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travoprost (Travatan Z / Travantan Z / Travatanz)

✓ Approved

Novartis AG · PTGFR · 小分子

什么是 travoprost？

travoprost 是一种小分子，由Novartis AG研发。该药已获批，用于治疗相关适应症，给药途径：Others。

药物档案

商品名Travatan Z, Travantan Z, Travatanz
公司Novartis AG
药物类别小分子
分子靶点PTGFR
给药途径Others
状态Approved
来源： ClinicalTrials.gov, Novartis AG

作用机制

分子靶点

travoprost 作用于 1 个分子靶点：

PTGFRprostaglandin F receptor (FP)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

travoprost 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Eye disordersGlaucoma✓ Approved

相关研究文献

PubMedClinical ophthalmology (Auckland, N.Z.)2026-09-10

Intraoperative Quantification of Incision-Site Descemet Membrane Detachment During Phacoemulsification: A Paired-Eye Comparison of Longitudinal and Torsional Ultrasound.

Bulir Petr P, Studeny Pavel P

To quantify the extent of clinically non-significant Descemet membrane detachment (DMD) at the clear corneal incision (CCI) during phacoemulsification and to compare its extent between longitudinal and torsional ultrasound modulation as a morphological marker of local tissue-instrument interaction. In this prospective contralateral-eye comparative randomized study, 14 patients (28 eyes) undergoing bilateral cataract surgery were included. One eye received longitudinal and the fellow eye torsional ultrasound (Constellation system, Alcon). DMD was assessed intraoperatively using microscope video recordings under red reflex illumination. Still images were analyzed, and DMD area (mm2) at the internal wound was measured. Correlations with cumulative dissipated energy (CDE) was evaluated. Incision-site DMD was detected in all analyzed cases (100%) using intraoperative red reflex-based visualization. Mean DMD area was 1.33 ± 0.43 mm2 (longitudinal) and 2.37 ± 0.67 mm2 (torsional), with a mean difference of 1.04 mm2 ± 0.74 mm2 (95% CI, 0.60-1.48). The paired analysis demonstrated a highly significant difference (p < 0.001). No correlation was found between DMD extent and CDE. Clinically non-significant incision-site DMD appears to be a frequent intraoperative morphological phenomenon during phacoemulsification when assessed using sensitive visualization techniques. Torsional ultrasound was associated with a significantly greater DMD extent than longitudinal modulation. Rather than indicating greater clinical damage, DMD area may serve as a sensitive quantitative morphological marker of local tissue-instrument interaction at the corneal incision. Its potential value therefore lies primarily in the comparative evaluation and future refinement of phacoemulsification technologies, while the clinical significance of these subtle morphological differences remains to be established.

PMID 42719804
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PubMedDalton transactions (Cambridge, England : 2003)2026-09-10

Magneto-structural correlations in multinuclear Dy/Zn complexes: controlling magnetic relaxation through anisotropy and exchange interactions.

Panja Anangamohan A, Jagličić Zvonko Z, Jana Narayan Ch NC, Brandão Paula P et al.

The rational design of lanthanide-based single-molecule magnets (SMMs) requires an understanding of how structural variations influence magnetic anisotropy, exchange interactions, and relaxation dynamics. Herein, we report a family of multinuclear Dy(III)/Zn(II) complexes supported by a compartmental Schiff-base ligand, including two tetranuclear Dy4 clusters, [Dy4(L)2(HL)2(μ-OH)2(NO3)2](NO3)2·H2O (1) and [Dy4(L)2(μ-OH)2(μ-pnba)4(pnba)2]·3CH3CN (2), and two heterometallic Zn-containing complexes, [Zn2Dy2(L)2(μ-CO3)2(NO3)2]·0.5H2O·CH3OH (3) and [ZnDy(L)(μ-tfa)(hfac)2] (4). Single-crystal X-ray diffraction studies reveal that variations in the bridging modes, coordination environments, and metal-ion arrangements generate distinct structural motifs. Magnetic studies demonstrate diverse magnetic behaviours arising from differences in Dy(III) magnetic interactions and relaxation pathways. In particular, the Dy4 complexes exhibit different magnetic responses despite comparable Dy⋯Dy separations, indicating that the relative arrangement of the Dy(III) coordination environments plays a crucial role in determining the nature of magnetic interactions. Ab initio CASSCF calculations provide further insight into the relationship between structural features and magnetic properties by revealing variations in Dy(III) magnetic anisotropy and easy-axis orientations. The Zn-containing complexes further highlight the influence of magnetic-ion arrangement and nuclearity on relaxation dynamics. Correlation of structural, magnetic, and theoretical results suggests that the orientation of Dy(III) anisotropy axes, together with the balance between exchange and dipolar interactions, governs the observed magnetic behaviour. This study provides insights into the magneto-structural relationships controlling magnetic relaxation in multinuclear Dy-based complexes.

PMID 42720195
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PubMedEuropean journal of oral sciences2026-09-10

Effect of chitosan-containing desensitizers applied prior to bleaching on the physical properties of enamel.

Barbato Júlia J, Passos Luís Otávio LO, Barbosa Carolina Meneghin CM, Benati Marcos Roberto de Lima MRL et al.

This in vitro study evaluated the effects of adding chitosan (Chi) to desensitizing agents applied before dental bleaching on enamel properties. Bovine enamel specimens were allocated to seven groups (n = 12): no treatment (negative control), 2% NaF (positive control), 2% NaF + 2% Chi, 2% NaF + 5% Chi, 2% NaF + 5% KNO3, 2% NaF + 5% KNO3 + 2% Chi, and 2% NaF + 5% KNO3 + 5% Chi. All specimens underwent three bleaching sessions with 35% hydrogen peroxide, each preceded by a 10-min application of desensitizing agents. Color change (∆L*, ∆a*, ∆b*, ∆Eab, and ∆E00), whiteness index (∆WID), surface roughness (Ra), and microhardness (SMH) were evaluated at baseline (T0) and after each session (T1-T3). Scanning electron microscopy analysis was performed at T3. Color parameters did not differ among groups (p > 0.05), indicating bleaching efficacy. Surface roughness increased in all groups (p < 0.0001), with greater increases in chitosan-containing groups. However, groups 2% NaF + 5% Chi and 2% NaF + 5% KNO3 + 5% Chi showed significantly higher microhardness values than controls at T2 and T3. Incorporation of chitosan into desensitizing agents increased enamel surface roughness but preserved microhardness without compromising bleaching efficacy. These findings suggest chitosan may represent strategy for protecting enamel during in-office bleaching.

PMID 42719982
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PubMedStress biology2026-09-10

Lycopene mitigates T-2 toxin-induced systemic inflammation and oxidative stress in association with gut microbiota and SCFAs regulation in mice.

Adam Saber Y SY, Ennab Wael W, Zhu Cuipeng C, Yuan Long L et al.

T-2 toxin is a trichothecene mycotoxin produced by Fusarium species and can cause disease after contaminated food or feed ingestion. This study aimed to investigate the impact of lycopene (Ly) on systemic inflammation, oxidative stress, and dysbiosis in mice exposed to T-2 toxin. A total of 20 male BALB/c mice (6 weeks old, weighing 23.5 ± 0.32 g) randomly divided into four groups (n = 5): Control (Cont), Ly, T-2, and T-2 + Ly groups. Findings revealed that Ly enhanced the body weight, feedd, and water intake that have been reduced by T-2. Ly increased the villus height (VH) and VH: crypt depth (CD) and decreased CD and villus width (VW) in ileum compared to the T-2 group. In alpha diversity, Staphylococcus and Corynebacterium were the most prevalent in Cont group; Staphylococcus, and Lactobacillus, were the most prevalent in T-2 group; Candidatus-Arthromitus and Staphylococcus were the most prevalent in T-2 + Ly group. Moreover, T-2 mice had significantly (p < 0.05) greater levels of interleukin-1 beta (IL-1β), interferon gamma (IFN-γ), Interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-α) than Cont, while the Ly significantly (p < 0.05) lowered their concentration. The T-2 mice had significantly (p < 0.05) higher levels of reactive oxygen species (ROS) and malondialdehyde (MDA), while their catalase (CAT),, glutathione (GSH), adenosine triphosphate (ATP), and superoxide dismutase 1(SOD1) activities were significantly (p < 0.05) lower than Cont. Ly significantly (p < 0.05) restored their concentration. Moreover, there was a significant reduction (p < 0.05) of hexanoic, butyric, acetic, pentanoic, and Heptanoic acids in the T-2 mice compared to Cont. In contrast, treatment with Ly was found to significantly restore their levels compared to T-2 group. We conclude that Ly administration in the context of T-2-induced toxicity may help attenuate systemic oxidative stress and inflammation, possibly through modulation of gut microbiota and fecal short-chain fatty acids (SCFAs).

PMID 42720699
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PubMedScandinavian journal of gastroenterology2026-09-10

Autoimmune pancreatitis type 2 and its relationship with inflammatory bowel disease: a narrative review.

Ejsing J G JG, Jensen M D MD, Jørgensen M T MT

This narrative review provides an update of the literature on autoimmune pancreatitis type 2 (AIP-2) and its relationship with inflammatory bowel disease (IBD) in adults. Due to the rarity of this condition, the literature on the topic is sparse. AIP-2 is a pancreas specific condition in contrast to autoimmune pancreatitis type 1, which is the pancreatic manifestation of immunoglobulin G4-related disease. AIP-2 has a strong association with IBD, especially ulcerative colitis. To establish this review a systematic search using the PubMed database was carried out for English language articles concerning AIP-2 and IBD in an adult population from inception until November of 2025. Every article was screened for eligibilty and included if found relevant. AIP-2 should be suspected in IBD patients with signs of acute pancreatitis, painless jaundice or a pancreatic mass without an obvious explanation. A definitive diagnosis requires a representative histological sample obtained preferentially with an endoscopic ultrasound guided needle biopsy. A probable diagnosis can be obtained through radiological findings, coexistence of IBD and clinical response to corticosteroids. Corticosteroids are the first-line treatment of an acute flare of AIP-2 if it doesn't resolve spontaneously. In patients with relapsing, steroid refractory or steroid dependent AIP-2, maintenance therapy can be considered to prevent flare-ups and progression to chronic pancreatitis. In patients with IBD and AIP-2, it is important to consider a relapse preventative strategy that has effect on both conditions.

PMID 42717776
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PubMedMicrobiology spectrum2026-09-10

A bireporter recombinant SARS-CoV-2 Omicron BA.5 for in vitro and in vivo studies.

Castro Esteban M EM, Barre Ramya S RS, Ye Chengjin C, Imbiakha Brian B et al.

The continuous emergence of variants of concern (VoCs) represents a significant challenge to effectively control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although FDA-approved vaccines and antivirals have been successfully developed and implemented for the prophylactic and therapeutic intervention of SARS-CoV-2 infection, recent VoCs could escape protection garnered by previous vaccine and antiviral approaches. Determining the efficacy of prophylactics and/or therapeutics against recent VoCs will assist in efficiently controlling currently circulating SARS-CoV-2 strains. We used our previously described bacterial artificial chromosome-based reverse genetics approach for Omicron BA.5 to generate a recombinant SARS-CoV-2 BA.5 encoding a fusion of ZsGreen to Nanoluciferase (rBA.5 ZsG-Nluc) from the locus of the viral nucleocapsid (N) protein separated by the porcine teschovirus-1 2A proteolytic cleavage site. The rBA.5 ZsG-Nluc replicates to levels comparable to recombinant BA.5 wild type (rBA.5 WT) and expresses high levels of ZsG and Nluc in cultured cells. This facilitates tracking viral infection and the identification of antivirals and neutralizing antibodies with EC50 and NT50 values, respectively, similar to those obtained with rBA.5 WT. Importantly, in Keratin-18 human angiotensin-converting enzyme-2 mice, rBA.5 ZsG-Nluc retains the same pathogenicity and ability to replicate in the lungs of infected mice as rBA.5 WT. Using rBA.5 ZsG-Nluc, we detected Nluc activity systemically and Nluc and ZsG expression in the lungs of infected mice using an in vivo imaging system. Our results demonstrate the feasibility of using rBA.5 ZsG-Nluc to track viral infections and identify prophylactics and therapeutics against recent SARS-CoV-2 VoCs in vitro, ex vivo, and in vivo.IMPORTANCESevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus of the coronavirus disease 2019 pandemic, is continually evolving to escape immunity acquired by previous natural infections or vaccinations. Moreover, recent SARS-CoV-2 variants of concern (VoCs) have acquired antiviral-resistant mutations to FDA-approved drugs. The emergence of these VoCs highlights the importance of identifying new prophylactics and therapeutics against currently circulating SARS-CoV-2 strains. We generated a recombinant bireporter Omicron BA.5 SARS-CoV-2 (rBA.5 ZsG-Nluc) that expresses reporter proteins, which are useful for cellular and whole animal studies, and has similar viral replication and pathogenicity to a wild-type recombinant Omicron BA.5 SARS-CoV-2. In Keratin-18 human angiotensin-converting enzyme-2 mice, rBA.5 ZsG-Nluc infection can be tracked systemically or in the lungs of infected mice using an in vivo imaging system. We establish a proof-of-concept platform of rBA.5 ZsG-Nluc in combination with an ancestral SARS-CoV-2 strain expressing mCherry to simultaneously identify antivirals and neutralizing antibodies against original and recent SARS-CoV-2 strains.

PMID 42720299
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