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ofloxacin (ofloxacin, Ranbaxy / Zanocin OD)

✓ Approved

Ranbaxy Laboratories Limited · 小分子 · 小分子

什么是 ofloxacin？

ofloxacin 是一种小分子，由Ranbaxy Laboratories Limited研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名ofloxacin, Ranbaxy, Zanocin OD
公司Ranbaxy Laboratories Limited
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Ranbaxy Laboratories Limited

治疗适应症

ofloxacin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsSalmonellosis✓ Approved

相关研究文献

PubMedCase reports in ophthalmology2026-10-25

Acute Keratoconjunctivitis Induced by Pine Processionary Caterpillar Hairs (Thaumetopoea pityocampa): A Case Report and Literature Review.

Aouni Jaafer J, Loukil Hajer H, Sioud Sabri S, Dlensi Aryj A et al.

The pine processionary caterpillar (Thaumetopoea pityocampa) is an important cause of environmental exposure in Mediterranean regions. Its urticating hairs can induce ocular inflammation ranging from superficial conjunctivitis to keratitis and, rarely, intraocular complications. With the recent expansion of its geographical distribution, awareness of this condition is increasingly important among ophthalmologists, particularly in areas where exposure may be overlooked. We report the case of a 43-year-old male farmer presenting with a 5-day history of unilateral ocular redness, foreign-body sensation, tearing, and pain in the left eye. Slit-lamp examination revealed conjunctival chemosis and multiple fine brownish hairs embedded beneath the corneal epithelium and within the anterior stroma, associated with mild stromal edema and superficial punctate keratitis. Best-corrected visual acuity was 5/10, with no anterior chamber or posterior segment involvement. Anterior segment optical coherence tomography demonstrated linear hyperreflective structures corresponding to retained corneal foreign material. A detailed occupational history revealed exposure to pine processionary caterpillars during forestry work, leading to the diagnosis of acute keratoconjunctivitis (ophthalmia nodosa) secondary to T. pityocampa hairs. The retained setae were removed under slit-lamp guidance using a G25 needle after topical anesthesia with benoxinate hydrochloride 0.4% eye drops. Treatment consisted of topical dexamethasone 0.1% with progressive tapering and topical ofloxacin 0.3%. Clinical improvement was rapid, with complete visual recovery within 2 weeks. Specular microscopy demonstrated preserved endothelial function, with stable endothelial parameters during the 6-month follow-up period. Ocular exposure to T. pityocampa hairs should be considered in patients with unexplained keratoconjunctivitis, especially those with occupational or environmental exposure. Early recognition, complete removal of retained hairs, and careful monitoring are essential to prevent migration and vision-threatening complications. This case highlights the importance of clinician awareness as the distribution of this species continues to expand.

PMID 42923501
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PubMedRSC advances2026-10-23

Lewis-acid activation of persulfate enables oxidation of antibiotics: a new green low-cost advanced oxidation process.

Lucas Anushka A, Kornweitz Haya H, Albo Yael Y, Meyerstein Dan D

Developing advanced oxidation processes (AOPs) that operate efficiently under environmentally relevant conditions remains a key challenge in water treatment. The results presented herein demonstrate that the -O-O- bond in persulfate is activated to react with substrates by forming (H2O)4Mg(OS(O)2OOSO3)/H(OS(O)2OOSO3)- that oxidise antibiotics (ciprofloxacin and ofloxacin). At pH 7.4, Mg2+/PDS achieved 75% degradation of ciprofloxacin and 89% degradation of ofloxacin after 24 h, with pseudo-first-order rate constants of 2.7 × 10-3 and 5.0 × 10-4 min-1, respectively. These values represent over a twentyfold enhancement over PDS alone at the same pH. In addition, for the reaction with DMSO, a novel mechanism was found, in which the oxidation processes are initiated by Lewis acid activation and do not involve initial radical formation; the substrates react directly with the activated O-O bond. Thus, its reactions with sulfoxides form the corresponding sulfones. This mechanism, for the reaction with DMSO is supported by DFT calculations. In contrast, the calculations indicate a radical mechanism for the reaction with phenol, suggesting that the substrate oxidation mechanism depends on the nature of the substrate. The results prove that peroxides can be activated towards oxidation processes not only via energy transfer (e.g., heat or light) or redox processes (e.g., Fenton-like or electrochemistry) but also via Lewis acid activation. The results establish an additional pathway for peroxide activation and provide a mechanistic basis for further exploring the development of potentially cost-effective and environmentally compatible advanced oxidation processes. This study highlights magnesium and protons as effective activators of persulfate for robust contaminant degradation in aqueous systems.

PMID 42909860
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PubMedEnvironmental geochemistry and health2026-10-23

Source-related patterns and ecological risk prioritization of antibiotics in a large lake-river system: insights from the Poyang Lake Basin.

Yao Na N, Li Jiaying J, Ye Naihui N, Yan Shuwen S et al.

Antibiotic mixtures in large floodplain lake basins are shaped by overlapping anthropogenic inputs, environmental mixing, and compound-specific toxicity, complicating source interpretation and risk prioritization. We measured 10 antibiotics in 158 samples collected during a high-water-period campaign from 26 to 30 August 2023 in the Poyang Lake basin, including 42 lake-water samples and 116 wastewater samples from sewage treatment plants, hospitals, livestock and aquaculture facilities, and pharmaceutical industries. Mean total antibiotic concentration in lake water was 73.9 ng L-1, dominated by oxytetracycline, chlortetracycline, and tetracycline. Exploratory socio-economic correlation analyses showed category-dependent patterns with economic activity, production intensity, and sector-related antibiotic use. Receptor-side positive matrix factorization resolved three compositional patterns accounting for 46.0%, 11.8%, and 42.1% of modeled antibiotic mass: an oxytetracycline-rich mixed pattern, a sulfamethazine-chlortetracycline-doxycycline mixed pattern, and a chlortetracycline-dominated tetracycline-rich pattern. Source-profile comparison and non-negative least squares fitting indicated mixed and spatially variable compositional consistency with the four wastewater categories rather than evidence for a single dominant source. In the primary Monte Carlo analysis, oxytetracycline, chlortetracycline, and enrofloxacin had the highest probabilities of exceeding a risk quotient of 1 (16.3%, 16.3%, and 14.8%, respectively), while mixture-level summed risk quotients exceeded 1 in 65.1% of simulations. Weighting by predicted no-effect concentrations further increased the relative priority of ciprofloxacin in wastewater profiles and shifted lake-water priorities from oxytetracycline toward enrofloxacin and ofloxacin. These results show that concentration-based composition does not directly represent ecological-risk priority and support source-sensitive, risk-oriented management of antibiotic mixtures in large floodplain lake basins.

PMID 42909666
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PubMedJournal of hazardous materials2026-10-22

Concentration-dependent impacts of ofloxacin on the mobilization-immobilization dynamics of geogenic arsenic in groundwater environment.

Liang Qianyong Q, Ning Junna J, Pi Kunfu K, Xie Xianjun X et al.

Arsenic (As) behaviors in aquifers can be altered by exogenetic antibiotics and antibiotic resistance genes (ARGs), which modifies evolution of originally geogenic As-contaminated groundwater while increasing environmental risk of ARGs. The roles of introduced antibiotics in As biogeochemical cycle in groundwater environments however remain elusive mechanistically. Using Shewanella oneidensis (S. oneidensis) as a model, this research elucidates the impacts of varying levels of antibiotic (e.g., ofloxacin) exposure on As fate during microbially-mediated reductive dissolution of host goethite. Under low-level ofloxacin exposure (≤1 μg/L), S. oneidensis restored secretion of riboflavin after a short period of stress adaptation. Conversely, high ofloxacin exposure (≥10 μg/L) consistently depleted aqueous riboflavin and weakened mineral-biomolecule interactions, restricting electron transfer and inhibiting goethite bioreduction. Contrasting changes in the abundances of ARGs (e.g., qnrA) and As efflux gene (e.g., arsB) indicate concentration-dependent reorganization of resistance-associated genetic potential under ofloxacin and As co-exposure, while aqueous As(III) accumulated despite declining arsB abundance. Therefore, the molecular mechanism underlying As migration differs depending upon antibiotic exposure levels. These findings provide novel insights into underestimated effects of concomitant antibiotics on As re-mobilization in geogenic contaminated groundwater.

PMID 42906338
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PubMedThe Annals of otology, rhinology, and laryngology2026-10-18

Acute Otitis Externa-Antimicrobial Resistance in the US and Canada: Phase III Study Outcomes.

Bentley Christine C, Lückermann Mark M, Dalhoff Axel A, Vente Andreas A

The goal of this investigation was to characterize the microbiological profile and antimicrobial susceptibility patterns of pathogens isolated from AOE patients of 2 vehicle-controlled Phase III clinical trials and evaluate pathogen eradication rates achieved with finafloxacin otic suspension. In vitro MIC comparisons to other fluoroquinolones (ciprofloxacin, ofloxacin) are reported as supplementary susceptibility data and do not reflect direct randomized clinical comparisons. A total of 2683 bacteria isolated from 1234 AOE patients enrolled in 2 Phase III clinical studies in the United States, Puerto Rico, and Canada were analyzed. Specimens were collected from the external ear of subjects with AOE. Species-level identification for each bacterial isolate recovered was obtained by combining phenotypic and genotypic data. End point minimum inhibitory concentration (MIC) testing was performed using Clinical and Laboratory Standards Institute recommended methods. 72.7% of the pre-therapy bacteria were Gram-positive and 27.3% Gram-negative. Most frequent bacterial isolates were Staphylococcus spp. (46.7%) followed by Pseudomonas spp. (19.5%). Methicillin resistance was detected in 17.0% of S. aureus (MRSA) and 33.2% of S. epidermidis (MRSE) isolates. Ciprofloxacin resistance was identified in 12.5% of S. aureus and 14.0% of S. epidermidis isolates. Finafloxacin eradicated 86.4% of the MRSA isolates and 80.6% of the MRSE isolates. Finafloxacin eradicated ciprofloxacin-resistant Staphylococcus spp. in 74.4% and ciprofloxacin-resistant Pseudomonas spp. in 87.5% of treated patients. Finafloxacin demonstrated high eradication rates in AOE patients with methicillin-resistant S. epidermidis and S. aureus, as well as in patients with ciprofloxacin-resistant Staphylococcus spp.- and Pseudomonas spp., irrespective of the pathogen's resistance profile. These in vitro findings, together with observed eradication rates in the vehicle-controlled trials, suggest that finafloxacin may offer advantages in the treatment of resistant organisms, particularly under acidic pH conditions. However, direct clinical trial comparisons have not been conducted. Clinical trial registry name: ClinicalTrials.gov. URL: https://clinicaltrials.gov/. Identifier: NCT01535599 and NCT01535560.

PMID 42892712
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PubMediScience2026-10-17

Resveratrol-mediated Fe(III)/peroxydisulfate activation for ofloxacin degradation at circumneutral pH.

Wu Yanlin Y, Yang Wenyu W, Zeng Yilan Y, Huang Dingfeng D et al.

Iron-mediated peroxydisulfate (PDS) activation is limited by slow Fe(III)/Fe(II) redox cycling under circumneutral conditions. Here, resveratrol (RES), a natural stilbene polyphenol, was introduced as a low-dose redox mediator to promote Fe(II) formation from Fe(III) for enhanced PDS activation. The Fe(III)/RES/PDS system showed higher ofloxacin (OFL) degradation than the corresponding single-reagent and binary systems and achieved approximately 90% OFL degradation at pH 6.5. Chemical quenching and competition-kinetic analysis indicated that sulfate radical (SO4 ·-) was the major contributor to OFL degradation, while hydroxyl radical (·OH) played a secondary role. Matrix experiments showed that Cl- and NO3 - had minor effects, whereas NO2 - strongly inhibited OFL degradation. This work provides a case study of RES-mediated Fe(III)/PDS activation for antibiotic degradation under near-neutral conditions.

PMID 42890338
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