Dong-A ST · CSF3R · 重组蛋白
CSF-G 是一种重组蛋白，由Dong-A ST研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。
| 公司 | Dong-A ST |
| 药物类别 | 重组蛋白 |
| 分子靶点 | CSF3R |
| 给药途径 | Injectable (Others), Subcutaneous Injection |
| 状态 | Approved |
CSF-G 作用于 1 个分子靶点：
| CSF3R | colony stimulating factor 3 receptor (CD114, GCSFR) |
CSF-G 针对 1 个适应症，涉及 1 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Blood and lymphatic system disorders | Neutropenia | ✓ Approved |
Memetoglu Onur O, Erbey Fatih F, Akan Tuba T, Ozdemirli Metin M et al.
Aljuhani Manal M, Ashraf Azhaar A, Alqarni Abdullah A, Alshuhri Mohammed S MS et al.
Background: The role of cerebrospinal fluid (CSF) transforming growth factor β (TGF-β) isoforms in Alzheimer's disease (AD) remains unclear. We examined associations of CSF TGF-β1, TGF-β2, and TGF-β3 with AD biomarkers, neurodegeneration, cognition, and clinical progression. Methods: In 294 ADNI participants with baseline CSF TGF-β measurements, adjusted regression, and mixed-effect models were used to evaluate associations with CSF biomarkers, neuroimaging, cognitive outcomes, and conversion. False-discovery-rate correction was applied. Results: Higher baseline TGF-β1 was associated with higher CSF total tau (β = 52.68 pg/mL per 1 SD increase; q < 0.001) and p-tau (β = 5.68 pg/mL; q < 0.001). Higher TGF-β2 was associated with faster hippocampal volume loss (β = -45.42 mm3/year; q < 0.001). No isoform was robustly associated with FDG-PET decline, cognitive decline, clinical conversion, or time to conversion. Conclusions: CSF TGF-β1 and TGF-β2 show distinct associations with tau-related pathology and hippocampal neurodegeneration, respectively, but do not appear to be prognostic biomarkers of clinical progression in AD.
Perera Charith C, Feng Zhiping Z, Nizari Shereen S, Muza Phillip P et al.
We developed a dynamic, heavily T2-weighted (hT2w) FLAIR protocol to resolve acute Mn2+ transport kinetics, as a proxy for Ca2+, across the choroid plexus (ChP)-cerebrospinal fluid (CSF) interface, in vivo. By quantifying intercompartmental Mn2+ dynamics, and comparing these with Gd-DOTA, we sought to characterize blood-CSF-barrier (BCSFB)-mediated tracer transport, combining high in-plane resolution and 4-min temporal sampling. hT2w-FLAIR DCE MRI was conducted in anesthetized C57BL/6 mice, receiving intravenous Mn2+ or Gd-DOTA. Semi-quantitative tracer kinetic modeling permitted regional and inter-tracer comparisons. Mn2+ rapidly crossed from the vasculature into the CSF, across the ChP, with similar arrival times and time-to-peak across compartments. Mn2+ delivery into the ChP exhibited a 5.7-fold steeper uptake rate (p = 0.031) and a 5.6-fold higher peak signal amplitude (p = 0.0028) than in the LV-CSF. In contrast, Gd-DOTA exhibited a 2.2-fold shorter ChP plateau duration (p = 0.034) and 2.2-fold faster ChP clearance rate (p = 0.0047), compared to Mn2+. Within the CSF, there were significant temporal delays with Gd-DOTA relative to Mn2+: a lengthened arrival (eight-fold, p = 0.045) and time-to-peak (six-fold, p = 0.024). Our hT2w-FLAIR DCE-MRI approach captured the early BCSFB transport window for Mn2+, providing distinct ChP and LV-CSF kinetics at a higher temporal resolution and with reduced CSF signal contamination compared to prior approaches. These findings highlight that MRI tracer choice strongly shapes measured BCSFB kinetics, and supports the use of Mn2+ as a tool for probing compartment-specific ChP transport.
Kapan Ali A, Iten Carolina C, Ulrich Christian C, Donnerstag Frank F
To evaluate long-term postoperative symptoms, recovery and treatment responses at least 12 months after surgical repair of spinal CSF leaks in patients with spontaneous intracranial hypotension (SIH) and iatrogenic CSF leaks. This cross-sectional, self-report, online survey was conducted from January to April 2025, with participants recruited through international patient support groups. Descriptive analyses included 92 individuals with SIH and 136 with iatrogenic CSF leaks. The questionnaire assessed pre- and postoperative symptoms, functional recovery, complications and the perceived effectiveness of pharmacological and interventional treatments. Among 228 respondents, complete recovery was reported by 13.6% (12/92) of patients with SIH and 5.8% (8/136) of those with iatrogenic CSF leaks. Orthostatic headache showed the greatest postoperative improvement, whereas fatigue, cognitive impairment and tinnitus improved only moderately. The median duration of sick leave was eight months, and 18% of participants remained on medical leave at the time of assessment. Clinician-diagnosed long-term complications were reported by 14.9% of respondents, including peripheral nerve injury. Acetazolamide was the most effective treatment for rebound high-pressure headache, particularly in patients with SIH. Occipital nerve blocks and therapeutic lumbar punctures provided moderate benefit in selected patients, while most other pharmacological treatments showed limited effectiveness. Many patients in this self-report cohort experience persistent symptoms years after undergoing surgery to repair spinal CSF leaks. These findings emphasise the importance of structured, multidisciplinary and long-term postoperative care.
Crudele Graziano Domenico Luigi GDL, Franceschetti Lorenzo L, Cecalupo Lorenza L, Amadasi Alberto A et al.
Background in forensic toxicology, the detection of pharmacologically active exogenous substances is routinely performed. Interpretation of analyte concentrations must consider multiple variables, markedly affected by diffusion and degradation. These factors complicate toxicological assessment and have stimulated interest in alternative substrates. To assess the toxicological informativeness of cerebrospinal fluid (CSF) through comparison with standard post-mortem matrices, and to investigate whether quantitative relationships exist between CSF and femoral blood concentrations of cocaine and benzoylecgonine. CSF and standard toxicological matrices were collected from 10 forensic cases and three controls. All specimens underwent solid-phase extraction followed by HPLC-Orbitrap mass spectrometry for detection and quantification of cocaine, benzoylecgonine, and other relevant substances. Cocaine and benzoylecgonine were consistently detected in cerebrospinal fluid whenever present in standard matrices, indicating their passage across the blood-brain barrier and supporting CSF as a reliable alternative post-mortem matrix. However, the limited sample size and absence of temporal or clinical information precluded robust quantitative interpretation, highlighting the need for larger studies to clarify pharmacokinetic relationships. Cocaine and benzoylecgonine are detectable in cerebrospinal fluid when present in peripheral blood, but no stable proportional relationship allowing quantitative extrapolation from CSF to femoral blood could be established.
García-Sancha Natalia N, Valencia-Ramos Juan J, Gundín Simón S, Martín-Palencia María M et al.
Neuron-specific enolase (NSE), S100 protein, and β2-microglobulin (B2M) are neurological biomarkers used to support early assessment of brain injury in neonatal and pediatric neurological disorders. Their clinical utility depends on pre-analytical conditions and may be affected by routine storage when immediate analysis or ultra-low temperature freezing is unavailable, potentially affecting interpretation. 74 CSF and 70 serum samples from 36 pediatric patients were analyzed at baseline and after storage under room temperature, +4 °C, -20 °C, -80 °C, and mixed freezing conditions. Storage times ranged from 12 h to 10 days, with primary analyses focused on the first 72 h. Biomarker variation was expressed as percentage change and interpreted according to predefined maximum permissible error (MPE) thresholds. CSF and serum were analyzed separately to assess matrix-dependent effects. CSF NSE decreased progressively at +4 °C (-4.5% to -10.9% up to 72 h) and showed a reduction of -61.3% after 24 h at -20 °C. Serum NSE decreased at +4 °C (-4.75% to -12.3%) and showed limited variation after -20 °C storage (-5.4%). CSF S100 decreased at +4 °C (-3.1% to -8.6%) and more markedly at room temperature (up to -36.6% at 72 h), while serum S100 showed decreases at +4 °C (up to -12.3%) and no relevant instability under freezing conditions. B2M concentrations remained within predefined MPE thresholds in both CSF and serum under all storage conditions. Short-term storage conditions significantly influence neurological biomarker concentrations in a biomarker- and matrix-dependent manner. These findings support standardized pre-analytical handling in pediatric neurological biomarker assessment, as variability may affect clinical interpretation and patient management.
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