北京若生智能科技有限公司
Drug Database
OR

Ortho-ATI (Ortho ATI / OrthoATI)

✓ Approved

Orthocell Pty, Ltd. · 细胞治疗 · 细胞治疗

什么是 Ortho-ATI？

Ortho-ATI 是一种细胞治疗，由Orthocell Pty, Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Surgical Implantation。

药物档案

商品名Ortho ATI, OrthoATI
公司Orthocell Pty, Ltd.
药物类别细胞治疗, 疫苗
给药途径Injectable (Others), Surgical Implantation
状态Approved
来源： ClinicalTrials.gov, Orthocell Pty, Ltd.

治疗适应症

Ortho-ATI 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsTendon injury✓ Approved
Injury, poisoning and procedural complicationsLigament rupture✓ Approved

相关研究文献

PubMedRSC advances2026-10-25

Design and synthesis of 3-(1H-indol-3-yl)-N-(3,4,5-trimethoxyphenyl) acrylamide derivatives as anticancer agents.

Ghafouri Seyedeh Niloufar SN, Ranjbar Parviz Rashidi PR, Mahdavi Mohammad M, Iraji Aida A

In this study, a new series of indole-based trimethoxy aniline hybrids (10a-o) was designed through a fragment-based hybridization strategy and synthesized via a multistep synthetic procedure. The cytotoxicity of the synthesized compounds was evaluated against human breast cancer cell lines (MCF-7 and MDA-MB-468), hepatocellular carcinoma cells (Hep-G2), and the non-cancerous HEK-293 cell line using MTT assay. Several analogs exhibited moderate antiproliferative activity, and compound 10b, bearing an ortho-methyl substituent, emerged as the most active derivative against MCF-7. Structure-activity relationship (SAR) analysis revealed that ortho-alkyl substituents favored selectivity toward MCF-7 cells, whereas 4-Br substitution and ethyl-alkyl extension preferentially enhanced activity against Hep-G2 cells. Mechanistic studies demonstrated that 10b primarily induced apoptotic cell death at lower concentrations and exposure times, whereas higher concentrations and prolonged treatment resulted in more necrotic cell death. Compound 10b also induced dose-dependent alterations in cell-cycle progression in MCF-7 cells, characterized by S-phase arrest.

PMID 42923786
阅读全文 →
PubMedOrganic letters2026-10-25

Enantioselective Pericyclization of Naphthol-Substituted Alkynyl Ketimines.

Singh Bhuvnesh B, Tewari Shreya S, Singh Ravi P RP

A vinylidene ortho-quinone methide (VQM)-mediated, organocatalyzed tandem 6π-azaelectrocyclization and dearomatizing spirocycloaddition of naphthol-substituted alkynyl ketimines, facilitated by NBS, have been realized. This strategy enables the enantioselective synthesis of axially chiral 3-haloquinolines and previously unexplored spirocyclic xanthenopyrroles under mild conditions, with excellent functional group tolerance and high efficiency. Significantly, this represents the first intramolecular method for constructing axially chiral biaryl quinolines via 6π-azaelectrocyclization of naphthol-substituted alkynyl ketimines. Furthermore, a range of downstream transformations highlights the broad synthetic utility of these halogenated heterobiaryls.

PMID 42925195
阅读全文 →
PubMedbioRxiv : the preprint server for biology2026-10-25

A mechanistic basis for CD8+ T cell expansion sensitivity as a predictor of HIV post-treatment control.

Phan Tin T, Pagane Nicole N, Kreig Jasmine J, Marc Aurelien A et al.

A key goal in HIV-1 cure research is to understand why some individuals control viral rebound after stopping antiretroviral therapy (ART). Recent human studies have identified responding CD8+ T cells expressing Ki-67 and the transcription factor TCF-1 as correlates of post-treatment control, but the mechanistic basis of this association remains unclear. Using the theoretical framework of Conway and Perelson, we fit mechanistic within-host models to viral load and CD8+ T cell data from 9 individuals in a combination immunotherapy trial following ART interruption. Although Ki-67 and TCF-1 measurements were not used for fitting, the inferred effector cell expansion sensitivity, i.e., the responsiveness of effector expansion to low antigen levels, shows a strong linear relationship with Ki-67 and TCF-1 levels at rebound (Pearson's r ≈ 0.8). Building on this, we show analytically that the post-rebound viral load set point is inversely proportional to the effector cell expansion sensitivity, and thus strongly correlates with cycling (Ki-67+) CD8+ T cells (r ≈ -0.8) at rebound, and a subset that expresses TCF-1 (r ≈ -0.9). In effect, individuals with a larger proportion of CD8+ T cells responding to viral rebound, and a greater representation of TCF-1 expressing cells within the responding subset, achieve markedly lower viral set points through a higher effector cell expansion sensitivity. This mechanism is consistent with prior modeling in a non-intervention ATI setting, suggesting it may generalize across more rebound contexts. Our results provide a mechanistic explanation why both Ki-67+ responding CD8+ T cells and their TCF-1-expressing subset predict post-treatment control, linking clinical correlation to its underlying cause and highlighting Ki-67 and TCF-1 as potential early biomarkers of HIV immunotherapy success.

PMID 42922473
阅读全文 →
PubMedJournal of computer-aided molecular design2026-10-25

Potent antimicrobial pyridyl-imine derivatives: experimental and computational insights into their biological activity.

Dragojević Jovana S JS, Milanović Žiko Ž, Milisavljević Kristina K, Petrović Nevena N et al.

Dermatophytic infections remain a persistent therapeutic challenge, particularly due to the increasing resistance to conventional antifungal agents. In search of alternative antifungal scaffolds, a series of 2-pyridyl-imine derivatives (PYE1-PYE11) was synthesized and evaluated for antimicrobial, cytotoxic, and biomolecular interaction properties. All compounds exhibited antimicrobial activity, with the ortho-vanillin derivative PYE10 showing the highest potency, including remarkable activity against Proteus mirabilis (MIC = 0.01 mg/mL) and Trichophyton mentagrophytes (MIC = 0.05 mg/mL). Fluorescence displacement assays provided evidence for PYE10-DNA interactions involving both intercalative and minor-groove-associated binding modes, while human serum albumin binding studies revealed 1:1 complex formation, indicating appreciable interaction with HSA. Molecular docking and molecular dynamics simulations identified favorable and stable binding of the most active compounds within the CYP51B active site, supporting the experimentally observed antifungal activity. Computational thermodynamic analysis indicated that Fe2⁺ chelation is protonation-dependent under physiological conditions. Structure-activity relationship analysis revealed that antimicrobial activity is influenced by the electronic nature of substituents, aromatic planarity, molecular flexibility, and the ability to establish multiple intermolecular interactions. In silico ADMET evaluation demonstrated favorable drug-likeness and pharmacokinetic profiles, highlighting these pyridyl-imine derivatives as promising candidates for further antimicrobial development.

PMID 42927568
阅读全文 →
PubMedPlant communications2026-10-24

Elucidation and reconstitution of the poplar salicortin biosynthetic pathway.

Lackus Nathalie D ND, Ma Dawei D, Nakamura Yoko Y, Luck Katrin K et al.

Salicinoids are specialized benzenoid (C6-C1) metabolites characteristic of the Salicaceae family. Although salicinoids have long been recognized as effective defense compounds and pharmacologically active constituents in willows and poplars, the biosynthetic pathway underlying their formation remains largely unresolved. Through integrated metabolomic and transcriptomic analyses of black cottonwood (Populus trichocarpa) roots, we identified candidate genes involved in salicinoid biosynthesis belonging to the cytochrome P450 monooxygenase family 92 (CYP92) and the progesterone 5β-reductase/iridoid synthase-like enzyme (PRISE) family of short-chain dehydrogenases/reductases. Co-expression of all identified candidate genes, together with the previously characterized glycosyltransferase gene PtUGT71L1, acyltransferase gene PtACT47, and cinnamic acid-CoA ligase gene PtCNL5, in Nicotiana benthamiana resulted in the production of salicortin, the most abundant salicinoid in poplar. Further characterization of the P450 candidates revealed that two enzymes catalyze ortho-hydroxylation of both aromatic rings of the proposed salicortin precursor, benzyl benzoate, while two other P450s catalyze the subsequent oxidative dearomatization of the benzoic acid-derived ring of benzyl benzoate. The resulting dieneone intermediate is converted by PRISE enzymes via a 1,4-reduction to form the characteristic 1-hydroxy-6-oxocyclohex-2-en-1-carboxylic ester moiety of salicortin. Functional redundancy among the identified CYP92 and PRISE enzymes may reflect the central role of these compounds in plant defense.

PMID 42920296
阅读全文 →
PubMedEnvironmental science & technology2026-10-23

Electrochemically Generating High-Spin MnIII for the Targeted Production of 1O2 from O2 Mediated by Dissolved Organic Matter.

Sun Min M, Hu Zhao-Jian ZJ, Xing Liang-Long LL, Xu Shu-Ya SY et al.

Dissolved organic matter (DOM), ubiquitously present in aquatic systems, exerts a significant impact on advanced oxidation processes (AOPs), typically acting as an inhibitor. However, our investigation in this work reveals that DOM can function as an activator of molecular oxygen (O2) for selective singlet oxygen (1O2) production through an innovative electrochemical regulation strategy. A positive electric field was utilized to trigger the electrochemical oxidation of MnII in MnO, generating high-spin MnIII that targets the transformation of ortho-hydroquinone moieties in DOM to ortho-semiquinone radical (ortho-SQ•-). The metal-ligand cooperation stabilized ortho-SQ•- on the MnO surface as MnII-ortho-SQ•- complexes, which effectively activated dissolved O2 into 1O2 with •O2- as an intermediate. Elementary electron-transfer steps among high-spin MnIII, ortho-hydroquinone, and O2 were systematically elucidated, based on which a quantitative relationship between the structural characteristics of ortho-hydroquinone and 1O2 production was established. Electron-donating groups on ortho-hydroquinone showed an enhancing effect on 1O2 production by promoting the formation of surface MnII-ortho-SQ•- complexes as well as their reactions with O2. By integrating the DOM-mediated O2 activation pathway into an electrochemical oxidation system, we achieved a remarkable improvement in phenol degradation efficiency, with a twofold acceleration of the degradation rate and over 50% reduction in energy consumption. This work establishes a mechanistic framework describing how DOM synergizes with electrochemical oxidation reactions to in situ activate dissolved O2 under an electric field drive, paving a new avenue for developing innovative water remediation processes by exploiting DOM-O2 interactions in aquatic systems.

PMID 42916249
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多Ortho-ATI