北京若生智能科技有限公司
Drug Database
S-

S-amlodipine gentisate (Nexad / Nexad TAb)

✓ Approved

SK Chemicals · CACNA1C · 小分子

什么是 S-amlodipine gentisate？

S-amlodipine gentisate 是一种小分子，由SK Chemicals研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Nexad, Nexad TAb
公司SK Chemicals
药物类别小分子
分子靶点CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, SK Chemicals

作用机制

分子靶点

S-amlodipine gentisate 作用于 1 个分子靶点：

CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

S-amlodipine gentisate 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

相关研究文献

PubMedHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026-10-26

A Practical Treatment Platform Version 3.0 for Using Angiotensin Receptor Blocker-Based Single-Pill Combinations in Patients With Hypertension.

Tocci Giuliano G, Burnier Michel M, de la Sierra Alejandro A, Grassi Guido G et al.

Elevated blood pressure (BP) is the leading cause of cardiovascular disease and a major contributor to mortality, affecting almost one third of the adult population worldwide. Despite strong scientific evidence, guidelines and multiple therapeutic options, many patients remain undertreated or uncontrolled, largely due to poor medication adherence and medical inertia. Complexity of multi-pill regimens contributes significantly to non-adherence, whereas single-pill combinations (SPCs) improve adherence and persistence, accelerate BP control, and promote better long-term outcomes than multiple combinations. Appropriate selection of SPC in individual hypertensive patients may be a difficult though very important task for physicians. Thus, development of tools that may facilitate use of SPC in clinical practice is desirable. Among renin-angiotensin system blockers, olmesartan (OM) has demonstrated sustained efficacy, favourable tolerability, both as monotherapy and in SPCs with amlodipine and/or hydrochlorothiazide, which are available in multiple dosages. The present OM-based platform builds on earlier frameworks and incorporates guidelines' updates complemented by a systematic review of available literature. This "3.0" proposal expands patient categorization to include comorbidities or complications often overlooked in clinical practice guidelines, providing a practical, evidence-based approach to support individualized hypertension management complementing guideline recommendations.

PMID 42928416
阅读全文 →
PubMedBMC infectious diseases2026-10-26

Clinical characteristics of infections due to Staphylococcus lugdunensis compared to other staphylococcal infections.

Bou Harb Souad S, Mansour Reem R, Al Zoghby Lea L, Khazzeka Alicia A et al.

Staphylococcus lugdunensis is a coagulase-negative staphylococcal species with virulence characteristics resembling those of Staphylococcus aureus. Despite its increasing recognition as a clinically significant pathogen, data comparing its clinical outcomes with other staphylococcal infections remain limited. This study aimed to compare the clinical characteristics, outcomes, and factors associated with unfavorable clinical outcomes among patients with S. lugdunensis, S. aureus, and Staphylococcus epidermidis infections. We conducted a retrospective cohort study at the American University of Beirut Medical Center between January 2019 and December 2023. Adult patients with S. lugdunensis infections were identified and matched by site of infection to patients with S. aureus and S. epidermidis infections. Demographic, clinical, microbiological, treatment, and outcome data were collected. Bivariable analyses and multivariable logistic regression were performed to identify factors independently associated with unfavorable clinical outcome, defined as a composite of in-hospital mortality and major infection-related complications. A total of 301 patients were included: 101 with S. lugdunensis, 103 with S. aureus, and 97 with S. epidermidis infections. Skin and soft tissue infections were the most common presentation of S. lugdunensis (72%), followed by urinary tract infections (16%), bacteremia (8%), and respiratory infections (4%). Compared with S. aureus, S. lugdunensis infections were associated with lower rates of persistent bacteremia (0% vs. 4.9%, p = 0.025) and higher rates of acute renal failure (8.9% vs. 1.9%, p = 0.028). No significant outcome differences were observed between S. lugdunensis and S. epidermidis infections. Overall in-hospital mortality rates were 7.9%, 5.8%, and 7.2% for S. lugdunensis, S. aureus, and S. epidermidis, respectively. In multivariable analysis, S. aureus infection was associated with lower odds of unfavorable clinical outcome than S. lugdunensis (aOR 0.31, 95% CI 0.13-0.75), whereas no significant difference was observed between S. lugdunensis and S. epidermidis. Diabetes mellitus (aOR 2.71, 95% CI 1.27-5.82) and hospitalization within the previous 30 days (aOR 1.97, 95% CI 1.26-3.06) were independently associated with unfavorable clinical outcome. S. lugdunensis demonstrates clinical characteristics and outcomes overlapping those of S. aureus and S. epidermidis. Prompt recognition and appropriate management remain essential to optimize clinical outcomes.

PMID 42928117
阅读全文 →
PubMedInorganic chemistry2026-10-26

Flexible Transparent Scintillation Films Based on Chiral Molecular Scintillators Showing Strong Circularly Polarized Luminescence and High-Resolution X-ray Imaging.

Tan Li-Hong LH, Yin Si-En SE, Shi Jia-Ran JR, Hu Jun-Jie JJ et al.

Flexible scintillation films based on chiral molecular scintillators have considerable potential for application in advanced technologies, such as three-dimensional displays, optical information storage, and high-resolution diagnostic imaging. Herein, a pair of chiral Cd-Tb complex enantiomers [(R, R)/(S, S)-(L)2TbCd2(H2O)4] (ClO4)3 (R/S -Cd-Tb) was synthesized, and they exhibit a high PLQY of 38.40% and strong circularly polarized luminescence (CPL) with asymmetry factors of 4.69 × 10-2. R/S -Cd-Tb has strong X-ray scintillation performance with a light yield of 2136 and 2111 ph·MeV-1 based on LuAG:Ce and the X-ray detection limit of 50.6 and 52.1 nGy·s-1, respectively. Chiral flexible transparent scintillation films of R/S -Cd-Tb@PMMA were prepared using R/S -Cd-Tb, and the asymmetry factor of the R/S -Cd-Tb@PMMA film is 2.4 × 10-2. The R/S -Cd-Tb@PMMA film exhibits strong circularly polarized radioluminescence (CPRL) and circularly polarized light-emitting diode emission (CP-LEDs). Moreover, it can deliver prominent CPRL signals and achieve high-resolution X-ray imaging with a spatial resolution of 23.96 lp/mm. The results indicate that chiral lanthanide complexes represent a promising class of chiral molecular scintillator materials.

PMID 42929642
阅读全文 →
PubMedJournal of applied toxicology : JAT2026-10-26

Large-Scale Monitoring, Biochemical Mechanism, and Fitness Cost of Resistance to Chlorfenapyr in a Near-Isogenic Strain of Spodoptera litura (Lepidoptera: Noctuidae) From China.

Liu Chenghong C, Tang Juan J, Qu Cheng C, Ma Xiaoli X et al.

Spodoptera litura is a globally important polyphagous herbivore that has developed resistance to many widely used insecticides. Chlorfenapyr is a pyrrole insecticide with demonstrated efficacy against lepidopteran pests, but the susceptibility baseline and field-evolved resistance in S. litura remain poorly characterized. In this study, we built a near-isogenic strain (JZ-NIL) based on one field-collected chlorfenapyr-resistant population of S. litura and characterized patterns of cross-resistance, fitness costs, and mechanism of metabolic resistance. In comparison with the susceptible Lab-S strain, the field-sampled JZ population displayed approximately 225.0-fold resistance to chlorfenapyr. The JZ-NIL strain was built and showed 124.2-fold chlorfenapyr resistance, with no apparent cross-resistance to broflanilide, chlorpyrifos, chlorantraniliprole, emamectin benzoate, indoxacarb, and spinetoram. Assays of enzyme activity and tests of synergism showed that diethyl maleate (DEM) made a synergistic ratio of 1.9 against chlorfenapyr, and glutathione S-transferase (GST) activity in JZ-NIL was 1.8-fold significantly higher than in the strain of Lab-S, indicating that GST-mediated metabolism contributes to chlorfenapyr resistance. In addition, pupation rate, fecundity, and hatchability were significantly lower in JZ-NIL than in Lab-S. The relative fitness of JZ-NIL was 0.54 compared with Lab-S. Overall, these results indicate that GST-mediated detoxification contributes to chlorfenapyr resistance in S. litura and that this resistance is associated with significant fitness costs. Further studies are needed to clarify the metabolic and target-site mechanisms underlying chlorfenapyr resistance.

PMID 42928584
阅读全文 →
PubMedInorganic chemistry2026-10-26

Terminal Oxygen as a Proton Acceptor: S-H Activation via Proton-Coupled Electron Transfer in Decavanadate-Catalyzed P(O)-S Coupling.

Wang Li Li LL, Shu Wei-Xuan WX, Wang Ya Y, Zhong Rong-Lin RL et al.

Polyoxometalates-catalyzed P-S oxidative coupling under mild conditions has emerged as a promising sustainable route to thiophosphates for pharmaceuticals and agrochemicals. This work reveals that the decavanadate cluster-catalyzed oxidative coupling between phosphine oxide and thiophenol involves four elementary steps, in which the rate-determining step is S-H bond activation via proton-coupled electron transfer (PCET). The polyoxovanadate cluster acts as a proton relay station, stabilizing the key proton in the transition state and facilitating its transfer. Interestingly, the proton preferentially transfers to a terminal oxygen rather than a bridging oxygen, with simultaneous electron transfer to the adjacent vanadium center. The terminal oxygen atom is more reactive than the bridging one because the [H3V10VO28]3- skeleton incurs a smaller electronic reorganization penalty for electron transfer in the terminal oxygen via a PCET pathway. On the other hand, the preferential activation of the S-H bond over the P-H bond in the [H3V10VO28]3--catalyzed reaction arises from both the smaller S-H bond dissociation energy and the better orbital energy match with the thiol substrate. These findings provide a theoretical foundation for understanding PCET in polyoxometalate catalysis and expanding the application of POMs in organic synthesis.

PMID 42929611
阅读全文 →
PubMedInorganic chemistry2026-10-26

Solvent-Directed Self-Assembly of Chiral Metal-Organic Cages and Coordination Polymers from Identical Components and Their Circularly Polarized Luminescence.

Zhang Xu-Zong XZ, Zhou Chuang-Wei CW, Lai Ya-Liang YL, Xie Mo M et al.

This work reports the solvent-directed synthesis, structures, and chiroptical properties of enantiomeric Zn(II) metal-organic cages (MOCs) and coordination polymers (CPs) assembled from identical subcomponents under the same conditions. Varying the DMF/MeOH ratio selectively produces either a discrete cubic cage (1-R/S) or a chain polymer (2-R/S). Both materials exhibit blue emission, with the MOCs demonstrating higher solid-state quantum yields. MOCs 1-R/S in poly(methyl methacrylate) films exhibit clear circularly polarized luminescence (CPL) (|glum| ≈ 4.0 × 10-4), whereas CPs 2-R/S display very weak CPL signals (|glum| ≈ 1.0 × 10-5). This work highlights that the supramolecular structure determines the CPL performance of excited-state chirality.

PMID 42929619
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多S-amlodipine gentisate