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travoprost (Travatan Z / Travantan Z / Travatanz)

✓ Approved

Novartis AG · PTGFR · 小分子

什么是 travoprost？

travoprost 是一种小分子，由Novartis AG研发。该药已获批，用于治疗相关适应症，给药途径：Others。

药物档案

商品名Travatan Z, Travantan Z, Travatanz
公司Novartis AG
药物类别小分子
分子靶点PTGFR
给药途径Others
状态Approved
来源： ClinicalTrials.gov, Novartis AG

作用机制

分子靶点

travoprost 作用于 1 个分子靶点：

PTGFRprostaglandin F receptor (FP)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

travoprost 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Eye disordersGlaucoma✓ Approved

相关研究文献

PubMedIndian dermatology online journal2026-10-26

In Vivo Study of Topical Bimatoprost, Latanoprost, Travoprost in Comparison with Minoxidil on Hair Growth in C57BL/6 Mice.

Navale Vrushali Shankar VS, Marathe Padmaja Anil PA, Patil Sharmila P SP

Alopecia significantly affects psychological well-being and social functioning. Standard treatments, like minoxidil and finasteride, are limited by delayed efficacy, need for lifelong use, and adverse effects. Prostaglandin analogs (PGAs), originally developed for ocular hypertension, have shown promise in promoting hair growth. This study compares their effects with minoxidil in a murine model. To compare the effects of bimatoprost, latanoprost, and travoprost on hair growth in C57BL/6 mice, with evaluation of hair density, follicle diameter, and growth rate using minoxidil as the comparator. After Institutional Animal Ethics Committee approval, 40 male C57BL/6 mice (aged 6-7 weeks, weighing 20-25 g) were randomized into five groups ( n = 8 in each group): (1) vehicle control, (2) minoxidil 5%, (3) latanoprost 0.005%, (4) bimatoprost 0.03%, and (5) travoprost 0.004%. Drugs were applied topically to shaved dorsal skin daily for 28 days. Hair growth was assessed by follicle density, bulb diameter, and area of regrowth using ImageJ from photographs taken on days 1, 7, 15, and 28. All PGAs significantly increased hair density compared to vehicle control (vehicle control: 1.50 ± 0.55 vs. latanoprost: 7.50 ± 1.69, bimatoprost: 7.75 ± 2.87, travoprost: 6.87 ± 3.40; P = 0.001). Latanoprost and bimatoprost showed higher hair density than minoxidil (3.75 ± 2.87; P = 0.038 and 0.010, respectively). Hair follicle diameter was greater with PGAs (latanoprost: 53.12 ± 5.30, bimatoprost: 51.87 ± 7.52, travoprost: 48.12 ± 3.47 μm) versus vehicle control (27.91 ± 5.57 μm, P = 0.001) and minoxidil (38.12 ± 5.46 μm, P = 0.001). Bimatoprost showed the greatest regrowth by day 28, while latanoprost demonstrated earlier onset by day 15. PGAs also caused darker pigmentation and longer hair. The present study duration was limited to 4 weeks. Minoxidil (positive control) did not show noticeable hair growth because its effects usually take 6-8 weeks to appear. Topical PGAs improved key hair growth parameters. Bimatoprost and latanoprost showed early and superior efficacy by day 28.

PMID 42929802
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PubMedPeerJ2026-10-26

In vitro evaluation of N-acetylcysteine, calcium hydroxide, chlorhexidine digluconate and their combinations effect against five dental obligate anaerobic bacteria.

de Carvalho Lara Steffany LS, de Oliveira Júlia Andrade JA, Cezarino Gabriel Manente GM, Dos Santos Luiz Augusto Rodrigues LAR et al.

This study aimed to evaluate the antibacterial action of N-acetylcysteine (NAC), calcium hydroxide Ca(OH)2, chlorhexidine digluconate (CHX), and their combinations against five obligate anaerobic bacteria including Fusobacterium nucleatum, Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella intermedia, and Parvimonas micra in planktonic and biofilm forms. Eight experimental groups were evaluated in this study including saline solution (SS) (control group), Ca(OH)2, CHX, NAC, NAC + Ca(OH)2, NAC + CHX, Ca(OH)2 + CHX, and NAC + Ca(OH)2 + CHX. The anti-planktonic evaluation was performed by determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) following Clinical and Laboratory Standards Institute guidelines (CLSI M11). The antibiofilm was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and crystal violet (CV) assays. Data were analyzed statistically considering a significant level of (α ≤ 0.05). It was found that the MIC and MBC values of the tested intracanal medications ranged from 1.95-500 mg/mL. MTT and CV assays showed significant, species-dependent antibiofilm activity. CHX was most effective against F. nucleatum; NAC-based medications, especially combined with Ca(OH)2 and/or CHX, were superior against P. endodontalis, P. intermedia, and P. micra. Ca(OH)2-containing groups were particularly effective against P. gingivalis. Therefore, NAC + Ca(OH)2 and NAC + Ca(OH)2 + CHX can be considered as effective combinations of intracanal medication against different obligate anaerobic bacteria.

PMID 42928779
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PubMedG3 (Bethesda, Md.)2026-10-26

Evaluation of Trialling Efficiency of the Australian Wheatbelt.

Arief Vivi V, Ramakers Jip J C JJC, Fernandez Javier J, Boer Martin P MP et al.

The Australian wheatbelt is divided into three main growing regions: the North (New South Wales and Queensland), the South (Victoria, South Australia and Tasmania), and the West (Western Australia). Using wheat yield data from the 2015-2022 multi-environmental trials (METs) conducted by the National Variety Trials (NVT), this study examines genotype-by-environment interactions (G×E) and trialling efficiencies, within and across regions. The North had the highest mean yield (390 gm-2) and the largest proportion of phenotypic variance explained by G×E (64%), while the West had the lowest yield (355 gm-2) and the lowest G×E contribution (44%). Despite regional differences, yield gains were approximately 1.4 gm-2 per year (or ∼ 0.5% annually) across all regions. The West also showed the highest repeatability (0.85 ± 0.02) and the lowest least significance difference (5% LSD, 22 gm-2 ± 1 gm-2) for a benchmark five-year MET, compared to the South (0.70 ± 0.04, 35 ± 1.4 gm-2) and the North (0.59 ± 0.05, 35 ± 1.4 gm-2). Modelling results were consistent across regions and indicated that 2 years of testing at 20 sites per year delivered efficiencies that could not be improved very much further.

PMID 42928464
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PubMedThe New phytologist2026-10-26

Phosphatidylcholine acyl turnover facilitates thylakoid lipid remodeling and promotes plant survival under heat stress.

Xie Dongling D, Wang Shasha S, Fan Jilian J, Xu Changcheng C

Heat stress destabilizes chloroplast membranes, requiring rapid lipid remodeling to maintain photosynthetic function. Although thylakoid lipid remodeling and triacylglycerol (TAG) accumulation are established heat responses, the role of phosphatidylcholine (PC) acyl turnover remains unclear. We investigated lysophosphatidylcholine acyltransferase 1 and 2 (LPCAT1/2), REDUCED OLEATE DESATURATION1 (ROD1), phospholipid:diacylglycerol acyltransferase 1 (PDAT1), and lipins in heat-induced lipid remodeling and thermotolerance in Arabidopsis thaliana. Using genetic, lipidomic, physiological, and photosynthetic analyses, we examined mutants defective in PC acyl editing, PC-diacylglycerol (DAG) interconversion, TAG synthesis, and phosphatidic acid dephosphorylation during heat stress. Loss of LPCAT1/2 severely impaired basal and acquired thermotolerance, caused irreversible photosystem II damage, and disrupted thylakoid lipid remodeling. rod1 showed minor defects, whereas rod1 lpcat1/2 exhibited enhanced thermosensitivity. In mature vegetative plants, pdat1-2 showed thermotolerance and photosystem II defects comparable to lpcat1/2. Lipin-mediated phosphatidic acid dephosphorylation provided the major DAG source for heat-induced TAG synthesis. Defective PC acyl turnover also increased free fatty acids and lipid peroxidation. These findings establish LPCAT1/2-mediated PC acyl turnover as a central regulator of heat-induced membrane remodeling and thermotolerance and link lipin-dependent DAG production and TAG synthesis with chloroplast membrane homeostasis.

PMID 42928459
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PubMedInorganic chemistry2026-10-26

A Wide-Band-Gap Pyromellitic Diimide-Based Coordination Polymer for Selective and Visual Detection of Ultraviolet Rays.

Zhang Shimin S, Yuan Shuting S, Hao Pengfei P, Chang Tong T et al.

Owing to one of the main factors causing skin cancer by ultraviolet (UV) radiation emitted from the sun, the development of the effective method for selectively detecting UV rays is of great significance for human health. In this work, two compounds, [(H2CMPMD)·2DMF] (1) and [Cd(CMPMD)(DMF)2] (2), were synthesized by successively introducing DMF and Cd2+ ions into the ligand [H2CMPMD] (L) (H2CMPMD = N, N'-bis(carboxymethyl)-pyromellitic diimide). Interestingly, the photochromic performance progressively enhanced from L to 1 and then to 2, which should be mainly attributed to the different interfacial contacts of electron donors/acceptors (EDs/EAs). The continuous regulation of photochromic performance was achieved. Notably, 2 exhibited both high sensitivity and selectivity for the detection of UV rays due to the usage of the PMD ligand with a wide band gap. Furthermore, 2 was developed into a portable test strip (2-paper) for the visual detection of UV rays and information encryption, which enabled its application in practical scenarios. This work not only offers an effective strategy for the continuous modulation of photochromic properties but also presents a simple method for the visual and selective detection of UV rays.

PMID 42929614
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PubMedDentistry journal2026-10-26

Fluence-Dependent Effects of 940-nm Photobiomodulation on the Proliferation and Osteoblastic Differentiation of Human Periodontal Ligament Stem Cells.

Marković Jovan J, Marković Milan M, Đokić Jelena J, Tomić Sergej S et al.

Background/Objectives: Photobiomodulation (PBM) has been proposed to regulate periodontal tissue remodeling, but its effects on osteoblastogenesis in periodontal ligament stem cells (PDLSCs) remain highly dependent on laser parameters. This study investigated the fluence-dependent effects of 940 nm diode laser irradiation on the proliferation and osteoblastic differentiation of human PDLSCs. Methods: Six primary human PDLSC cultures were established and characterized using flow cytometry and multilineage differentiation assays. Cell proliferation was assessed after a single irradiation at fluences of 1, 2, 4, and 10 J/cm2. Osteoblastogenesis was induced using repeated irradiation regimens initiated at 2, 4, or 10 J/cm2 under suboptimal or complete osteogenic conditions and evaluated by Alizarin Red staining on day 21. The expression of osteogenic genes (RUNX2, BMP2, SPP1, TGFB1, COL1A1, ALPL, and BGLAP) was evaluated by qRT-PCR at different time points. Culture supernatants were analyzed for soluble osteogenic mediators. Results: The established PDLSC cultures had an MSC-like phenotype, robust osteogenic potential, moderate chondrogenic potential, and weak or no adipogenic potential. Proliferation of PDLSCs was considerably increased by PBM at 2 J/cm2 on day 7, whereas fluences of 4 and 10 J/cm2 inhibited proliferation. Osteoblastic mineralization was increased with the 2 J/cm2 irradiation regimen but was markedly reduced with the 10 J/cm2 regimen. Gene expression analysis confirmed this fluence-dependent response under optimal culture conditions. The 2 J/cm2 irradiation regimen significantly upregulated each analyzed osteogenic gene at one or more time points, whereas the 10 J/cm2 regimen downregulated RUNX2, BMP2, SPP1, COL1A1, and BGLAP. PBM at 2 J/cm2 also increased production of soluble BMP-2, OPG, PDGF-BB, ALP, and Leptin in a time-dependent manner. Conclusions: PBM exerts a fluence-dependent effect on human PDLSCs. A single irradiation at 2 J/cm2 increased proliferation, whereas the irradiation regimen initiated at 2 J/cm2 promoted osteoblastogenesis. In contrast, higher-fluence conditions, particularly the regimen initiated at 10 J/cm2, were inhibitory.

PMID 42930442
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