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rabies immunoglobulin (human) (HyperRAB S/D)

✓ Approved

Grifols, S.A. · 多克隆抗体 · 多克隆抗体

什么是 rabies immunoglobulin (human)？

rabies immunoglobulin (human) 是一种多克隆抗体，由Grifols, S.A.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名HyperRAB S/D
公司Grifols, S.A.
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Grifols, S.A.

治疗适应症

rabies immunoglobulin (human) 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsRabies✓ Approved

相关研究文献

PubMedVeterinary world2026-10-26

Knowledge, attitudes, and preventive behaviors toward rabies among urban residents in Bangkok, Thailand: Implications for targeted One Health rabies elimination strategies.

Luenglertamorn Kittithat K, Borvornpadungkitti Taksaporn T, Luangyawee Rapee R, Choksuchat Siwat S et al.

Rabies remains a fatal zoonotic disease and an important public health concern despite substantial reductions in human cases in Thailand. Continued circulation of rabies among animal populations highlights the need to strengthen public awareness and preventive behaviors. This study aimed to assess knowledge, attitudes, and preventive behaviors regarding rabies among Bangkok residents, identify sociodemographic factors associated with these outcomes, and examine relationships among knowledge, attitudes, and preventive behaviors to support urban rabies prevention and control strategies. A cross-sectional online survey was conducted among Bangkok residents between December 2024 and August 2025 using a structured, content-validated questionnaire. Of 262 respondents, 258 met the eligibility criteria and were included in the analysis. Descriptive statistics summarized participant characteristics and knowledge, attitudes, and preventive behaviors. Binary logistic regression identified factors associated with these domains, while Pearson's chi-square test evaluated associations among knowledge, attitudes, and preventive behaviors. Overall, 58.9% of participants demonstrated sufficient knowledge, whereas attitudes and preventive behaviors were generally favorable. Correct responses were highest for rabies transmission (97.7%), clinical signs in dogs (98.8%), and animal vaccination (96.9%), whereas only 36.1% correctly identified the recommended observation period following a bite incident. Participation in rabies awareness activities was limited (26.7%), although 73.6% reported routine pet rabies vaccination. Multivariable logistic regression showed that private sector employees were less likely to demonstrate sufficient knowledge (adjusted odds ratio [AOR] = 0.268, 95% confidence interval [CI]: 0.148-0.483; p < 0.001) and positive attitudes (AOR = 0.337, 95% CI: 0.186-0.610; p < 0.001) than students/unemployed participants. Participants aged 26-40 years had lower odds of appropriate preventive behaviors (AOR = 0.338, 95% CI: 0.173-0.657; p = 0.001), whereas participants whose pets had received rabies vaccination were more likely to report appropriate preventive behaviors (AOR = 2.512, 95% CI: 1.413-4.465; p = 0.002). Significant positive associations were identified between knowledge and attitudes and between knowledge and preventive behaviors (both p < 0.001). Although participants generally demonstrated favorable rabies-related knowledge, attitudes, and preventive behaviors, important gaps persisted regarding post-bite animal observation and participation in rabies awareness activities. Occupation and age were important determinants of knowledge, attitudes, and preventive behaviors, while responsible pet vaccination was positively associated with preventive practices. These findings support targeted, culturally appropriate educational interventions, workplace- and community-based awareness programs, and stronger One Health collaboration to advance urban rabies prevention and support Thailand's progress toward the WHO "Zero by 30" rabies elimination goal.

PMID 42928789
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PubMedCurrent oncology (Toronto, Ont.)2026-10-26

Serum Free Light Chains in Lymphoma: A Phenotype-First Framework for Biological Interpretation, Analytical Control, and Clinical Use.

Bibas Michele M, Amoroso Barbara B, Matteini Elena E, Antinori Andrea A et al.

Serum free light chains (sFLC) reflect immunoglobulin production and renal clearance, making abnormal results biologically heterogeneous in lymphoma. We reviewed clinical, translational, and analytical evidence using a documented PubMed search. Three operational patterns should be distinguished: monoclonal-pattern elevation, polyclonal-pattern elevation, and ratio-only abnormality. The kappa-plus-lambda concentration is an overlapping measure of total circulating burden rather than a fourth exclusive phenotype. In diffuse large B-cell lymphoma, some cohorts reported International Prognostic Index-adjusted associations and improved model discrimination, whereas other studies did not confirm independent prognostic value. Evidence in classical Hodgkin lymphoma and chronic lymphocytic leukemia also depends on endpoint, adjustment, and treatment setting. Prediagnostic associations in human immunodeficiency virus infection, transplantation, and population cohorts do not establish screening utility. In Waldenström macroglobulinemia, involved-chain kinetics may supplement established assessment in selected patients, although clinical benefit from sFLC-directed management has not been demonstrated. Historical treatment regimens, overlapping cohorts, inconsistent renal adjustment, assay differences, and limited external validation restrict transferability. The proposed framework integrates phenotype, renal function, assay, sampling time, and disease context. It is an interpretive proposal, not a validated prognostic score or treatment algorithm.

PMID 42930147
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PubMedAntibodies (Basel, Switzerland)2026-10-26

Antibody-Related Mechanisms in Ocular Diseases: Autoimmunity, Malignancy, and Therapeutic Targeting.

Xiao Yehan Y, Zou Yaru Y, Yang Mingming M, Gu Wendong W et al.

Antibodies in ocular disease have heterogeneous biological meanings: they may act as direct pathogenic effectors, systemic diagnostic biomarkers, indicators of B-cell clonality, or therapeutic agents. This distinction is particularly important in the eye, where immune privilege and the blood-ocular barrier restrict tissue access, whereas inflammation may permit entry of immunoglobulins, complement, and immune cells or support local humoral responses. This narrative review integrates antibody and B-cell biology across autoimmune and paraneoplastic retinopathies, aquaporin-4-immunoglobulin G-positive neuromyelitis optica spectrum disorder, myelin oligodendrocyte glycoprotein antibody-associated disease, ocular mucous membrane pemphigoid, ocular myasthenia gravis, thyroid eye disease, systemic autoimmune and fibroinflammatory disorders with ocular involvement, and B-cell malignancies including vitreoretinal and ocular adnexal lymphoma. We distinguish the evidence for direct antibody pathogenicity from disease association and emphasize that a positive result is interpretable only in relation to the ocular phenotype, assay platform, titer, specimen compartment, and orthogonal confirmation. Serum testing, ocular-fluid analysis, electrophysiology, multimodal imaging, cytology, histopathology, immunophenotyping, immunoglobulin clonality, and molecular testing have complementary roles. Therapeutic strategies include B-cell or B-lineage depletion, complement inhibition, cytokine- or receptor-directed monoclonal antibodies, insulin-like growth factor-1 receptor blockade, and emerging FcRn- or plasma-cell-directed approaches; however, regulatory status and ocular-specific evidence vary substantially among diseases. A mechanistically stratified framework may reduce overdiagnosis, improve recognition of malignant masquerade syndromes, and support more precise selection of targeted therapy.

PMID 42930036
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PubMedDiseases (Basel, Switzerland)2026-10-26

The Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum: A Report of Two Contrasting Cases Managed in a Burn Unit.

Constantinescu Mihai-Codrin MC, Moraru Dan-Cristian DC, Poroch Vladimir V, Avadanei-Luca Stefana S et al.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, potentially life-threatening mucocutaneous reactions classified based on body surface area (BSA) involvement: SJS affects less than 10% BSA, SJS/TEN overlap affects 10-30% BSA, and TEN affects more than 30% BSA. The mortality rates range from 4.8-9% for SJS to 14.8-48% for TEN. Treatment remains controversial, with corticosteroids and intravenous immunoglobulin (IVIg) being the most debated therapeutic options. While some studies suggest IVIg may block Fas-mediated keratinocyte apoptosis, meta-analyses have shown conflicting results regarding mortality benefit. We describe two patients from opposite ends of the SJS/TEN spectrum, managed in a burn unit with different therapeutic approaches. The first patient, a 47-year-old man with systemic lupus erythematosus, developed TEN with approximately 35% body surface area involvement, complicated by sepsis and rhabdomyolysis; he was treated with systemic corticosteroids and intravenous immunoglobulin (IVIg, 0.4 g/kg/day for 3 days). The second patient, a 66-year-old woman, developed SJS attributed to amoxicillin-clavulanic acid and was treated with systemic corticosteroids alone. Both patients achieved complete re-epithelialization without major sequelae. These two cases illustrate the clinical heterogeneity of the SJS/TEN spectrum and the central role of early recognition, prompt withdrawal of the culprit drug, transfer to a specialized unit, and multidisciplinary supportive care. Given the substantial differences between the two patients in age, sex, comorbidities, culprit drugs, and disease severity, no comparative or causal inference regarding the relative efficacy of the two treatment strategies can be drawn; no efficacy claim is made for either therapeutic approach; this report is descriptive, and the two cases are presented as contrasting rather than comparable.

PMID 42929981
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PubMedOxford medical case reports2026-10-26

One trigger, two systems: post-infectious severe Guillain-Barre syndrome with concurrent central nervous system demyelination": a case report.

Numan Mohammad M, Alhatou Mohammad M, Hussain Zaeem Z, Hussain Maidah M et al.

Combined central and peripheral demyelination is a rare but serious neurological condition that is associated with poor outcomes. We report a 31-year-old male presenting with rapidly progressive Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) variant of Guillain-Barré syndrome following an upper respiratory tract infection. The course was complicated by respiratory failure requiring intubation and significant autonomic dysfunction. Despite treatment with intravenous immunoglobulin, there was minimal clinical improvement. Further imaging of the central nervous system revealed multiple acute demyelinating lesions involving the brain and spinal cord. The patient subsequently received plasmapheresis and high-dose intravenous steroids without significant neurological recovery. A severe hospital-acquired infection delayed rituximab initiation until four months after symptom onset; however, neurological recovery remained minimal. This case highlights the rare coexistence of post-infectious central and peripheral demyelination. Early recognition of central involvement in patients with poor response to standard GBS therapy may help guide escalation of immunotherapy and potentially improve outcomes.

PMID 42928892
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PubMedCureus2026-10-26

Bilateral Earlobe Purpura as an Unusual Initial Manifestation of Systemic Lupus Erythematosus: A Case Report.

Atherton Lucy L

Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by autoantibody production, particularly antinuclear antibodies (ANAs). The broad clinical spectrum and absence of pathognomonic features can make diagnosis challenging, particularly when alternative autoimmune, infectious, and hematological conditions must be considered. We report a case of a 31-year-old woman who presented to the emergency department with a two-week history of bilateral earlobe purpura. Initial investigations demonstrated severe thrombocytopenia and normocytic anemia, and subsequent imaging revealed widespread lymphadenopathy. Early multidisciplinary assessment by acute medicine, hematology, and rheumatology, together with exclusion of hematological malignancy and positive autoimmune serology, supported a diagnosis of SLE. Despite initial treatment with intravenous immunoglobulin (IVIg) and corticosteroids, the bicytopenia persisted. Mycophenolate mofetil was commenced; however, worsening cytopenias and concern for secondary hemophagocytic lymphohistiocytosis led to the initiation of rituximab infusions. Her platelet count subsequently improved, and she was discharged with rheumatology and hematology follow-up. This case highlights an unusual cutaneous presentation of newly diagnosed SLE and the diagnostic challenges associated with severe hematological involvement at initial presentation. It also demonstrates the importance of multidisciplinary assessment and timely escalation of immunosuppressive therapy in severe disease.

PMID 42928827
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