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miconazole + benzoyl peroxide (Acnidazil / Acne Creme Plus)

✓ Approved

Teva Pharmaceutical Industries Ltd. · 小分子 · 小分子

什么是 miconazole + benzoyl peroxide？

miconazole + benzoyl peroxide 是一种小分子，由Teva Pharmaceutical Industries Ltd.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名Acnidazil, Acne Creme Plus
公司Teva Pharmaceutical Industries Ltd.
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Teva Pharmaceutical Industries Ltd.

治疗适应症

miconazole + benzoyl peroxide 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersAcne✓ Approved

相关研究文献

PubMedJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]2026-09-10

Implications of European Union Sodium Perborate Restrictions for Intracoronal Bleaching Procedures: A Narrative Review.

Herz Marco M MM, Meller Christian C, Klein Christian C, Österreicher Johannes J

To critically evaluate current and emerging intracoronal bleaching agents and to provide an evidence-informed framework for clinical decision-making in the postsodium perborate era. The declining availability of sodium perborate, particularly within the European Union, has substantially altered contemporary intracoronal bleaching practice. A narrative review was conducted using a structured PubMed/MEDLINE literature search and manual reference screening. Evidence regarding bleaching efficacy, biological safety, peroxide diffusion, cervical root resorption, dentin-related effects, restorative implications, regulatory developments, and emerging bleaching materials was critically synthesized. Hydrogen peroxide, carbamide peroxide, and sodium percarbonate all achieve clinically relevant whitening but differ in biological characteristics and the strength of supporting evidence. Hydrogen peroxide remains effective but raises greater concerns regarding peroxide diffusion and concentration-dependent biological effects. Carbamide peroxide is supported by extensive contemporary clinical evidence and long-term outcome data, whereas sodium percarbonate represents a promising borate-free alternative currently supported primarily by laboratory and ex vivo studies. Among currently available intracoronal bleaching agents, carbamide peroxide is supported by one of the largest bodies of contemporary clinical literature and represents one of the most extensively documented contemporary alternatives to sodium perborate. Sodium percarbonate shows considerable potential but requires prospective clinical validation before more definitive clinical recommendations can be made. This review provides an evidence-informed framework for selecting contemporary intracoronal bleaching agents to achieve predictable esthetic outcomes in the postsodium perborate era while identifying priorities for future clinical research.

PMID 42717716
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PubMedInternational journal of dental hygiene2026-09-10

Does Hydrogen Peroxide/Colloidal-Silver Reduce the Aerosolized Bacteria Generated During Dental Procedures?

Bulut Ayşe A, Özsoy Faik Serhat FS, Akca Gülçin G, Tuncay Nazime N et al.

Bioaerosols containing live microorganisms that may cause disease development are formed during many dental procedures. Although some recent studies have addressed reduction of the aerosolized bacterial load, none have examined the use of hydrogen peroxide (H2O2)/colloidal-silver for this purpose. The current study aimed to evaluate the reduction of aerosolized bacteria during dental procedures at different distances and directions and investigate the efficacy of H2O2/Colloidal-silver on Staphylococcus aureus. Group A (n = 300) was the control group where sterile distilled water was used. Group B (n = 300) was the study group, where sterile distilled water with 500 ppm H2O2/Colloidal-silver was used. Blood agar plates were placed at the 3, 6, and 9 o'clock positions and the head position (relative to 12 o'clock) at different distances; the head phantom's jaws were then contaminated with bacterial suspension at each position. The plates were then incubated for 24-48 h. The grown colonies were counted and expressed as colony-forming units (CFU)/plate. Statistical analysis was performed using the Mann-Whitney U test for comparing independent samples. There were statistically significant differences between Group A and Group B bacterial counts at 50, 100, and 200 cm distances at the 6 o'clock position, and at 100 and 200 cm distances at the 9 o'clock position (p < 0.001, remaining significant after Bonferroni correction). There was a notable reduction in Group B at the head position compared to Group A. The findings showed that H2O2/Colloidal-silver (0.05%) had bactericidal efficacy against settled Staphylococcus aureus contamination at the positions tested.

PMID 42717286
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PubMedThe journal of physical chemistry. A2026-09-10

Hydrogen-Bonded Complex of the Simplest Phosphine Oxide with Water.

Zhu Bifeng B, Ma Ziting Z, Zhou Can C, Chu Xianxu X et al.

The simplest phosphine oxide OPH3, a key intermediate in the oxidation of phosphine PH3, has been of long-term interest in theoretical and experimental chemistry. By UV photolysis (254 nm) of an atmospherically important complex between PH3 and hydrogen peroxide H2O2, the elusive OPH3 has been generated as a hydrogen-bonded water complex in cryogenic N2 and Ar matrices at 10 K. The spectroscopic identification of this complex is supported by D-isotope labeling and quantum-chemical calculations. Calculations on the potential energy profile for the rearrangement from PH3···H2O2 to OPH3···H2O demonstrate that the concerted mechanism is energetically preferred at the CCSD(T)-F12a/aug-cc-pVTZ//B3LYP/6-311++G(3df,3pd) level of theory. The formation of the molecular complex between PH3 and H2O2 and its subsequent photoisomerization to OPH3···H2O might be of interest for understanding the networks of the atmospheric phosphorus chemistry.

PMID 42720379
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PubMedChemistry (Weinheim an der Bergstrasse, Germany)2026-09-10

Mechanistic Insights Into Luminol Chemiexcitation: The Role of the Amide Carbonyls.

Cuéllar-Zuquin Juliana J, Vila-Cervera Héctor H, Giussani Angelo A, Roca-Sanjuán Daniel D

Luminol chemiluminescence originates from a chemiexcitation process that occurs during the decomposition of its bicyclic endoperoxide intermediate, involving peroxide bond cleavage and molecular nitrogen release. In this work, we investigated the mechanism of this decomposition using multiconfigurational quantum chemistry and density functional theory. Calculations on a reduced model without the aniline ring and without the alkoxide groups, which come from the amide carbonyl groups of luminol, showed that the pathway initiated by O-O bond cleavage is inaccessible, whereas the route starting by nitrogen loss and the concerted decomposition display similar activation barriers. However, only the stepwise mechanism reaches regions favorable for population transfer to the emissive excited state. The concerted mechanism therefore acts as a competing channel that reduces the chemiexcitation and chemiluminescence yields. By extending the study to a larger model (including the alkoxide groups) and to the complete luminol molecule, the energetic trends change in favor of the stepwise or asynchronous decomposition with the C-N bond breaking preceding the O-O bond cleavage, which drives the system toward the chemiexcitation region. Through the analysis of natural bond orbitals, it was shown that it is the donation of the lone pairs of the alkoxide groups that weakens the C-N bond.

PMID 42720402
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PubMedBiomaterials research2026-09-10

Photodynamically Sensitized Mitochondrial-Damage Amplification Strategy Promotes Pyroptosis-Induced Immunotherapy of Osteosarcoma.

Ding Tao T, Xiong Tongyin T, Xu Xinzhong X, Sun Qiuting Q et al.

The heterogeneity of osteosarcoma (OS) is the main reason for ineffective treatment and uncontrolled disease. Immunotherapy provides an ideal strategy to overcome the heterogeneity of OS, but effective activation of tumor-intrinsic immunogenicity remains challenging. We developed a biomimetic nanoplatform utilizing mitochondrial damage as a potent immunogenic trigger by employing the mitochondria-targeting compound cinnamaldehyde (CA) derived from traditional Chinese medicine. OS cell membrane-coated hollow MnO2 nanoparticles were used to deliver CA and chlorin e6. After accumulating at the tumor site and being internalized by tumor cells, CA release induces mitochondrial oxidative damage and produces hydrogen peroxide in combination with hollow manganese dioxide to alleviate the hypoxic microenvironment. Finally, a mitochondrial-damage amplification mechanism is formed to trigger tumor pyroptosis under the synergy of adjustable photodynamic therapy. Released damage-associated molecule patterns and damaged double-stranded DNA inside tumor cells promote dendritic cell maturation by activating the cGAS-STING (cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes) signaling axis. Through CA-triggered amplification of mitochondrial damage, dual immunogenic pathways reshape the immunosuppressive microenvironment, overcoming OS heterogeneity and inhibiting distal metastasis. This strategy provides new opportunities for tumor-intrinsic immunogenic activation.

PMID 42719493
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PubMedEuropean journal of oral sciences2026-09-10

Effect of chitosan-containing desensitizers applied prior to bleaching on the physical properties of enamel.

Barbato Júlia J, Passos Luís Otávio LO, Barbosa Carolina Meneghin CM, Benati Marcos Roberto de Lima MRL et al.

This in vitro study evaluated the effects of adding chitosan (Chi) to desensitizing agents applied before dental bleaching on enamel properties. Bovine enamel specimens were allocated to seven groups (n = 12): no treatment (negative control), 2% NaF (positive control), 2% NaF + 2% Chi, 2% NaF + 5% Chi, 2% NaF + 5% KNO3, 2% NaF + 5% KNO3 + 2% Chi, and 2% NaF + 5% KNO3 + 5% Chi. All specimens underwent three bleaching sessions with 35% hydrogen peroxide, each preceded by a 10-min application of desensitizing agents. Color change (∆L*, ∆a*, ∆b*, ∆Eab, and ∆E00), whiteness index (∆WID), surface roughness (Ra), and microhardness (SMH) were evaluated at baseline (T0) and after each session (T1-T3). Scanning electron microscopy analysis was performed at T3. Color parameters did not differ among groups (p > 0.05), indicating bleaching efficacy. Surface roughness increased in all groups (p < 0.0001), with greater increases in chitosan-containing groups. However, groups 2% NaF + 5% Chi and 2% NaF + 5% KNO3 + 5% Chi showed significantly higher microhardness values than controls at T2 and T3. Incorporation of chitosan into desensitizing agents increased enamel surface roughness but preserved microhardness without compromising bleaching efficacy. These findings suggest chitosan may represent strategy for protecting enamel during in-office bleaching.

PMID 42719982
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