北京若生智能科技有限公司
Drug Database
MO

morphine SR (Pacif / morphine SR, Takeda)

✓ Approved

Terumo · OPRD1 · 小分子

什么是 morphine SR？

morphine SR 是一种小分子，由Terumo研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Pacif, morphine SR, Takeda
公司Terumo
药物类别小分子
分子靶点OPRD1, OPRK1, OPRM1
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Terumo

作用机制

分子靶点

morphine SR 作用于 3 个分子靶点：

OPRD1opioid receptor delta 1 (DOR, OPRD)
OPRK1opioid receptor kappa 1 (KOR1, OPRK)
OPRM1opioid receptor mu 1 (MOR1, LMOR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

morphine SR 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Cancer pain✓ Approved

相关研究文献

PubMedRapid communications in mass spectrometry : RCM2026-10-26

TIMS Techniques for Measuring Strontium Isotope Ratios in Apatite Grains and Application to Igneous Rock Petrology.

Neto Carla C, de Morisson Valeriano Claudio C, Paravidini Gabriel G, Bruno Henrique H et al.

This study evaluates the potential of Sr isotopic compositions in apatite grains from magmatic rocks as a proxy for initial 87Sr/86Sr ratios, addressing the need for alternative approaches to conventional whole-rock analyses in isotopic studies of granitoid systems. Chemical and spectrometric procedures were optimized and validated for the determination of Sr isotopic ratios in apatite by TIMS. Three representative samples from the Ribeira Orogen, Brazil, were selected, and apatite Sr isotopic compositions were compared with initial whole-rock 87Sr/86Sr ratios calculated from U-Pb zircon crystallization ages, whole-rock isotopic ratios, and Rb and Sr concentrations. The reliability of the analytical approach was evaluated using the EN-1 and Durango apatite reference materials. Apatite grains yielded Sr concentrations ranging from 80 to 950 μg g-1, with total Sr masses between 0.5 and 50 ng. Comparisons between apatite-derived and whole-rock initial 87Sr/86Sr ratios show isotopic variability below 0.05%, indicating high analytical precision. Validation results demonstrate consistent agreement between methods, with uncertainties within 0.5%. The proposed TIMS-based method for Sr isotope analysis in apatite grains provides a potential approach for investigating the initial Sr isotopic compositions of granitoid magmatic systems. This approach represents a cost-effective and time-efficient alternative to traditional whole-rock analyses, with strong potential for large-scale isotopic applications in orogenic terrains.

PMID 42928975
阅读全文 →
PubMedThe British journal of radiology2026-10-26

Intravenous oxycodone versus morphine patient-controlled analgesia (PCA) after uterine artery embolisation: A propensity matched case-control study.

Clements Warren W, Markakis Demi D, Koukounaras Jim J, Venn Georgina G et al.

The use of intravenous oxycodone is still limited in the Interventional Radiology setting. This study aimed to assess the safety and efficacy of intravenous oxycodone used in patient-controlled analgesia (PCA) after uterine fibroid embolisation (UFE), compared to morphine. Retrospective case-control study. The study group consisted of patients treated with UFE between March and December 2024, using an oxycodone protocol. The control group consisted of a previously published dataset using morphine protocol. Primary outcomes were safety and the incidence of severe nausea. There were 57 patients in the oxycodone group compared to 69 in the morphine group. After propensity score matching, this left 43 in the oxycodone group and 60 in the morphine group. Groups were similar in terms of background demographics, however the use of smaller 355-500 micrometre polyvinyl alcohol particles were higher in the oxycodone group (100% vs 18%, p < 0.001).No analgesic-related adverse events were observed in either group. The incidence of severe nausea was lower in the oxycodone group (43.3% vs 37.2%, p = 0.533) despite a higher rate of post-embolisation syndrome (65.1% vs 48.3%, p = 0.091). After multiparametric logistic regression, oxycodone was associated with a 64% reduced odds of severe nausea (OR 0.36, p = 0.217). Intravenous oxycodone PCA is safe and showed a trend towards a lower incidence of severe nausea compared with morphine PCA. There is limited evidence of the use of oxycodone PCA to treat post-embolisation syndrome. This study showed it was safe and resulted in reduced nausea compared to morphine.

PMID 42928627
阅读全文 →
PubMedStrabismus2026-10-26

A case of highly myopic strabismus with large exotropia after Yokoyama procedure.

Simpao Juan Lorenzo JL, Goseki Toshiaki T, Onouchi Hiromi H

Highly myopic strabismus (heavy eye syndrome) is characterized by superotemporal prolapse of the elongated globe, resulting in nasal displacement of the superior rectus (SR) muscle and inferior displacement of the lateral rectus (LR) muscle. This abnormal extraocular muscle configuration can result in restrictive esotropia, limitation of abduction, and progressive binocular diplopia. The Yokoyama procedure restores the extraocular muscle paths by uniting the SR and LR muscle bellies and generally provides excellent ocular alignment. Persistent postoperative exotropia is uncommon and its management has rarely been described. We report a case of persistent large-angle exotropia following an uncomplicated bilateral Yokoyama procedure despite satisfactory postoperative muscle repositioning on orbital magnetic resonance imaging (MRI). A 72-year-old woman with high myopia and progressive horizontal diplopia underwent ophthalmologic and strabismus evaluation, including orbital MRI before and after bilateral Yokoyama procedures. Ocular alignment, axial length, and SR-LR displacement angles were assessed. Following development of persistent postoperative exotropia, the patient was observed for six months. Because the deviation did not improve spontaneously and postoperative MRI demonstrated satisfactory SR and LR repositioning, bilateral medial rectus (MR) plication was subsequently performed while preserving the SR-LR union. Preoperatively, the patient had 35 prism diopters (PD) of esotropia at distance with limitation of bilateral abduction and elevation. Axial lengths were 27.19 mm in the right eye and 26.91 mm in the left eye. Orbital MRI demonstrated nasal displacement of the SR and inferior displacement of the LR, with SR-LR displacement angles of 142° and 144°, respectively. Following bilateral Yokoyama procedures, approximately 55 PD of exotropia developed on the first postoperative day and persisted with little spontaneous improvement over three months. Repeat MRI demonstrated restoration of the normal SR-LR relationship, with displacement angles improving to 97° and 95°, confirming successful anatomical correction despite persistent exotropia. After six months of observation, bilateral 7-mm MR plication was performed. One month later, ocular alignment improved to near orthotropia, with resolution of diplopia and recovery of stereopsis. Persistent large-angle exotropia may occur despite successful anatomical correction following the Yokoyama procedure. Postoperative orbital MRI can help distinguish persistent muscle malposition from successful SR and LR repositioning. When satisfactory muscle positioning is confirmed and spontaneous improvement does not occur, preserving the SR-LR union and addressing the residual horizontal deviation with MR plication may provide an effective secondary surgical strategy. This case highlights the value of postoperative imaging in guiding management of unexpected overcorrection after the Yokoyama procedure.

PMID 42929265
阅读全文 →
PubMedRevista espanola de enfermedades digestivas2026-10-26

Spontaneous complete regression of hepatocellular carcinoma with histopathological confirmation.

Jiménez González Laura L, Velasco Martínez Elena E, Jordán de la Fuente María M, Lillo Díez Jorge J et al.

Spontaneous regression (SR) of hepatocellular carcinoma (HCC) is an exceptional phenomenon, with an estimated incidence of 0.4% (1,2). Although various mechanisms have been proposed, including tumor ischemia and immune activation, its pathogenesis remains uncertain. Most published cases lack histological confirmation of tumor disappearance and have insufficiently documented follow-up. We present a case of SR with histopathological confirmation of complete tumor necrosis following exploratory laparoscopy, suggesting a possible ischemic mechanism and highlighting the challenges in therapeutic decision-making and in assessing the indication for liver transplantation.

PMID 42929260
阅读全文 →
PubMedActas espanolas de psiquiatria2026-10-26

Prevalence and Associated Factors of Opioid Withdrawal Syndrome in Adults Admitted to an Intensive Care Unit: A Retrospective Observational Descriptive Study.

Zalba-Etayo Begoña B, Serrano-Ferrer Clara C, Cabrerizo-García José Luis JL

Prolonged opioid administration for pain control and to facilitate tolerance of mechanical ventilation in the intensive care unit (ICU) may lead to tolerance and physical dependence. Following opioid discontinuation, opioid withdrawal syndrome (OWS) may occur. Although this condition has been well described in pediatric populations, its incidence and associated factors in critically ill adults remain uncertain because of diagnostic heterogeneity and the frequent clinical overlap with delirium. The aim of this study was to assess the prevalence of OWS and to identify factors associated with its development in adult patients. We conducted a retrospective, descriptive, observational study including patients evaluated at the post-ICU follow-up clinic of Lozano Blesa University Clinical Hospital (Zaragoza, Spain) over a 12-month period. This study investigated the association between multiple opioid medications and adjunctive medications and the occurrence of OWS. Eligible patients had an ICU stay of >7 days, received mechanical ventilation for >48 hours, and had been exposed to opioids. Demographic, clinical, and pharmacological variables were collected, including types of opioids, weight-adjusted cumulative dose, and use of adjuvant medications. OWS was diagnosed during the first 48 hours after opioid discontinuation using a combination of the Clinical Opiate Withdrawal Scale (COWS) and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria. Receiver operating characteristic (ROC) curve analyses were performed to evaluate the impact of morphine exposure. A total of 66 patients were included (mean age 59.9 ± 13.6 years; predominantly male). The leading cause of ICU admission was respiratory disease (48.5%). Mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score at admission was 17.0 ± 6.1, and median ICU length of stay was 19 days. Twenty-two patients (33.3%) developed OWS, which was mild in 90.9% and moderate in 9.1% according to the COWS. No significant differences were observed between groups in baseline characteristics or delirium occurrence. Patients who developed OWS were more likely to have received morphine (100% vs. 75%; p = 0.010) and had a higher weight-adjusted cumulative morphine dose (3.15 ± 2.33 vs. 2.21 ± 2.50 mg/kg; p = 0.047), whereas no differences were found for fentanyl exposure. In addition, they more frequently required benzodiazepines (68.2% vs. 18.2%), neuroleptics (68.2% vs. 6.8%), and dexmedetomidine (31.8% vs. 4.5%) (p < 0.01 for all comparisons). Cumulative morphine dose showed modest discriminatory performance for OWS (area under the curve (AUC) 0.653; p = 0.048). OWS is a common complication among adult ICU survivors, although it is predominantly mild in severity. A higher cumulative dose of morphine was associated with its onset, although no association was found with the total duration of exposure. Clinical overlap with delirium and the reactive use of psychoactive medications may contribute to under-recognition of this condition, underscoring the need for structured OWS screening during ICU stay and in post-intensive care syndrome (PICS) follow-up.

PMID 42928669
阅读全文 →
PubMedDalton transactions (Cambridge, England : 2003)2026-10-26

Unravelling average, local and magnetic structure in Sr-Sc-M-O oxides (M = Co, Fe) by neutron scattering.

Ceretti Monica M, Cuello Gabriel J GJ, Sheptyakov Denis D, Ritter Clemens C et al.

Oxygen-deficient Sr-Sc-M-O oxides (M = Fe, Co) were synthesized and characterized in cubic and brownmillerite forms, with the brownmillerite phase Sr2ScCoO5 reported here for the first time. The cubic phases, described as SrSc0.5M0.5O3-x, and the brownmillerite phases, Sr2ScMO5, exhibit different oxygen contents and distinct degrees of structural ordering. Neutron diffraction and pair distribution function analysis reveal short-range oxygen-vacancy and B-cation ordering at the local scale within the cubic structure. In contrast, the brownmillerite phases exhibit long-range oxygen-vacancy and cation ordering, adopting Imma and I2mb symmetries for Sr2ScFeO5 and Sr2ScCoO5, respectively. Magnetic measurements indicate weak antiferromagnetic interactions, with brownmillerite Sr2ScFeO5 showing only short-range magnetic correlations. In contrast, Sr2ScCoO5 exhibits long-range magnetic ordering at 1.5 K, with the Co magnetic moment aligned along the stacking axis. This represents the first observation of coexisting cation and three-dimensional magnetic ordering in this system, despite the large Co-Co distances of 7.63 Å. These findings highlight the role of oxygen content in driving structural ordering and underscore the need for a multiscale approach to understanding the complex structure-property relationships of oxygen-deficient perovskites.

PMID 42929422
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多morphine SR