. To synthesize in vitro and ex vivo evidence and to compare, rank, and appraise the immediate color-change efficacy of internal-bleaching agents and activation approaches and to summarize color stability and structural effects. Following a PROSPERO-registered protocol (CRD420261277168) and PRISMA 2020, four databases (MEDLINE, Scopus, Web of Science, and CENTRAL) were searched up to 10 June 2026. In vitro and ex vivo studies of internal bleaching of discolored nonvital teeth were included. Risk of bias was assessed with the QUIN tool. A frequentist random-effects network meta-analysis expressed color change as the standardized mean difference (SMD) versus control; treatments were ranked by P-score and certainty appraised with GRADE. Twenty-six reports were included; the primary network comprised eight studies. Every peroxide node produced significantly greater color change than control: carbamide peroxide (CP) SMD 2.90 (95% confidence interval: 1.61-4.20), activated hydrogen peroxide (HP) 2.64 (1.14-4.13), sodium perborate 2.06 (0.79-3.33), and HP 2.04 (0.81-3.27). No active agent was superior to another; CP ranked highest (P-score 0.844). Heterogeneity was high and certainty low to very low. All peroxide-based internal-bleaching agents effectively lighten nonvital teeth with no clear superiority among them; because efficacy is comparable, agent choice should also weigh effects on dental hard tissue.

PMID 42936803
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PubMedBiomedicines2026-10-27

Serum Peroxides and Galectin-3 in Chronic Heart Failure: Cross-Sectional Associations with NT-proBNP and Cardiac Structure.

Ardelean Samuel S, Buzzi Diana E DE, Zavragiu Andrei-Catalin AC, Gogan Alexandra A et al.

Background/Objectives: Oxidative stress and galectin-3-related fibro-inflammatory processes contribute to heart failure pathophysiology, but their concurrent relationships with natriuretic peptides and structural/cardiorenal parameters remain incompletely characterized. We evaluated baseline associations of serum peroxide burden and galectin-3 with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and related phenotypic parameters in chronic heart failure. Methods: This cross-sectional analysis included 57 patients from a prospective single-center cohort. Serum peroxides were quantified using the ferrous oxidation-xylenol orange assay and expressed as nmol H2O2 equivalents/mL. Associations were assessed using Spearman correlation and linear regression with ln-transformed NT-proBNP. Benjamini-Hochberg correction was applied to eight secondary/exploratory correlations. Results: Serum peroxide burden correlated with NT-proBNP (ρ = 0.387, p = 0.0095; n = 44) and remained significantly associated after adjustment for age, sex, and left ventricular ejection fraction (B = 0.1756, p = 0.0420; n = 43). After additional estimated glomerular filtration rate (eGFR) adjustment, the effect estimate remained similar, although statistical significance was not reached (B = 0.1646, p = 0.0525; n = 39). Galectin-3 correlated with NT-proBNP, left ventricular end-diastolic volume index (LVEDVi), and serum uric acid; all associations remained significant after false-discovery-rate correction. Serum peroxide burden and galectin-3 were not significantly correlated. In an exploratory joint model (n = 29), both biomarkers remained significantly associated with ln(NT-proBNP) (adjusted R2 = 0.4294). Conclusions: Serum peroxide burden and galectin-3 showed different cross-sectional association patterns with NT-proBNP and selected structural/cardiorenal parameters. Given the limited sample size, missing data, and exploratory nature of the joint model, these findings should be considered hypothesis-generating and do not establish biological independence or incremental clinical value.

PMID 42939972
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PubMedJournal of the American Chemical Society2026-10-27

Single-Atom Ce Enables Interfacial Pathway Regulation of Fe2 Atomic Pairs in Alkaline Oxygen Reduction.

Zhang Canhui C, Li Xiaofan X, Wang Ning N, Jiang Wenxiao W et al.

Fe2 atomic pairs are among the most active motifs in Fe-N-C catalysts for the alkaline oxygen reduction reaction (ORR), but their performance is limited by an activity-stability trade-off. In alkaline media, slow interfacial water dissociation restricts proton-coupled electron transfer (PCET). Under these proton-deficient conditions, the more proton-demanding 4e- pathway is suppressed, whereas the competing 2e- route becomes more favorable, leading to peroxide/reactive oxygen species (ROS) accumulation and accelerated Fe demetalation. Here we show that atomically dispersed Ce can mitigate this limitation by regulating the interfacial reaction environment around Fe2 atomic pairs. In situ spectroscopy, kinetic isotope measurements, and theoretical calculations indicate that Ce promotes the main 4e- pathway by improving the interfacial water/proton environment, while also reducing peroxide-related species formed through the competing 2e- route near Fe2 sites. Accordingly, the resulting FeAPCeSA-NHCS catalyst, consisting of Fe2 atomic pairs and isolated Ce species on N-doped hollow carbon spheres, delivers a high half-wave potential of 0.92 V with a peroxide yield of only 1.6% in alkaline media. It also mitigates Fe demetalation, retains 96% of its current after 50,000 s of ORR operation, sustains Zn-air battery cycling for over 1100 h, and achieves peak power densities of 1.0 W cm-2 in anion-exchange membrane fuel cells. This work establishes an interfacial pathway-regulation strategy for decoupling activity and stability in alkaline ORR catalysis.

PMID 42937988
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PubMedJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]2026-10-27

A Randomized Clinical Trial on Hydrogen Peroxide Whitening Systems: Prefilled Trays Versus Whitening Strips.

da Silva Douglas Ferreira DF, Mailart Mariane Cintra MC, Torres Carlos Rocha Gomes CRG, Borges Alessandra Bühler AB

This randomized clinical trial evaluated the efficacy, safety, and patient satisfaction of hydrogen peroxide (HP)-based whitening systems, comparing prefilled trays (PT) with different application times and whitening strips (WS). Participants were randomly allocated into three groups (n = 40): PT-30 (11% HP, 30 min/day); PT-60 (11% HP, 60 min/day); and WS (9.5% HP, 60 min/day). Treatments were applied once daily for 7 days. Tooth color was assessed at baseline and after 1, 3, 7, and 21 days using shade guide (ΔSGU) and spectrophotometer (ΔE00 and ΔWID). Tooth sensitivity, gingival condition, and patient satisfaction were also assessed. Overall, groups treated for 60 min/day showed greater tooth color change, regardless of the whitening system (PT-60 and WS). After 21 days, this whitening effect was maintained, with PT-60 showing greater color change (ΔE00) than PT-30 (mean difference, 1.509; 95% CI, 0.551 to 2.468; p = 0.001). Tooth sensitivity was low and similar among groups. Gingival irritation occurred more frequently in PT-60 but was mild and transient. Participants reported satisfaction and comfort/retention with both systems. No significant differences in color change were detected between prefilled trays and whitening strips applied for 60 min daily. Reducing tray application time to 30 min resulted in less color change after 7 days of treatment. No severe adverse effects were observed at final assessment, and both systems were well accepted by participants. Hydrogen peroxide-based whitening systems using prefilled trays or whitening strips offer safe, effective, and patient-friendly options for providing noticeable color change.

PMID 42937215
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PubMedMicroorganisms2026-10-27

Calcium Peroxide Addition Suppresses ARG Dissemination by Modulating Host Succession and MGE-Mediated Horizontal Transfer During Swine Manure Composting.

Yang Wenxi W, Wang Yuqiong Y, Lan Ting T, Wang Tianxiang T et al.

Applying exogenous additives during composting can help to effectively mitigate the environmental dissemination of antibiotic resistance genes (ARGs). Calcium peroxide (CaO2)-a strong oxidizing agent-has achieved significant efficacy in degrading various pollutants. This study aims to evaluate the effects of CaO2 at varying doses (0, 1% and 3% DW) on the variation in ARGs, mobile genetic elements (MGEs), and bacterial community succession during swine manure composting. Compared to the control (CK), adding 1% and 3% CaO2 reduced total ARGs and MGEs by 50.29% and 64.62% in the LCP and by 68.96% and 79.74% in the HCP treatment, respectively. Adding 1% and 3% CaO2 significantly increased the relative abundances (RAs) of Actinobacteriota and Firmicutes while decreasing those of Proteobacteria and Bacteroidetes during the thermophilic phase, especially under the high-dose treatment. Redundancy analysis (RDA) revealed that MGEs accounted for 54.20% of the total variation in ARGs, followed by environmental factors (30.3%). Network analysis further revealed that 1% and 3% CaO2 treatments disrupted the association between ARGs and their host bacteria. Overall, adding CaO2 can reduce the risks of spreading ARGs in compost products.

PMID 42943533
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