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trimethoprim hydrochloride (Primsol)

✓ Approved

Sun Pharmaceutical Industries Ltd. · 小分子 · 小分子

什么是 trimethoprim hydrochloride？

trimethoprim hydrochloride 是一种小分子，由Sun Pharmaceutical Industries Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Primsol
公司Sun Pharmaceutical Industries Ltd.
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Sun Pharmaceutical Industries Ltd.

治疗适应症

trimethoprim hydrochloride 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsOtitis media✓ Approved
Ear and labyrinth disordersMiddle ear inflammation✓ Approved
Infections and infestationsUrinary tract infection✓ Approved

相关研究文献

PubMedInfection and drug resistance2026-10-26

Tropheryma whipplei Pneumonia with Myelofibrosis: A Rare Actinomycetia Case Report and Literature Review.

Liu Junbao J, Wang Xing X, Xie Peitao P, Dong Lisen L et al.

Tropheryma whipplei (T. whipplei) is an uncommon pathogen that infects multiple sites, predominantly the gastrointestinal tract. However, pulmonary involvement is uncommon, and its clinical manifestations and imaging features lack specificity, making it prone to misdiagnosis. However, with the development of metagenomic next-generation sequencing (mNGS), clinicians have a potent tool at their disposal for detecting T. whipplei infections. We report a case of an elderly woman with a history Myelofibrosis who presented with a dry cough, fever, fatigue and difficulty breathing. Routine microbiological tests were negative; mNGS of bronchoalveolar lavage fluid (BALF) suggested T. whipplei infection. Following a definitive diagnosis, the patient was treated with a regimen of meropenem in combination with trimethoprim-sulfamethoxazole (TMP-SMX) for 16 days followed by 2 weeks of TMP-SMX maintenance, after which the patient improved and was discharged uneventfully.

PMID 42928761
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PubMedBMC infectious diseases2026-10-26

Clinical features and outcomes of nocardiosis in Thai patients with childhood-onset systemic lupus erythematosus.

Tangcheewinsirikul Sirikarn S, Nuntasri Sirin S, Rungmaitree Supattra S, Piyaphanee Nuntawan N et al.

Nocardiosis is a rare but life-threatening opportunistic infection in systemic lupus erythematosus (SLE), although data on childhood-onset SLE remain scarce. The objectives of this study were to determine the prevalence, clinical features, associated factors, and outcomes of nocardiosis in cSLE. A retrospective cohort study was conducted in a tertiary academic center including cSLE patients followed between January 2009 and August 2024. Culture-confirmed nocardiosis cases were identified through systematic review of electronic medical records. Firth penalized logistic regression was used to explore baseline factors associated with the development of nocardiosis. Seven out of 323 patients (2.2%) developed culture-confirmed nocardiosis. All were female with a mean age at diagnosis of 11.9 ± 3.1 years. The median (interquartile range) duration from cSLE diagnosis to nocardiosis diagnosis was 4.3 (2.1-13.4) months, with 71.4% occurring within the first year. All patients were receiving corticosteroids at a mean prednisolone-equivalent dose of 1.7 ± 1.3 mg/kg/day at the time of infection. The respiratory tract involvement manifesting as pneumonia was the most common infection site (71.4%). Proliferative lupus nephritis had an exploratory association with nocardiosis (OR 5.03, 95% CI 1.19-28.36, p = 0.028). Rapidly progressive glomerulonephritis at initial SLE diagnosis was significantly more frequent in the nocardiosis group (28.6% vs. 4.4%, p = 0.014). Carbapenem-based induction followed by trimethoprim-sulfamethoxazole (TMP/SMX) consolidation was used in the majority of patients. The in-hospital mortality rate from the index nocardiosis episode was 0%, and the 12-month all-cause mortality rate was 14.3%, attributable to secondary Corynebacterium septicemia in the patient with the most multiple immunosuppressive drug therapy with cumulative burden. Nocardiosis affects 2.2% of cSLE patients and occurs predominantly early in the disease course. Proliferative lupus nephritis had an exploratory association with nocardiosis, highlighting the need for heightened clinical vigilance and the use of antimicrobial susceptibility testing to guide management in high-risk patients.

PMID 42928109
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PubMedGels (Basel, Switzerland)2026-10-26

Insights into the Protonation State and Counterion Interactions of Linear Polyethyleneimine Materials.

Byrne Agustín J AJ, Vladimir Daniel D, Garro-Linck Yamila Y, Copello Guillermo J GJ et al.

Polyethyleneimine (PEI) polymers are widely used in the synthesis of nanoparticles, hydrogels and composite materials for biotechnological and environmental applications. However, the solid-state structural organization of linear PEI (L-PEI) materials, and how it is influenced by molecular weight, protonation state and counterion type, have not yet been comprehensively studied. In this work, solid-state nuclear magnetic resonance (ss-NMR), X-ray powder diffraction (XRD), small-angle X-ray scattering (SAXS) and time-domain NMR (TD-NMR) experiments were combined with theoretical calculations to analyze the local chemical environments, crystalline and nanoscale organization, and molecular mobility of L-PEI materials with different molecular weights. The analyzed materials were the free base (PEI·FB), the hydrochloride (PEI·HCl), the trifluoroacetate (PEI·TFA), and the sulfate-containing forms of L-PEI (PEI·Na2SO4 and PEI·H2SO4), as well as an intermediate protonation state obtained by the heterogeneous treatment with HCl-saturated isopropanol. Proton, 13C or 15N ss-NMR studies evidenced different chemical environments associated with changes in protonation state and counterion identity. Furthermore, XRD and SAXS showed that these variables, together with molecular weight and sample preparation conditions, influenced the crystalline arrangement and characteristic nanoscale organization of the polymer chains. Moreover, TD-NMR revealed the presence of three dynamically distinct proton populations, assigned to rigid, interfacial, and mobile domains, whose relative contributions and relaxation behavior varied among the PEI materials. Finally, high-resolution magic-angle spinning (HRMAS) NMR experiments were used to study different PEI-gel materials and films as well as the crosslinking of protonated PEI and sulfate ions.

PMID 42929946
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PubMedGels (Basel, Switzerland)2026-10-26

Dual-Drug Chitosan Hydrogel Loaded with Metformin and Cefazolin for Antibacterial, Anti-Inflammatory and Antioxidant Treatment of Drug-Resistant Bacteria-Infected Skin Wounds.

Zhang Yilin Y, Cao Jie J, Yan Yong Y, Li Zhaoyang Z et al.

Bacterial-infected skin wounds, especially those caused by drug-resistant pathogens accompanied by persistent inflammation, remain a major clinical therapeutic challenge. Rising antimicrobial resistance compromises the therapeutic effect of conventional single-agent antibiotics, creating an urgent demand for novel wound therapeutics that integrate bactericidal potency, immunomodulation and tissue regeneration capacity. In this work, an injectable multifunctional chitosan-based hydrogel (C@MC) was developed, which simultaneously incorporates metformin hydrochloride (as a potential antibiotic adjuvant) and cefazolin sodium (as a β-lactam class antibacterial drug). The optimized C@MC possesses interconnected three-dimensional pores with an initial storage modulus of ~0.83 kPa (C@MC360), featuring desirable mechanical strength, injectability, tissue adhesion and dual pH/glucose-responsive sustained drug release. In vitro evaluations revealed the dose-dependent bactericidal activity of C@MC against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and New Delhi metallo-β-lactamase-1-producing E. coli (NDM-1 E. coli, resistant bacteria). The highest drug-laden group nearly eliminated all wound bacteria in vitro. It scavenged reactive oxygen species (ROS) to lower cellular MDA levels and suppress pro-inflammatory TNF-α and IL-6 in LPS-stimulated RAW 264.7 macrophages. In full-thickness mouse wounds infected with NDM-1 E. coli, C@MC360 achieved nearly complete wound closure, with only a 4.2% residual wound area on day 14, accompanied by suppressed inflammatory infiltration and accelerated wound regeneration. This dual-drug hydrogel integrates antibiotic potentiation, anti-inflammation and antioxidation, providing an intervention regimen for skin wounds infected with drug-resistant bacteria.

PMID 42929911
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PubMedPharmaceutical science advances2026-10-25

Corrigendum to "Protective effect of lycorine hydrochloride against diabetic nephropathy in high-fat diet and streptozotocin-induced diabetic mice" [Pharm. Sci. Adv. 2 (2024) 100035].

Fang Kai-Li KL, Qi Xin-Yu XY, Han Qing-Tong QT, Chen Lu-Zhou LZ et al.

[This corrects the article DOI: 10.1016/j.pscia.2024.100035.].

PMID 42926922
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PubMedFood chemistry: X2026-10-25

Effects of microencapsulated ε-Polylysine hydrochloride on quality and microbial indicators of salted bamboo shoots.

Cai Xianfen X, Du Haonan H, Wang Yang Y, Fei Sitao S et al.

Salted bamboo shoots are susceptible to microbial spoilage and quality deterioration, while ε-polylysine hydrochloride (ε-PL·HCl) suffers from poor stability and hygroscopicity. To address this, ε-PL·HCl-loaded microcapsules were fabricated via complex coacervation using soy protein isolate (SPI) and chitosan (CS) as wall materials. The resulting microcapsules achieved an encapsulation efficiency of 98.63% and exhibited enhanced thermal stability, with a 25-30 °C increase in decomposition temperature compared with free ε-PL·HCl. SEM and XRD supported the incorporation of ε-PL·HCl into the SPI-CS matrix, while in-vitro release studies demonstrated sustained-release behavior in an aqueous medium. During 13 days of storage of salted bamboo shoots, ε-PL·HCl microcapsules (ε-PL·HCl-MCs) maintained hardness at approximately 300 N, reduced total bacterial counts to below 1 × 107 CFU/g, delayed the decrease in b* value (yellowness), and slowed the decline in pH. This SPI-CS-based delivery system provides a promising strategy for natural antimicrobial preservation.

PMID 42920860
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