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CSF-G

✓ Approved

Dong-A ST · CSF3R · 重组蛋白

什么是 CSF-G？

CSF-G 是一种重组蛋白，由Dong-A ST研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

公司Dong-A ST
药物类别重组蛋白
分子靶点CSF3R
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Dong-A ST

作用机制

分子靶点

CSF-G 作用于 1 个分子靶点：

CSF3Rcolony stimulating factor 3 receptor (CD114, GCSFR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

CSF-G 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersNeutropenia✓ Approved

相关研究文献

PubMedBiosensors2026-10-26

Label-Free Acoustic Wave Detection of Myelin Basic Protein for Monitoring of Neurodegenerative Disease.

Spagnolo Sandro S, Mikuličová Sára S, Davoudian Katharina K, Sontakke Kiran K et al.

Myelin basic protein (MBP) is released into cerebrospinal fluid during demyelination and is therefore a promising biomarker for the detection of neurodegenerative diseases such as multiple sclerosis. For the label-free detection of MBP, we developed an antifouling aptasensor based on thickness shear mode sensing. DNA aptamers were immobilized on gold-coated piezoelectric crystals functionalized with an engineered antifouling self-assembled monolayer based on 3-(2-mercaptoethoxy)propanoic acid (HS-MEG-COOH) combined with either 2-(2-mercaptoethoxy)ethanol (HS-MEG-OH) or dithiothreitol (DTT) as spacers. The binding of recombinant human MBP to the aptamer was confirmed with a corresponding decrease in resonance frequency in both phosphate-buffered saline (PBS) and artificial cerebrospinal fluid (aCSF). The aptasensor achieved a limit of detection of 11 ng mL-1 in PBS and 2 ng mL-1 in aCSF. PBS measurements were primarily applied to determine the aptasensor functionality, whereas experiments in aCSF evaluated MBP detection at concentrations relevant to reported levels in biological CSF. Selectivity was assessed with aptamer-free surfaces, cytochrome c, and human serum albumin (HSA) with much lower responses, while concentration-dependent MBP detection was maintained in aCSF despite the increased complexity of the matrix. The antifouling performance of the modified sensing surface was further demonstrated in aCSF by the significantly reduced frequency and dissipation responses compared to bare gold. With future validation in human cerebrospinal fluid (CSF) samples, the developed biosensor has the potential to enable sensitive, label-free detection of MBP in CSF for the identification and monitoring of neurodegenerative diseases.

PMID 42930111
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PubMedNMR in biomedicine2026-10-26

Automated Cerebrospinal Fluid Flow Quantification in Hydrocephalus Using Phase-Contrast Magnetic Resonance Imaging.

Rodríguez Martínez Eder Alejandro EA, Liu Pan P, Owashi Kimi K, Gayet Antoine A et al.

Quantitative cerebrospinal fluid (CSF) flow analysis with phase-contrast magnetic resonance imaging depends on segmentation and is affected by operator variability. This cohort method-comparison study evaluated whether a flow-aware deep learning (DL) model provides reproducible C2-C3 CSF segmentation and flow quantification compared with repeated manual segmentation. Ten hydrocephalus patients underwent 3-T phase-contrast magnetic resonance imaging at C2-C3, with 32 magnitude and phase frames across the cardiac cycle. Three experts and one novice segmented each case twice using semi-automatic software, generating 80 manual annotations. A pretrained flow-aware 2D-UNet generated one fixed automatic segmentation per case. The inference pipeline was deterministic, meaning that repeated processing of the same input with fixed model weights and settings produced identical masks. A multi-expert reference was defined as the arithmetic mean of the expert measurements. Region of interest (ROI) surface area, peak flow amplitude, and stroke volume were compared using mean difference, Bland-Altman 95% limits of agreement, Lin's concordance correlation coefficient (CCC), and intraclass correlation coefficient (ICC). Expert ICC(1,1) was 0.88-0.97 for surface area, 0.97-1.00 for peak flow amplitude, and 0.97-0.99 for stroke volume; novice values were 0.63, 0.95, and 0.92, respectively. Compared with the multi-expert reference, model mean differences were -0.42 mm2 for surface area, -0.00 mL/s for peak flow amplitude, and -0.01 mL for stroke volume, with CCC values of 0.50, 0.87, and 0.86. Bland-Altman limits of agreement were -69.12 to 68.27 mm2, -1.47 to 1.46 mL/s, and -0.34 to 0.31 mL. The model provided rapid, deterministic CSF segmentation with small cohort-level mean differences in peak flow amplitude and stroke volume; however, individual-level agreement with the flow-derived multi-expert reference was lower than for expert and novice segmentations obtained using the semi-automatic workflow.

PMID 42929072
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PubMedCells2026-10-26

Circulating Immune-Related Biomarkers in Egyptian Women with Early Breast Cancer: An Exploratory Case-Control Study Across IHC-Defined Clinicopathological Subgroups.

Zaki Rania R, Nassar Auhood A, Al Najar Rania A RA, Sabit Hussein H et al.

Breast cancer (BC) progression depends on immune dysregulation and complex interactions between tumor cells and host immune components. Soluble immune checkpoints, growth factors, chemokines, and cytokines are promising circulating biomarkers; however, their clinical relevance across IHC-defined clinicopathological subgroups in Egyptian BC patients remains poorly characterized. Seventy Egyptian women with pathologically confirmed early-stage BC and 20 healthy controls were recruited for this case-control study. Patients were classified into IHC-defined clinicopathological groups. Eleven circulating proteins (ICOSLG, LAG-3, TIM-3, TNFRSF-14 (HVEM), FGF-21, M-CSF, CX3CR1, CCL5, CX3CL1/fractalkine, IFN-A2A, and TGF-β1) were quantified by sandwich ELISA. Associations with IHC-defined clinicopathological subgroups was assessed using univariate and multivariate analyses. Biomarker performance was assessed by receiver operating characteristic (ROC) analysis and heatmaps. The cohort comprised Luminal A-like (n = 20), Luminal-HER2-like (n = 18), Luminal B-like (n = 16), HER2-positive (n = 9), and TNBC (n = 7) groups. BC cases had significantly higher circulating levels of ICOSLG, TIM-3, FGF-21, M-CSF, CX3CR1, CCL5, CX3CL1/fractalkine, TGF-β1, and TNFRSF-14 (HVEM), and significantly lower levels of LAG-3 than healthy controls (all p < 0.05). Statistically significant subtype-related differences were observed for ICOSLG, LAG-3, FGF-21, M-CSF, CX3CL1/fractalkine, TGF-β1, and TNFRSF-14 (HVEM). In multivariate logistic regression, Spearman rank correlation analysis confirmed that CX3CL1/fractalkine and TNFRSF-14 (HVEM) were independently associated with IHC-defined clinicopathological subgroups and can distinguish Luminal-HER2 BC from the Luminal A subtype [CX3CL1/Fractalkine: AUC of 0.789 (95% CI: 0.643-0.935), p = 0.002; TNFRSF-14 (HVEM): AUC of 0.858 (95% CI: 0.735-0.981), p < 0.001). For HER2 positivity, a combined LAG-3/CCL5 ROC for HER2-positive vs. HER2-negative was yielded AUC = 0.775 (95% CI: 0.659-0.882). Early BC appears to trigger significant systemic immune dysregulation, marked by altered circulating levels of immune checkpoints, inflammatory mediators, and growth factors. CX3CL1/fractalkine and TNFRSF-14 (HVEM) can independently discriminate Luminal-HER2 BC from the Luminal A subtype and may serve as potential biomarkers for disease stratification and precision immuno-oncology.

PMID 42929822
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PubMedPublic health nutrition2026-10-26

Are intervention effects on fruit and vegetable intake maintained after 48 months of follow-up? A randomised controlled community trial.

de Carvalho Maria Cecília Ramos MCR, Lopes Mariana Souza MS, de Freitas Patrícia Pinheiro PP, Lopes Aline Cristine Souza ACS

To assess whether participants from a transtheoretical model-based intervention maintained increases in fruit and vegetables (FV) intake 48 months after baseline. Randomised controlled community trial. A Brazilian primary health care service. Primary health care service users. The control group (CG) received usual care, and the intervention group (IG) received usual care and a 7-month collective intervention to promote FV intake. We analysed individuals with positive changes 12 months after baseline (baseline intake <400 g/d with any increase at 12 months or baseline intake ≥400 g which remained ≥400 g at 12 months, n 2·232). Outcomes were FV intakes at 36 and 48 months after baseline compared to previous intakes to identify maintenance. We used generalised estimating equations models to assess time and intervention effects in follow-up intake. Participants were mostly adult women. We identified decreases of 54.4 g/d in fruit intake and 38.5 g/d in vegetable intake at 36 months and increases of 6.9 g/d in fruit intake and 23.4 g/d in vegetable intake at 48 months. According to adjusted models, at 36 months, CG and IG participants presented similar decreases in FV intakes, which means initial changes in the IG were not maintained. At 48 months, small increases in intakes were also similar between IG and CG. Intervention participants did not maintain initial changes on FV intake in the long term, and boosters might be necessary to maintain initial increases.

PMID 42929269
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PubMedGels (Basel, Switzerland)2026-10-26

Preparation of Cellulose Nanofiber Aerogels from Paper Sludge Waste and Their Use for the Removal of Metal Ions Used in Batteries from Water.

Abou-Elseoud Wafaa W, Fadel Shaimaa S, Hassan Enas E, Quemener Damien D et al.

Developing cost-effective, bio-based adsorbents for hazardous battery industry effluents is a major environmental challenge. This study isolated cellulose nanofibers (CNFs) from primary paper sludge (PS)-a tissue manufacturing waste-via chemical modification using (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl oxidation (TEMPO oxidation) and ultrasonication to fabricate highly porous aerogels. The PS-CNF aerogels were evaluated for removing battery-related metal ions (Pb2+, Cd2+, Co2+, Mn2+, Ni2+, and Li+). To assess the structural impact of residual kaolin in the sludge, performance was compared against aerogels derived from fiber dust (FD) waste, as well as a commercial resin (Purolite C-100). The PS-CNF aerogels demonstrated superior maximum adsorption capacities of 39.28 mg/g for Pb2+, 29.80 mg/g for Cd2+, 21.05 mg/g for Co2+, 20.19 mg/g for Mn2+, 16.80 mg/g for Ni2+, and 11.33 mg/g for Li+. They consistently outperformed the FD-CNF matrix across the entire series. This enhanced efficiency is attributed to the residual kaolin in the paper sludge, which also acts as a physical spacer, increasing the aerogel's internal porosity. Adsorption generally followed the Langmuir isotherm and pseudo-second-order kinetics. Furthermore, the PS-CNF aerogels exhibited higher efficiency than the commercial Purolite C-100 cation exchange resin. Ultimately, this work demonstrates the potential of upcycling paper sludge into sustainable, high-performance adsorbents for treating toxic battery effluents.

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PubMedGels (Basel, Switzerland)2026-10-26

Preparation of Itaconic Acid-Modified Guar Gum Composite Hydrogel for Water Retention in Mine Ecological Restoration.

He Shixue S, Zhao Ting T, Lang Daning D, Wu Ronglan R

To tackle poor water retention in degraded mine soil and the low stability and short water-holding duration of natural polymer hydrogels, an itaconic acid-modified guar gum composite hydrogel (IAGG hydrogel) was developed using guar gum (GG) as the polymer substrate and itaconic acid (IA) as the functional monomer. This study aimed to improve the stability, water-retention duration, and water-absorption performance of GG-based hydrogels through a covalent-dynamic multiple-crosslinking design and to evaluate their potential for mine ecological restoration. The hydrogel network was constructed through IA-related covalent interactions, ECH-mediated ether crosslinking, and borax-mediated dynamic interactions, forming a covalent-dynamic multiple-crosslinked structure. IA-introduced carboxyl groups enhanced hydrophilicity and water retention via hydrogen bonding and ionic hydration, while covalent-dynamic crosslinking synergy improved network stability and wet-dry cycle resistance. Under the optimized preparation conditions, the IAGG hydrogel exhibited a water absorption capacity of 370.7 g/g in deionized water, and the I5G5 hydrogel retained a water absorption capacity of 255.4 g/g after 10 swelling-dehydration cycles. Soil experiments showed that IAGG increased mine soil water-holding capacity from 13.3 to 77.6 g/g, extended retention from 5 to 14 days, and supported the germination and subsequent seedling development of Suaeda salsa. After 4 months of soil burial, the hydrogel exhibited approximately 63% weight loss, indicating substantial structural deterioration under the tested soil-burial conditions. These results demonstrate the potential of IAGG as a water-retention material for mine ecological restoration.

PMID 42929955
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