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clindamycin (ResiDerm A / Zindaclin)

✓ Approved

Teva Pharmaceutical Industries Ltd. · 小分子 · 小分子

什么是 clindamycin？

clindamycin 是一种小分子，由Teva Pharmaceutical Industries Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名ResiDerm A, Zindaclin
公司Teva Pharmaceutical Industries Ltd.
药物类别小分子
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Teva Pharmaceutical Industries Ltd.

治疗适应症

clindamycin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersAcne✓ Approved

相关研究文献

PubMedBioorganic chemistry2026-10-25

Development of cinnamyl derivatives as antibiotic-potentiating agents.

Hympanova Michaela M, Kufa Martin M, Muckova Lubica L, Prchal Lukas L et al.

Here, we report the discovery and optimization of 1-cinnamylpiperazine derivatives as antibiotic-potentiating agents inspired by the known RND efflux pump inhibitor 1-(1-naphthylmethyl)piperazine (NMP). A structurally diverse series of analogues was synthesized and evaluated for intrinsic antibacterial activity, cytotoxicity, and ability to potentiate antibiotic activity against Escherichia coli. Most derivatives showed low intrinsic antibacterial activity, consistent with an adjuvant mode of action. In combination assays, several compounds enhanced the antibiotic activity of erythromycin and linezolid, with halogenated derivatives showing the strongest potentiating effects. Compound 27 displayed the broadest potentiation profile, showing synergistic interactions with five of the seven tested antibiotics, namely linezolid, novobiocin, fusidic acid, pyridomycin, and clindamycin. Notably, it showed a superior potency to the structurally related reference inhibitor NMP. Experiments with AcrAB-TolC-deficient E. coli mutants, together with dye accumulation (Hoechst 33342) and membrane-permeabilization assays, suggested that 1-cinnamylpiperazine derivatives modulate efflux-associated resistance in a manner distinct from NMP, with increased membrane permeability likely contributing to their overall potentiating effect. Beyond planktonic cultures, compound 27 also potentiated erythromycin and linezolid against mature E. coli biofilms. These findings identify 1-cinnamylpiperazines as promising antibiotic adjuvant scaffolds for further optimization against drug-resistant Gram-negative infections.

PMID 42927674
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PubMedThe Journal of veterinary medical science2026-10-25

Bacterial distribution and antimicrobial susceptibility profile of ascitic fluid isolates from dogs and cats in Japan.

Sakamoto Mei M, Oyama Yukihiro Y, Satake Chikara C, Harada Kazuki K

Septic peritonitis is a life-threatening condition in dogs and cats, requiring appropriate antimicrobial therapy. Thus, knowledge of local bacterial epidemiology and antimicrobial susceptibility is crucial. However, large-scale comparative data in Japan are lacking. This retrospective cross-sectional study investigated bacterial isolates from canine and feline ascitic fluid samples submitted to a diagnostic laboratory in Japan between October 2022 and March 2026. Bacterial distribution was evaluated in 673 isolates from 496 ascitic fluid samples, and antimicrobial susceptibility was assessed for Enterobacterales, Enterococcus spp., and anaerobic bacteria. Gram-negative bacilli were the most frequently isolated bacterial group (55.6%), followed by gram-positive cocci (29.6%) and anaerobic bacteria (12.0%). Escherichia coli was the most frequently isolated bacterium (39.4%). Dogs had significantly higher isolation rates of Enterobacterales, whereas anaerobic bacteria were significantly more prevalent in cats. Polymicrobial infection rates were similar between the two host species. Antimicrobial susceptibility profiles of Enterobacterales and Enterococcus spp. were largely comparable between dogs and cats. Amikacin exhibited the highest antimicrobial activity against Enterobacterales, whereas enrofloxacin demonstrated limited activity against Enterobacterales and Enterococcus spp. Chloramphenicol exhibited potent activity against all major bacterial groups. Feline anaerobic isolates were significantly more susceptible to cefmetazole and clindamycin than canine isolates. To our knowledge, this is the first large-scale epidemiological study of bacterial distribution and antimicrobial susceptibility in canine and feline ascitic fluid isolates in Japan. These findings provide valuable epidemiological evidence to guide the selection of appropriate antimicrobial therapy in canine and feline abdominal infections.

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PubMedFrontiers in microbiology2026-10-25

Phenotypic and genotypic characterization of listeria monocytogenes strains isolated from meat industries.

Vougiouklaki Despina D, Dalezios Markos M, Kyriakou Konstantina K, Papaparaskevas Marios M et al.

Listeria monocytogenes is a major foodborne pathogen of concern for the food industry due to its ability to persist in processing environments and contaminate ready-to-eat foods. This study aimed to characterize phenotypically and genotypically L. monocytogenes isolates recovered from meat-processing environments in Greece, with emphasis on antimicrobial susceptibility, resistance determinants, plasmid content, and sequence types. Eighteen environmental isolates were analyzed using broth microdilution MIC testing and Oxford Nanopore whole-genome sequencing followed by in silico screening for antimicrobial resistance genes and plasmids. All isolates were susceptible to ampicillin, erythromycin, and trimethoprim-sulfamethoxazole according to EUCAST criteria. For agents categorized by EUCAST as having insufficient evidence ("IE") for clinical categorization in Listeria (moxifloxacin and linezolid), MICs were reported descriptively. Elevated MICs were observed for clindamycin (≥ 8 mg/L) in three isolates and for tetracycline (≥ 16 mg/L) in two isolates, while all isolates showed high fosfomycin MICs (≥ 128 mg/L) and intermediate fusidic acid MICs (4-8 mg/L). Genomic screening identified two acquired resistance genes, vga (G) and tet (M), and detected plasmids in a subset of isolates, including plasmid types previously associated with stress tolerance and persistence in food environments. MLST revealed four sequence types (ST87, ST155, ST6, and ST504), including lineages linked to food-processing persistence and clinically relevant clonal complexes. Overall, the findings indicate limited clinically relevant resistance among the examined isolates, while highlighting the contribution of mobile genetic elements and diverse sequence types to environmental fitness and potential public-health risk in meat-processing settings.

PMID 42923197
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PubMedFrontiers in microbiology2026-10-25

Diverse Staphylococcus aureus lineages in a tertiary hospital in North Central Nigeria: emergence of CC1-ST772-MRSA, CC8-ST789-MRSA, and ST152-MRSA.

Raheem Rasaki Adewole RA, Nwabuisi Charles C, Fadeyi Abayomi A, Olanipekun Bashirat Ayobola BA et al.

Staphylococcus aureus is a human pathogen associated with both hospital- and community-acquired infections. Data on its molecular epidemiology in North Central Nigeria are currently unavailable. This study investigated the antibiotic resistance, virulence genes, and the population structure of S. aureus in a tertiary hospital in North Central Nigeria. S. aureus strains from various clinical specimens collected between July 2017 and July 2021 were characterized based on antibiotic susceptibility testing and PCR detection of nuc, mecA, PVL (lukS-PV/lukF-PV), and immune evasion (scn, sak, chp) genes. Genotyping of the strains was performed by spa typing and whole-genome sequencing (WGS) of representative strains. Of the 169 S. aureus strains, 52% (n = 88) were recovered from wound infections. The resistance rates were highest for penicillin (n = 162; 96%), followed by trimethoprim-sulfamethoxazole (n = 128; 76%), tetracycline (n = 66; 39%), gentamicin (n = 54; 32%), ciprofloxacin (n = 53; 31%), erythromycin (n = 31; 18%), and clindamycin (n = 3; 2%). Overall, 90 (53%) were mecA-positive (MRSA), and 81 strains (48%) were multidrug-resistant (MDR). Genotyping revealed a diverse S. aureus population, comprising 37 spa types and 19 sequence types (STs) in nine clonal complexes (CC1, CC5, CC8, CC15, CC22, CC30, CC45, CC88, CC121) and two singletons (ST152 and ST7572). The predominant MRSA lineages comprised CC1-ST772-MRSA-V-t657, CC8-ST789-MRSA-V-t091, and ST152-MRSA-Vc-t4690, while the common methicillin-susceptible S. aureus (MSSA) lineages were ST152-MSSA-t355, CC15-ST15-MSSA-t084, and CC5-ST5-MSSA-t311. The dfrG gene was detected across lineages, and 65% of all strains (MSSA: 68%; MRSA: 62%) were PVL-positive. Phylogenetic analysis revealed strain diversity, suggesting the dissemination of different lineages across various wards within the hospital. The S. aureus population at a tertiary hospital in North-Central Nigeria is highly diverse. The detection of PVL-positive ST152-MRSA-Vc and MDR CC1-ST722-MRSA-V is of significant public health concern. Genomic surveillance of S. aureus, combined with clinical data, is essential for effective infection prevention and control strategies.

PMID 42921311
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PubMedInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2026-10-23

Clinical Characteristics, 90-Day Functional Outcomes, Antimicrobial Susceptibility, and Exploratory Genomic Analysis of Invasive Human Streptococcus suis Infection: A Multicenter Retrospective Study in China.

Zhang Huatang H, Lai Xueping X, Chen Chunlin C, Yan Xiaoli X et al.

Streptococcus suis is a zoonotic pathogen; survivors of invasive infection may have persistent auditory or vestibular sequelae. To address limited multicenter evidence from China, we characterized 90-day outcomes, antimicrobial susceptibility, and exploratory genomic findings. We retrospectively studied 34 patients with invasive S. suis infection at eight hospitals in four Chinese provinces (2017-2025). Unfavorable outcome was defined as death within 90 days or persistent sequelae at day 90. Minimum inhibitory concentrations were reinterpreted using CLSI viridans-group streptococcal surrogate breakpoints; six recoverable isolates underwent whole-genome sequencing. Acute cochleovestibular involvement occurred in 11/27 (40.7%) patients with meningitis and 0/7 with nonmeningitic bacteremia/sepsis. Unfavorable outcomes occurred in 17/34 (50.0%) patients, including two deaths; 12/32 (37.5%) survivors had hearing-related sequelae. Acute cochleovestibular involvement was more frequent among patients with unfavorable outcomes (64.7% versus 0%; P < 0.001). All evaluable isolates were susceptible to penicillin (21/21), cefotaxime (19/19), and ceftriaxone (5/5). Resistance was observed in 17/20, 16/20, and 20/20 isolates tested for erythromycin, clindamycin, and tetracycline, respectively. Sequence types were ST1 (n = 3), ST7 (n = 2), and ST25 (n = 1); epf and sly were each detected in five isolates, and mrp in four. Substantial hearing-related morbidity supports structured audiological follow-up. Clinical associations and genomic findings remain exploratory and do not establish independent prognostic value or genotype-phenotype causality.

PMID 42918323
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PubMedBioactive materials2026-10-23

Oxygen-vacancy-rich LDH sonosensitizers potentiate narrow-spectrum antibiotics via membrane-disruption strategy for mixed bacterial wound infections.

Xi Licheng L, Liu Xue X, Yu Chaojie C, Wang Tao T et al.

Mixed bacterial infections, including Gram-positive and Gram-negative pathogens, remain a major global health concern. Achieving efficient treatment of synergistic polymicrobial infections stills a tremendous clinical challenge due to antibiotic permeability barriers and resistance. Here, we construct a defect-engineered layered double hydroxide (LDH)-based sonosensitizer platform loaded with clindamycin (a-CoW/CLD) for mixed bacterial infection therapy, which not only demonstrates high efficacy against Gram-positive bacteria, but also exploits reactive oxygen species (ROS)-mediated membrane disruption of Gram-negative bacteria to facilitate CLD penetration, thereby achieving broad-spectrum and highly efficient killing of mixed bacteria. The amorphous a-CoW nanosheets, enriched with oxygen vacancies via acid etching, exhibit a substantially narrowed bandgap (1.22 eV) and markedly enhanced charge separation, producing 22.1-fold higher singlet oxygen under ultrasound (US) irradiation compared with pristine CoW. This ROS burst synergized with CLD achieves potent killing of Staphylococcus aureus (>99.9% at 20 μg mL-1). More critically, ROS disrupt the outer membrane of Gram-negative Escherichia coli, promoting CLD internalization and consequently boosting its lethality by 18.4-fold (from ∼5% to >92.1%). Mechanistic transcriptomics reveals ROS and CLD synergy: ROS disrupt the bacterial membrane via lipid peroxidation, enabling CLD penetration to block protein synthesis and metabolism, while ROS also induce oxidative stress, collectively leading to bacterial death. In a murine wound model co-infected with both pathogens, a-CoW/CLD plus US eradicates >99.9% of mixed bacteria, suppresses systemic inflammation, and significantly accelerates angiogenesis and re-epithelialization. This paradigm establishes a low-dose, broad-spectrum sonodynamic-antibiotic strategy that overcomes antibiotic permeability bottleneck, offering a promising therapeutic avenue against mixed bacterial infections.

PMID 42910182
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