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BCG polysaccharide and nucleic acid injection (intramuscular) (Disu / DI SU)

✓ Approved

3SBio · 细胞治疗 · 细胞治疗

什么是 BCG polysaccharide and nucleic acid injection (intramuscular)？

BCG polysaccharide and nucleic acid injection (intramuscular) 是一种细胞治疗，由3SBio研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名Disu, DI SU
公司3SBio
药物类别细胞治疗, 疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, 3SBio

治疗适应症

BCG polysaccharide and nucleic acid injection (intramuscular) 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Respiratory, thoracic and mediastinal disordersBronchitis chronic✓ Approved
Infections and infestationsRhinovirus infection✓ Approved

相关研究文献

PubMedDisease models & mechanisms2026-10-26

Human-relevant disease models to accelerate the development of nucleic acid-based therapies and other advanced therapeutics.

Colin Marguerite M MM, Thaventhiran James E D JED, Willis Anne E AE

Advanced therapeutics, including programmable nucleic acid-based therapies (NATs), such as small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs), CRISPR-Cas 9 editing systems, modified in vitro transcribed messenger RNAs (mRNAs) and Adeno-associated viruses (AAVs), have the potential to transform healthcare. However, while there have been considerable successes, there have also been notable clinical failures in early-stage human trials, which slowed down the progression of these therapeutic platforms. Multiple trials of NATs have been halted or discontinued, or approved products carry black box warnings as unforeseen or underestimated toxicities and poor efficacy have been observed in humans. There are a variety of reasons for failure of NATs, one of which is that many preclinical studies lack disease modelling in a human-relevant manner and, therefore, do not capture disease-specific effects on therapy tolerability and efficacy. This Perspective provides a short overview of why better human disease modelling is required to understand the potential therapeutic liabilities of NATs across modalities.

PMID 42929528
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PubMedACS applied bio materials2026-10-26

A Modular Fluorescence Biosensing Strategy Based on Target-Responsive Hairpin Adapters and Dual Catalytic Hairpin Assembly.

Xie Min M, Zhang Yue Y, Lu Keyan K, Li Chunhong C

Accurate detection of tumor-associated biomarkers from different molecular classes is important for early diagnosis and disease monitoring. However, the development of a single sensing strategy that can be adapted to nucleic acids, proteins, and small molecules remains challenging because of their distinct recognition mechanisms and physicochemical properties. In this work, we developed a modular biosensing strategy based on a hairpin adapter-initiated dual catalytic hairpin assembly (dCHA), for the sensitive and separate detection of representative biomarkers from three molecular classes using a unified signal transduction framework. In this design, target-specific recognition events were converted into a unified intermediate DNA trigger, thereby coupling different recognition modules with a common nucleic acid amplification module. As proof-of-concept targets, miRNA-183 (miR-183), prostate-specific antigen (PSA), and sarcosine were selected to represent nucleic acid, protein, and small-molecule biomarkers, respectively. The proposed system showed sensitive analytical performance, with limits of detection of 0.070 nM for miR-183, 0.48 ng/mL for PSA, and 0.26 nM for sarcosine, which are comparable to or within the range of gold-standard methods. In addition, recovery experiments in spiked human urine samples demonstrated the preliminary applicability of the assay in a complex biological matrix. This study provides a modular signal transduction strategy for detecting representative biomarkers of different molecular types and may offer a useful basis for further development of multiplexed and clinically validated biosensing systems.

PMID 42928556
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PubMedBiosensors2026-10-26

A Porous Chitosan Film-Based Dual-Modal Biosensor Integrated with Catalytic Hairpin Assembly for Sensitive Detection of Escherichia coli.

Wei Yuhuan Y, Wu Qibin Q, Zhang Hui H, Lin Jiayao J et al.

Catalytic hairpin assembly (CHA), as an enzyme-free isothermal nucleic acid amplification technique, offers significant advantages in biosensing owing to its exponential signal gain. Integrating CHA with dual-modal signal output holds promise for further improving the sensitivity and reliability of pathogen detection in complex matrices through cross-validation of multi-dimensional information. However, when two signals are generated within the same reaction system, they are prone to crosstalk and competition, while the interfacial reaction is inherently constrained by steric hindrance and limited mass transfer. To address these issues, we report herein a CHA-based dual-modal detection strategy for Escherichia coli nucleic acid. In this design, the electrochemiluminescence (ECL) signal is localized at the electrode interface, whereas the fluorescence signal is released in the bulk solution, thereby circumventing energy competition and channel crosstalk between the two signals. Concurrently, a three-dimensional scaffold is constructed using the porous structure of phase-transformed chitosan, which provides a high specific surface area to enhance the interfacial loading of hairpin probes and offers unobstructed channels for efficient mass transfer of co-reactants and target molecules, thus alleviating steric hindrance and diffusion limitations. Upon recognition of the target E. coli nucleic acid, the CHA cascade is triggered, driving a programmed conformational transition of the hairpin probes and simultaneously modulating the fluorescence resonance energy transfer (FRET) between FAM-BHQ pairs as well as the electrochemiluminescence resonance energy transfer (ECL-RET) between CdS quantum dots and AuNPs, enabling synchronous output and mutual validation of the dual-modal signals. Under optimized conditions, the proposed strategy exhibits satisfactory sensitivity, stability, and selectivity. This work provides a feasible approach for the deep integration of CHA amplification with dual-modal sensing, offering a reliable tool for rapid and accurate screening of pathogenic microorganisms.

PMID 42930103
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PubMedBiosensors2026-10-26

Isothermal Strand Displacement Amplification for Chemical Sensing: From Molecular Design to Integrated and Intelligent Platforms.

Lee Chia-Chun CC, Hsueh Wei-Ting WT, Tseng Chin-Chung CC, Fu Lung-Ming LM

Strand displacement amplification (SDA) provides a versatile isothermal framework for chemical and biosensing, coupling polymerase-driven strand displacement with programmable nucleic-acid signal generation. Its analytical scope now extends beyond direct nucleic-acid detection because aptamers, DNAzymes, antibodies, and responsive probes can convert diverse recognition events into amplifiable DNA triggers. This review develops a unified view of SDA from molecular design to practical implementation, with particular emphasis on programmable amplicon generation, recognition-to-DNA transduction, interfacial confinement, cascaded amplification, and CRISPR coupling. The review follows SDA across biomedical, food, and environmental applications, including RNA biomarkers, liquid biopsy, genetic and epigenetic targets, proteins, enzymes, small molecules, and viruses. It also considers how these assays are being transferred into microfluidic, paper-based, lateral-flow, self-powered, regenerative, and intelligent systems. The important distinction is that analytical sensitivity does not necessarily predict practical performance. Extremely low detection limits often depend on cascaded processing beyond SDA itself, whereas real samples expose weaknesses in matrix tolerance, background suppression, reagent stability, fluid control, assay duration, and manufacturing reproducibility. Comparison with commercially established isothermal methods further shows that wider adoption will depend on converting flexible molecular chemistry into robust, standardized, sample-to-answer systems.

PMID 42930116
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Phosphate-Engineered DNA Reporters Boost CRISPR-Cas12a Trans-Cleavage for Rapid and Sensitive Nucleic Acid Detection.

Yang Rui R, Guo Chong C, Pei Minjie M, Zhang Jiongyu J et al.

CRISPR-Cas12a molecular diagnostics rely on target-activated collateral cleavage of single-stranded DNA (ssDNA) reporters to generate fluorescence signals, yet the mechanisms governing reporter substrate processing remain poorly understood. Here we show that Cas12a trans-cleavage involves both endonucleolytic cleavage and exonucleolytic trimming. We further demonstrate that terminal phosphate modification of ssDNA substrates accelerates substrate cleavage activity and modulates trans-cleavage kinetics, thereby enhancing fluorescence output. Guided by this mechanistic insight, we engineered fluorophore-quencher ssDNA reporters bearing terminal phosphate modifications and identified a 3'-phosphate-engineered reporter that enables faster signal generation and higher fluorescence intensity. Incorporation of the engineered reporter into the CRISPR-Cas12a system enabled the development of Phos-CRISPR (Phosphate-engineered DNA reporters boost CRISPR), a rapid, sensitive, and specific nucleic acid detection platform that achieves results within 20 min, approximately threefold faster than conventional CRISPR assays. Applied to herpes simplex virus 1 detection, the Phos-CRISPR combined with recombinase polymerase amplification achieved a limit of detection of 20 aM and accurately identified clinical swab samples. These findings provide a general framework for understanding Cas12a trans-cleavage activity and establish a mechanistically informed strategy for enhancing next-generation CRISPR diagnostics.

PMID 42928415
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PubMedNanoscale2026-10-26

Assembly of negatively charged gold nanoparticles induced by a negatively charged polysaccharide (gum arabic).

Zeharia Tal T, Schiltt Yael Y, Cohen Ariel A, Raviv Uri U et al.

The self-assembly of like-(negatively) charged gold nanoparticles (GNPs) into hexagonal structures was observed in salt-free, dilute solutions of negatively charged branched polysaccharide, Gum Arabic (GA). The core-shell GNPs, consisting of a gold core coated with a p-mercaptobenzoic acid (pMBA) ligand shell, were highly monodisperse. It was observed that the presence of solvated, non-adsorbing GA induced crowding of the negatively charged GNPs into strings that further assembled into finite-sized clusters of low fractal dimensions. Cryo-TEM imaging, cryo-Electron Tomography (cryo-ET), small angle X-ray scattering (SAXS) and zeta potential measurements reveal finite-sized, long-lived clusters of like-charged close-packed GNPs. Assuming that GNPs crowding and assembly are induced by depletion interactions, this would suggest that, in this system, depletion-induced crowding of like-charged GNPs occurs even though the particle diameter is comparable to the characteristic dimensions of GA. These results suggest that GA may induce crowding in seemingly stable suspensions of like-charged nanoparticles, leading to entropically driven clustering in natural and synthetic complex fluids.

PMID 42929797
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