北京若生智能科技有限公司
Drug Database
PR

prothrombin complex (Kanokad / Kaskadil)

✓ Approved

LFB · F2 · 细胞治疗

什么是 prothrombin complex？

prothrombin complex 是一种细胞治疗，由LFB研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Kanokad, Kaskadil
公司LFB
药物类别细胞治疗
分子靶点F2, F7, F9, F10
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, LFB

作用机制

分子靶点

prothrombin complex 作用于 4 个分子靶点：

F2coagulation factor II, thrombin (THPH1, PT)
F7coagulation factor VII (SPCA)
F9coagulation factor IX (P19, F9 p22)
F10coagulation factor X (FXA, FX)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

prothrombin complex 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersExtravasation blood✓ Approved
Vascular disordersHaemorrhage✓ Approved

相关研究文献

PubMedBiologics : targets & therapy2026-10-26

What's New and What's Next for Emicizumab for the Treatment of Hemophilia A?

Mahlangu Johnny N JN

Emicizumab, a bispecific factor VIIIa-mimetic antibody, has transformed hemophilia A prophylaxis by providing an effective subcutaneous treatment regardless of factor VIII inhibitor status. The HAVEN program established sustained reductions in treated bleeding, favorable safety, and reduced treatment burden across children and adults. More recent evidence has expanded its use into infancy, previously untreated patients, and selected people with moderate or mild hemophilia A, shifting treatment toward prevention before recurrent bleeding and joint damage occur. Real-world experience broadly confirms the trial's efficacy but also highlights important limitations. Zero treated bleeds does not necessarily indicate absence of pain, synovitis, or progressive arthropathy. At the same time, breakthrough bleeding, laboratory assay interference, rare neutralizing anti-drug antibodies, and thrombotic complications associated principally with excessive activated prothrombin complex concentrate remain clinically relevant. Emicizumab controls bleeding in patients with factor VIII inhibitors but does not induce immune tolerance, leaving unresolved questions regarding inhibitor eradication, delayed factor VIII exposure, and optimal induction of immune tolerance. The next phase of development will require moving beyond uniform weight-based dosing and annualized bleeding rates toward individualized exposure, validated biomarkers, and outcomes that encompass joint structure, physical participation, quality of life, and treatment burden. Emicizumab must also be positioned against next-generation factor VIII mimetics, rebalancing therapies, sustained-exposure factor VIII replacement, and gene therapy. This review critically examines the established and emerging evidence, practical management challenges, unresolved scientific questions, and future therapeutic positioning of emicizumab. Its ultimate impact will depend not only on broader eligibility, but also on precision use, long-term safety, rational treatment sequencing, and equitable global access.

PMID 42928872
阅读全文 →
PubMedTraffic (Copenhagen, Denmark)2026-10-26

TMEM55B Maintains Lysosomal Homeostasis and Promotes ER-Lysosome Calcium Signaling.

Mukae Nagi N, Maki Honoka H, Shirane Michiko M

At membrane contact sites (MCSs) between the endoplasmic reticulum (ER) and endolysosomal compartments, the Protrudin-PDZD8 complex promotes the maturation of endosomes into lysosomes, a process accompanied by acidification. Endosomal maturation is closely associated with both lysosomal acidification and calcium signaling; however, the molecular mechanisms linking the Protrudin-PDZD8 complex to these processes remain unclear. Here, we identified TMEM55B, a lysosome-localized protein, as a binding partner of the Protrudin-PDZD8 complex. TMEM55B has been reported to interact with the v-ATPase complex, suggesting a role in lysosomal function. Suppression of TMEM55B expression reduced the fluorescence of a lysosomal acidification probe, suggesting impaired lysosomal acidification. In addition, TMEM55B depletion attenuated lysosomal Ca2+ release and reuptake and reduced ATP-induced Ca2+ responses in the ER. These findings suggest impaired calcium-induced calcium release (CICR) at ER-lysosome MCSs. By contrast, mitochondrial Ca2+ dynamics were unaffected. Together, these results identify TMEM55B as a factor involved in maintaining lysosomal homeostasis and regulating calcium dynamics. Our findings suggest that TMEM55B cooperates with the Protrudin-PDZD8 complex to contribute to the regulation of lysosomal function at ER-lysosome MCSs.

PMID 42928446
阅读全文 →
PubMedInternational journal of general medicine2026-10-26

Development and Internal Validation of a Nomogram for Predicting Severe Complications After Snakebite: A Retrospective Cohort Study.

Guan Jiahao J, Zhao Zhenkai Z, Wang Fei F, Zhang Wenli W et al.

Snakebite envenomation is a global public health concern with high mortality and morbidity. Given the highly heterogeneous clinical progression and the potential for rapid deterioration in severe cases, early risk stratification is crucial for improving outcomes. This study aimed to develop a nomogram based on simple laboratory indicators to assist primary care clinicians in rapidly identifying high-risk patients, thereby optimizing interventions and reducing mortality and healthcare burden. We conducted a retrospective analysis of 10,505 snakebite envenomation cases admitted to the Medical Laboratory Center of Shaanxi Provincial People's Hospital between March 2014 and October 2025. After applying strict eligibility criteria, 2762 patients were randomly assigned to a training cohort (n=2072) and a validation cohort (n=690) at a 3:1 ratio. LASSO regression and multivariate logistic regression were used to identify independent risk factors for severe complications, which were then incorporated into a nomogram. Model performance was assessed by the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analysis (DCA). Of the 2762 patients, 64 (2.32%) developed severe complications, most commonly acute myocardial injury, acute liver injury, coagulopathy, and multiple organ dysfunction; the majority presented with two or more. Time from bite to presentation (OR=1.017, 95% CI 1.005-1.027), white blood cell count (OR=1.116, 95% CI 1.043-1.190), and prothrombin time (OR=1.103, 95% CI 1.011-1.203) were identified as independent predictors. The nomogram demonstrated strong discrimination, with AUCs of 0.812 (95% CI 0.741-0.882) and 0.839 (95% CI 0.734-0.945) in the training and validation cohorts, respectively. Calibration was excellent (Hosmer-Lemeshow P>0.05), and decision curve analysis confirmed net clinical benefit. This readily accessible nomogram, based on time to presentation, WBC, and PT, demonstrates strong predictive performance, high operability, and clinical accessibility, facilitating early identification of high-risk patients and optimization of treatment decisions.

PMID 42928901
阅读全文 →
PubMedArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2026-10-26

Editorial Commentary: Maintaining the Ideal Balance in Complex Orthopaedic Surgical Procedures.

Lykos Alexandros A, Ditsiou Athina Zacharoula AZ, Paschos Nikolaos K NK

The management of patellofemoral instability can be extremely challenging and occasionally requires complex interventions that can be associated with high complication risk. Tibial tubercle osteotomy has a high complication rate and, in the attempt to decrease the risk of hardware irritation, can sometimes lead to unintended consequences, resulting in worse overall outcomes or additional complications. In orthopaedics, it is extremely common that the surgical decision is a careful balancing act between potential benefits and risks and sometimes questions even the necessity of a complex intervention.

PMID 42929497
阅读全文 →
PubMedDevelopment (Cambridge, England)2026-10-26

Blender tissue cartography: An intuitive tool for analyzing 3D microscopy data.

Claussen Nikolas N, Regis Cécile C, Wopat Susan S, Lefebvre Matthew F MF et al.

We present a powerful and user-friendly tool for tissue cartography, a 3D image analysis and visualization method that maps curved surfaces, like epithelial sheets, onto 2D projections. Volumetric microscopy can image complex 3D tissues, but 3D image data remains difficult to visualize and quantify. Many biological systems are organized as thin, curved sheets. Tissue cartography extracts and cartographically projects these curved surfaces from volumetric images. This converts 3D into 2D image data, facilitating visualization, analysis, and computational processing. Existing tools, however, demand advanced coding expertise and are limited to simple tissue geometries. Here, we describe https://nikolas-claussen.github.io/blender-tissue-cartography/blender tissue cartography (btc), an interactive add-on for the 3D editor Blender that makes tissue cartography user-friendly through a graphical interface and handles complex biological shapes through powerful computer graphics algorithms. An accompanying Python library supports faithful 3D measurements in 2D cartographic projections and custom analysis pipelines. Time-lapse data can be batch-processed by algorithmically aligning all time points to a single key frame. We demonstrate btc on diverse and complex tissue shapes from Drosophila, stem-cell organoids, Arabidopsis, and zebrafish. btc enables quantitative cartographic analysis of complex 3D tissues, broadening access to methods previously restricted to specialists, while leveraging tools from computer graphics to unlock new capabilities.

PMID 42929470
阅读全文 →
PubMedBMC pediatrics2026-10-26

Moral distress in pediatric complex care coordinators: a reflexive thematic analysis.

Chahal Simran S, Currie Genevieve G, Ha Seong Eon SE, Kaushik Skanda S et al.

Moral distress can occur in situations where one wants to follow a desired course of action but experiences restraints from internal and external barriers. Unaddressed moral distress is associated with negative outcomes (e.g., burnout). Due to the nature of their work with medically and neurodevelopmentally complex children and their families, pediatrics complex care coordinators are at risk of experiencing moral distress. However, there is limited understanding of moral distress in this professional population. Study objectives were to: (1) understand how pediatric complex care coordinators at a tertiary pediatric hospital defined moral distress; (2) explore factors that influence and modulate moral distress in these care coordinators; and (3) explore the impacts of moral distress on care coordinators. Semi-structured virtual interviews were conducted with twelve pediatric complex care coordinators from a pediatric tertiary care centre to explore experiences with moral distress. Interviews ranged from 25 to 60 min. Interview transcripts were examined by two researchers using inductive reflexive thematic analysis for each objective. The data were analyzed and coded and a 15-point checklist was utilized throughout each phase of the analysis process for consistency amongst coders. All participants reported experiencing moral distress using the seminal definition of moral distress. Care coordinators added additional context and depth to this definition. Factors influencing and modulating moral distress in care coordinators were identified: (1) restrictiveness of their scope and capacity; (2) individual experiences; (3) availability of coping mechanisms; (4) the nature of their interactions; and (5) resolution. Four themes on the impact of moral distress were also identified: (1) changes in perspective; (2) impacts on well-being; (3) need for internal and external change; and (4) influence on interpersonal relationships. An expanded definition of moral distress was co-created with care coordinators and identified factors that influenced moral distress and impacts of moral distress. This work is an important first step to developing a better understanding of moral distress in care coordinators and could inform future interventions to address moral distress in this population.

PMID 42928190
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多prothrombin complex