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SH-U-454

✓ Approved

Bayer AG · 小分子 · 小分子

什么是 SH-U-454？

SH-U-454 是一种小分子，由Bayer AG研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

公司Bayer AG
药物类别小分子, 影像药物
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Bayer AG

治疗适应症

SH-U-454 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersArteriosclerosis coronary artery✓ Approved

相关研究文献

PubMedMarine drugs2026-07-27

Low-Molecular-Weight Fish Collagen Peptide Enhances Hair Regrowth via Activation of Proliferative Signaling and Suppression of Inhibitory Pathways.

Kim Hyelim H, Lee Yeonhwa Y, Park Seong-Hoo SH, Choi Hyunyoung H et al.

Collagen peptides have been widely studied for their beneficial effects on skin health; however, their potential role in hair growth remains insufficiently explored. This study aimed to investigate the effects of orally administered low-molecular-weight fish collagen peptide (SH-GT) on hair regrowth and its underlying mechanisms in a hair-removed C57BL/6J mouse model. Mice were administered SH-GT (100, 300, or 600 mg/kg body weight) or a positive control (Pansidil, 400 mg/kg) daily for 28 days. SH-GT significantly enhanced hair regrowth, as evidenced by the increased hair growth area. Histological analysis revealed increased dermal thickness and visible hair follicle structures in SH-GT-treated groups. At the molecular level, SH-GT upregulated proliferation-related proteins, including PCNA and Cyclin D1, and activated Wnt/β-catenin signaling. In addition, SH-GT enhanced PI3K/Akt/mTOR signaling, suggesting improved cellular growth and survival. Conversely, SH-GT suppressed hair growth inhibitory pathways by reducing BMP4 expression and decreasing Smad phosphorylation. Furthermore, SH-GT increased the mRNA expression of growth factors such as IGF-1, HGF, VEGF, EGF, and FGF7. In conclusion, SH-GT promotes hair regrowth by simultaneously activating proliferation-related signaling pathways and suppressing inhibitory mechanisms, thereby improving the dorsal skin microenvironment associated with hair regrowth. These findings suggest that SH-GT may serve as a promising functional ingredient for improving hair growth.

PMID 42505973
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PubMedCureus2026-07-27

Incarcerated Spigelian Hernia: A Case Report.

Preza Estrada Arym P AP

Spigelian hernia (SH) is a rare abdominal wall defect that frequently presents a diagnostic challenge because of its non-specific symptoms and deep anatomical location. We report the case of a 64-year-old woman with adequately controlled hypertension who presented with localized abdominal wall pain and a long-standing lateral abdominal bulge. Physical examination revealed an incarcerated SH without signs of strangulation or bowel obstruction. Computed tomography confirmed a Spigelian fascial defect containing incarcerated ileal loops without evidence of bowel compromise, allowing appropriate preoperative planning. The patient underwent elective open hernioplasty with polypropylene mesh placement without intraoperative complications. Postoperative recovery was uneventful, with satisfactory wound healing and progressive return to normal daily activities. At six months of follow-up, the patient remained asymptomatic, with no evidence of recurrence or mesh-related complications. This case highlights the importance of maintaining a high index of suspicion for SH in patients presenting with lateral abdominal wall pain or swelling. Computed tomography remains a valuable diagnostic tool for confirming the diagnosis and facilitating surgical planning, while timely mesh repair represents a safe and effective treatment option that may prevent progression to incarceration, strangulation, and bowel compromise.

PMID 42504387
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PubMedGels (Basel, Switzerland)2026-07-27

Synergistic Hydrogels Enabled by Dual-Regulatory Mussel Foot Protein for Advancing Wound Healing.

Xu Jiren J, Li Na N, Wang Chen C, Elango Jeevithan J et al.

Impaired wound healing is often caused by persistent inflammation, bacterial infection, and insufficient extracellular matrix remodeling. Natural polymer-based hydrogels represent ideal wound dressings but often struggle to balance structural stability and biological activity. Herein, we report a dual-functional network regulation strategy enabled by highly soluble mussel foot protein (HMFP) that acts simultaneously as a structural crosslinking regulator and bioactive effector to fabricate synergistic hydrogels (CS-SH-H) from β-chitosan (CS) and sodium hyaluronate (SH). HMFP homogenizes the porous microstructure, strengthens intermolecular interactions, and significantly improves thermal and structural stability via multivalent non-covalent bonding. In vitro, CS-SH-H shows excellent cytocompatibility, significantly promotes fibroblast proliferation and migration, and exerts potent antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). In a mouse full-thickness skin defect model, the hydrogel dramatically accelerates wound closure, reducing the residual wound area to 25% on day 7, outperforming the control groups. Immunohistochemistry confirms that HMFP suppresses TNF-α-mediated inflammation and enhances Ki-67-positive cell proliferation, leading to accelerated re-epithelialization and collagen deposition. This study establishes HMFP as a promising marine-derived dual-functional network regulator for designing high-performance hydrogel dressings. This strategy is scalable and translatable for treating infected and inflammatory wounds.

PMID 42505309
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PubMedThe journal of physical chemistry. A2026-07-27

Anion Photoelectron Spectroscopy and Electronic Structure of UC2-/0.

Tufekci Burak A BA, Ariyarathna Isuru R IR, Wang Shiying S, Foreman Kathryn K et al.

Anion photoelectron spectroscopy (aPES) of the uranium dicarbide molecular anion, UC2-, was performed in conjunction with ab initio electronic structure calculations to investigate the molecular and electronic structures of anionic and neutral UC2-/0. Our combined experimental-theoretical approach assigns both UC2- and neutral UC2 to structurally similar non-linear U(CC) geometries, with U(CC) adopting a slightly lower symmetry Cs 4A″ structure and neutral U(CC) adopting the C2v 5A2 structure, herein described as the T-shaped U(CC) isomer. The experimental vertical detachment energy (VDE) of UC2- was determined to be 1.58 ± 0.05 eV, in reasonable agreement with the calculated VDE of 1.30 eV obtained from Franck-Condon simulation. This assignment is further supported by the vibrational progression observed in the experimental spectrum, with spacings in the range of 480-565 cm-1, which agrees with the calculated U-C2 stretching mode of neutral UC2 at 518.76 cm-1. These results provide evidence for the long-predicted non-linear ground-state structure of UC2.

PMID 42503783
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PubMedChemical communications (Cambridge, England)2026-07-27

Stabilizing a perovskite precursor for efficient air-processed inorganic perovskite solar cells with superior reproducibility.

Liu Hanqing H, Fan Qiyu Q, Wang Guiqiang G, Meng Fanning F et al.

An effective precursor stabilization strategy is developed through introducing pentaerythrityl tetrakis(3-mercaptopropionate) (PETMP) containing -SH and -COO- functional groups as stabilizers for fabricating high-quality CsPbI2Br perovskite films with high reproducibility in ambient air. We achieve reproducible carbon-based CsPbI2Br perovskite solar cells with an attractive efficiency of 15.20% under ambient air.

PMID 42505067
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PubMedMarine biotechnology (New York, N.Y.)2026-07-27

Integrated Genomic, Transcriptomic and Metabolomic Analyses Identify Key Genetic Determinants and Regulatory Networks for Salinity Tolerance in Macrobrachium rosenbergii.

Jiahua Zhang Z, Min Zhang Z, Chungui Huang H, Xiaohan Liu L et al.

Salinity stress severely restricts the culture and geographical expansion of Macrobrachium rosenbergii. Artificial selective breeding has generated a salt-tolerant (NY) strain that can survive and grow normally under 10‰ salinity, while the commercial Suhu No.1 (SH) strain and commercial population (PT) exhibit weaker salt adaptability. In the present study, we performed whole-genome resequencing, transcriptome and untargeted metabolomic analyses to systematically reveal the molecular basis of salinity tolerance in the NY strain. Population genetic analyses including ADMIXTURE, PCA and phylogenetic tree demonstrated obvious genetic differentiation among NY, SH and PT populations, and genome-wide Fst scanning screened candidate genes mainly enriched in ion transport, osmotic regulation and energy metabolism pathways. Transcriptomic analysis identified 156 differentially expressed genes (DEGs) between NY and SH strains, with principal component analysis showing clear inter-group separation. Functional enrichment indicated that DEGs were predominantly involved in starch and sucrose metabolism, glycolysis/gluconeogenesis, autophagy and cellular homeostasis. qRT-PCR validation confirmed the reliability of transcriptome expression patterns of key salt-tolerance genes such as NKA, NHX, TPS and HSP70. Untargeted metabolomics identified a total of 1079 metabolites and 69 differentially accumulated metabolites (DAMs). DAMs were significantly enriched in starch and sucrose metabolism, phosphotransferase system (PTS) and ABC transporters under both positive and negative ion modes. Integrated transcriptomic and metabolomic analysis revealed 9 shared KEGG pathways in positive ion mode and 14 in negative ion mode, and key genes and metabolites displayed coordinated variation in carbohydrate metabolism, transmembrane transport and osmotic adjustment. Collectively, the NY strain achieves strong salinity tolerance by integrating genetic variation, transcriptional reprogramming and metabolic remodeling, synergistically maintaining ion homeostasis, osmotic balance and energy supply. This study provides important genetic resources and a theoretical framework for molecular breeding and salinity adaptation mechanism research of M. rosenbergii.

PMID 42507198
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