北京若生智能科技有限公司
Drug Database
TR

trans-retinoic acid (tretinoin, Heron / Renova, Micro)

✓ Approved

Johnson & Johnson Services, Inc. · 治疗药物

什么是 trans-retinoic acid？

trans-retinoic acid 是一种治疗药物，由Johnson & Johnson Services, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名tretinoin, Heron, Renova, Micro
公司Johnson & Johnson Services, Inc.
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Johnson & Johnson Services, Inc.

治疗适应症

trans-retinoic acid 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Skin and subcutaneous tissue disordersAcne✓ Approved

相关研究文献

PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion.

Ping Jieming J, Wang Wenliang W, Xu Jinnuo J, Yang Mengyun M et al.

Plasma membrane (PM) phospholipid asymmetry is a fundamental feature of eukaryotic cells that regulates signaling, trafficking, and cell fate. Whether it also controls passive diffusion across the PM remains unknown. Here, we show that phospholipid asymmetry is a critical determinant of PM permeability to hydrophobic molecules. Using genetic and biochemical approaches, we demonstrate that disruption of lipid asymmetry by the Ca2 +-activated scramblase TMEM16F or apoptotic scramblase XKR8 profoundly alters the permeation and intracellular accumulation of diverse hydrophobic compounds, including widely used fluorescent probes, while preserving the barrier to membrane-impermeable molecules. Lipid scrambling is sufficient to remodel membrane permeability to lipophilic molecules, alter membrane biophysical properties, and differentially affect their intracellular accumulation, suggesting selective regulation of passive diffusion rather than nonspecific membrane leakage. Physiological lipid scrambling during T cell activation was also accompanied by altered membrane permeability. Moreover, lipid asymmetry regulates the cellular entry of doxorubicin, 17β-estradiol, and all-trans retinoic acid. Together, our findings identify PM lipid asymmetry as a previously unrecognized regulator of membrane permeability and establish a link between membrane organization and molecular transport.

PMID 42928505
阅读全文 →
PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-26

Phosphate-Engineered DNA Reporters Boost CRISPR-Cas12a Trans-Cleavage for Rapid and Sensitive Nucleic Acid Detection.

Yang Rui R, Guo Chong C, Pei Minjie M, Zhang Jiongyu J et al.

CRISPR-Cas12a molecular diagnostics rely on target-activated collateral cleavage of single-stranded DNA (ssDNA) reporters to generate fluorescence signals, yet the mechanisms governing reporter substrate processing remain poorly understood. Here we show that Cas12a trans-cleavage involves both endonucleolytic cleavage and exonucleolytic trimming. We further demonstrate that terminal phosphate modification of ssDNA substrates accelerates substrate cleavage activity and modulates trans-cleavage kinetics, thereby enhancing fluorescence output. Guided by this mechanistic insight, we engineered fluorophore-quencher ssDNA reporters bearing terminal phosphate modifications and identified a 3'-phosphate-engineered reporter that enables faster signal generation and higher fluorescence intensity. Incorporation of the engineered reporter into the CRISPR-Cas12a system enabled the development of Phos-CRISPR (Phosphate-engineered DNA reporters boost CRISPR), a rapid, sensitive, and specific nucleic acid detection platform that achieves results within 20 min, approximately threefold faster than conventional CRISPR assays. Applied to herpes simplex virus 1 detection, the Phos-CRISPR combined with recombinase polymerase amplification achieved a limit of detection of 20 aM and accurately identified clinical swab samples. These findings provide a general framework for understanding Cas12a trans-cleavage activity and establish a mechanistically informed strategy for enhancing next-generation CRISPR diagnostics.

PMID 42928415
阅读全文 →
PubMedCurrent oncology (Toronto, Ont.)2026-10-26

Secondary Intracranial Hypertension During ATRA/ATO Therapy in High-Risk Acute Promyelocytic Leukemia: A Case Report and Practical Management Framework.

Roeh Luca L, Schaeper Nigel N, Schröder Sebastian S, Scheitz Jan Friedrich JF et al.

All-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) is the standard of care for acute promyelocytic leukemia (APL), including high-risk disease. Secondary intracranial hypertension (SIH), historically termed pseudotumor cerebri (PTC), is a recognized but uncommon and potentially therapy-limiting complication of retinoid exposure, reported predominantly in pediatric and young-adult patients and most frequently during induction. We report a 31-year-old man with high-risk microgranular APL in whom SIH was diagnosed during the first ATRA/ATO consolidation cycle. The clinical course included progressive headache, ocular pain, pulsatile tinnitus, focusing difficulties, visual deterioration, and diplopia. Ophthalmological assessment demonstrated bilateral papilledema with marked peripapillary retinal nerve fiber layer thickening despite preserved central visual acuity. Magnetic resonance imaging showed bilateral optic nerve sheath distension, prominent optic nerve heads, mild pituitary flattening, and bilateral transverse sinus stenosis. Lumbar puncture demonstrated an opening pressure of 32 cm H2O with otherwise unremarkable cerebrospinal fluid; removal of approximately 30 mL resulted in immediate symptomatic improvement. Management consisted of temporary ATRA interruption, therapeutic lumbar punctures, acetazolamide, and individualized ATRA rechallenge and dose titration. Repeated attempts at dose escalation reproduced symptoms, and ATRA was ultimately maintained at a maximally tolerated dose of 30 mg/m2/day while full-dose ATO was continued. Molecular remission was achieved after the first consolidation cycle and remains sustained at 18-month follow-up. This case highlights the importance of recognizing ATRA-associated SIH throughout the treatment course and illustrates a pragmatic strategy for preserving ATRA exposure when standard-dose treatment is limited by neurological toxicity. However, the oncological equivalence of reduced-dose ATRA cannot be inferred from a single case.

PMID 42930178
阅读全文 →
PubMedThe Journal of chemical physics2026-10-26

How much do VSCF optimized curvilinear coordinates accelerate the convergence of state-specific VCI calculations?

Yachmenev Andrey A, Rauhut Guntram G

The computational demands of vibrational configuration interaction (VCI) calculations are largely determined by the size of the correlation space. We show that this space can be substantially reduced in state-specific VCI calculations by using curvilinear coordinates optimized to minimize the vibrational self-consistent field ground-state energy. For fundamental, overtone, and combination bands of formaldehyde, fluoromethane, and trans-formic acid, optimized coordinates reduce the number of required configurations by factors of 3-7 compared to standard valence coordinates. The improvement is even greater for states in dense spectral regions with strong coupling between nearby states. For the C-H stretching excitations of trans-formic acid, optimized coordinates suppress resonant couplings and reduce the number of interacting states that must be tracked in state-specific VCI calculations, yielding configuration spaces being several tens of times smaller than with valence coordinates.

PMID 42929510
阅读全文 →
PubMedCells2026-10-26

Molecular Characterization of ALDH1A1 and Its Association with Secondary Hair Follicle Stem Cell Proliferation in Liaoning Cashmere Goats.

Yang Yuxin Y, Wang Meijie M, Li Fang F, Zhang Xiaoyi X et al.

Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is broadly expressed in mammalian tissues and is a key enzyme in retinoic acid (RA) biosynthesis, a process closely linked to hair follicle regeneration. Its expression pattern and function in cashmere goats, however, remain poorly defined. In this study, we isolated and characterized the full-length open reading frame (ORF) of ALDH1A1 cDNA from Liaoning cashmere goat skin, examined its expression across multiple tissues and seasonally assigned hair-cycle periods, and evaluated its effects on the proliferation of secondary hair follicle stem cells (SHFSCs). Nine male goats were used for seasonal skin sampling (n = 3 per period), primary SHFSCs were derived from one additional female donor (n = 1), and cell-based assays were independently repeated three times. The ALDH1A1 ORF was 1506 bp and encoded a 501-amino-acid protein; its nucleotide sequence shared 90.07-99.14% identity with corresponding mammalian sequences. Conserved-domain analysis assigned the goat ALDH1A1 protein to the aldehyde dehydrogenase superfamily (ALDH-SF), and phylogenetic analysis showed that the experimentally obtained sequence clustered with the Capra hircus reference sequence and other ruminant ALDH1A1 sequences. Among the tissues examined, ALDH1A1 transcripts were most abundant in skin, and both mRNA and protein levels in skin were highest during the seasonally assigned anagen period. In SHFSCs, ALDH1A1 overexpression increased multiple proliferation-related readouts, whereas knockdown produced the opposite changes. Overall, these findings characterize goat ALDH1A1 at the molecular and functional levels and support an association between ALDH1A1 perturbation and proliferation-related phenotypes in this primary-cell model; however, they do not establish whether these effects are mediated by RA-dependent signaling.

PMID 42929837
阅读全文 →
PubMedChemistry & biodiversity2026-10-26

Phytochemical Profiling, Molecular Docking Study, and Gastroprotective Effect of Matricaria chamomilla L. Aqueous Extract in Ethanol-Induced Gastric Ulcer in Mice.

Bouhadjar Meroua M, Naimi Dalila D, Cheriet Mouna M, Barros Lillian L et al.

While Matricaria chamomilla L. is renowned for its medicinal properties, most research has focused on its essential oils or organic extracts, neglecting the traditionally used aqueous preparation. This study investigated the chemical composition and the molecular interactions of phenolic compounds in chamomile aqueous extract (CAE), focusing on its unique water-soluble components. CAE, prepared from dried chamomile flowers, was analyzed by UHPLC-DAD-ESI-MS, revealing 19 phenolic constituents dominated by flavonoids and phenolic acids. In silico studies of the major compounds -trans-3,5-di-O-caffeoylquinic acid, myricetin-3-O-glucoside, and 4-O-caffeoylquinic acid, showed high binding affinities (-7.5 to -10.4 kcal/mol) via hydrogen bonding with the catalytic residues of cyclooxygenase-2, metalloproteinase-9, and gastric H+/K+ ATPase, providing a mechanistic of analytical findings. These computational findings were supported by in vitro antioxidant and anti-inflammatory assays and in vivo evaluation in ethanol-induced gastric ulcer mouse models. CAE treatment provided exceptional protection (99% at 500 mg/kg) and reduced the ulcer index from 4.5 to 0.24, significantly outperforming conventional omeprazole treatment. Histopathology confirmed improved mucosal integrity and reduced tissue damage. This work represents the first study combining phytochemical profiling of chamomile aqueous extract with multi-target molecular docking and in vivo validation of its gastro-protective efficacy.

PMID 42928570
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多trans-retinoic acid