若生智能
Drug Database
S-

S-amlodipine gentisate (Nexad / Nexad TAb)

✓ Approved

SK Chemicals · CACNA1C · 小分子

什么是 S-amlodipine gentisate？

S-amlodipine gentisate 是一种小分子，由SK Chemicals研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Nexad, Nexad TAb
公司SK Chemicals
药物类别小分子
分子靶点CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, SK Chemicals

作用机制

分子靶点

S-amlodipine gentisate 作用于 1 个分子靶点：

CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

S-amlodipine gentisate 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

相关研究文献

PubMedMedical sciences (Basel, Switzerland)2026-07-27

Real-World Pharmacotherapy-Driven Cardiovascular Risk Prediction Using Interpretable Machine Learning and Jordanian EHR Data.

Moshawih Said S, Gharaibeh Lobna L, Alfreahat Islam I, Shnoudeh Abeer Jabra AJ

Background: Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with over 75% of deaths occurring in low- and middle-income countries, where conventional risk models often demonstrate poor calibration and limited generalizability. Objective: This study aimed to develop an interpretable, pharmacotherapy-informed machine learning model for cardiovascular risk prediction using national electronic health record (EHR) data from Jordan. Methods: A retrospective cohort study was conducted using approximately 600,000 individuals from the national Hakeem EHR system (2018-2022). Demographic, clinical, blood pressure, laboratory, and medication data were integrated to construct three datasets reflecting varying levels of feature completeness. Multiple machine learning models were benchmarked, followed by optimization, hybrid modeling, and probability calibration. Model interpretability was assessed using SHAP analysis. Results: The national cohort demonstrated a high cardiometabolic burden, with prevalence of hypertension (50.2%), hyperlipidemia (54.9%), and diabetes (47.9%). Antihypertensive and lipid-lowering therapies were more frequently used among CVD patients (56.9% and 49.6%, respectively). Treatment patterns were dominated by amlodipine (19.9%) and atorvastatin (74.4%). The final calibrated seed-bagged gradient boosting model achieved robust performance (ROC-AUC 0.844; PR-AUC 0.813) with consistent generalization across datasets. Key predictors included antihyperlipidemic therapy, systolic blood pressure variability, age, and sex. Conclusions: This study presents JoRisk, a calibrated and interpretable machine learning framework that integrates pharmacotherapy and clinical data for short-term cardiovascular risk prediction. The model demonstrates strong performance using routinely available EHR variables and offers a scalable decision-support tool for risk stratification in resource-constrained healthcare systems.

PMID 42506312
阅读全文 →
PubMedInternational journal of biological macromolecules2026-07-27

Functional role of the diadenylate cyclase gene cdaA in stress responses of the dairy starter Streptococcus thermophilus.

Fan Yizhou Y, Liu Xinxin X, Song Xin X, Wang Guangqiang G et al.

Streptococcus thermophilus is a key dairy starter culture widely used in the production of yogurt and cheese, where its robustness in stress adaptation and growth performance is critical for industrial fermentation efficiency. Cyclic di-AMP (c-di-AMP) is a key second messenger involved in regulating osmotic homeostasis and stress adaptation in bacteria. However, the role of c-di-AMP in S. thermophilus remains unexplored. Here, cdaA, encoding a diadenylate cyclase containing a conserved DisA_N domain responsible for c-di-AMP synthesis, was identified in S. thermophilus S-3 through bioinformatic analysis and validated by LC-MS/MS. The cdaA gene knockout strain, S-3ΔcdaA, was unable to synthesize c-di-AMP and exhibited a markedly shortened lag phase. Stress response assays revealed that S-3ΔcdaA was sensitive to osmotic and ethanol stress, indicating that cdaA is essential for stress tolerance. Specifically, S-3ΔcdaA showed almost no growth in chemically defined medium (CDM) supplemented with 300 mM potassium or sodium chloride, whereas the wild-type S-3 reached OD600 values of 0.72 and 0.52, respectively. Under 5% ethanol stress, the specific growth rate of S-3ΔcdaA dropped significantly to 0.35 relative to S-3 compared to 1.10 in CDM medium alone. Interestingly, S-3ΔcdaA retained the ability to grow under 0.01% oxgall stress, reaching an OD600 of 0.83, while growth of S-3 was completely abolished. It suggested that absence of cdaA confers a survival advantage under bile salt stress. Taken together, these results showed that cdaA is critical for osmotic and ethanol tolerance but negatively modulates bile salt resistance in S. thermophilus.

PMID 42503376
阅读全文 →
PubMedDentistry journal2026-07-27

Quantitative Assessment of Primary Colonizer Adhesion on Different Resin-Based Restorative Materials Using SYBR Green qPCR.

Schmitz Lea Aylin LA, Parkhoo Kamelia K, Heitkamp Stefan S, Romanos Georgios E GE et al.

Background/Objectives: The aim of this study was to investigate primary colonizers adhering to the oral biofilm on five adhesive restorative materials. Methods: For each material (Admira Fusion, Clearfil AP-X, Durafill VS, Filtek Supreme XTE, and Venus Diamond), sixteen test specimens were prepared according to a standardized protocol. For pellicle formation, the specimens were incubated for two hours at 37 °C with sterile-filtered inactivated human saliva. The bacteria (Streptococcus oralis (S. oralis), Streptococcus gordonii (S. gordonii), Streptococcus sanguinis (S. sanguinis), Streptococcus mitis (S. mitis), and Actinomyces naeslundii (A. naeslundii)) were cultivated and suspended. A bacteria mix was prepared from the suspensions. The specimens with pellicles were wetted with the bacterial mix and incubated at 37 °C for 8 h. The total genomic DNA of the adhered bacteria was isolated and subsequently quantified using SYBR Green qPCR. Results: For S. gordonii, S. oralis, and A. spp., no significant differences in the amount of adhered bacterial DNA were found between the different materials. S. mitis DNA concentration was significantly higher on Filtek Supreme XTE compared to the other materials. Significantly higher DNA concentrations of S. sanguinis could also be detected on Filtek Supreme XTE compared to Clearfil AP-AX and Durafill VS. Conclusions: The investigated restorative materials showed species-specific differences in bacterial adhesion, with Filtek Supreme XTE exhibiting higher adhesion of S. mitis and S. sanguinis, whereas no differences were observed for the other tested species.

PMID 42505696
阅读全文 →
PubMedMikrochimica acta2026-07-27

DNA tetrahedrons based DNA microcapsules for sensitive fluorescence sensing of Staphylococcus aureus.

Li Zongbing Z, Cui Yanyang Y, Pan Zhouqi Z, Feng Qiumei Q et al.

A sensitive fluorescence (FL) biosensor was developed for the detection of Staphylococcus aureus (S. aureus) using DNA tetrahedrons (DTNs) based stimuli-responsive DNA microcapsules. FAM-labeled DTNs were initially encapsulated within the inner pores of DNA microcapsules. Owing to the physical shielding effect of the DNA shell, no FL signal was detected, maintaining the biosensor in a "fluorescence off" state. Upon exposure to S. aureus, the aptamer specifically bound to the target bacteria, triggering the disassembly of the DTN-loaded DNA microcapsules. This led to the controlled release of FAM-labeled DTNs and the subsequent recovery of the FL signal. Based on this, sensitive and specific detection of S. aureus was achieved with a detection limit of 0.36 CFU∙mL- 1. Moreover, satisfactory results were obtained for S. aureus detection in spinach leaves, milk and human serum, demonstrating that the proposed sensing system held promising application prospects for the detection of S. aureus in food and related complex matrices.

PMID 42506997
阅读全文 →
PubMedPlant physiology2026-07-27

Methionine overaccumulation reinforces heterochromatic non-CG hypermethylation and transposon silencing in Arabidopsis.

Yerushalmy Yonatan Y, Lieberman-Lazarovich Michal M, Mohanty Devasantosh D, Mittler Ron R et al.

Methionine is a key sulfur-containing amino acid and the precursor of S-adenosylmethionine, the universal methyl donor for DNA and histone methylation. While reduced S-adenosylmethionine availability is known to cause DNA hypomethylation, the effects of elevated methionine/S-adenosylmethionine remain poorly understood. Here, we addressed the effect of elevated methionine using the mto1 mutant of Arabidopsis thaliana, which over-accumulates methionine and S-adenosylmethionine due to a mutation in cystathionine γ-synthase, the first committed enzyme of methionine biosynthesis. Whole-genome bisulfite sequencing analysis revealed widespread hypermethylation in mto1, particularly in non-CG contexts (CHG and CHH), with the strongest changes found in pericentromeric heterochromatin. Hypermethylation was concentrated within transposable elements (TEs), especially from the Gypsy and Copia superfamilies. Transcriptome profiling showed that TE-genes were broadly downregulated, consistent with reinforced TE silencing due to hypermethylation. When the expression level of ONSEN (copia 78) was examined under heat stress, it was found to be significantly lower than in the wild type. In addition, compared to wild type, mto1 showed significantly greater reactive oxygen species accumulation. These findings suggest a link between elevated methionine levels and altered stress responses. Despite the observed epigenetic changes, the expression of core DNA methyltransferases and demethylases genes was essentially unchanged, suggesting that increased S-adenosylmethionine availability enhances enzymatic activity rather than gene expression. Together, these findings demonstrate that an excess of methionine/S-adenosylmethionine reinforces heterochromatic DNA methylation and transposon silencing, providing new insights into the connection between amino acid metabolism and epigenetic regulation in plants.

PMID 42506985
阅读全文 →
PubMedJournal of clinical microbiology2026-07-27

Clinical implications of a single Staphylococcus lugdunensis-positive blood culture: true bacteremia vs. contamination.

Yogo A A, Krishnan J J, Lewin G R GR, Hojat L S LS et al.

Staphylococcus lugdunensis is a common skin commensal. However, S. lugdunensis found in multiple blood culture sets is concerning for life-threatening bacteremia. When a single set is positive, the National Healthcare Safety Network classifies S. lugdunensis as a common commensal (contaminant), while multiple publications found bacteremia and suggested an Infectious Diseases (ID) consultation. Here, a retrospective review spanning 9 years at a large health system evaluated the clinical significance of a single-positive S. lugdunensis blood culture when multiple cultures were collected. S. lugdunensis was found in blood cultures from 137 patients, who were stratified into single (n = 46) and multiple (n = 91) set-positive groups. The single-positive group was more likely to be deemed contaminants by clinicians, less likely to have a diagnosis of endocarditis or catheter-related bloodstream infection, and less likely to have an intravascular device (P < 0.01). Treatment occurrence and duration were also statistically different (P < 0.01). Single-positive cultures were statistically more likely to be polymicrobial (P = 0.04). Additionally, each case was reclassified as significant bacteremia, indeterminate bacteremia, or contamination using the Souvenir criteria. In single-positive cultures, significant bacteremia occurred less often (12.1% vs. 43.5%, P < 0.01), while contamination was more common (81.3% vs. 32.6%, P < 0.01). Of note, nearly all significant bacteremia cases involved an intravascular device (96.8%). Taken together, these findings suggest single-positive S. lugdunensis blood cultures are often contaminants, but certain clinical features, including intravascular devices, strongly predict bacteremia. A single-positive blood culture set with Staphylococcus lugdunensis can be difficult to distinguish between contamination and bacteremia. Conflicting clinical guidance has added to the confusion and emphasizes the need for additional studies. Our results suggest a single-positive S. lugdunensis blood culture set often reflects contamination and polymicrobial cultures, whereas multiple-positive sets strongly predict significant bacteremia. We also identified predictors of significant bacteremia, such as the presence of an intravascular device, emphasizing the need to incorporate additional metrics into clinical decision-making algorithms. Our findings underscore the role of clinical judgment when S. lugdunensis is recovered from a blood culture. Taken together, the proposed practice for the microbiology laboratory is to include a contamination comment on the report of a single-positive S. lugdunensis blood culture set and to recommend an infectious disease consultation for clinical adjudication.

PMID 42506932
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多S-amlodipine gentisate