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ganglioside ester (Sinassial / ganglioside ester / Sinaxial ester)

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Fidia · 小分子 · 小分子

什么是 ganglioside ester？

ganglioside ester 是一种小分子，由Fidia研发。该药已获批，用于治疗相关适应症。

药物档案

商品名Sinassial, ganglioside ester, Sinaxial ester
公司Fidia
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Fidia

相关研究文献

PubMedAnalytical methods : advancing methods and applications2026-10-26

A multi-responsive fluorescent probe for simultaneous detection of mitochondrial esterase and viscosity.

Yue Jingfang J, Chen Han H, Xu Xingjian X, Wu Yisheng Y et al.

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, with early detection severely hampered by its asymptomatic progression. Carboxylesterases (CEs) are significantly upregulated in HCC cells, making them promising biomarkers for cancer diagnosis. Herein, we report a tri-lock fluorescent probe, CMA, capable of simultaneous detection of mitochondrial CE - an enzyme closely linked to metabolism and drug resistance - and viscosity for early cancer diagnosis. The probe incorporates a CE-cleavable benzoate ester and a molecular rotor formed by an indolium-coumarin conjugated system. Upon hydrolysis of the benzoate ester, the released product displays enhanced fluorescence with red-shifted absorption through strengthened ICT. High viscosity restricts intramolecular rotation and suppresses the TICT pathway, whereas the alkaline mitochondrial pH further modulates the emission via deprotonation of the phenolic hydroxyl group. These three orthogonal stimuli converge to produce a 654-fold fluorescence enhancement under coexistent conditions. Cell imaging confirms that CMA effectively differentiates HCC cells from normal cells and detects drug-induced viscosity changes, suggesting its potential for early-stage liver cancer diagnosis.

PMID 42929085
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PubMedOrganic & biomolecular chemistry2026-10-26

Chemoselective aryllithium addition to an α-cyanoester under continuous-flow conditions.

Qenawy Mohmmad S MS, Zhong Xianzhu X, Nagaki Aiichiro A

Chemoselective addition of aryllithium reagents to an α-cyanoester was achieved under continuous-flow conditions, enabling selective ester-to-ketone conversion while retaining the nitrile group. Optimized mixing, temperature, and residence time improved product yield and selectivity compared with batch conditions. The method accommodated diverse aryllithium nucleophiles, affording products in up to 92% yield, and enabled multistage flow synthesis using a challenging aryllithium intermediate in 69% yield.

PMID 42929771
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PubMedArchiv der Pharmazie2026-10-26

Clarifying Problems in the Synthetic Pathway Towards Methylene-Type Levodopa Acylals as Potential Prodrugs.

Keydel Tobias T, Theele Yann Y, Link Andreas A

Here, we report a practical synthetic pathway towards levodopa (l-DOPA) acylals with a special emphasis on problems occurring during preparation, low yields or unmanageable side reactions, and how to circumvent them. The key step can be performed rapidly by microwave irradiation in a green chemistry manner. Final compounds can be achieved after deprotection approaches but exhibit inadequate properties in terms of stability, thwarting the adaptation of the double ester concept discussed here to the important active pharmaceutical ingredient levodopa. However, a future outlook is provided, discussing potential structural and chemical changes for stable levodopa acylals.

PMID 42929392
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PubMedGels (Basel, Switzerland)2026-10-26

Copper Peroxide-Loaded Dual-Responsive Hydrogel for Enhanced Diabetic Wound Healing Through Oxygen Release and Promotion of Angiogenesis.

Yu Lanqin L, Jia Xiang X, Xu Lejia L, Li Xiaojun X et al.

Diabetic foot ulcers (DFUs) present a major clinical challenge because of persistent hyperglycemia, hypoxia, impaired angiogenesis, and chronic inflammation. Conventional dressings have limited capacity to modulate these pathological processes. Here, we report a glucose/pH dual-responsive hydrogel, denoted CBOD, constructed through a dynamic covalent network comprising Schiff base and boronate ester bonds between phenylboronic acid-grafted chitosan (CS-BA) and dopamine-modified oxidized sodium alginate (OSA-DA). Copper peroxide (CuO2) nanoparticles are encapsulated within this network to form CuO2/CBOD. Under acidic (pH 5.5) and high-glucose conditions, competitive binding and bond hydrolysis promote network relaxation, facilitating the stimuli-dependent release of oxygen and copper ions. In vitro assessments demonstrate good cytocompatibility and enhanced migration and tube formation of human umbilical vein endothelial cells (HUVECs). In a diabetic rat model of full-thickness excisional wounds, the hydrogel accelerates wound closure, with closure approaching 100% by day 14. Treatment is associated with reduced expression of the M1-associated markers interleukin-1β (IL-1β) and cluster of differentiation 80 (CD80), increased expression of the M2-associated markers interleukin-10 (IL-10) and cluster of differentiation 163 (CD163), and enhanced expression of the vascular markers cluster of differentiation 31 (CD31) and alpha-smooth muscle actin (α-SMA). These findings support the potential of CuO2/CBOD as a multifunctional dressing for diabetic wound management.

PMID 42929899
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PubMedGels (Basel, Switzerland)2026-10-26

Microwave-Assisted Degradation of Unsaturated Polyester Resin into HDPE-Modified Aerogels for Oil Adsorption and Oil/Water Separation.

He Shixue S, Qian Qianqian Q, Lang Daning D, Wu Ronglan R

Thermosetting unsaturated polyester resin (UPR) is difficult to reprocess because curing generates an irreversible three-dimensional network. Here, cured UPR was treated in a microwave-assisted hydrazine hydrate/NaOH medium at 70 °C for 30 min to produce a water-swellable UPR-derived product (NUPR). NUPR was combined with glutaraldehyde, subjected to freeze-thaw processing and freeze-drying, and subsequently modified with high-density polyethylene (HDPE) to fabricate porous aerogels. FTIR results were consistent with partial cleavage of ester-containing structures, while TGA and SEM revealed changes in thermal behavior and morphology. Among the tested aerogels, AAS-6 exhibited a density of approximately 0.036 g cm-3 and a porosity of 96.6%. After HDPE treatment, the aerogel exhibited a water contact angle of 135.2° while maintaining rapid oil wetting. Its 5 min liquid uptake for the tested oils and organic solvents ranged from 20.14 to 38.31 g g-1. After ten adsorption-regeneration cycles, 89-96% of the initial oil uptake was retained, depending on the oil, whereas uptake of the tested volatile solvents remained comparatively unchanged under the respective regeneration conditions. H-6 also enabled free-oil uptake from water and gravity-driven treatment of surfactant-stabilized water-in-oil (W/O) emulsions, yielding high separation efficiencies and markedly reduced dispersed-droplet signals after filtration. These results demonstrate a route for coupling the chemical conversion of cured UPR with fabrication of porous materials for oil uptake and W/O emulsion separation.

PMID 42929956
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PubMedbioRxiv : the preprint server for biology2026-10-25

Autoantibodies from recovered Guillain-Barré syndrome patients exhibit altered effector functions that prevent subsequent neuron degeneration.

Rogers Ashley M AM, McAlpine Jessica L JL, Yang Xu X, Jahan Israt I et al.

Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy that is the leading cause of nonpoliovirus-associated acute flaccid paralysis worldwide. In most cases, GBS occurs following an infection, most commonly Campylobacter jejuni , through the induction of antibodies recognizing bacterial ganglioside-mimicking lipooligosaccharides that cross-react with human neuronal gangliosides. This post-infectious autoimmune cascade causes neuropathy, from which patients can recover as their anti-ganglioside antibody titers diminish and immunostimulation decreases. In this study, we find 10% of clinically confirmed GBS patients maintain high titers of circulating anti-ganglioside antibodies more than one decade after recovery. These antibodies no longer cause neuropathy compared to acute sera from the same patients using a human pluripotent stem cell-derived sensory neuron model with human complement. We found both IgG subclass and glycoform differences between paired acute and recovered GBS patient sera, including anti-inflammatory modifications on isolated anti-GM1 ganglioside antibodies. Together, these data suggest that patients with GBS select for non-pathogenic variants of autoantibodies that are no longer capable of damaging their neurons, but may still protect against C. jejuni infection.

PMID 42922744
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