若生智能
Drug Database
MI

miconazole + benzoyl peroxide (Acnidazil / Acne Creme Plus)

✓ Approved

Teva Pharmaceutical Industries Ltd. · 小分子 · 小分子

什么是 miconazole + benzoyl peroxide？

miconazole + benzoyl peroxide 是一种小分子，由Teva Pharmaceutical Industries Ltd.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名Acnidazil, Acne Creme Plus
公司Teva Pharmaceutical Industries Ltd.
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Teva Pharmaceutical Industries Ltd.

治疗适应症

miconazole + benzoyl peroxide 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersAcne✓ Approved

相关研究文献

PubMedPatient preference and adherence2026-07-27

Patient Expectations, Safety Concerns, and Adherence to Topical Acne Medications: Findings from a Web-Based Survey.

Yang Yutong Y, Fan Qing Q, Zhang Linglin L, Liu Xiaojing X et al.

Suboptimal adherence to first-line topical medications (eg, topical retinoids, benzoyl peroxide, and topical antibiotics) is a major barrier to effective acne vulgaris (AV) management. The influence of patients' pre-treatment expectations and concerns about adverse effects on adherence behavior remains inadequately quantified. To evaluate young patients' perceptions of acne and their expectations, concerns, and adherence regarding topical medications. A web-based cross-sectional survey was conducted from December 2023 to January 2024. Patients aged 16-29 with a history of AV and topical medication use were recruited. Data on demographics, disease perception, medication knowledge, usage patterns, and adherence were collected via a structured questionnaire and analyzed using descriptive and comparative statistics. A total of 501 valid questionnaires were collected. Patients acquired their knowledge about acne through various channels, with dermatologists being the most reliable source of information. Although 82.83% of patients recognized AV as a chronic disease, substantial misconceptions regarding its etiology and treatment persisted. Topical medications were commonly used, most frequently adapalene (40.92%), tretinoin (32.93%), benzoyl peroxide (24.75%), and clindamycin (20.96%). However, patients demonstrated limited knowledge regarding the proper application. Expectations for the onset of topical medications were overly optimistic, whereas the actual duration of use was often inadequate. The information that respondents had the strongest desire to access included the side effects, method of use, onset time, and duration of use. Medication discontinuation was primarily attributed to perceived slow efficacy or concerns about adverse effects, which contributed to a relatively high recurrence rate following treatment cessation. Young patients demonstrated limited comprehension of AV and lacked knowledge of topical medications and their appropriate application, as well as unrealistic expectations regarding onset time. Enhanced education on the nature of AV, along with detailed instructions on topical medication use, is crucial for improving patients' disease awareness and treatment adherence.

PMID 42504315
阅读全文 →
PubMedACS applied bio materials2026-07-27

Fabrication of an Antifungal PMMA Denture Nanocomposite Functionalized with Miconazole-Pectin-Silver Nanoparticles against Denture Stomatitis.

Yadav Bhawana B, Alhariry Jinan J, Kumar Amit A, Rajaram Shoba S et al.

Denture stomatitis is a highly prevalent oral mucosal infection caused by Candida biofilm formation on the denture surface. In this study, an antifungal polymethyl methacrylate (PMMA) denture nanocomposite (MCZ-P-AgNPs/PMMA) was prepared by incorporating miconazole-loaded pectin-stabilized silver nanoparticles (MCZ-P-AgNPs) into the PMMA matrix. Response surface methodology was used to finalize the synthesis of AgNPs via the pectin-mediated green reduction method. To address the poor aqueous solubility of miconazole, the β-cyclodextrin inclusion complexation strategy was employed. MCZ-P-AgNPs exhibited potent antifungal activity with an MIC80 of 40 μg/mL and an MFC of 80 μg/mL for Candida albicans (CA) and Candida glabrata (CG). Biofilm inhibition and eradication assays demonstrated a BIC80 of 40 μg/mL for CA and 20-40 μg/mL for CG, along with a BEC80 of 80 μg/mL for both species. Mechanistic investigations revealed ergosterol depletion, oxidative and nitrosative stress induction, and disruption of extracellular matrix components. Subsequently, MCZ-P-AgNPs were incorporated into PMMA (0.53 wt%) using conventional heat polymerization, developing MCZ-P-AgNPs/PMMA. Physicochemical characterization by ATR-FTIR, Vickers microhardness, and SEM-EDX analyses confirmed polymerization and successful nanoparticle integration. The nanocomposites exhibited low water sorption (8.6% after 60 days) and a high water contact angle (104.45 ± 0.49°), which indicated a hydrophobic surface maintaining material integrity. In vitro release profile demonstrated sustained miconazole release. ICP-MS analysis confirmed minimal silver-ion release from the nanocomposites. Antifungal evaluation showed reduced fungal adhesion and metabolic activity on the nanocomposite surface, confirmed by XTT assay, CFU enumeration, and crystal violet staining. Additionally, in vitro cytotoxicity assay on the HEK293 cell line and the seed germination study on Brassica rapa established biosafety and ecological compatibility of MCZ-P-AgNPs. Collectively, MCZ-P-AgNPs/PMMA nanocomposite offers a promising approach in transforming conventional PMMA into an inherently antifungal denture material against denture stomatitis.

PMID 42504423
阅读全文 →
PubMedBiomimetics (Basel, Switzerland)2026-07-27

Objective Image-Based Assessment of Tooth Translucency Changes Following Different Bleaching Protocols: A Retrospective Cohort Study.

Pereira Ruben R, Silveira João J, Dias Susana S, Monteiro Sofia S et al.

Background: Tooth bleaching is a conservative aesthetic treatment that may influence tooth translucency, an optical property relevant to biomimetic dentistry. The purpose of this study is to evaluate changes in tooth translucency after three bleaching protocols, while preliminarily testing an objective, image-based, and spatially resolved method. Materials and Methods: A retrospective analysis used data from a previously published randomised clinical trial comparing three bleaching systems: in-office 6% hydrogen peroxide paint-on varnish; at-home 6% hydrogen peroxide prefilled tray; and at-home 16% carbamide peroxide custom tray. Spectrophotometric images of maxillary central incisors and canines were retrieved at different stages, and their translucency maps were processed with ImageJ to quantify the percentage of translucent area, histogram-derived grey intensity and RGB-blue channel metrics. Statistical tests were performed appropriately (α = 0.05). Results: All bleaching protocols produced significant post-treatment increases in translucency-related parameters (p < 0.05), although the in-office protocol showed smaller changes than the at-home techniques (p < 0.05). At six months, the translucent area remained significantly higher in most conditions, whereas histogram-derived metrics showed no significant changes. Correlations between translucency-related parameters and colour/whiteness differences were mostly negligible to weak. Conclusions: The preliminary image-based assessment detected significant and technique-dependent changes in translucency-related parameters following bleaching, with a weak linear association between these changes and colour outcomes.

PMID 42505487
阅读全文 →
PubMedDentistry journal2026-07-27

Microhardness Recovery Kinetics, Surface Roughness Trajectories, and Erosive Wear Susceptibility of Enamel After Three In-Office Bleaching Protocols: A 28-Day In Vitro Investigation.

Buzatu Berivan Laura Rebeca BLR, Luca Magda Mihaela MM, Buzatu Roxana R

Background and Objectives: In-office bleaching is one of the most requested aesthetic procedures, but its biomechanical aftermath on enamel-particularly the recovery trajectory of microhardness, surface roughness, and erosive vulnerability-remains incompletely characterised. The present study quantified the 28-day mechanical recovery profile of enamel after three commonly used chairside bleaching protocols and examined inter-relationships between mechanical, topographic and erosive endpoints. Methods: Forty-two human molars and premolars (27 molars, 15 premolars) extracted for clinical reasons and previously catalogued in the institutional biobank were sectioned along the cervical-occlusal axis to obtain matched control and experimental halves. The experimental halves were assigned (n = 14 per group) to Opalescence Quick (45% carbamide peroxide, no light), Opalescence Boost (40% hydrogen peroxide, chemically activated), or BlancOne Ultra+ (35% hydrogen peroxide with light activation). Vickers microhardness (VHN), profilometric roughness (Ra), and erosive wear after a standardised citric-acid challenge were measured at baseline, immediately post-bleaching, and at 24 h, 7 d, 14 d, and 28 d in artificial saliva. Wilcoxon signed-rank, Kruskal-Wallis with Dunn-Bonferroni post hoc, linear mixed-effects models, multiple linear regression, ROC analysis, and Spearman correlations were used (α = 0.05). Results: Immediate VHN drops were -13.2 ± 3.9%, -22.6 ± 3.6%, and -29.6 ± 4.7% for Opalescence Quick, Opalescence Boost, and BlancOne Ultra+, respectively. By 28 days, recovery reached 97.4 ± 2.2%, 96.0 ± 2.9%, and 91.6 ± 2.3% of baseline (p < 0.001). Exponential rate constants were 0.137, 0.075, and 0.092 d-1. Erosive wear after acid challenge was 2.1×, 2.8×, and 3.8× control values. ROC analysis identified Δ-immediate Ra as the strongest predictor of incomplete recovery (AUC = 0.859). Conclusions: Higher-aggression protocols delayed mechanical recovery and amplified erosive susceptibility, with light-activated systems carrying the greatest residual risk. These in vitro findings provide an evidence base for the design of future clinical studies on post-bleaching enamel recovery and remineralisation.

PMID 42505742
阅读全文 →
PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-07-27

Atomically Correlated Phosphorus-Sulfur Sites in Carbon Nitride for Efficient Hydrogen Peroxide Production.

Ahmad Adnan A, Abass Gbemi F GF, Naing Myat Thwe MT, Yang Cheng C et al.

Photocatalytic oxygen reduction offers a sustainable route to hydrogen peroxide (H2O2) production; however, rapid charge-carrier recombination and sluggish oxygen-reduction reaction (ORR) kinetics remain the primary bottlenecks. Herein, an atomically correlated phosphorus-sulfur co-doped graphitic carbon nitride (g-C3N4), referred to as P-S:gCN, is demonstrated to enable efficient H2O2 photogeneration in O2-saturated water without sacrificial agents. Introducing atomically correlated P-S sites within the heptazine framework creates an asymmetric charge distribution that suppresses trap-mediated recombination and promotes efficient charge separation. These coupled heteroatom sites also enhance oxygen adsorption and activation on the catalytic surface, directing the reaction through the selective 2e- ORR pathway to increase H2O2 generation. Under visible-light irradiation, P-S:gCN achieves an apparent quantum yield of 6.80% at 420 nm and a solar-to-chemical conversion efficiency of 0.49% in pure water. Combined experimental and theoretical evidence reveals that atomically correlated P-S sites regulate charge transport, suppress recombination, and promote selective 2e- ORR more effectively than isolated dopants. This atomically correlated dual-site engineering opens avenues for tuning charge transport, electronic structure, and the stability of reaction intermediates in metal-free photocatalytic systems.

PMID 42505114
阅读全文 →
PubMedMembranes2026-07-27

Recent Advances in Membrane Technologies for Electronic-Grade Hydrogen Peroxide Purification and Concentration.

Zhang Canli C, Lei Jiaofei J, Li Wenpeng W, Yang Penglin P et al.

Hydrogen peroxide (H2O2) is widely used in semiconductor cleaning and etching, where ultralow levels of metallic, anionic, organic, and particulate impurities must be strictly controlled. Industrially produced H2O2 therefore requires extensive downstream purification before it can meet electronic-grade specifications. Conventional purification routes based on distillation or rectification, adsorption, ion exchange, and final filtration are technically mature, but they remain constrained by substantial energy consumption, multiple treatment stages, chemical regeneration, secondary waste generation, and safety risks associated with H2O2 decomposition. This review critically evaluates membrane technologies for purifying and concentrating electronic-grade H2O2. Microfiltration and ultrafiltration are discussed as front-end clarification processes, nanofiltration as an intermediate impurity-load-reduction step, and reverse osmosis as the membrane process with the strongest direct experimental for ionic-impurity removal from concentrated H2O2. Pervaporation and membrane distillation are assessed as emerging water-removal technologies, although their industrial applicability remains insufficiently validated. Membrane material strategies, including oxidation-resistant polymers, inorganic and hybrid membranes, antioxidant-containing composites, and emerging MOF- and two-dimensional-material-based membranes, are also evaluated. Particular attention is paid to the limited direct evidence available for emerging materials and to the risks of H2O2 decomposition, material leaching, particle release, and deterioration of membrane selectivity. The available evidence indicates that membrane processes are currently more appropriately regarded as complementary clarification, purification, polishing, or concentration units rather than complete replacements for established industrial technologies. Future studies should prioritize long-term oxidative stability, ppb- and ppt-level impurity validation, low H2O2 loss, module-material compatibility, process safety, and continuous pilot-scale techno-economic assessment.

PMID 42506194
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多miconazole + benzoyl peroxide