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epoetin alfa (Epiao 36000IU)

✓ Approved

3SBio · EPOR · 重组蛋白

什么是 epoetin alfa？

epoetin alfa 是一种重组蛋白，由3SBio研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Epiao 36000IU
公司3SBio
药物类别重组蛋白
分子靶点EPOR
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, 3SBio

作用机制

分子靶点

epoetin alfa 作用于 1 个分子靶点：

EPORerythropoietin receptor (EPO-R)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

epoetin alfa 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAnaemia✓ Approved
Blood and lymphatic system disordersNephrogenic anaemia✓ Approved

相关研究文献

PubMedCureus2026-10-26

High-Dose Tigecycline for Multidrug-Resistant Serratia Infections in Critically Ill Adults: A Systematic Review of Direct and Indirect Clinical Evidence.

Choudhury Arnab A, Chaturvedi Ashutosh A, Ashraf Adil A, Padmaprakash K V KV

Evidence for high-dose tigecycline in severe multidrug-resistant Gram-negative infections comes mainly from non-Serratia cohorts. Its value in critically ill adults with resistant Serratia infection is uncertain. PubMed/MEDLINE, CENTRAL, and Consensus were searched up to July 17, 2026. Two evidence sets addressed high-dose tigecycline effectiveness, pharmacokinetics, and safety, and clinical and microbiological evidence for resistant Serratia. Study-level risk ratios were presented without pooling. Searches identified 2,294 records, and 36 studies reported in 37 publications were included. No study reported a verified high-dose regimen in confirmed resistant Serratia infection with a separately extractable organism-specific outcome. Six observational studies used the same high-dose and standard-dose definitions. Fixed 28-day or 30-day mortality risk ratios ranged from 0.34 to 1.30, and all 95% confidence intervals crossed 1.0. Clinical response favored high dose in two studies, with risk ratios of 1.73 (95% confidence interval: 1.22-2.46) and 1.48 (95% confidence interval: 1.08-2.02). Microbiological response favored high dose in two studies, with risk ratios of 1.75 (95% confidence interval: 1.09-2.81) and 1.92 (95% confidence interval: 1.12-3.28). No pooled estimate was calculated. High dose produced a greater fibrinogen decline in one cohort (-3.05 ± 1.67 versus -1.75 ± 1.90 g/L; p=0.038) and more hepatic or platelet abnormalities in another. Direct evidence for high-dose tigecycline in resistant Serratia infection is absent. Indirect studies show possible response benefits without a consistent survival advantage. Treatment decisions should consider infection site, susceptibility, active alternatives, and coagulation risk. By synthesizing both pathogen-specific studies and relevant indirect clinical evidence, this review aimed to provide a more comprehensive assessment of the potential role of high-dose tigecycline in critically ill adults with resistant S. marcescens infections.

PMID 42928831
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PubMedBMC psychiatry2026-10-26

Rapid and robust effects of high-dose intermittent Transcranial Brain Stimulation (iTBS) on depression and suicidal ideation in adolescents with acute major depression: a 10-day randomised, controlled, single-blind trial.

Yang Yiling Y, Ye Qian Q, Peng Zhizhen Z, Cai Weiyu W et al.

Depression is extremely common among adolescents and can significantly increase the risk of suicide when severe. High-dose intermittent theta burst stimulation (iTBS) is a secure and efficacious physical treatment. However, clinical evidence in adolescents remains limited. This research is designed to assess the therapeutic impacts of high-dose iTBS on depressive symptoms, anxiety symptoms, and suicidal ideation in adolescents suffering from acute depression, along with the factors linked to treatment response. A total of 61 patients were randomly assigned to either the high-dose iTBS group or the sham stimulation group. All participants received 10 daily sessions of high dose iTBS stimulation over a two-week period, targeting the left dorsolateral prefrontal cortex (DLPFC). Outcome measures assessed at baseline, post-intervention, and 1-month follow-up included 24-item Hamilton Depression Rating Scale (HAMD-24) scores, Beck Scale for Suicide Ideation - Chinese Version (BSI-CV), and Hamilton Anxiety Rating Scale (HAMA). Clinical factors influencing iTBS efficacy were further analyzed. At the end of the 10-day intervention, the high-dose iTBS group exhibited significantly lower HAMD-24 (p = 0.008, Cohen`s d = 0.71 [95%CI: 0.188-1.224]) and BSI-CV (p = 0.011, Cohen`s d = 0.67[95%CI: 0.154-1.186]) scores compared with the sham group, and this advantage persisted at the 1-month follow-up (Week 6) (HAMD-24: Cohen`s d = 0.96[ 95%CI: 0.43-1.49]; BSI-CV: Cohen`s d = 0.76[95%CI: 0.24-1.28]). In contrast, between-group differences in HAMA scores were non-significant both post-intervention (Week 2) and at the 1-month follow-up (Week 6) (p > 0.05). Moreover, poorer family functioning within the high-dose iTBS cohort was associated with diminished therapeutic benefit (p < 0.05). Current research indicates that a 10-day course of high-dose iTBS is effective in alleviating depressive symptoms and suicidal ideation in adolescents with depression, and that the therapeutic effects persist for up to one month after the end of treatment. We also found that high-dose iTBS was less effective in patients with poor baseline family functioning. Chinese clinical trial Registry (ChiCTR2500101152), trial registration date: April 21, 2025(retrospectively registered).

PMID 42928194
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PubMedJournal of medical case reports2026-10-26

High-dose regular insulin as a potential rescue therapy in severe aluminum phosphide poisoning: a case report.

Sedaghattalab Moslem M, Akbari Ghaidafeh G

Aluminum phosphide (rice tablet) can cause cardiocirculatory collapse and has negative cardiac inotropic effect. Positive inotropic effect of insulin on the cardiac myocytes is through calcium flux. Insulin increases the intramyocytes calcium concentration by increasing conductance of calcium through the L-type calcium channels and by increasing intramyocytes concentration of cyclic adenosine monophosphate. In addition to increasing the intramyocytes calcium level, insulin also enhances the responsiveness of the cardiac cells to calcium. High-dose insulin is a potential therapy for hypodynamic and hypotensive septic shock due to its positive inotropic qualities. In this paper, a critical aluminum phosphide poisoning patient (a 25-year-old Iranian young woman), presented with mixed severe metabolic acidosis and respiratory alkalosis, tachypnea, tachycardia, and hypotension. In contrast to our previous experiences that ingestion of aluminum phosphide tablets associated with multiple organ failure and severe shock in approximately all critical poisoning patients, early initiation of high-dose intravenous regular insulin for this patient prevented multiorgan dysfunction and death. Treatment with high-dose intravenous insulin associated with IV fluids, sodium bicarbonate, hydrocortisone, potassium, dextrose therapy and supportive care resolved completely signs and symptoms of patient after 3 days in ICU. High-dose intravenous regular insulin may be act as a rescue therapy for aluminum phosphide poisoning patients. While this single case suggests a potential benefit, further studies are required to confirm these findings.

PMID 42928247
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PubMedCurrent oncology (Toronto, Ont.)2026-10-26

Secondary Intracranial Hypertension During ATRA/ATO Therapy in High-Risk Acute Promyelocytic Leukemia: A Case Report and Practical Management Framework.

Roeh Luca L, Schaeper Nigel N, Schröder Sebastian S, Scheitz Jan Friedrich JF et al.

All-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) is the standard of care for acute promyelocytic leukemia (APL), including high-risk disease. Secondary intracranial hypertension (SIH), historically termed pseudotumor cerebri (PTC), is a recognized but uncommon and potentially therapy-limiting complication of retinoid exposure, reported predominantly in pediatric and young-adult patients and most frequently during induction. We report a 31-year-old man with high-risk microgranular APL in whom SIH was diagnosed during the first ATRA/ATO consolidation cycle. The clinical course included progressive headache, ocular pain, pulsatile tinnitus, focusing difficulties, visual deterioration, and diplopia. Ophthalmological assessment demonstrated bilateral papilledema with marked peripapillary retinal nerve fiber layer thickening despite preserved central visual acuity. Magnetic resonance imaging showed bilateral optic nerve sheath distension, prominent optic nerve heads, mild pituitary flattening, and bilateral transverse sinus stenosis. Lumbar puncture demonstrated an opening pressure of 32 cm H2O with otherwise unremarkable cerebrospinal fluid; removal of approximately 30 mL resulted in immediate symptomatic improvement. Management consisted of temporary ATRA interruption, therapeutic lumbar punctures, acetazolamide, and individualized ATRA rechallenge and dose titration. Repeated attempts at dose escalation reproduced symptoms, and ATRA was ultimately maintained at a maximally tolerated dose of 30 mg/m2/day while full-dose ATO was continued. Molecular remission was achieved after the first consolidation cycle and remains sustained at 18-month follow-up. This case highlights the importance of recognizing ATRA-associated SIH throughout the treatment course and illustrates a pragmatic strategy for preserving ATRA exposure when standard-dose treatment is limited by neurological toxicity. However, the oncological equivalence of reduced-dose ATRA cannot be inferred from a single case.

PMID 42930178
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PubMedChemistry & biodiversity2026-10-26

Auricularia auricula-judae Peptides Modulate Lipid Metabolic Disturbances and Gut Microbiota Composition in High-Fat-Diet-Fed Mice.

Yang Feiyu F, Tao Jia J, Li Xin X, Sun Jing J et al.

High-calorie diets and sedentary lifestyles have led to a rising global prevalence of obesity, which constitutes a serious publichealth challenge. In this study, we investigated the antiobesity effects and underlying molecular mechanisms of Auricularia auricula-judae peptides (AAP) in high-fat-diet-induced obese mice. AAP intervention markedly restrained bodyweight gain. At the highest dose, the final body weight of AAP-treated mice was approximately 20% lower than that of the untreated high-fat-diet group. AAP reduced plasma and hepatic triglyceride (TG) and total cholesterol (TC) levels with a dose-dependent tendency and restored the histological morphology of liver and epididymal white adipose tissue. AAP mediated reshaped gut microbiota composition, improved intestinal homeostasis, and mitigated hepatic chronic inflammation. Moreover AAP significantly elevated fecal total bile acid (TBA) content and up-regulated the hepatic mRNA expression of lipolysis-related genes Cpt1, Ppar-α, Atgl and cholesterol catabolic gene Cyp7a1 thereby restoring hepatic lipid metabolic homeostasis. Collectively these findings demonstrate that AAP exerts promising antiobesity activity in obese mice and has great potential for development as functional food ingredients.

PMID 42928628
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PubMedThe Medical journal of Australia2026-10-26

Short-Term Adverse Events Following Recombinant Zoster Vaccination in Older Adults in Australia: A Survey Study Comparing Dose 1 and Dose 2 and Influence of Dose Interval.

Dawes Lucy L, Nguyen Thuy T, Macartney Kristine K, Deng Lucy L

Self-reported adverse events following first and second recombinant zoster vaccination (RZV) doses in older adults (n = 41,069) collected through AusVaxSafety were analysed. Adverse event rates were higher following Dose 2 (54%; 95% CI, 53%-54%) than after Dose 1 (45%; 95% CI, 45%-46%), particularly with 3-6- and 7-9-month dose intervals, although medical review rates remained low (1.1%; 95% CI, 1.0%-1.2%), suggesting RZV is reactogenic but with no serious outcomes.

PMID 42928968
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