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anti-varicella zoster immunoglobulins

✓ Approved

Kedrion · 多克隆抗体 · 多克隆抗体

什么是 anti-varicella zoster immunoglobulins？

anti-varicella zoster immunoglobulins 是一种多克隆抗体，由Kedrion研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

公司Kedrion
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Kedrion

治疗适应症

anti-varicella zoster immunoglobulins 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsVaricella zoster virus infection✓ Approved

相关研究文献

PubMedCureus2026-10-26

Atypical Presentation of Ramsay Hunt Syndrome in an Immunocompromised Patient: A Case Report.

Rash David J DJ, Mangeni Owori O

Ramsay Hunt syndrome (RHS), or herpes zoster oticus, is a rare neurological complication of varicella-zoster virus reactivation within the geniculate ganglion, leading to unilateral facial pain, facial paralysis, otalgia, sensorineural hearing loss, and a painful vesicular rash on the face or ear. Reactivation of the virus most often affects the vestibulocochlear (cranial nerve eight) and facial (cranial nerve seven) nerves in RHS. Early recognition of RHS is important as delays in treatment can lead to permanent facial paralysis, scarring, or irreversible sensorineural hearing loss. In this case, we examine an 84-year-old immunocompromised female patient whose diagnosis of RHS was delayed by multiple medical comorbidities and an atypical initial presentation.

PMID 42928848
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PubMedCardiology in review2026-10-26

Herpes Zoster and Cardiovascular Disease: An Unexpected Association.

Patel Dhruv D, Kallash Mohammed M, Frishman William H WH

Herpes zoster (HZ), the reactivation of latent varicella zoster virus (VZV), is increasingly being recognized as more than a dermatologic and neurologic disease. In recent years, multiple meta-analyses have linked HZ infection to a clinically significant increase in the risk of stroke, myocardial infarction (MI), and other major adverse cardiovascular events, an effect that is most pronounced in the first days to weeks following the acute HZ infection, with a gradual decrease in risk over time. The proposed mechanism centers on a productive viral infection of arterial walls, a phenomenon described as VZV vasculopathy, with transmural inflammation, endothelial dysfunction, and thrombosis, all superimposed on the systemic inflammatory and prothrombotic state that accompanies the acute HZ infection. The evidence for an association between HZ infection and cardiovascular events has grown stronger with recent multiple large cohort studies demonstrating that patients who received HZ vaccination had a significantly lower rate of major adverse cardiovascular events, MI, stroke, heart failure, and arrhythmia. However, while these cohort studies have helped researchers identify the potential association of HZ vaccination and reduced cardiovascular risk, there remains a need for a randomized controlled trial to establish causality between these factors. Currently underway, a randomized controlled trial is directly evaluating whether HZ vaccination in a large population lowers the incidence of cardiovascular events, including stroke, MI, and cardiovascular death. Nevertheless, the 2026 American College of Cardiology guidelines now include a strong recommendation for HZ vaccination given the growing body of evidence regarding the association of HZ vaccination with cardiovascular events.

PMID 42928087
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PubMedGenomics, proteomics & bioinformatics2026-10-26

RNASTOP: A Deep Learning Framework for mRNA Chemical Stability Prediction and Optimization.

Lin Shenggeng S, Chen Junwei J, Sun Heqi H, Zhang Yufang Y et al.

Messenger RNA (mRNA) vaccines offer promising therapeutic potential for combating various diseases, yet their inherent chemical instability hampers long-term efficacy. Although several methods have been developed to predict mRNA degradation, they often suffer from limited accuracy and lack the capability for rational codon optimization. Here, we propose RNASTOP, a novel framework that integrates deep learning with heuristic search to simultaneously predict and optimize mRNA chemical stability. RNASTOP achieves a 13% improvement in accuracy over the top-performing model on the Stanford OpenVaccine competition dataset and demonstrates robust generalization in predicting full-length mRNA degradation. When applied to mRNA codon optimization, RNASTOP reduces the minimum free energy of the varicella-zoster virus vaccine sequence by 75.73% while maintaining high translation efficiency. Overall, RNASTOP serves as a powerful tool for predicting and optimizing mRNA chemical stability, accelerating the development of mRNA therapeutics. The source code of RNASTOP is available at https://github.com/xlab-BioAI/RNASTOP.

PMID 42928593
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PubMedCureus2026-10-26

Evaluation of the Cytotoxic Effect of Calcium Silicate-Based Bioceramic Sealers: An In Vitro Comparative Study.

Bagade Prashikkumar P, Borthakur Bikash Jyoti BJ, S Ganesan G, B Swathika S

Calcium silicate-based bioceramic sealers have become increasingly popular due to their biocompatibility, bioactivity, and potential for periapical tissue integration. However, evaluating their cytotoxic effects on fibroblast cell lines remains limited. The aim of this study was to compare the cytotoxic effects of two commercially available calcium silicate-based bioceramic root canal sealers on L929 mouse fibroblast cells, using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to assess cell viability following exposure to serial dilutions (100%-6.25%) of sealer extracts. Leachates were prepared by incubating for 24 hours in 2 mL of serum-free Dulbecco's Modified Eagle Medium (DMEM) through 0.2 μm polyethersulfone (PES) syringe filters from sets of specimens from both sealers. L929 mouse fibroblast cells were seeded at a density of 1×104 cells/well and treated with five serial dilutions (100%, 50%, 25%, 12.5%, and 6.25%) of sealer extracts. Cell viability was determined spectrophotometrically at 570 nm by MTT assay. Dimethyl sulfoxide (DMSO) (10%) was used as a positive control, and cells without treatment were used as a negative control. Cell viability was significantly decreased with both 100% and 50% concentrations of Bio-C Sealer (Angelus Indústria de Produtos Odontológicos S/A, Londrina, Brazil) (4.89% and 9.31%, respectively) and Prime MTA Bioceramic Root Canal Sealer (Prime Dental Products Pvt Ltd, Maharashtra, India) (5.28% and 8.30%, respectively). However, at lower concentrations, cell viability recovered significantly and approached the control level at 6.25%. At 25% concentration, a statistically significant difference (p=0.002) was observed, with Bio-C Sealer showing better cytocompatibility (92.86% vs 68.35%). Bio-C Sealer and Prime MTA Bioceramic demonstrated significant cytotoxicity at high extract concentrations with acceptable biocompatibility at clinically relevant dilute concentrations. Bio-C Sealer exhibited superior cytocompatibility at the 25% concentration and a higher IC₅₀ value, indicating better overall cytocompatibility. The comparatively favourable cytocompatibility profile of Bio‑C Sealer at intermediate concentrations suggests that material selection may be influenced by its reduced cytotoxic potential, particularly in scenarios where periapical tissue contact is likely. These findings highlight the importance of considering biological performance alongside physicochemical properties when choosing endodontic sealers.

PMID 42928799
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PubMedThe Medical journal of Australia2026-10-26

Short-Term Adverse Events Following Recombinant Zoster Vaccination in Older Adults in Australia: A Survey Study Comparing Dose 1 and Dose 2 and Influence of Dose Interval.

Dawes Lucy L, Nguyen Thuy T, Macartney Kristine K, Deng Lucy L

Self-reported adverse events following first and second recombinant zoster vaccination (RZV) doses in older adults (n = 41,069) collected through AusVaxSafety were analysed. Adverse event rates were higher following Dose 2 (54%; 95% CI, 53%-54%) than after Dose 1 (45%; 95% CI, 45%-46%), particularly with 3-6- and 7-9-month dose intervals, although medical review rates remained low (1.1%; 95% CI, 1.0%-1.2%), suggesting RZV is reactogenic but with no serious outcomes.

PMID 42928968
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PubMedGels (Basel, Switzerland)2026-10-26

Conceptual Frameworks and Practice on Nano-Micro Pore Structure Design of Bio-Aerogels.

Yuan Shuai S, Yang Jiaren J, Wu Kao K, Qian Hong H et al.

Bio-aerogels have garnered significant attention due to their environmental friendliness and potential for exceptional performance. The pore structure of bio-aerogels includes both pore size and distribution, which significantly determine their functional behaviors, such as filtration, thermal insulation, and sound absorption. This review proposes several conceptual frameworks regarding the design of the pore structure of bio-aerogels, some of which are validated through practical cases. The ice crystal pore-making conceptual framework approach involves controlling the growth of ice crystals to achieve a pre-designed pore structure. The space occupying pore-making conceptual framework is the proactive addition of nano materials to occupy space prior to the formation of ice crystals, facilitating the design of the aerogel's nanoscale pore structure. The conceptual framework of blocks building involves assembling multiple aerogels to create a composite aerogel with a multi-level pore structure. These theoretical considerations contribute to the development of aerogel structural design theory to obtain aerogels with different micro-nano structures.

PMID 42929920
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